array:21 [
  "pii" => "X2013251411051160"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
  "estado" => "S300"
  "fechaPublicacion" => "2011-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2011;31:107-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3654
    "formatos" => array:3 [
      "EPUB" => 314
      "HTML" => 2756
      "PDF" => 584
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699511051163"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
      "estado" => "S300"
      "fechaPublicacion" => "2011-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2011;31:107-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7498
        "formatos" => array:3 [
          "EPUB" => 318
          "HTML" => 6523
          "PDF" => 657
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Acidosis láctica y pancitopenia por linezolid"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "107"
            "paginaFinal" => "108"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Lactic acidosis and linezolid-induced pancytopaenia"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "T. Carbajo, M. Fenollosa, R. Pons, C. Calvo"
            "autores" => array:5 [
              0 => null
              1 => array:2 [
                "Iniciales" => "T."
                "apellidos" => "Carbajo"
              ]
              2 => array:2 [
                "Iniciales" => "M."
                "apellidos" => "Fenollosa"
              ]
              3 => array:2 [
                "Iniciales" => "R."
                "apellidos" => "Pons"
              ]
              4 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Calvo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251411051160"
          "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051160?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051163?idApp=UINPBA000064"
      "url" => "/02116995/0000003100000001/v0_201502091419/X0211699511051163/v0_201502091420/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251411051179"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Nov.10714"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2011;31:107"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3838
      "formatos" => array:3 [
        "EPUB" => 312
        "HTML" => 2944
        "PDF" => 582
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Page kidney Doppler ultrasound"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "107"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Ecografía doppler del riñón de Page"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maite Rivera Gorrin"
          "autores" => array:2 [
            0 => null
            1 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Rivera Gorrin"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699511051171"
        "doi" => "10.3265/Nefrologia.pre2010.Nov.10714"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051171?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051179?idApp=UINPBA000064"
    "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051179/v0_201502091644/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251411051187"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Jun.10279"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2011;31:97-106"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4612
      "formatos" => array:3 [
        "EPUB" => 304
        "HTML" => 3304
        "PDF" => 1004
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Psychological predictors for health-related quality of life in patients on peritoneal dialysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "106"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Predictores psicológicos de la calidad de vida relacionada con la salud en pacientes en tratamiento de diálisis peritoneal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Laura Varela, L. Varela, Mª Isabel Vázquez, M.I. Vázquez, Luis Bolaños, L. Bolaños, Rafael Alonso, R. Alonso"
          "autores" => array:9 [
            0 => null
            1 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Varela"
            ]
            2 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "Varela"
            ]
            3 => array:2 [
              "nombre" => "Mª Isabel"
              "apellidos" => "Vázquez"
            ]
            4 => array:2 [
              "Iniciales" => "M.I."
              "apellidos" => "Vázquez"
            ]
            5 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Bolaños"
            ]
            6 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "Bolaños"
            ]
            7 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Alonso"
            ]
            8 => array:2 [
              "Iniciales" => "R."
              "apellidos" => "Alonso"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X021169951105118X"
        "doi" => "10.3265/Nefrologia.pre2010.Jun.10279"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951105118X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051187?idApp=UINPBA000064"
    "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051187/v0_201502091644/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Lactic acidosis and linezolid-induced pancytopaenia"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "107"
        "paginaFinal" => "108"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "T. Carbajo, M. Fenollosa, R. Pons, C. Calvo"
        "autores" => array:5 [
          0 => null
          1 => array:4 [
            "Iniciales" => "T."
            "apellidos" => "Carbajo"
            "email" => array:1 [
              0 => "tenguerengue@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "M."
            "apellidos" => "Fenollosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          3 => array:3 [
            "Iniciales" => "R."
