array:20 [
  "pii" => "X2013251412001043"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
  "estado" => "S300"
  "fechaPublicacion" => "2012-05-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2012;32:417-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4788
    "formatos" => array:3 [
      "EPUB" => 302
      "HTML" => 3779
      "PDF" => 707
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512001046"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
      "estado" => "S300"
      "fechaPublicacion" => "2012-05-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:417-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 13192
        "formatos" => array:3 [
          "EPUB" => 308
          "HTML" => 11643
          "PDF" => 1241
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "titulo" => "Hipertrigliceridemia severa. Tratamiento con plasmaféresis"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "417"
            "paginaFinal" => "418"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Severe hypertriglyceridaemia. Treatment with plasmapheresis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier España"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11394_108_27439_es_11394_t1.jpg"
                "Alto" => 149
                "Ancho" => 600
                "Tamanyo" => 66594
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Niveles de colesterol total, triglicéridos, HDL y LDL tras la primera sesión de aféresis"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin"
            "autores" => array:2 [
              0 => array:2 [
                "Iniciales" => "M.J."
                "apellidos" => "Izquierdo-Ortiz"
              ]
              1 => array:2 [
                "Iniciales" => "P."
                "apellidos" => "Abaigar-Luquin"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251412001043"
          "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001046?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000003/v0_201502091350/X0211699512001046/v0_201502091351/es/main.assets"
    ]
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412001051"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Feb.11326"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:416-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4477
      "formatos" => array:3 [
        "EPUB" => 308
        "HTML" => 3467
        "PDF" => 702
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Bilateral renal infarctions"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "416"
          "paginaFinal" => "417"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Infartos renales bilaterales"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11326_16025_30599_en_f11511326.jpg"
              "Alto" => 573
              "Ancho" => 646
              "Tamanyo" => 304581
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Abdominal axial computed tomography"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marta Cuberes-Izquierdo, Nerea Yanguas-Barea, Olga Martorell-Almau, Ángel Gamen-Pardo, Eduardo Parra-Moncasi, Raquel Artal-Sánchez, Rosa Cozcolluela-Cabrejas"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Cuberes-Izquierdo"
            ]
            1 => array:2 [
              "nombre" => "Nerea"
              "apellidos" => "Yanguas-Barea"
            ]
            2 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Martorell-Almau"
            ]
            3 => array:2 [
              "nombre" => "Ángel"
              "apellidos" => "Gamen-Pardo"
            ]
            4 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Parra-Moncasi"
            ]
            5 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "Artal-Sánchez"
            ]
            6 => array:2 [
              "nombre" => "Rosa"
              "apellidos" => "Cozcolluela-Cabrejas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512001054"
        "doi" => "10.3265/Nefrologia.pre2012.Feb.11326"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001054?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001051?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001051/v0_201502091614/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Severe hypertriglyceridaemia. Treatment with plasmapheresis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "417"
        "paginaFinal" => "418"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin"
        "autores" => array:2 [
          0 => array:4 [
            "Iniciales" => "M.J."
            "apellidos" => "Izquierdo-Ortiz"
            "email" => array:1 [
              0 => "maridetrespa@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "P."
