Autosomal dominant polycystic kidney disease and sickle cell trait
Poliquistosis renal autosómica dominante y hemoglobina con rasgo falciforme
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Peces, C. Peces" "autores" => array:3 [ 0 => null 1 => array:4 [ "Iniciales" => "R." "apellidos" => "Peces" "email" => array:1 [ 0 => "cpeces@varnetmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "Iniciales" => "C." "apellidos" => "Peces" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario La Paz. IdiPAZ, Madrid " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 1 => array:3 [ "entidad" => "Área de Tecnología de la Información, SESCAM, Toledo, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Poliquistosis renal autosómica dominante y hemoglobina con rasgo falciforme" ] ] "textoCompleto" => "<p class="elsevierStylePara">Macroscopic haematuria due to the rupture of renal cysts is a common manifestation of autosomal dominant polycystic kidney disease (ADPKD). Many patients with ADPKD have frequent episodes of haematuria or evidence of intracystic haemorrhage throughout the progression of the disease.<span class="elsevierStyleSup">1</span> The presence of sickle cell trait (Hb AS) is also accompanied by manifestations in the kidney, particularly haematuria, and papillary necrosis is the most frequent cause of macroscopic haematuria in heterozygous carriers of this haemoglobinopathy.<span class="elsevierStyleSup">2-6</span> In one study, macroscopic haematuria was the cause for 4% of all hospital admissions of Afro-Americans with sickle cell trait.<span class="elsevierStyleSup">7</span> As such, it is not surprising that the simultaneous inheritance of both genetic diseases can create a synergy with regard to the appearance of these haemorrhagic complications. Despite the fact that the association of these two hereditary diseases, ADPKD and sickle cell trait, was first recorded in the 1990’s, when a study suggested that Afro-American patients with ADPKD and sickle cell trait could develop chronic renal failure (CRF) early in life,<span class="elsevierStyleSup">8,9</span> only recently was it pointed out that sickle cell trait is a risk factor for the development of chronic kidney disease in a population of Afro-Americans with CRF.<span class="elsevierStyleSup">10,11</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Haemoglobin S is the result of glutamic acid being replaced by valine as the sixth amino acid in the beta globin chain, which produces a haemoglobin tetramer (alpha2/beta S2) that is poorly soluble when deoxygenated.<span class="elsevierStyleSup">4</span> Polymerisation of this type of deoxyhaemoglobin (HB S) is essential to vaso-occlusive phenomena.<span class="elsevierStyleSup">4,7,12,13</span> The polymer assumes the form of an elongated fibre that becomes aligned with other fibres, resulting in the distortion of the erythrocyte into the classic crescent-moon or sickle shape, and a drastic reduction in the flexibility of the cell. The common renal manifestations of this disease in homozygous individuals (Hb SS) include defects in urine concentrations (altered counter current mechanism), distal renal tubular acidosis, abnormal proximal tubular function, and in early stages, increased glomerular filtration rate.<span class="elsevierStyleSup">14,15</span> The primary cause of these symptoms appears to be the deformation of erythrocytes (which adopt the sickle shape) in the <span class="elsevierStyleItalic">vasa recta</span> capillaries of the renal medulla. It is well established that dehydration, acidosis, decreased oxygen pressure, and high osmolarity are the primary triggers for erythrocytes to adopt the sickle shape. The normal medullary medium plays an important role in this process, as it has a low oxygen pressure and high osmolarity. Furthermore, blood flow in <span class="elsevierStyleItalic">vasa recta</span> capillaries is much slower than in cortical vessels, leading to a longer transit time. Congestion and stasis in <span class="elsevierStyleItalic">vasa recta</span> capillaries can cause focal haemorrhage and necrosis. Finally, these processes can lead to interstitial inflammation and fibrosis, tubular atrophy, and papillary infarctions due to vascular lesions. These lesions are more severe in patients with Hb SS genotypes than in Hb AS carriers. In very early stages, the physiopathology of hyperfiltration is believed to be attributed to the vasculopathy associated with haemolysis more than vaso-occlusive processes related to viscosity.