Intraperitoneal daptomycin
Administración intraperitoneal de daptomicina
Read
7544
Timeswas read the article
2240
Total PDF
5304
Total HTML
Share statistics
array:21 [ "pii" => "X2013251411051817" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Mar.10806" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:375-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3591 "formatos" => array:3 [ "EPUB" => 280 "HTML" => 2772 "PDF" => 539 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X021169951105181X" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2011.Mar.10806" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2011;31:375-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7533 "formatos" => array:3 [ "EPUB" => 308 "HTML" => 6620 "PDF" => 605 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Administración intraperitoneal de daptomicina" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "375" "paginaFinal" => "376" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Intraperitoneal daptomycin" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. García-López, L. Gómez Sayago, M.J. Fernández-Reyes Luis" "autores" => array:3 [ 0 => array:2 [ "Iniciales" => "L." "apellidos" => "García-López" ] 1 => array:2 [ "Iniciales" => "L." "apellidos" => "Gómez Sayago" ] 2 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Fernández-Reyes Luis" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251411051817" "doi" => "10.3265/Nefrologia.pre2011.Mar.10806" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051817?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951105181X?idApp=UINPBA000064" "url" => "/02116995/0000003100000003/v0_201502091414/X021169951105181X/v0_201502091415/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251411051809" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Mar.10818" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:376-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5345 "formatos" => array:3 [ "EPUB" => 325 "HTML" => 4495 "PDF" => 525 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Relapses in patient with microscopic polyangiitis with persistently positive antimyeloperoxidase for 4 years using maintenance immunosuppressants" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "376" "paginaFinal" => "378" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Recaídas en paciente con poliangeitis microscópica con anti-mpo persistentemente positivo durante 4 años y con inmunosupresores de mantenimiento" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10818_108_17660_en_t110818.jpg" "Alto" => 213 "Ancho" => 600 "Tamanyo" => 143191 ] ] "descripcion" => array:1 [ "en" => "Evolution of ANCA titre, kidney function parameters, immunosuppressive treatment and relapses" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "MANUEL HERAS, M. Heras, MARIA JOSE FERNANDEZ-REYES, M.J. Fernández-Reyes, ROSA SANCHEZ, R. Sánchez, HENAR MUÑOZ, H. Muñoz, MARIA JOSE JIMENEZ, M.J. Jiménez, ALVARO MOLINA, A. Molina" "autores" => array:12 [ 0 => array:2 [ "nombre" => "MANUEL" "apellidos" => "HERAS" ] 1 => array:2 [ "Iniciales" => "M." "apellidos" => "Heras" ] 2 => array:2 [ "nombre" => "MARIA JOSE" "apellidos" => "FERNANDEZ-REYES" ] 3 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Fernández-Reyes" ] 4 => array:2 [ "nombre" => "ROSA" "apellidos" => "SANCHEZ" ] 5 => array:2 [ "Iniciales" => "R." "apellidos" => "Sánchez" ] 6 => array:2 [ "nombre" => "HENAR" "apellidos" => "MUÑOZ" ] 7 => array:2 [ "Iniciales" => "H." "apellidos" => "Muñoz" ] 8 => array:2 [ "nombre" => "MARIA JOSE" "apellidos" => "JIMENEZ" ] 9 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Jiménez" ] 10 => array:2 [ "nombre" => "ALVARO" "apellidos" => "MOLINA" ] 11 => array:2 [ "Iniciales" => "A." "apellidos" => "Molina" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699511051801" "doi" => "10.3265/Nefrologia.pre2011.Mar.10818" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051801?