            "apellidos" => "Pons"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Calvo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital General de Castellón,    "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Acidosis l&#225;ctica y pancitopenia por linezolid"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44; </span></p><p class="elsevierStylePara">Linezolid<span class="elsevierStyleSup">1-3</span> is an antibiotic in the oxazolidinone group with a tricyclic structure responsible for its efficacy against methicillin-resistant staphylococci&#46; It inhibits protein synthesis by using a different site from other antibiotics&#46; It is active<span class="elsevierStyleSup">3</span> against numerous microbes&#44; such as staphylococci&#44; including methicillin-resistant ones&#44; streptococci&#44; enterococci and other gram-positive types&#44; like <span class="elsevierStyleItalic">Corynebacterium </span>and<span class="elsevierStyleItalic"> Listeria</span>&#44; as well as some anaerobes such as <span class="elsevierStyleItalic">Clostridium difficile</span>&#46;</p><p class="elsevierStylePara">It is being increasingly used in current clinical practice for the treatment of nosocomial pneumonia caused by MRSA or <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#44; community pneumonia due to gram-positive organisms and complicated and uncomplicated skin infections&#44; including diabetic foot infections without concomitant osteomyelitis&#46;</p><p class="elsevierStylePara">60&#37; is metabolised<span class="elsevierStyleSup">3</span> by the liver and 30&#37; by the kidney&#44; therefore the dosage does not require adjustment in moderate renal or hepatic failure&#44; although there is no experience in serious failures&#46;</p><p class="elsevierStylePara">Like any drug&#44; it has side effects&#46;<span class="elsevierStyleSup">1-3</span> The most frequently reported &#40;between 1&#37; and 10&#37;&#41; are gastrointestinal problems&#44; headache and abnormalities in laboratory tests such as pancytopenia and lactic acidosis&#46; Central nervous system disorders and bacterial or fungal superinfection appear less frequently&#46;</p><p class="elsevierStylePara">We present the case of a 79-year-old man with a history of with drug-controlled hypertension&#44; benign prostatic hyperplasia and chronic kidney disease stage 4 in outpatient nephrology follow-up for 8 months&#46; He underwent surgery for a prosthetic left knee in a local hospital on 18 March 2010&#44; and needed subsequent surgical cleaning for prosthetic infection on April 26&#44; when antibiotic treatment with linezolid and levofloxacin was started&#46; He was discharged on 28 May&#46; The patient maintained treatment with linezolid for 7 weeks&#46; The germ causing the prosthetic infection was unknown&#46;</p><p class="elsevierStylePara">On June 10 the patient visited the emergency department of our hospital for malaise&#44; asthenia&#44; anorexia&#44; vomiting and weight loss&#46; Upon arrival&#44; the patient was in good general condition&#44; without signs of poor peripheral perfusion&#46; Blood pressure was 118&#47;52mm Hg&#44; temperature of 36&#46;5&#176;C and the heart rate was 72 beats&#47;min&#46; There was a slight increase in local temperature of the left knee&#44; with minimal effusion&#46; Laboratory tests included the following&#58; urea 184mg&#47;dl&#44; creatinine 2&#46;6mg&#47;dl&#44; potassium 5&#46;7mmol&#47;l&#44; leukocytes 4000&#47;&#956;l&#44; with 61&#46;3&#37; neutrophils&#44; haemoglobin 9g&#47;dl&#44; platelets 45 000&#47;&#956;l&#44; lactic acid 3&#46;11mmol&#47;l&#44; pH 7&#46;25 and bicarbonate 18&#46;5mmol&#47;l&#46; The patient was admitted to trauma&#46;</p><p class="elsevierStylePara">Given these laboratory findings and the absence of signs of systemic infection justifying lactic acidosis or pancytopaenia&#44; they were considered as side effects of linezolid&#46; This was therefore withdrawn without any antibiotic alternative&#46;</p><p class="elsevierStylePara">Progressive improvement of the pancytopaenia and renal function after hydration of the patient were reported in subsequent days&#44; so the patient was transferred to the hospital where underwent surgery&#46; On being discharged&#44; the following results were found&#58; creatinine 1&#46;51mg&#47;dl&#44; total leukocyte count 5300&#47;&#956;l&#44; haemoglobin 9g&#47;dl and platelets 59 000&#47;&#956;l&#46;</p><p class="elsevierStylePara">Although linezolid is a very effective antibiotic in cases refractory to conventional antibiotics&#44; its possible side effects must always be taken into account&#46; In this case it caused pancytopaenia and lactic acidosis&#44; which improved after withdrawal of the drug&#46;</p>"
    "pdfFichero" => "P1-E515-S2804-A10552-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Uptodate."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "https://sinaem4.agemed.es/consaem/fichasTecnicas.do?metodo=buscar"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:1 [
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827808000433"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nefrologia 2008, Supl 6: 119-124."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051160/v0_201502091644/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35438"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief papers about basic research or clinical experiences"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003100000001/v0_201502091643/X2013251411051160/v0_201502091644/en/P1-E515-S2804-A10552-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051160?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Lactic acidosis and linezolid-induced pancytopaenia
Acidosis láctica y pancitopenia por linezolid
, T.. Carbajob, M.. Fenollosab, R.. Ponsb, C.. Calvob
