was read the article
array:20 [ "pii" => "X2013251412001043" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Feb.11394" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:417-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4788 "formatos" => array:3 [ "EPUB" => 302 "HTML" => 3779 "PDF" => 707 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699512001046" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2012.Feb.11394" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2012;32:417-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 13192 "formatos" => array:3 [ "EPUB" => 308 "HTML" => 11643 "PDF" => 1241 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Hipertrigliceridemia severa. Tratamiento con plasmaféresis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "417" "paginaFinal" => "418" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Severe hypertriglyceridaemia. Treatment with plasmapheresis" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11394_108_27439_es_11394_t1.jpg" "Alto" => 149 "Ancho" => 600 "Tamanyo" => 66594 ] ] "descripcion" => array:1 [ "es" => "Niveles de colesterol total, triglicéridos, HDL y LDL tras la primera sesión de aféresis" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin" "autores" => array:2 [ 0 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Izquierdo-Ortiz" ] 1 => array:2 [ "Iniciales" => "P." "apellidos" => "Abaigar-Luquin" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251412001043" "doi" => "10.3265/Nefrologia.pre2012.Feb.11394" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001046?idApp=UINPBA000064" "url" => "/02116995/0000003200000003/v0_201502091350/X0211699512001046/v0_201502091351/es/main.assets" ] ] "itemAnterior" => array:17 [ "pii" => "X2013251412001051" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Feb.11326" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:416-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4477 "formatos" => array:3 [ "EPUB" => 308 "HTML" => 3467 "PDF" => 702 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Bilateral renal infarctions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "416" "paginaFinal" => "417" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infartos renales bilaterales" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11326_16025_30599_en_f11511326.jpg" "Alto" => 573 "Ancho" => 646 "Tamanyo" => 304581 ] ] "descripcion" => array:1 [ "en" => "Abdominal axial computed tomography" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marta Cuberes-Izquierdo, Nerea Yanguas-Barea, Olga Martorell-Almau, Ángel Gamen-Pardo, Eduardo Parra-Moncasi, Raquel Artal-Sánchez, Rosa Cozcolluela-Cabrejas" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Marta" "apellidos" => "Cuberes-Izquierdo" ] 1 => array:2 [ "nombre" => "Nerea" "apellidos" => "Yanguas-Barea" ] 2 => array:2 [ "nombre" => "Olga" "apellidos" => "Martorell-Almau" ] 3 => array:2 [ "nombre" => "Ángel" "apellidos" => "Gamen-Pardo" ] 4 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Parra-Moncasi" ] 5 => array:2 [ "nombre" => "Raquel" "apellidos" => "Artal-Sánchez" ] 6 => array:2 [ "nombre" => "Rosa" "apellidos" => "Cozcolluela-Cabrejas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699512001054" "doi" => "10.3265/Nefrologia.pre2012.Feb.11326" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001054?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001051?idApp=UINPBA000064" "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001051/v0_201502091614/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Severe hypertriglyceridaemia. Treatment with plasmapheresis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "417" "paginaFinal" => "418" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin" "autores" => array:2 [ 0 => array:4 [ "Iniciales" => "M.J." "apellidos" => "Izquierdo-Ortiz" "email" => array:1 [ 0 => "maridetrespa@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "P." "apellidos" => "Abaigar-Luquin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Sección de Nefrología, Complejo Asistencial Universitario de Burgos, Burgos, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hipertrigliceridemia severa. Tratamiento con plasmaféresis" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11394_16025_30568_en_t1_1611394.jpg" "Alto" => 330 "Ancho" => 1427 "Tamanyo" => 172082 ] ] "descripcion" => array:1 [ "en" => "Total cholesterol, triglycerides, HDL, and LDL levels after the first apheresis session" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor,</span></p><p class="elsevierStylePara">The application of apheresis treatments is gaining more importance in nephrological practice. In patients with metabolic diseases, clear indications exist for apheresis procedures, such as in familial hypercholesterolaemia.