The role of interleukin 6 in the pathogenesis of hyponatremia associated with Guillain-Barré syndrome
Read
7964
Timeswas read the article
2321
Total PDF
5643
Total HTML
Share statistics
array:21 [ "pii" => "X2013251412000464" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Jan.11115" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:114" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4148 "formatos" => array:3 [ "EPUB" => 370 "HTML" => 3165 "PDF" => 613 ] ] "Traduccion" => array:1 [ "en" => array:17 [ "pii" => "X0211699512000467" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2012.Jan.11115" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2012;32:114" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5247 "formatos" => array:3 [ "EPUB" => 293 "HTML" => 4265 "PDF" => 689 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "The role of interleukin 6 in the pathogenesis of hyponatremia associated with Guillain-Barré syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "114" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The role of interleukin 6 in the pathogenesis of hyponatremia associated with Guillain-Barré syndrome" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Se Jin Park, Ki Soo Pai, Ji Hong Kim, Jae II Shin" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Se Jin" "apellidos" => "Park" ] 1 => array:2 [ "nombre" => "Ki Soo" "apellidos" => "Pai" ] 2 => array:2 [ "nombre" => "Ji Hong" "apellidos" => "Kim" ] 3 => array:2 [ "nombre" => "Jae II" "apellidos" => "Shin" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251412000464" "doi" => "10.3265/Nefrologia.pre2012.Jan.11115" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412000464?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512000467?idApp=UINPBA000064" "url" => "/02116995/0000003200000001/v0_201502091357/X0211699512000467/v0_201502091357/en/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251412000448" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Dec.11235" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:115-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8308 "formatos" => array:3 [ "EPUB" => 389 "HTML" => 7209 "PDF" => 710 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Estimating glomerular filtration rate in order to adjust drug doses: confusion abounds" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "115" "paginaFinal" => "117" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estimación de la tasa de filtración glomerular para el ajuste posológico de los fármacos. Reina la confusión" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11235_16025_26340_en_11235t1.jpg" "Alto" => 433 "Ancho" => 1459 "Tamanyo" => 215119 ] ] "descripcion" => array:1 [ "en" => "Recommended dabigatran dose adjustments according to the glomerular filtration rate estimated by different equations" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Javier Peral-Aguirregoitia, Unax Lertxundi-Etxebarria, Ramon Saracho-Rotaeche, Sira Iturrizaga-Correcher, M. José Martínez-Bengoechea" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Javier" "apellidos" => "Peral-Aguirregoitia" ] 1 => array:2 [ "nombre" => "Unax" "apellidos" => "Lertxundi-Etxebarria" ] 2 => array:2 [ "nombre" => "Ramon" "apellidos" => "Saracho-Rotaeche" ] 3 => array:2 [ "nombre" => "Sira" "apellidos" => "Iturrizaga-Correcher" ] 4 => array:2 [ "nombre" => "M. José" "apellidos" => "Martínez-Bengoechea" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699512000440" "doi" => "10.3265/Nefrologia.pre2011.Dec.11235" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512000440?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412000448?idApp=UINPBA000064" "url" => "/20132514/0000003200000001/v0_201502091620/X2013251412000448/v0_201502091620/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251412000456" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Nov.11247" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2012;32:114-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9398 "formatos" => array:3 [ "EPUB" => 354 "HTML" => 7131 "PDF" => 1913 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Acyclovir and valacyclovir neurotoxicity in patients with renal failure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "114" "paginaFinal" => "115" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neurotoxicidad por aciclovir-valaciclovir en enfermos con insuficiencia renal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gloria Ruiz-Roso, Antonio Gomis, Milagros Fernández-Lucas, Martha Díaz-Domínguez, José L. Teruel-Briones, Carlos Quereda" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Gloria" "apellidos" => "Ruiz-Roso" ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Gomis" ] 2 => array:2 [ "nombre" => "Milagros" "apellidos" => "Fernández-Lucas" ] 3 => array:2 [ "nombre" => "Martha" "apellidos" => "Díaz-Domínguez" ] 4 => array:2 [ "nombre" => "José L." "apellidos" => "Teruel-Briones" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Quereda" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699512000459" "doi" => "10.3265/Nefrologia.pre2011.Nov.11247" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512000459?