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051809?idApp=UINPBA000064" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051809/v0_201502091639/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251411051825" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Mar.10810" "estado" => "S300" "fechaPublicacion" => "2011-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:374-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4517 "formatos" => array:3 [ "EPUB" => 316 "HTML" => 3632 "PDF" => 569 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Treatment with intravenous daptomycin for a peritonitis relapse caused by Staphylococcus epidermidis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "374" "paginaFinal" => "375" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento con daptomicina intravenosa en una recidiva de peritonitis por Staphylococcus epidermidis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Levy, V. Camarero Temiño, A. Blasco Mollá, M.P. Ortega Lafont, P. Abaigar Luquin, M.J. Izquierdo Ortiz, G. Torres Torres" "autores" => array:7 [ 0 => array:2 [ "Iniciales" => "F." "apellidos" => "Levy" ] 1 => array:2 [ "Iniciales" => "V." "apellidos" => "Camarero Temiño" ] 2 => array:2 [ "Iniciales" => "A." "apellidos" => "Blasco Mollá" ] 3 => array:2 [ "Iniciales" => "M.P." "apellidos" => "Ortega Lafont" ] 4 => array:2 [ "Iniciales" => "P." "apellidos" => "Abaigar Luquin" ] 5 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Izquierdo Ortiz" ] 6 => array:2 [ "Iniciales" => "G." "apellidos" => "Torres Torres" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699511051828" "doi" => "10.3265/Nefrologia.pre2011.Mar.10810" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051828?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051825?idApp=UINPBA000064" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051825/v0_201502091639/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Intraperitoneal daptomycin" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "375" "paginaFinal" => "376" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "L. García-López, L. Gómez Sayago, M.J. Fernández-Reyes Luis" "autores" => array:3 [ 0 => array:3 [ "Iniciales" => "L." "apellidos" => "García-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "L." "apellidos" => "Gómez Sayago" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "M.J." "apellidos" => "Fernández-Reyes Luis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Farmacia, Hospital General de Segovia, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital General de Segovia, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Administración intraperitoneal de daptomicina" ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor, </span></p><p class="elsevierStylePara">Peritonitis is one of the main causes of morbidity in patients undergoing peritoneal dialysis (PD). Although the usual treatments with vancomycin, aminoglycosides or semi-synthetic penicillins recommended in treatment guidelines for peritonitis<span class="elsevierStyleSup">1</span> are efficient in most cases, situations such as colonisation by methicillin-resistant microorganisms with some degree of resistance to vancomycin are common. These treatments are ineffective in these cases.</p><p class="elsevierStylePara">The proliferation of multi-resistant gram-positive pathogens has led to the antibiotic daptomycin being brought back and its clinical development has started again. It was approved by the United States Food and Drug Administration (FDA) in 2003 for the treatment of endocarditis caused by gram-positive pathogens, and skin and white-tissue infections.</p><p class="elsevierStylePara">A case study has been published of peritonitis which was not linked to the peritoneal catheter that was treated with intravenous daptomycin. This study analysed the concentration of daptomycin reached in the peritoneal fluid after intravenous administration. It was found to be 5mg/ml (minimum inhibitory concentration [MIC]=4mg/ml).<span class="elsevierStyleSup">2</span> Therefore, the concentrations in the intraperitoneal fluid as a result of intraperitoneal administration of the antibiotic would be less close to the microorganism MIC for daptomycin.</p><p class="elsevierStylePara">The clinical experience published to date is limited to two cases. Intraperitoneal daptomycin was used in these cases to treat peritonitis caused by vancomycin-resistant gram-positive bacteria.