<span class="elsevierStyleSup">1</span> However, in other diseases, this type of treatment is applied only as an alternative when normal therapies fail to garner a response, such as in primary hypertriglyceridaemia (HTG).</p><p class="elsevierStylePara">Very little experience has been gained in the treatment of HTG with apheresis, although the few studies in the medical literature describing the treatment of this pathology with apheresis have obtained very positive results.<span class="elsevierStyleSup">2,3</span></p><p class="elsevierStylePara">The current guidelines of the American Society for Apheresis (ASFA) consider this a category III practice, and have approved its use in the case of HTG and in the presence or possibility of severe pancreatitis, which is quite probable when triglyceride (TG) levels exceed 2000mg/dl, and always when the patient does not respond to normal medical treatment. There are few comparative studies, but they have shown that 1-3 sessions of plasmapheresis in patients with pancreatitis and HTG can reduce symptoms by 46%-80%, the same results as for drug treatment.<span class="elsevierStyleSup">4</span> In a study of 8 patients with recurring pancreatitis undergoing chronic treatment with plasmapheresis, the frequency of pancreatitis was reduced by 67% when TG levels were maintained below 150mg/dl, thus preventing patient hospitalisations and reducing health costs.</p><p class="elsevierStylePara">For filtration techniques, we can use double filtration or cascade filtration, where one filter separates blood from the plasma, which is then passed through a second filter with a smaller pore size that does not allow the passage of molecules with a larger molecular weight; in this case, TG.5 In the DALI (Direct Absorption of Lipoproteins) system, the TG are directly absorbed from the blood using a filter that consists of modified polyacrylate ligands immobilized on a polyacrylamide matrix.</p><p class="elsevierStylePara">Here we discuss the case of a 45 year-old male with no relevant medical history and no symptoms, but whose laboratory tests revealed a TG value of 7916mg/dl. The patient was admitted to our department for therapeutic and preventative plasmapheresis against pancreatitis. Only two sessions were administered. We used an apheresis monitor that first passed the blood through a plasma separating filter, and then the plasma was passed through another filter that trapped TG from plasma using hydrophobic interactions, finally returning the treated plasma to the patient. This procedure does not require plasma or albumin supplements. The plasma volume treated was 2.5 litres, calculated by patient weight and haematocrit values, with a mean time per session of approximately 1 hour and 45 minutes. After the first session, TG levels decreased to 1500mg/dl. After the second session, the value was 476mg/dl (Table 1 and Table 2). The patient was then discharged with prescriptions for rosuvastatin at 10mg/24h and fenofibrate at 145mg/24h. Currently, the patient is asymptomatic, with good lipid control under medical treatment, and does not require hospitalisation despite such high levels of TG.</p><p class="elsevierStylePara">With this case, we wish to awaken interest amongst nephrologists in understanding and implementing apheresis techniques. This is another type of extracorporeal purification that can obtain positive clinical results, avoiding unnecessary health costs and hospitalisations, as in our case.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article.</p><p class="elsevierStylePara"><a href="grande/11394_16025_30568_en_t1_1611394.jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30568_en_t1_1611394.jpg" alt="Total cholesterol, triglycerides, HDL, and LDL levels after the first apheresis session"></img></a></p><p class="elsevierStylePara">Table 1. Total cholesterol, triglycerides, HDL, and LDL levels after the first apheresis session</p><p class="elsevierStylePara"><a href="grande/11394_16025_30569_en_t2_1611394.jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30569_en_t2_1611394.jpg" alt="Total cholesterol, triglycerides, HDL, and LDL levels after the second apheresis session"></img></a></p><p class="elsevierStylePara">Table 2. Total cholesterol, triglycerides, HDL, and LDL levels after the second apheresis session</p>" "pdfFichero" => "P1-E536-S3514-A11394-EN.