b Servicio de Nefrología, Hospital General de Castellón,
Read
6930
Times
was read the article
2337
Total PDF
4593
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251411051160"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
  "estado" => "S300"
  "fechaPublicacion" => "2011-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2011;31:107-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3654
    "formatos" => array:3 [
      "EPUB" => 314
      "HTML" => 2756
      "PDF" => 584
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699511051163"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
      "estado" => "S300"
      "fechaPublicacion" => "2011-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2011;31:107-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7498
        "formatos" => array:3 [
          "EPUB" => 318
          "HTML" => 6523
          "PDF" => 657
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Acidosis l&#225;ctica y pancitopenia por linezolid"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "107"
            "paginaFinal" => "108"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Lactic acidosis and linezolid-induced pancytopaenia"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "T. Carbajo, M. Fenollosa, R. Pons, C. Calvo"
            "autores" => array:5 [
              0 => null
              1 => array:2 [
                "Iniciales" => "T."
                "apellidos" => "Carbajo"
              ]
              2 => array:2 [
                "Iniciales" => "M."
                "apellidos" => "Fenollosa"
              ]
              3 => array:2 [
                "Iniciales" => "R."
                "apellidos" => "Pons"
              ]
              4 => array:2 [
                "Iniciales" => "C."
                "apellidos" => "Calvo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251411051160"
          "doi" => "10.3265/Nefrologia.pre2010.Jul.10552"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051160?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051163?idApp=UINPBA000064"
      "url" => "/02116995/0000003100000001/v0_201502091419/X0211699511051163/v0_201502091420/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251411051179"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Nov.10714"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2011;31:107"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3838
      "formatos" => array:3 [
        "EPUB" => 312
        "HTML" => 2944
        "PDF" => 582
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Page kidney Doppler ultrasound"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "107"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Ecograf&#237;a doppler del ri&#241;&#243;n de Page"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maite Rivera Gorrin"
          "autores" => array:2 [
            0 => null
            1 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Rivera Gorrin"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699511051171"
        "doi" => "10.3265/Nefrologia.pre2010.Nov.10714"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511051171?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051179?idApp=UINPBA000064"
    "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051179/v0_201502091644/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251411051187"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2010.Jun.10279"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2011;31:97-106"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4612
      "formatos" => array:3 [
        "EPUB" => 304
        "HTML" => 3304
        "PDF" => 1004
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Psychological predictors for health-related quality of life in patients on peritoneal dialysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "106"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Predictores psicol&#243;gicos de la calidad de vida relacionada con la salud en pacientes en tratamiento de di&#225;lisis peritoneal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Laura Varela, L. Varela, M&#170; Isabel V&#225;zquez, M.I. V&#225;zquez, Luis Bola&#241;os, L. Bola&#241;os, Rafael Alonso, R. Alonso"
          "autores" => array:9 [
            0 => null
            1 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Varela"
            ]
            2 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "Varela"
            ]
            3 => array:2 [
              "nombre" => "M&#170; Isabel"
              "apellidos" => "V&#225;zquez"
            ]
            4 => array:2 [
              "Iniciales" => "M.I."
              "apellidos" => "V&#225;zquez"
            ]
            5 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Bola&#241;os"
            ]
            6 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "Bola&#241;os"
            ]
            7 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Alonso"
            ]
            8 => array:2 [
              "Iniciales" => "R."
              "apellidos" => "Alonso"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X021169951105118X"
        "doi" => "10.3265/Nefrologia.pre2010.Jun.10279"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951105118X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051187?idApp=UINPBA000064"
    "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051187/v0_201502091644/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Lactic acidosis and linezolid-induced pancytopaenia"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "107"
        "paginaFinal" => "108"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "T. Carbajo, M. Fenollosa, R. Pons, C. Calvo"
        "autores" => array:5 [
          0 => null
          1 => array:4 [
            "Iniciales" => "T."