            "apellidos" => "Abaigar-Luquin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Sección de Nefrología, Complejo Asistencial Universitario de Burgos, Burgos,   "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Hipertrigliceridemia severa&#46; Tratamiento con plasmaf&#233;resis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30568_en_t1_1611394.jpg"
            "Alto" => 330
            "Ancho" => 1427
            "Tamanyo" => 172082
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44;</span></p><p class="elsevierStylePara">The application of apheresis treatments is gaining more importance in nephrological practice&#46; In patients with metabolic diseases&#44; clear indications exist for apheresis procedures&#44; such as in familial hypercholesterolaemia&#46;<span class="elsevierStyleSup">1</span> However&#44; in other diseases&#44; this type of treatment is applied only as an alternative when normal therapies fail to garner a response&#44; such as in primary hypertriglyceridaemia &#40;HTG&#41;&#46;</p><p class="elsevierStylePara">Very little experience has been gained in the treatment of HTG with apheresis&#44; although the few studies in the medical literature describing the treatment of this pathology with apheresis have obtained very positive results&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">The current guidelines of the American Society for Apheresis &#40;ASFA&#41; consider this a category III practice&#44; and have approved its use in the case of HTG and in the presence or possibility of severe pancreatitis&#44; which is quite probable when triglyceride &#40;TG&#41; levels exceed 2000mg&#47;dl&#44; and always when the patient does not respond to normal medical treatment&#46; There are few comparative studies&#44; but they have shown that 1-3 sessions of plasmapheresis in patients with pancreatitis and HTG can reduce symptoms by 46&#37;-80&#37;&#44; the same results as for drug treatment&#46;<span class="elsevierStyleSup">4</span> In a study of 8 patients with recurring pancreatitis undergoing chronic treatment with plasmapheresis&#44; the frequency of pancreatitis was reduced by 67&#37; when TG levels were maintained below 150mg&#47;dl&#44; thus preventing patient hospitalisations and reducing health costs&#46;</p><p class="elsevierStylePara">For filtration techniques&#44; we can use double filtration or cascade filtration&#44; where one filter separates blood from the plasma&#44; which is then passed through a second filter with a smaller pore size that does not allow the passage of molecules with a larger molecular weight&#59; in this case&#44; TG&#46;5 In the DALI &#40;Direct Absorption of Lipoproteins&#41; system&#44; the TG are directly absorbed from the blood using a filter that consists of modified polyacrylate ligands immobilized on a polyacrylamide matrix&#46;</p><p class="elsevierStylePara">Here we discuss the case of a 45 year-old male with no relevant medical history and no symptoms&#44; but whose laboratory tests revealed a TG value of 7916mg&#47;dl&#46; The patient was admitted to our department for therapeutic and preventative plasmapheresis against pancreatitis&#46; Only two sessions were administered&#46; We used an apheresis monitor that first passed the blood through a plasma separating filter&#44; and then the plasma was passed through another filter that trapped TG from plasma using hydrophobic interactions&#44; finally returning the treated plasma to the patient&#46; This procedure does not require plasma or albumin supplements&#46; The plasma volume treated was 2&#46;5 litres&#44; calculated by patient weight and haematocrit values&#44; with a mean time per session of approximately 1 hour and 45 minutes&#46; After the first session&#44; TG levels decreased to 1500mg&#47;dl&#46; After the second session&#44; the value was 476mg&#47;dl &#40;Table 1 and Table 2&#41;&#46; The patient was then discharged with prescriptions for rosuvastatin at 10mg&#47;24h and fenofibrate at 145mg&#47;24h&#46; Currently&#44; the patient is asymptomatic&#44; with good lipid control under medical treatment&#44; and does not require hospitalisation despite such high levels of TG&#46;</p><p class="elsevierStylePara">With this case&#44; we wish to awaken interest amongst nephrologists in understanding and implementing apheresis techniques&#46; This is another type of extracorporeal purification that can obtain positive clinical results&#44; avoiding unnecessary health costs and hospitalisations&#44; as in our case&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11394&#95;16025&#95;30568&#95;en&#95;t1&#95;1611394&#46;jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30568_en_t1_1611394.jpg" alt="Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"></img></a></p><p class="elsevierStylePara">Table 1&#46; Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session</p><p class="elsevierStylePara"><a href="grande&#47;11394&#95;16025&#95;30569&#95;en&#95;t2&#95;1611394&#46;jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30569_en_t2_1611394.jpg" alt="Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session"></img></a></p><p class="elsevierStylePara">Table 2&#46; Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session</p>"
    "pdfFichero" => "P1-E536-S3514-A11394-EN.pdf"
    "tienePdf" => true
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30568_en_t1_1611394.jpg"
            "Alto" => 330
            "Ancho" => 1427
            "Tamanyo" => 172082
