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she started periodical haemodialysis treatment again due to chronic allograft nephropathy&#46; Co-morbidities included secondary hyperparathyroidism treated with calcitriol&#44; hyperuricaemia treated with alopurinol&#44; anaemia treated with subcutaneous epoetin alfa and oral iron supplements&#44; and hypertension treated with calcium channel blockers&#44; beta blockers and diuretics&#46;</p><p class="elsevierStylePara">When the patient returned to dialysis&#44; immunosuppressant drugs were gradually discontinued &#40;steroids&#44; calcineurin inhibitors and mycophenolate mofetil&#41; and the patient was transitioned to darbepoetin alfa and intravenous iron supplements Transfusion of 2 units of red blood cells was necessary during the first session due to anaemia with a haemoglobin level of 6&#46;9g&#46;</p><p class="elsevierStylePara">On 13 August 2008 the patient reported amenorrhea lasting 2 months&#46; Human chorionic gonadotropin-beta levels and a vaginal ultrasound revealed that she was approximately 4 weeks pregnant&#46; In light of these results&#44; the patient started a daily haemodialysis programme&#46;</p><p class="elsevierStylePara">For the dialyser&#44; we used a high-flux polyethersulfone membrane with a surface area of 2&#46;1m<span class="elsevierStyleSup">2</span> and a dialysate bath consisting of 3mEq&#47;l calcium and 1&#46;5mEq&#47;l K<span class="elsevierStyleBold"><span class="elsevierStyleSup">&#43;</span></span>&#44; although this was adjusted depending on laboratory results&#46; Dalteparin was administered as an anticoagulant agent at an initial dose of 2500IU per session&#46; Dry weight was adjusted by applying increases of 0&#46;3-0&#46;5kg per week from the second trimester&#46;</p><p class="elsevierStylePara">Regarding drug treatment&#44; tacrolimus was suspended and steroid and calcitriol treatments were maintained&#46; We did not continue to decrease steroids in order to prevent graft rejection&#44; using a dose of 5mg daily&#46; The diuretic agents and the calcium channel blocker were suspended and folic acid and Vitamin B complex were increased&#46; No oral iodine supplement was prescribed due to lack of experience and because it is excreted in urine&#46; The patient received no zinc supplements because plasma levels were normal &#40;Table 1&#41;&#46;</p><p class="elsevierStylePara">The patient was placed on an unrestricted diet&#46;</p><p class="elsevierStylePara">Our goal was to maintain pre-dialysis urea levels below 100mg&#47;dl and normal calcium levels&#44; prevent acid-base balance disorders and maintain haemoglobin levels at approximately 11g&#47;dl&#46; The dialysis dose that we established as our target was an equivalent renal urea clearance of 30ml&#47;min according to the Casino and L&#243;pez method&#46;</p><p class="elsevierStylePara">In this case&#44; evolution of anaemia during the pregnancy was slow&#44; and maintaining haemoglobin levels above 9g&#47;dl was difficult&#46; The patient required 2 units of red blood cells in week 21 &#40;Table 2&#41;&#46;</p><p class="elsevierStylePara">Session duration was gradually increased from an initial length of 3 hours&#46; After gestation&#44; the patient&#8217;s programme consisted of 6 weekly sessions of 4&#46;5 hours &#40;27 hours weekly&#41;&#46; No relevant episodes of hypotension were recorded and the maximum ultrafiltration rate was 500ml&#47;h&#46;</p><p class="elsevierStylePara">It was necessary to increase the anticoagulant dose to 5000IU dalteparin per session&#46; The only incident was graft thrombosis in week 24 and doctors placed a jugular tunnelled catheter so as not to expose the patient to thrombolytic drugs or excessive radioscopy&#46;</p><p class="elsevierStylePara">Regarding obstetrics&#44; hypertension was recorded in week 16&#44; and treatment with methyldopa was initiated&#46; Polyhydramnios and foetal macrosomia were detected in week 20&#46; In week 32&#44; the patient was referred to a tertiary hospital for assessment and to end the pregnancy due to the foetal monitor showing poor responsiveness&#46; A planned caesarean section was performed 2 weeks later&#44; delivering a live newborn weighing 2200g&#46;</p><p class="elsevierStylePara">Available information on managing pregnant patients in haemodialysis programmes is scarce&#59; it is mainly based on small cohorts and a handful of meta-analyses published by different hospitals around the world&#46; This