<span class="elsevierStyleSup">3</span> This treatment succeeded in these cases where conventional therapies had previously failed. The intraperitoneal administration of daptomycin was well tolerated in these patients and they had no peritoneal irritation or negative effects associated with the administration of drugs through this route.</p><p class="elsevierStylePara">Furthermore, daptomycin is a drug that is currently used to treat catheter-related bacteriaemias<span class="elsevierStyleSup">4</span> due to its efficacy in controlling biofilm growth, and that is why it may be considered useful in the treatment of biofilm on intraperitoneal catheters.</p><p class="elsevierStylePara">We report here the clinical case of a 61-year-old man who had been diagnosed with advanced chronic kidney disease (CKD) secondary to diabetic nephropathy since 2001. He started PD in December 2006. The patient has had three episodes of peritonitis since February 2008 that led us to consider removing the catheter in October 2009 due to suspected biofilm.</p><p class="elsevierStylePara">In May 2010 he had a new episode of peritonitis and was started on intraperitoneal empiric treatment with vancomycin following normal dosage guidelines (a shock dosage of 2g followed by 2g/3 days and a shock dosage of 100mg of tobramycin and 50mg/24h). The presence of <span class="elsevierStyleItalic">Staphylococcus epidermidis</span> and <span class="elsevierStyleItalic">Streptococcus viridans </span>which were only sensitive to carbapenems<span class="elsevierStyleItalic"> </span>was found four days later when the culture results were received. We, therefore, continued with the intraperitoneal treatment with vancomycin at a dose of 2g a week (3 weeks), and tobramycin was changed for 1g of imipenem/24h for 14 days.</p><p class="elsevierStylePara">He had a new relapse in June 2010 and <span class="elsevierStyleItalic">S. epidermidis </span>with intermediate sensitivity to vancomycin (MIC=2) was isolated. Treatment with vancomycin was started according to protocol, with a positive clinical response, although after this relapse, it was suspected that the peritoneal catheter had been colonised by <span class="elsevierStyleItalic">S. epidermidis </span>biofilm. An application was made for the compassionate use of intraperitoneal daptomycin on the basis of the previous experience of two clinical cases published. Treatment with vancomycin was maintained until daptomycin was authorised.</p><p class="elsevierStylePara">We used the following treatment plan with daptomycin:</p><p class="elsevierStylePara">A shock dosage of 200mg (in a 2l PD1 solution), followed by 40mg in each change of the intraperitoneal fluid (four times a day) for 10 days. After finishing this treatment plan, the catheter was then put in an antibiotic lock with 350mg in 7ml for 12h once a week for one month. The patient responded positively to this treatment and has had no relapses or new episodes of peritonitis.</p>" "pdfFichero" => "P1-E521-S2971-A10806-EN.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441212" "palabras" => array:1 [ 0 => "Intraperitoneal" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441214" "palabras" => array:1 [ 0 => "Daptomycin" ] ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "1.\u{A0}Furgeson SB,\u{A0}Teiltelbaum I. New treatment options and protocols for peritoneal dialysis-related peritonitis. Contrib Nephrol 2009;163:169-76. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19494611" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Burklein D, Heyn J, Kirchhoff C, Ozimek A, Traunmuller F, Joukhadar C, et al. Analysis of plasma and peritoneal fluid concentrations of daptomycin in a patient with Enterococcus faecium peritonitis. Int J Antimicrob Agents 2008;32(4):369-71. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18701260" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Huem SC, Hall I, Topal J, Mahnenmith R, Brewster U, Abu-alfa A. Successful use of intraperitoneal daptomicyn in the treatment of vancomycin-resistant enterococcus peritonitis. Am J Kidney Dis 2009;54(3):538-41. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19237231" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Raad I, Hanna H, Jiang Y, Dvorak T, Reitzel R, Chaiban G, et al. Comparative activities of daptomycin, linezolid and tigecycline against catheter-related methicilin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob Agents Chemother 2007;51:1656-60. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17353249" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:1 [ "itemHostRev" => array:3 [ "pii" => "S0735109711050364" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003100000003/v0_201502091638/X2013251411051817/v0_201502091639/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003100000003/v0_201502091638/X2013251411051817/v0_201502091639/en/P1-E521-S2971-A10806-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051817?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 10 | 17 |
| 2024 October | 33 | 28 | 61 |
| 2024 September | 47 | 24 | 71 |
| 2024 August | 44 | 53 | 97 |
| 2024 July | 48 | 28 | 76 |
| 2024 June | 46 | 36 | 82 |
| 2024 May | 50 | 43 | 93 |
| 2024 April | 44 | 35 | 79 |
| 2024 March | 34 | 23 | 57 |
| 2024 February | 29 | 32 | 61 |
| 2024 January | 25 | 25 | 50 |
| 2023 December | 30 | 27 | 57 |
| 2023 November | 26 | 25 | 51 |
| 2023 October | 38 | 35 | 73 |
| 2023 September | 19 | 29 | 48 |
| 2023 August | 26 | 21 | 47 |
| 2023 July | 26 | 26 | 52 |
| 2023 June | 28 | 23 | 51 |
| 2023 May | 29 | 49 | 78 |
| 2023 April | 17 | 32 | 49 |
| 2023 March | 26 | 20 | 46 |
| 2023 February | 28 | 18 | 46 |
| 2023 January | 39 | 22 | 61 |
| 2022 December | 32 | 30 | 62 |
| 2022 November | 35 | 38 | 73 |
| 2022 October | 30 | 62 | 92 |
| 2022 September | 35 | 25 | 60 |
| 2022 August | 32 | 39 | 71 |
| 2022 July | 30 | 39 | 69 |
| 2022 June | 37 | 43 | 80 |
| 2022 May | 24 | 32 | 56 |
| 2022 April | 27 | 57 | 84 |
| 2022 March | 47 | 41 | 88 |
| 2022 February | 46 | 37 | 83 |
| 2022 January | 28 | 23 | 51 |
| 2021 December | 29 | 37 | 66 |
| 2021 November | 41 | 37 | 78 |
| 2021 October | 70 | 43 | 113 |
| 2021 September | 611 | 43 | 654 |
| 2021 August | 29 | 42 | 71 |
| 2021 July | 44 | 22 | 66 |
| 2021 June | 25 | 19 | 44 |
| 2021 May | 35 | 34 | 69 |
| 2021 April | 104 | 71 | 175 |
| 2021 March | 54 | 26 | 80 |
| 2021 February | 55 | 27 | 82 |
| 2021 January | 40 | 19 | 59 |
| 2020 December | 13 | 10 | 23 |
| 2020 November | 25 | 10 | 35 |
| 2020 October | 21 | 21 | 42 |
| 2020 September | 21 | 15 | 36 |
| 2020 August | 32 | 17 | 49 |
| 2020 July | 29 | 8 | 37 |
| 2020 June | 24 | 20 | 44 |
| 2020 May | 25 | 9 | 34 |
| 2020 April | 26 | 14 | 40 |
| 2020 March | 22 | 13 | 35 |
| 2020 February | 26 | 26 | 52 |
| 2020 January | 27 | 19 | 46 |
| 2019 December | 30 | 19 | 49 |
| 2019 November | 14 | 14 | 28 |
| 2019 October | 9 | 10 | 19 |
| 2019 September | 15 | 21 | 36 |
| 2019 August | 9 | 9 | 18 |
| 2019 July | 22 | 24 | 46 |
| 2019 June | 12 | 9 | 21 |
| 2019 May | 12 | 12 | 24 |
| 2019 April | 38 | 37 | 75 |
| 2019 March | 13 | 11 | 24 |
| 2019 February | 16 | 14 | 30 |
| 2019 January | 23 | 16 | 39 |
| 2018 December | 68 | 36 | 104 |
| 2018 November | 63 | 24 | 87 |
| 2018 October | 46 | 16 | 62 |
| 2018 September | 68 | 9 | 77 |
| 2018 August | 36 | 20 | 56 |
| 2018 July | 47 | 18 | 65 |
| 2018 June | 44 | 9 | 53 |
| 2018 May | 57 | 16 | 73 |
| 2018 April | 31 | 8 | 39 |
| 2018 March | 43 | 9 | 52 |
| 2018 February | 37 | 7 | 44 |
| 2018 January | 29 | 5 | 34 |
| 2017 December | 50 | 13 | 63 |
| 2017 November | 29 | 6 | 35 |
| 2017 October | 32 | 8 | 40 |
| 2017 September | 35 | 9 | 44 |
| 2017 August | 31 | 5 | 36 |
| 2017 July | 32 | 8 | 40 |
| 2017 June | 28 | 7 | 35 |
| 2017 May | 34 | 11 | 45 |
| 2017 April | 44 | 13 | 57 |
| 2017 March | 29 | 7 | 36 |
| 2017 February | 25 | 6 | 31 |
| 2017 January | 29 | 9 | 38 |
| 2016 December | 39 | 3 | 42 |
| 2016 November | 37 | 9 | 46 |
| 2016 October | 70 | 5 | 75 |
| 2016 September | 83 | 4 | 87 |
| 2016 August | 174 | 7 | 181 |
| 2016 July | 120 | 5 | 125 |
| 2016 June | 110 | 0 | 110 |
| 2016 May | 96 | 0 | 96 |
| 2016 April | 79 | 0 | 79 |
| 2016 March | 75 | 0 | 75 |
| 2016 February | 80 | 0 | 80 |
| 2016 January | 90 | 0 | 90 |
| 2015 December | 89 | 0 | 89 |
| 2015 November | 72 | 0 | 72 |
| 2015 October | 58 | 0 | 58 |
| 2015 September | 62 | 0 | 62 |
| 2015 August | 69 | 0 | 69 |
| 2015 July | 54 | 0 | 54 |
| 2015 June | 39 | 0 | 39 |
| 2015 May | 50 | 0 | 50 |
| 2015 April | 8 | 0 | 8 |
Show all