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30569_en_t2_1611394.jpg"
            "Alto" => 325
            "Ancho" => 1439
            "Tamanyo" => 162231
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session"
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/P1-E536-S3514-A11394-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Severe hypertriglyceridaemia. Treatment with plasmapheresis
Hipertrigliceridemia severa. Tratamiento con plasmaféresis
M.J.. Izquierdo-Ortiza, P.. Abaigar-Luquina
a Sección de Nefrología, Complejo Asistencial Universitario de Burgos, Burgos,
Read
9329
Times
was read the article
2669
Total PDF
6660
Total HTML
Share statistics
 array:20 [
  "pii" => "X2013251412001043"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
  "estado" => "S300"
  "fechaPublicacion" => "2012-05-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:417-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4788
    "formatos" => array:3 [
      "EPUB" => 302
      "HTML" => 3779
      "PDF" => 707
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512001046"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
      "estado" => "S300"
      "fechaPublicacion" => "2012-05-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:417-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 13192
        "formatos" => array:3 [
          "EPUB" => 308
          "HTML" => 11643
          "PDF" => 1241
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "titulo" => "Hipertrigliceridemia severa&#46; Tratamiento con plasmaf&#233;resis"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "417"
            "paginaFinal" => "418"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Severe hypertriglyceridaemia&#46; Treatment with plasmapheresis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier Espa&#241;a"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11394_108_27439_es_11394_t1.jpg"
                "Alto" => 149
                "Ancho" => 600
                "Tamanyo" => 66594
              ]
            ]
            "descripcion" => array:1 [
              "es" => "Niveles de colesterol total&#44; triglic&#233;ridos&#44; HDL y LDL tras la primera sesi&#243;n de af&#233;resis"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin"
            "autores" => array:2 [
              0 => array:2 [
                "Iniciales" => "M.J."
                "apellidos" => "Izquierdo-Ortiz"
              ]
              1 => array:2 [
                "Iniciales" => "P."
                "apellidos" => "Abaigar-Luquin"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251412001043"
          "doi" => "10.3265/Nefrologia.pre2012.Feb.11394"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001046?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000003/v0_201502091350/X0211699512001046/v0_201502091351/es/main.assets"
    ]
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412001051"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Feb.11326"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:416-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4477
      "formatos" => array:3 [
        "EPUB" => 308
        "HTML" => 3467
        "PDF" => 702
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Bilateral renal infarctions"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "416"
          "paginaFinal" => "417"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Infartos renales bilaterales"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11326_16025_30599_en_f11511326.jpg"
              "Alto" => 573
              "Ancho" => 646
              "Tamanyo" => 304581
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Abdominal axial computed tomography"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marta Cuberes-Izquierdo, Nerea Yanguas-Barea, Olga Martorell-Almau, &#193;ngel Gamen-Pardo, Eduardo Parra-Moncasi, Raquel Artal-S&#225;nchez, Rosa Cozcolluela-Cabrejas"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Cuberes-Izquierdo"
            ]
            1 => array:2 [
              "nombre" => "Nerea"
              "apellidos" => "Yanguas-Barea"
            ]
            2 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Martorell-Almau"
            ]
            3 => array:2 [
              "nombre" => "&#193;ngel"
              "apellidos" => "Gamen-Pardo"
            ]
            4 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Parra-Moncasi"
            ]
            5 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "Artal-S&#225;nchez"
            ]
            6 => array:2 [
              "nombre" => "Rosa"
              "apellidos" => "Cozcolluela-Cabrejas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512001054"
        "doi" => "10.3265/Nefrologia.pre2012.Feb.11326"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001054?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001051?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001051/v0_201502091614/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Severe hypertriglyceridaemia&#46; Treatment with plasmapheresis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "417"
        "paginaFinal" => "418"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "M.J. Izquierdo-Ortiz, P. Abaigar-Luquin"
        "autores" => array:2 [
          0 => array:4 [
            "Iniciales" => "M.J."
            "apellidos" => "Izquierdo-Ortiz"
            "email" => array:1 [
              0 => "maridetrespa&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "P."