<span class="elsevierStyleSup">14,15</span> In order to control haematuria resulting from papillary necrosis, several different medical treatments have been used, such as administering vasopressin, tranexamic acid, and oral urea, or direct haemostasis over the affected papillae, which includes the use of laser treatment.<span class="elsevierStyleSup">4,16-19</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Sickle cell disease (Hb SS) affects approximately 300 000 live births per year.<span class="elsevierStyleSup">4,7</span> The prevalence of sickle cell trait is approximately 8%-10% in Afro-Americans,<span class="elsevierStyleSup">4</span> and can be as high as 25%-30% in certain areas of western Africa.<span class="elsevierStyleSup">4,7</span> Roughly 2.5 million people in the USA and 30 million people in the world are heterozygous for the gene that causes sickle cell disease. The presence of sickle cell trait Hb AS), the most common haemoglobinopathy in the United States, is estimated to be 40 to 50 times more common than sickle cell anaemia (Hb SS), and is particularly prevalent among individuals that descend from Sub-Saharan Africa,India, Saudi Arabia and Mediterranean countries<span class="elsevierStyleSup">4,7</span> With the current patterns of global migration, the number of carriers of the sickle cell haemoglobin gene is increasing in Europe, and is estimated to be around 1% of the total population. As such, many European countries have introduced early detection programmes for haemoglobinopathies in newborn infants.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Sickle cell trait is a benign disorder with no haematological manifestations in the heterozygous carrier, since the morphology of the erythrocytes, red blood cell indices, reticulocyte count, and peripheral blood smears are normal. In spite of the generally benign nature of Hb AS, several different potentially severe complications have been described. For instance, Hb AS carriers can develop rhabdomyolysis, heat stroke, acute renal failure, papillary necrosis, splenic infarction, and sudden death.<span class="elsevierStyleSup">4,7,12,13,20</span> Some of these events can occur during conditions of extreme physical stress, and are occasionally attributed to vaso-occlusive crises, suggesting that, although sickle cell trait is usually quiescent, it is not always benign. Sickle cell trait is associated with health deterioration in terms of urine concentration, haematuria, and renal papillary necrosis.<span class="elsevierStyleSup">21 </span>A less common cause of haematuria in these cases is renal medullary carcinoma, which is a tumour that is almost exclusively found in Hb AS patients.<span class="elsevierStyleSup">22</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">Although sickle cell trait alone may not be sufficient for the development of chronic kidney disease, it could contribute to the progression of CRF in the presence of additional factors such as ADPKD, diabetes, and hypertension. Since patients with sickle cell trait and diabetes mellitus are prone to suffering from papillary necrosis and episodes of haematuria,<span class="elsevierStyleSup">23,24</span> it is possible that the pathophysiological factors induced by sickle cell trait could exacerbate the microvascular complications that arise from diabetes mellitus. Meanwhile, it is unknown if sickle cell trait patients have an increased risk of developing microvascular complications associated with diabetes mellitus. Recently, association with sickle cell trait has been recognised as an indicator of poor prognosis in diabetic patients, and patients with African heritage develop renal failure on average 10 years earlier than Caucasian patients.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">KEY CONCEPTS</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">1. Sickle cell trait (Hb AS) is a benign disorder carried by heterozygous individuals, with no haematological manifestations. The morphology of erythrocytes, red blood cell indices, reticulocyte counts, and peripheral blood smears are all normal.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">2. Dehydration, acidosis, reduced O<span class="elsevierStyleInf">2</span> pressure, and high osmolarity are the primary triggers for the sickle shape taken by erythrocytes in the <span class="elsevierStyleItalic">vasa recta</span> capillaries.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">3. Hb AS is associated with deteriorating urine concentrations, haematuria, and renal papillary necrosis.