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412000456?idApp=UINPBA000064" "url" => "/20132514/0000003200000001/v0_201502091620/X2013251412000456/v0_201502091620/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "The role of interleukin 6 in the pathogenesis of hyponatremia associated with Guillain-Barré syndrome" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "114" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Se Jin Park, Ki Soo Pai, Ji Hong Kim, Jae II Shin" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Se Jin" "apellidos" => "Park" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Ki Soo" "apellidos" => "Pai" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Ji Hong" "apellidos" => "Kim" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 3 => array:4 [ "nombre" => "Jae II" "apellidos" => "Shin" "email" => array:1 [ 0 => "shinji@yuhs.ac" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Pediatrics, Ajou University School of Medicine, Ajou University, Suwon, Korea, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Department of Pediatrics, Yonsei University College of Medicine, Severance Children¿s Hospital, Seoul, Korea, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara">We read with great interest the contribution by Monzón et al.<span class="elsevierStyleSup">1</span> They reported a significant case of a man who had Guillain-Barré syndrome (GBS) with syndrome of inappropriate antidiuretic hormone (SIADH) and speculated that increased sensitivity to vasopressin in the renal tubule and a long-lasting hypo-osmolarity or antidiuretic substances might cause GBS-related SIADH. However, we would like to add a possible pathomechanism in the development of hyponatremia associated with GBS.</p><p class="elsevierStylePara">According to a previous study by Maimone et al.,<span class="elsevierStyleSup">2</span> interleukin (IL)-6, a multifunctional cytokine, might be implicated in the immunopathogenesis of GBS. In their study, serum IL-6 levels were increased in six (26%) of 23 GBS patients, and detectable levels of IL-6 were also found in the cerebrospinal fluid in 13 (57%).<span class="elsevierStyleSup">2</span> Using enzyme-linked immunospot assays, Press et al.<span class="elsevierStyleSup">3</span> found elevated numbers of IL-6-secreting blood mononuclear cells during the acute phase in patients with GBS.</p><p class="elsevierStylePara">Quite recently and importantly, Swart et al.<span class="elsevierStyleSup">4</span> depicted the cascade-like fashion of events initiated by an inflammatory stimulus (lipopolysaccharides), with tumor necrosis factor-α secreted first, IL-1β second, and IL-6 last, suggesting possible pathways connecting IL-6 to vasopressin release. These pro-inflammatory cytokines are secreted into the systemic circulation to initiate the acute phase response which is involved in the innate immune system.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">Furthermore, Mastorakos et al.<span class="elsevierStyleSup">6</span> reported that plasma antidiuretic hormone levels were elevated after IL-6 injection in cancer patients, suggesting that IL-6 activated the magnocellular ADH-secreting neurons and that it might be involved in SIADH. Activation of the subfornical organ and the organum vasculosum of the lamina terminalis by IL-6 could eventually lead to thirst and increased vasopressin secretion by neurons from the supraoptic nucleus and paraventricular nucleus.<span class="elsevierStyleSup">4</span> The combination of antidiuresis and increased water intake may result in hyponatremia.</p><p class="elsevierStylePara">Therefore, there is a possibility that IL-6 may play a central role in the pathogenesis of hyponatremia associated with GBS. However, further studies are necessary to elucidate if IL-6 crosses the blood-brain barrier (BBB), or whether lipopolysaccharides crosse the BBB and then increases IL-6 locally in the brain in the future.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara">The authors declare they have no potential conflicts of interest related to the contents of this article.</p>" "pdfFichero" => "P1-E532-S3401-A11115-EN.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Monzón Vázquez T, Florit E, Marqués Vidas M, Rodríguez Cubillo B, Delgado Conde P, Barrientos Guzmán A. Syndrome of inappropriate antidiuretic hormone hypersecretion associated with Guillain-Barré syndrome. Nefrologia 2011;31:498-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21738258" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Maimone D, Annunziata P, Simone IL, Livrea P, Guazzi GC. Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 1993;47:55-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8376548" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Press R, Ozenci V, Kouwenhoven M, Link H. Non-T(H)1 cytokines are augmented systematically early in Guillain-Barré syndrome. Neurology 2002;58:476-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11839856" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Swart RM, Hoorn EJ, Betjes MG, Zietse R. Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation. Nephron Physiol 2011;118:45-51. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21196778" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340:448-54. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9971870" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Mastorakos G, Weber JS, Magiakou MA, Gunn H, Chrousos GP. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J Clin Endocrinol Metab 1994;79:934-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7962300" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003200000001/v0_201502091620/X2013251412000464/v0_201502091620/en/main.assets" "Apartado" => array:4 [ "identificador" => "35439" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Comments on published articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000001/v0_201502091620/X2013251412000464/v0_201502091620/en/P1-E532-S3401-A11115-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412000464?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 9 | 15 |
| 2024 October | 49 | 25 | 74 |
| 2024 September | 47 | 25 | 72 |
| 2024 August | 55 | 57 | 112 |
| 2024 July | 42 | 32 | 74 |
| 2024 June | 78 | 39 | 117 |
| 2024 May | 68 | 34 | 102 |
| 2024 April | 61 | 42 | 103 |
| 2024 March | 43 | 22 | 65 |
| 2024 February | 51 | 39 | 90 |
| 2024 January | 34 | 29 | 63 |
| 2023 December | 22 | 26 | 48 |
| 2023 November | 43 | 32 | 75 |
| 2023 October | 61 | 31 | 92 |
| 2023 September | 22 | 34 | 56 |
| 2023 August | 37 | 15 | 52 |
| 2023 July | 36 | 28 | 64 |
| 2023 June | 42 | 29 | 71 |
| 2023 May | 62 | 40 | 102 |
| 2023 April | 65 | 26 | 91 |
| 2023 March | 67 | 28 | 95 |
| 2023 February | 51 | 24 | 75 |
| 2023 January | 25 | 29 | 54 |
| 2022 December | 50 | 44 | 94 |
| 2022 November | 31 | 33 | 64 |
| 2022 October | 44 | 40 | 84 |
| 2022 September | 48 | 37 | 85 |
| 2022 August | 52 | 43 | 95 |
| 2022 July | 31 | 41 | 72 |
| 2022 June | 43 | 30 | 73 |
| 2022 May | 48 | 23 | 71 |
| 2022 April | 27 | 45 | 72 |
| 2022 March | 41 | 52 | 93 |
| 2022 February | 40 | 51 | 91 |
| 2022 January | 42 | 23 | 65 |
| 2021 December | 46 | 37 | 83 |
| 2021 November | 32 | 34 | 66 |
| 2021 October | 32 | 41 | 73 |
| 2021 September | 54 | 34 | 88 |
| 2021 August | 33 | 35 | 68 |
| 2021 July | 42 | 25 | 67 |
| 2021 June | 38 | 30 | 68 |
| 2021 May | 49 | 39 | 88 |
| 2021 April | 102 | 69 | 171 |
| 2021 March | 42 | 35 | 77 |
| 2021 February | 43 | 18 | 61 |
| 2021 January | 41 | 16 | 57 |
| 2020 December | 21 | 19 | 40 |
| 2020 November | 35 | 10 | 45 |
| 2020 October | 25 | 21 | 46 |
| 2020 September | 27 | 9 | 36 |
| 2020 August | 41 | 7 | 48 |
| 2020 July | 28 | 10 | 38 |
| 2020 June | 34 | 12 | 46 |
| 2020 May | 49 | 13 | 62 |
| 2020 April | 43 | 18 | 61 |
| 2020 March | 38 | 12 | 50 |
| 2020 February | 38 | 19 | 57 |
| 2020 January | 34 | 25 | 59 |
| 2019 December | 41 | 19 | 60 |
| 2019 November | 42 | 21 | 63 |
| 2019 October | 28 | 12 | 40 |
| 2019 September | 17 | 20 | 37 |
| 2019 August | 21 | 12 | 33 |
| 2019 July | 19 | 20 | 39 |
| 2019 June | 22 | 16 | 38 |
| 2019 May | 18 | 14 | 32 |
| 2019 April | 45 | 29 | 74 |
| 2019 March | 26 | 19 | 45 |
| 2019 February | 26 | 21 | 47 |
| 2019 January | 24 | 19 | 43 |
| 2018 December | 79 | 43 | 122 |
| 2018 November | 92 | 14 | 106 |
| 2018 October | 79 | 16 | 95 |
| 2018 September | 78 | 18 | 96 |
| 2018 August | 47 | 21 | 68 |
| 2018 July | 57 | 22 | 79 |
| 2018 June | 53 | 13 | 66 |
| 2018 May | 59 | 14 | 73 |
| 2018 April | 78 | 12 | 90 |
| 2018 March | 71 | 5 | 76 |
| 2018 February | 59 | 7 | 66 |
| 2018 January | 71 | 4 | 75 |
| 2017 December | 70 | 11 | 81 |
| 2017 November | 47 | 11 | 58 |
| 2017 October | 38 | 8 | 46 |
| 2017 September | 37 | 13 | 50 |
| 2017 August | 41 | 6 | 47 |
| 2017 July | 41 | 5 | 46 |
| 2017 June | 39 | 6 | 45 |
| 2017 May | 57 | 9 | 66 |
| 2017 April | 47 | 18 | 65 |
| 2017 March | 33 | 33 | 66 |
| 2017 February | 22 | 6 | 28 |
| 2017 January | 22 | 5 | 27 |
| 2016 December | 30 | 2 | 32 |
| 2016 November | 40 | 4 | 44 |
| 2016 October | 44 | 15 | 59 |
| 2016 September | 72 | 3 | 75 |
| 2016 August | 162 | 5 | 167 |
| 2016 July | 151 | 5 | 156 |
| 2016 June | 105 | 0 | 105 |
| 2016 May | 103 | 0 | 103 |
| 2016 April | 66 | 0 | 66 |
| 2016 March | 56 | 0 | 56 |
| 2016 February | 70 | 0 | 70 |
| 2016 January | 84 | 0 | 84 |
| 2015 December | 101 | 0 | 101 |
| 2015 November | 64 | 0 | 64 |
| 2015 October | 82 | 0 | 82 |
| 2015 September | 56 | 0 | 56 |
| 2015 August | 58 | 0 | 58 |
| 2015 July | 51 | 0 | 51 |
| 2015 June | 32 | 0 | 32 |
| 2015 May | 34 | 0 | 34 |
| 2015 April | 5 | 0 | 5 |
Show all