            "apellidos" => "Abaigar-Luquin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Sección de Nefrología, Complejo Asistencial Universitario de Burgos, Burgos,   "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Hipertrigliceridemia severa&#46; Tratamiento con plasmaf&#233;resis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30568_en_t1_1611394.jpg"
            "Alto" => 330
            "Ancho" => 1427
            "Tamanyo" => 172082
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44;</span></p><p class="elsevierStylePara">The application of apheresis treatments is gaining more importance in nephrological practice&#46; In patients with metabolic diseases&#44; clear indications exist for apheresis procedures&#44; such as in familial hypercholesterolaemia&#46;<span class="elsevierStyleSup">1</span> However&#44; in other diseases&#44; this type of treatment is applied only as an alternative when normal therapies fail to garner a response&#44; such as in primary hypertriglyceridaemia &#40;HTG&#41;&#46;</p><p class="elsevierStylePara">Very little experience has been gained in the treatment of HTG with apheresis&#44; although the few studies in the medical literature describing the treatment of this pathology with apheresis have obtained very positive results&#46;<span class="elsevierStyleSup">2&#44;3</span></p><p class="elsevierStylePara">The current guidelines of the American Society for Apheresis &#40;ASFA&#41; consider this a category III practice&#44; and have approved its use in the case of HTG and in the presence or possibility of severe pancreatitis&#44; which is quite probable when triglyceride &#40;TG&#41; levels exceed 2000mg&#47;dl&#44; and always when the patient does not respond to normal medical treatment&#46; There are few comparative studies&#44; but they have shown that 1-3 sessions of plasmapheresis in patients with pancreatitis and HTG can reduce symptoms by 46&#37;-80&#37;&#44; the same results as for drug treatment&#46;<span class="elsevierStyleSup">4</span> In a study of 8 patients with recurring pancreatitis undergoing chronic treatment with plasmapheresis&#44; the frequency of pancreatitis was reduced by 67&#37; when TG levels were maintained below 150mg&#47;dl&#44; thus preventing patient hospitalisations and reducing health costs&#46;</p><p class="elsevierStylePara">For filtration techniques&#44; we can use double filtration or cascade filtration&#44; where one filter separates blood from the plasma&#44; which is then passed through a second filter with a smaller pore size that does not allow the passage of molecules with a larger molecular weight&#59; in this case&#44; TG&#46;5 In the DALI &#40;Direct Absorption of Lipoproteins&#41; system&#44; the TG are directly absorbed from the blood using a filter that consists of modified polyacrylate ligands immobilized on a polyacrylamide matrix&#46;</p><p class="elsevierStylePara">Here we discuss the case of a 45 year-old male with no relevant medical history and no symptoms&#44; but whose laboratory tests revealed a TG value of 7916mg&#47;dl&#46; The patient was admitted to our department for therapeutic and preventative plasmapheresis against pancreatitis&#46; Only two sessions were administered&#46; We used an apheresis monitor that first passed the blood through a plasma separating filter&#44; and then the plasma was passed through another filter that trapped TG from plasma using hydrophobic interactions&#44; finally returning the treated plasma to the patient&#46; This procedure does not require plasma or albumin supplements&#46; The plasma volume treated was 2&#46;5 litres&#44; calculated by patient weight and haematocrit values&#44; with a mean time per session of approximately 1 hour and 45 minutes&#46; After the first session&#44; TG levels decreased to 1500mg&#47;dl&#46; After the second session&#44; the value was 476mg&#47;dl &#40;Table 1 and Table 2&#41;&#46; The patient was then discharged with prescriptions for rosuvastatin at 10mg&#47;24h and fenofibrate at 145mg&#47;24h&#46; Currently&#44; the patient is asymptomatic&#44; with good lipid control under medical treatment&#44; and does not require hospitalisation despite such high levels of TG&#46;</p><p class="elsevierStylePara">With this case&#44; we wish to awaken interest amongst nephrologists in understanding and implementing apheresis techniques&#46; This is another type of extracorporeal purification that can obtain positive clinical results&#44; avoiding