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">4. Simultaneous inheritance of sickle cell trait and ADPKD can create a synergy, causing recurrent haematuria.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">5. In Afro-American patients with ADPKD, sickle cell trait must be ruled out.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">6. Although the existence of sickle cell trait alone may not be enough for developing chronic kidney disease, it could contribute to the progression of CRF in the presence of other factors such as ADPKD, diabetes, and arterial hypertension.</p>" "pdfFichero" => "P1-E518-S2892-A10773-EN.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Masoumi A, Reed-Gitomer B, Kelleher C, Bekheirnia MR, Schrier RW. Developments\u{A0}in the management of autosomal dominant polycystic kidney disease. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 10 | 12 |
| 2024 October | 58 | 34 | 92 |
| 2024 September | 55 | 50 | 105 |
| 2024 August | 62 | 56 | 118 |
| 2024 July | 54 | 45 | 99 |
| 2024 June | 65 | 52 | 117 |
| 2024 May | 65 | 33 | 98 |
| 2024 April | 62 | 36 | 98 |
| 2024 March | 36 | 28 | 64 |
| 2024 February | 45 | 39 | 84 |
| 2024 January | 29 | 27 | 56 |
| 2023 December | 24 | 28 | 52 |
| 2023 November | 41 | 31 | 72 |
| 2023 October | 44 | 39 | 83 |
| 2023 September | 69 | 35 | 104 |
| 2023 August | 85 | 24 | 109 |
| 2023 July | 55 | 32 | 87 |
| 2023 June | 105 | 16 | 121 |
| 2023 May | 76 | 35 | 111 |
| 2023 April | 76 | 18 | 94 |
| 2023 March | 89 | 24 | 113 |
| 2023 February | 57 | 24 | 81 |
| 2023 January | 64 | 23 | 87 |
| 2022 December | 52 | 30 | 82 |
| 2022 November | 46 | 20 | 66 |
| 2022 October | 55 | 37 | 92 |
| 2022 September | 38 | 28 | 66 |
| 2022 August | 59 | 48 | 107 |
| 2022 July | 43 | 38 | 81 |
| 2022 June | 39 | 22 | 61 |
| 2022 May | 37 | 31 | 68 |
| 2022 April | 50 | 43 | 93 |
| 2022 March | 101 | 42 | 143 |
| 2022 February | 52 | 24 | 76 |
| 2022 January | 37 | 27 | 64 |
| 2021 December | 33 | 35 | 68 |
| 2021 November | 24 | 29 | 53 |
| 2021 October | 47 | 50 | 97 |
| 2021 September | 27 | 38 | 65 |
| 2021 August | 31 | 31 | 62 |
| 2021 July | 44 | 42 | 86 |
| 2021 June | 34 | 18 | 52 |
| 2021 May | 43 | 34 | 77 |
| 2021 April | 64 | 58 | 122 |
| 2021 March | 62 | 45 | 107 |
| 2021 February | 38 | 14 | 52 |
| 2021 January | 25 | 21 | 46 |
| 2020 December | 37 | 14 | 51 |
| 2020 November | 21 | 10 | 31 |
| 2020 October | 32 | 12 | 44 |
| 2020 September | 55 | 9 | 64 |
| 2020 August | 35 | 11 | 46 |
| 2020 July | 43 | 5 | 48 |
| 2020 June | 33 | 15 | 48 |
| 2020 May | 41 | 9 | 50 |
| 2020 April | 81 | 19 | 100 |
| 2020 March | 29 | 12 | 41 |
| 2020 February | 39 | 21 | 60 |
| 2020 January | 61 | 16 | 77 |
| 2019 December | 35 | 20 | 55 |
| 2019 November | 28 | 17 | 45 |
| 2019 October | 30 | 7 | 37 |
| 2019 September | 27 | 18 | 45 |
| 2019 August | 22 | 13 | 35 |
| 2019 July | 31 | 20 | 51 |
| 2019 June | 19 | 14 | 33 |
| 2019 May | 22 | 16 | 38 |
| 2019 April | 59 | 29 | 88 |
| 2019 March | 29 | 16 | 45 |
| 2019 February | 21 | 12 | 33 |
| 2019 January | 31 | 18 | 49 |
| 2018 December | 71 | 32 | 103 |
| 2018 November | 117 | 12 | 129 |
| 2018 October | 103 | 14 | 117 |
| 2018 September | 58 | 10 | 68 |
| 2018 August | 32 | 11 | 43 |
| 2018 July | 33 | 7 | 40 |
| 2018 June | 27 | 4 | 31 |
| 2018 May | 42 | 14 | 56 |
| 2018 April | 41 | 6 | 47 |
| 2018 March | 35 | 7 | 42 |
| 2018 February | 25 | 4 | 29 |
| 2018 January | 40 | 4 | 44 |
| 2017 December | 29 | 15 | 44 |
| 2017 November | 44 | 21 | 65 |
| 2017 October | 36 | 8 | 44 |
| 2017 September | 34 | 12 | 46 |
| 2017 August | 27 | 14 | 41 |
| 2017 July | 40 | 21 | 61 |
| 2017 June | 26 | 13 | 39 |
| 2017 May | 50 | 13 | 63 |
| 2017 April | 38 | 8 | 46 |
| 2017 March | 21 | 11 | 32 |
| 2017 February | 28 | 8 | 36 |
| 2017 January | 28 | 10 | 38 |
| 2016 December | 94 | 13 | 107 |
| 2016 November | 80 | 10 | 90 |
| 2016 October | 98 | 12 | 110 |
| 2016 September | 142 | 3 | 145 |
| 2016 August | 232 | 7 | 239 |
| 2016 July | 215 | 4 | 219 |
| 2016 June | 120 | 0 | 120 |
| 2016 May | 145 | 0 | 145 |
| 2016 April | 99 | 0 | 99 |
| 2016 March | 90 | 0 | 90 |
| 2016 February | 98 | 0 | 98 |
| 2016 January | 119 | 0 | 119 |
| 2015 December | 122 | 0 | 122 |
| 2015 November | 85 | 0 | 85 |
| 2015 October | 81 | 0 | 81 |
| 2015 September | 66 | 0 | 66 |
| 2015 August | 77 | 0 | 77 |
| 2015 July | 67 | 0 | 67 |
| 2015 June | 42 | 0 | 42 |
| 2015 May | 66 | 0 | 66 |
| 2015 April | 5 | 0 | 5 |
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