            "apellidos" => "Carbajo"
            "email" => array:1 [
              0 => "tenguerengue&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "M."
            "apellidos" => "Fenollosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          3 => array:3 [
            "Iniciales" => "R."
            "apellidos" => "Pons"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          4 => array:3 [
            "Iniciales" => "C."
            "apellidos" => "Calvo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrología, Hospital General de Castellón,    "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Acidosis l&#225;ctica y pancitopenia por linezolid"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#44; </span></p><p class="elsevierStylePara">Linezolid<span class="elsevierStyleSup">1-3</span> is an antibiotic in the oxazolidinone group with a tricyclic structure responsible for its efficacy against methicillin-resistant staphylococci&#46; It inhibits protein synthesis by using a different site from other antibiotics&#46; It is active<span class="elsevierStyleSup">3</span> against numerous microbes&#44; such as staphylococci&#44; including methicillin-resistant ones&#44; streptococci&#44; enterococci and other gram-positive types&#44; like <span class="elsevierStyleItalic">Corynebacterium </span>and<span class="elsevierStyleItalic"> Listeria</span>&#44; as well as some anaerobes such as <span class="elsevierStyleItalic">Clostridium difficile</span>&#46;</p><p class="elsevierStylePara">It is being increasingly used in current clinical practice for the treatment of nosocomial pneumonia caused by MRSA or <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#44; community pneumonia due to gram-positive organisms and complicated and uncomplicated skin infections&#44; including diabetic foot infections without concomitant osteomyelitis&#46;</p><p class="elsevierStylePara">60&#37; is metabolised<span class="elsevierStyleSup">3</span> by the liver and 30&#37; by the kidney&#44; therefore the dosage does not require adjustment in moderate renal or hepatic failure&#44; although there is no experience in serious failures&#46;</p><p class="elsevierStylePara">Like any drug&#44; it has side effects&#46;<span class="elsevierStyleSup">1-3</span> The most frequently reported &#40;between 1&#37; and 10&#37;&#41; are gastrointestinal problems&#44; headache and abnormalities in laboratory tests such as pancytopenia and lactic acidosis&#46; Central nervous system disorders and bacterial or fungal superinfection appear less frequently&#46;</p><p class="elsevierStylePara">We present the case of a 79-year-old man with a history of with drug-controlled hypertension&#44; benign prostatic hyperplasia and chronic kidney disease stage 4 in outpatient nephrology follow-up for 8 months&#46; He underwent surgery for a prosthetic left knee in a local hospital on 18 March 2010&#44; and needed subsequent surgical cleaning for prosthetic infection on April 26&#44; when antibiotic treatment with linezolid and levofloxacin was started&#46; He was discharged on 28 May&#46; The patient maintained treatment with linezolid for 7 weeks&#46; The germ causing the prosthetic infection was unknown&#46;</p><p class="elsevierStylePara">On June 10 the patient visited the emergency department of our hospital for malaise&#44; asthenia&#44; anorexia&#44; vomiting and weight loss&#46; Upon arrival&#44; the patient was in good general condition&#44; without signs of poor peripheral perfusion&#46; Blood pressure was 118&#47;52mm Hg&#44; temperature of 36&#46;5&#176;C and the heart rate was 72 beats&#47;min&#46; There was a slight increase in local temperature of the left knee&#44; with minimal effusion&#46; Laboratory tests included the following&#58; urea 184mg&#47;dl&#44; creatinine 2&#46;6mg&#47;dl&#44; potassium 5&#46;7mmol&#47;l&#44; leukocytes 4000&#47;&#956;l&#44; with 61&#46;3&#37; neutrophils&#44; haemoglobin 9g&#47;dl&#44; platelets 45 000&#47;&#956;l&#44; lactic acid 3&#46;11mmol&#47;l&#44; pH 7&#46;25 and bicarbonate 18&#46;5mmol&#47;l&#46; The patient was admitted to trauma&#46;</p><p class="elsevierStylePara">Given these laboratory findings and the absence of signs of systemic infection justifying lactic acidosis or pancytopaenia&#44; they were