unnecessary health costs and hospitalisations&#44; as in our case&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11394&#95;16025&#95;30568&#95;en&#95;t1&#95;1611394&#46;jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30568_en_t1_1611394.jpg" alt="Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"></img></a></p><p class="elsevierStylePara">Table 1&#46; Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session</p><p class="elsevierStylePara"><a href="grande&#47;11394&#95;16025&#95;30569&#95;en&#95;t2&#95;1611394&#46;jpg" class="elsevierStyleCrossRefs"><img src="11394_16025_30569_en_t2_1611394.jpg" alt="Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session"></img></a></p><p class="elsevierStylePara">Table 2&#46; Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session</p>"
    "pdfFichero" => "P1-E536-S3514-A11394-EN.pdf"
    "tienePdf" => true
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig1"
        "etiqueta" => "Tab.  1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30568_en_t1_1611394.jpg"
            "Alto" => 330
            "Ancho" => 1427
            "Tamanyo" => 172082
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the first apheresis session"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig2"
        "etiqueta" => "Tab.  2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "copyright" => "Elsevier Espa&#241;a"
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "11394_16025_30569_en_t2_1611394.jpg"
            "Alto" => 325
            "Ancho" => 1439
            "Tamanyo" => 162231
          ]
        ]
        "descripcion" => array:1 [
          "en" => "Total cholesterol&#44; triglycerides&#44; HDL&#44; and LDL levels after the second apheresis session"
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000003/v0_201502091613/X2013251412001043/v0_201502091614/en/P1-E536-S3514-A11394-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001043?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 9 10 19
2024 October 66 37 103
2024 September 60 47 107
2024 August 59 75 134
2024 July 50 52 102
2024 June 69 60 129
2024 May 85 42 127
2024 April 63 42 105
2024 March 43 32 75
2024 February 36 34 70
2024 January 52 29 81
2023 December 27 26 53
2023 November 53 45 98
2023 October 77 31 108
2023 September 55 35 90
2023 August 39 16 55
2023 July 42 39 81
2023 June 45 22 67
2023 May 58 43 101
2023 April 34 27 61
2023 March 52 29 81
2023 February 45 26 71
2023 January 47 35 82
2022 December 64 38 102
2022 November 46 35 81
2022 October 65 53 118
2022 September 59 43 102
2022 August 51 42 93
2022 July 43 54 97
2022 June 37 42 79
2022 May 54 27 81
2022 April 60 60 120
2022 March 46 66 112
2022 February 45 44 89
2022 January 49 35 84
2021 December 50 38 88
2021 November 37 45 82
2021 October 38 33 71
2021 September 53 30 83
2021 August 52 41 93
2021 July 55 32 87
2021 June 50 21 71
2021 May 38 36 74
2021 April 141 71 212
2021 March 84 43 127
2021 February 77 23 100
2021 January 60 18 78
2020 December 39 36 75
2020 November 35 7 42
2020 October 19 12 31
2020 September 19 8 27
2020 August 41 11 52
2020 July 30 29 59
2020 June 29 12 41
2020 May 50 9 59
2020 April 31 16 47
2020 March 47 13 60
2020 February 36 23 59
2020 January 51 23 74
2019 December 46 24 70
2019 November 48 23 71
2019 October 29 11 40
2019 September 38 25 63
2019 August 37 17 54
2019 July 36 20 56
2019 June 34 18 52
2019 May 40 25 65
2019 April 69 30 99
2019 March 36 27 63
2019 February 21 18 39
2019 January 31 19 50
2018 December 72 34 106
2018 November 101 20 121
2018 October 85 13 98
2018 September 72 16 88
2018 August 59 29 88
2018 July 45 17 62
2018 June 59 18 77
2018 May 55 22 77
2018 April 74 17 91
2018 March 62 7 69
2018 February 70 5 75
2018 January 71 9 80
2017 December 72 9 81
2017 November 58 12 70
2017 October 45 5 50
2017 September 50 11 61
2017 August 56 13 69
2017 July 36 8 44
2017 June 40 13 53
2017 May 33 18 51
2017 April 24 12 36
2017 March 28 17 45
2017 February 25 7 32
2017 January 25 21 46
2016 December 45 10 55
2016 November 57 11 68
2016 October 90 8 98
2016 September 94 5 99
2016 August 156 8 164
2016 July 160 14 174
2016 June 125 0 125
2016 May 146 0 146
2016 April 94 0 94
2016 March 93 0 93
2016 February 109 0 109
2016 January 96 0 96
2015 December 149 0 149
2015 November 94 0 94
2015 October 101 0 101
2015 September 74 0 74
2015 August 72 0 72
2015 July 69 0 69
2015 June 48 0 48
2015 May 51 0 51
2015 April 8 0 8
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)