highlights the need for creating national and international registers&#46;<span class="elsevierStyleSup">6 </span>In these series&#44; we observed a proportional relationship between the time the patient remained on dialysis and the prognosis for the pregnancy&#46; In general&#44; programmes of more than 20 hours weekly are related to longer gestational periods and decreased risk of preterm birth&#46;<span class="elsevierStyleSup">6</span> It also seems that increasing dialysis frequency to a programme of 6 weekly sessions is better than scheduling longer&#44; less frequent sessions&#46;</p><p class="elsevierStylePara">One hypothesis is that prolonging dialysis sessions may decrease risk of polyhydramnios and foetal distress and improve the patient&#8217;s nutritional state&#44; thereby decreasing the risk of preterm birth&#46;<span class="elsevierStyleSup">7</span></p><p class="elsevierStylePara">Anaemia&#44; another chronic complication of patients on dialysis&#44; must be monitored and treated with iron and folic acid supplements&#44; and erythropoietin treatment must be increased in order to maintain haemoglobin levels at 10g&#47;dl and transferrin saturation above 30&#37;&#46;<span class="elsevierStyleSup">8</span></p><p class="elsevierStylePara">Although there is still very little available information on the management of these patients&#44; the most recent published results give us a more optimistic view&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11061&#95;19157&#95;29378&#95;en&#95;t1&#95;11061&#46;jpg" class="elsevierStyleCrossRefs"><img src="11061_19157_29378_en_t1_11061.jpg" alt="Haemodialysis and treatment parameters"></img></a></p><p class="elsevierStylePara">Table 1&#46; Haemodialysis and treatment parameters</p><p class="elsevierStylePara"><a href="grande&#47;11061&#95;19157&#95;29379&#95;en&#95;t2&#95;11061&#46;jpg" class="elsevierStyleCrossRefs"><img src="11061_19157_29379_en_t2_11061.jpg" alt="Laboratory data"></img></a></p><p class="elsevierStylePara">Table 2&#46; Laboratory data</p>"
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Pregnancy and haemodialyisis: a case study
Embarazo en hemodiálisis, a propósito de un caso
María Ruiz-Campuzanoa, Silvia Soto-Alarcónb, Antonio Martínez-Ruizb, Eladio Lucas-Guillénb
a Servicio de Medicina Interna, Hospital Rafael Méndez, Lorca, Murcia
b Sección de Nefrología, Hospital Rafael Méndez, Lorca, Murcia,
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she started periodical haemodialysis treatment again due to chronic allograft nephropathy&#46; Co-morbidities included secondary hyperparathyroidism treated with calcitriol&#44; hyperuricaemia treated with alopurinol&#44; anaemia treated with subcutaneous epoetin alfa and oral iron supplements&#44; and hypertension treated with calcium channel blockers&#44; beta blockers and diuretics&#46;</p><p class="elsevierStylePara">When the patient returned to dialysis&#44; immunosuppressant drugs were gradually discontinued &#40;steroids&#44; calcineurin inhibitors and mycophenolate mofetil&#41; and the patient was transitioned to darbepoetin alfa and intravenous iron supplements Transfusion of 2 units of red blood cells was necessary during the first session due to anaemia with a haemoglobin level of 6&#46;9g&#46;</p><p class="elsevierStylePara">On 13 August 2008 the patient reported amenorrhea lasting 2 months&#46; Human chorionic gonadotropin-beta levels and a vaginal ultrasound revealed that she was approximately 4 weeks pregnant&#46; In light of these results&#44; the patient started a daily haemodialysis programme&#46;</p><p class="elsevierStylePara">For the dialyser&#44; we used a high-flux polyethersulfone membrane with a surface area of 2&#46;1m<span class="elsevierStyleSup">2</span> and a dialysate bath consisting of 3mEq&#47;l calcium and 1&#46;5mEq&#47;l K<span class="elsevierStyleBold"><span class="elsevierStyleSup">&#43;</span></span>&#44; although this was adjusted depending on laboratory results&#46; Dalteparin was administered as an anticoagulant agent at an initial dose of 2500IU per session&#46; Dry weight was adjusted by applying increases of 0&#46;3-0&#46;5kg per week from the second trimester&#46;</p><p class="elsevierStylePara">Regarding drug treatment&#44; tacrolimus was suspended and steroid and calcitriol treatments were maintained&#46; We did not continue to decrease steroids in order to prevent graft rejection&#44; using a dose of 5mg daily&#46; The diuretic agents and the calcium channel