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11394_16025_30568_en_t1_1611394.jpg" "Alto" => 330 "Ancho" => 1427 "Tamanyo" => 172082 ] ] "descripcion" => array:1 [ "en" => "Total cholesterol, triglycerides, HDL, and LDL levels after the first apheresis session" ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11394_16025_30569_en_t2_1611394.jpg" "Alto" => 325 "Ancho" => 1439 "Tamanyo" => 162231 ] ] "descripcion" => array:1 [ "en" => "Total cholesterol, triglycerides, HDL, and LDL levels after the second apheresis session" ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/P1-E536-S3514-A11394-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 9 | 10 | 19 |
2024 October | 66 | 37 | 103 |
2024 September | 60 | 47 | 107 |
2024 August | 59 | 75 | 134 |
2024 July | 50 | 52 | 102 |
2024 June | 69 | 60 | 129 |
2024 May | 85 | 42 | 127 |
2024 April | 63 | 42 | 105 |
2024 March | 43 | 32 | 75 |
2024 February | 36 | 34 | 70 |
2024 January | 52 | 29 | 81 |
2023 December | 27 | 26 | 53 |
2023 November | 53 | 45 | 98 |
2023 October | 77 | 31 | 108 |
2023 September | 55 | 35 | 90 |
2023 August | 39 | 16 | 55 |
2023 July | 42 | 39 | 81 |
2023 June | 45 | 22 | 67 |
2023 May | 58 | 43 | 101 |
2023 April | 34 | 27 | 61 |
2023 March | 52 | 29 | 81 |
2023 February | 45 | 26 | 71 |
2023 January | 47 | 35 | 82 |
2022 December | 64 | 38 | 102 |
2022 November | 46 | 35 | 81 |
2022 October | 65 | 53 | 118 |
2022 September | 59 | 43 | 102 |
2022 August | 51 | 42 | 93 |
2022 July | 43 | 54 | 97 |
2022 June | 37 | 42 | 79 |
2022 May | 54 | 27 | 81 |
2022 April | 60 | 60 | 120 |
2022 March | 46 | 66 | 112 |
2022 February | 45 | 44 | 89 |
2022 January | 49 | 35 | 84 |
2021 December | 50 | 38 | 88 |
2021 November | 37 | 45 | 82 |
2021 October | 38 | 33 | 71 |
2021 September | 53 | 30 | 83 |
2021 August | 52 | 41 | 93 |
2021 July | 55 | 32 | 87 |
2021 June | 50 | 21 | 71 |
2021 May | 38 | 36 | 74 |
2021 April | 141 | 71 | 212 |
2021 March | 84 | 43 | 127 |
2021 February | 77 | 23 | 100 |
2021 January | 60 | 18 | 78 |
2020 December | 39 | 36 | 75 |
2020 November | 35 | 7 | 42 |
2020 October | 19 | 12 | 31 |
2020 September | 19 | 8 | 27 |
2020 August | 41 | 11 | 52 |
2020 July | 30 | 29 | 59 |
2020 June | 29 | 12 | 41 |
2020 May | 50 | 9 | 59 |
2020 April | 31 | 16 | 47 |
2020 March | 47 | 13 | 60 |
2020 February | 36 | 23 | 59 |
2020 January | 51 | 23 | 74 |
2019 December | 46 | 24 | 70 |
2019 November | 48 | 23 | 71 |
2019 October | 29 | 11 | 40 |
2019 September | 38 | 25 | 63 |
2019 August | 37 | 17 | 54 |
2019 July | 36 | 20 | 56 |
2019 June | 34 | 18 | 52 |
2019 May | 40 | 25 | 65 |
2019 April | 69 | 30 | 99 |
2019 March | 36 | 27 | 63 |
2019 February | 21 | 18 | 39 |
2019 January | 31 | 19 | 50 |
2018 December | 72 | 34 | 106 |
2018 November | 101 | 20 | 121 |
2018 October | 85 | 13 | 98 |
2018 September | 72 | 16 | 88 |
2018 August | 59 | 29 | 88 |
2018 July | 45 | 17 | 62 |
2018 June | 59 | 18 | 77 |
2018 May | 55 | 22 | 77 |
2018 April | 74 | 17 | 91 |
2018 March | 62 | 7 | 69 |
2018 February | 70 | 5 | 75 |
2018 January | 71 | 9 | 80 |
2017 December | 72 | 9 | 81 |
2017 November | 58 | 12 | 70 |
2017 October | 45 | 5 | 50 |
2017 September | 50 | 11 | 61 |
2017 August | 56 | 13 | 69 |
2017 July | 36 | 8 | 44 |
2017 June | 40 | 13 | 53 |
2017 May | 33 | 18 | 51 |
2017 April | 24 | 12 | 36 |
2017 March | 28 | 17 | 45 |
2017 February | 25 | 7 | 32 |
2017 January | 25 | 21 | 46 |
2016 December | 45 | 10 | 55 |
2016 November | 57 | 11 | 68 |
2016 October | 90 | 8 | 98 |
2016 September | 94 | 5 | 99 |
2016 August | 156 | 8 | 164 |
2016 July | 160 | 14 | 174 |
2016 June | 125 | 0 | 125 |
2016 May | 146 | 0 | 146 |
2016 April | 94 | 0 | 94 |
2016 March | 93 | 0 | 93 |
2016 February | 109 | 0 | 109 |
2016 January | 96 | 0 | 96 |
2015 December | 149 | 0 | 149 |
2015 November | 94 | 0 | 94 |
2015 October | 101 | 0 | 101 |
2015 September | 74 | 0 | 74 |
2015 August | 72 | 0 | 72 |
2015 July | 69 | 0 | 69 |
2015 June | 48 | 0 | 48 |
2015 May | 51 | 0 | 51 |
2015 April | 8 | 0 | 8 |