considered as side effects of linezolid&#46; This was therefore withdrawn without any antibiotic alternative&#46;</p><p class="elsevierStylePara">Progressive improvement of the pancytopaenia and renal function after hydration of the patient were reported in subsequent days&#44; so the patient was transferred to the hospital where underwent surgery&#46; On being discharged&#44; the following results were found&#58; creatinine 1&#46;51mg&#47;dl&#44; total leukocyte count 5300&#47;&#956;l&#44; haemoglobin 9g&#47;dl and platelets 59 000&#47;&#956;l&#46;</p><p class="elsevierStylePara">Although linezolid is a very effective antibiotic in cases refractory to conventional antibiotics&#44; its possible side effects must always be taken into account&#46; In this case it caused pancytopaenia and lactic acidosis&#44; which improved after withdrawal of the drug&#46;</p>"
    "pdfFichero" => "P1-E515-S2804-A10552-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Uptodate."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "https://sinaem4.agemed.es/consaem/fichasTecnicas.do?metodo=buscar"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:1 [
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827808000433"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nefrologia 2008, Supl 6: 119-124."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003100000001/v0_201502091643/X2013251411051160/v0_201502091644/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35438"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief papers about basic research or clinical experiences"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003100000001/v0_201502091643/X2013251411051160/v0_201502091644/en/P1-E515-S2804-A10552-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411051160?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 3 6 9
2024 October 45 36 81
2024 September 46 27 73
2024 August 69 60 129
2024 July 41 32 73
2024 June 49 42 91
2024 May 62 34 96
2024 April 39 38 77
2024 March 34 28 62
2024 February 35 37 72
2024 January 25 28 53
2023 December 19 25 44
2023 November 34 30 64
2023 October 26 31 57
2023 September 33 31 64
2023 August 24 29 53
2023 July 23 29 52
2023 June 28 31 59
2023 May 28 31 59
2023 April 36 24 60
2023 March 28 29 57
2023 February 19 21 40
2023 January 31 20 51
2022 December 47 34 81
2022 November 32 24 56
2022 October 37 46 83
2022 September 23 32 55
2022 August 34 42 76
2022 July 33 49 82
2022 June 35 37 72
2022 May 38 40 78
2022 April 25 51 76
2022 March 34 59 93
2022 February 31 50 81
2022 January 30 31 61
2021 December 19 45 64
2021 November 21 34 55
2021 October 39 46 85
2021 September 20 35 55
2021 August 27 37 64
2021 July 23 27 50
2021 June 30 22 52
2021 May 33 28 61
2021 April 68 55 123
2021 March 49 28 77
2021 February 30 22 52
2021 January 40 17 57
2020 December 34 16 50
2020 November 21 16 37
2020 October 21 11 32
2020 September 20 11 31
2020 August 18 15 33
2020 July 30 21 51
2020 June 23 26 49
2020 May 31 16 47
2020 April 38 15 53
2020 March 14 10 24
2020 February 31 21 52
2020 January 41 24 65
2019 December 28 23 51
2019 November 32 18 50
2019 October 20 14 34
2019 September 26 22 48
2019 August 21 13 34
2019 July 20 23 43
2019 June 20 10 30
2019 May 23 17 40
2019 April 30 51 81
2019 March 17 15 32
2019 February 18 15 33
2019 January 33 14 47
2018 December 58 34 92
2018 November 71 13 84
2018 October 55 12 67
2018 September 57 19 76
2018 August 42 12 54
2018 July 42 14 56
2018 June 36 13 49
2018 May 46 9 55
2018 April 37 12 49
2018 March 32 9 41
2018 February 44 3 47
2018 January 39 5 44
2017 December 55 9 64
2017 November 28 4 32
2017 October 33 8 41
2017 September 34 10 44
2017 August 34 11 45
2017 July 33 14 47
2017 June 32 7 39
2017 May 31 12 43
2017 April 30 15 45
2017 March 16 12 28
2017 February 14 7 21
2017 January 18 19 37
2016 December 43 7 50
2016 November 38 7 45
2016 October 64 4 68
2016 September 89 1 90
2016 August 138 3 141
2016 July 106 5 111
2016 June 102 0 102
2016 May 105 0 105
2016 April 97 0 97
2016 March 61 0 61
2016 February 76 0 76
2016 January 63 0 63
2015 December 106 0 106
2015 November 60 0 60
2015 October 63 0 63
2015 September 61 0 61
2015 August 74 0 74
2015 July 65 0 65
2015 June 31 0 31
2015 May 42 0 42
2015 April 7 0 7
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?