blocker were suspended and folic acid and Vitamin B complex were increased&#46; No oral iodine supplement was prescribed due to lack of experience and because it is excreted in urine&#46; The patient received no zinc supplements because plasma levels were normal &#40;Table 1&#41;&#46;</p><p class="elsevierStylePara">The patient was placed on an unrestricted diet&#46;</p><p class="elsevierStylePara">Our goal was to maintain pre-dialysis urea levels below 100mg&#47;dl and normal calcium levels&#44; prevent acid-base balance disorders and maintain haemoglobin levels at approximately 11g&#47;dl&#46; The dialysis dose that we established as our target was an equivalent renal urea clearance of 30ml&#47;min according to the Casino and L&#243;pez method&#46;</p><p class="elsevierStylePara">In this case&#44; evolution of anaemia during the pregnancy was slow&#44; and maintaining haemoglobin levels above 9g&#47;dl was difficult&#46; The patient required 2 units of red blood cells in week 21 &#40;Table 2&#41;&#46;</p><p class="elsevierStylePara">Session duration was gradually increased from an initial length of 3 hours&#46; After gestation&#44; the patient&#8217;s programme consisted of 6 weekly sessions of 4&#46;5 hours &#40;27 hours weekly&#41;&#46; No relevant episodes of hypotension were recorded and the maximum ultrafiltration rate was 500ml&#47;h&#46;</p><p class="elsevierStylePara">It was necessary to increase the anticoagulant dose to 5000IU dalteparin per session&#46; The only incident was graft thrombosis in week 24 and doctors placed a jugular tunnelled catheter so as not to expose the patient to thrombolytic drugs or excessive radioscopy&#46;</p><p class="elsevierStylePara">Regarding obstetrics&#44; hypertension was recorded in week 16&#44; and treatment with methyldopa was initiated&#46; Polyhydramnios and foetal macrosomia were detected in week 20&#46; In week 32&#44; the patient was referred to a tertiary hospital for assessment and to end the pregnancy due to the foetal monitor showing poor responsiveness&#46; A planned caesarean section was performed 2 weeks later&#44; delivering a live newborn weighing 2200g&#46;</p><p class="elsevierStylePara">Available information on managing pregnant patients in haemodialysis programmes is scarce&#59; it is mainly based on small cohorts and a handful of meta-analyses published by different hospitals around the world&#46; This highlights the need for creating national and international registers&#46;<span class="elsevierStyleSup">6 </span>In these series&#44; we observed a proportional relationship between the time the patient remained on dialysis and the prognosis for the pregnancy&#46; In general&#44; programmes of more than 20 hours weekly are related to longer gestational periods and decreased risk of preterm birth&#46;<span class="elsevierStyleSup">6</span> It also seems that increasing dialysis frequency to a programme of 6 weekly sessions is better than scheduling longer&#44; less frequent sessions&#46;</p><p class="elsevierStylePara">One hypothesis is that prolonging dialysis sessions may decrease risk of polyhydramnios and foetal distress and improve the patient&#8217;s nutritional state&#44; thereby decreasing the risk of preterm birth&#46;<span class="elsevierStyleSup">7</span></p><p class="elsevierStylePara">Anaemia&#44; another chronic complication of patients on dialysis&#44; must be monitored and treated with iron and folic acid supplements&#44; and erythropoietin treatment must be increased in order to maintain haemoglobin levels at 10g&#47;dl and transferrin saturation above 30&#37;&#46;<span class="elsevierStyleSup">8</span></p><p class="elsevierStylePara">Although there is still very little available information on the management of these patients&#44; the most recent published results give us a more optimistic view&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11061&#95;19157&#95;29378&#95;en&#95;t1&#95;11061&#46;jpg" class="elsevierStyleCrossRefs"><img src="11061_19157_29378_en_t1_11061.jpg" alt="Haemodialysis and treatment parameters"></img></a></p><p class="elsevierStylePara">Table 1&#46; Haemodialysis and treatment parameters</p><p class="elsevierStylePara"><a href="grande&#47;11061&#95;19157&#95;29379&#95;en&#95;t2&#95;11061&#46;jpg" class="elsevierStyleCrossRefs"><img src="11061_19157_29379_en_t2_11061.jpg" alt="Laboratory data"></img></a></p><p class="elsevierStylePara">Table 2&#46; Laboratory data</p>"
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