Pentosan polysulfate sodium prevents kidney morphological changes and albuminuria in rats with Type 1 diabetes
El pentosán polisulfato de sodio previene las alteraciones morfológicas renales y la albuminuria en ratas con diabetes tipo 1
, Yaira Mathison Naterab, Y.. Mathison Naterac, Hector José Finold, H.J.. Finole, Zaida Querob, Z.. Queroc, Roschman Gonzálezd, R.. Gonzáleze, Julio Gonzálezf, J.. Gonzálezg
b Cátedra de Farmacología de la Escuela José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela,
c Cátedra de Farmacología, Escuela José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela,
d Centro de Microscopía Electrónica "Dr. Mitsuo Ogura", Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela,
e Centro de Microscopía Electrónica Dr. Mitsuo Ogura, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela,
f Centro de Investigaciones Médicas y Biotecnológicas, Universidad de Carabobo., Valencia, Venezuela,
g Centro de Investigaciones Médicas y Biotecnológicas, Universidad de Carabobo, Valencia, Venezuela,
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"apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "affg" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => " Cátedra de Farmacología de la Escuela José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 1 => array:3 [ "entidad" => "Cátedra de Farmacología, Escuela José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] 2 => array:3 [ "entidad" => " Centro de Microscopía Electrónica "Dr. Mitsuo Ogura", Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] 3 => array:3 [ "entidad" => "Centro de Microscopía Electrónica Dr. Mitsuo Ogura, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "affe" ] 4 => array:3 [ "entidad" => " Centro de Investigaciones Médicas y Biotecnológicas, Universidad de Carabobo., Valencia, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "afff" ] 5 => array:3 [ "entidad" => "Centro de Investigaciones Médicas y Biotecnológicas, Universidad de Carabobo, Valencia, Venezuela, " "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "affg" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El pentosán polisulfato de sodio previene las alteraciones morfológicas renales y la albuminuria en ratas con diabetes tipo 1" ] ] "pdfFichero" => "P1-E506-S2860-A10543-EN.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:4 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec441519" "palabras" => array:1 [ 0 => "Diabetes" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec441521" "palabras" => array:1 [ 0 => "Daño renal" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec441523" "palabras" => array:1 [ 0 => "Microalbuminuria" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec441525" "palabras" => array:1 [ 0 => "Glicosaminoglicanos" ] ] ] "en" => array:4 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441520" "palabras" => array:1 [ 0 => "Diabetes" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441522" "palabras" => array:1 [ 0 => "kidney damage" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441524" "palabras" => array:1 [ 0 => "Microalbuminuria" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec441526" "palabras" => array:1 [ 0 => "Glycosaminoglycans" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleItalic">Decreased levels of glycosaminoglycans (GAGs) have been observed in the kidney and other organs, in human and animal models of diabetes. Long-term administration of heparins and other glycosaminoglycans has demonstrated a beneficial effect on morphological and functional kidney abnormalities in diabetic rats. We assessed the effect of pentosan polysulfate sodium (PPS), a semi-synthetic glycosaminoglycan with low anticoagulant activity, on kidney involvement in streptozotocin diabetic rats. Diabetes was induced in male Sprague-Dawley rats by i.v. administration of streptozotocin (STZ). Animals were randomly allocated to three groups: C = control, STZ and STZ + PPS = pretreated with PPS (15mg/kg, s.c.). After three months of follow-up, blood and 24 h-urine samples were obtained, the animals were sacrificed and the kidney microdissected for morphometric analysis. Urinary albumin excretion was markedly increased in untreated diabetic rats (C = 0.26 ± 0.03 vs STZ = 7.75 ± 1.8 mg/24 h) and PPS treatment partially prevented the albumin rise (3.7 ± 0.7 mg/24 h), without affecting the metabolic control HbA<span class="elsevierStyleInf">1c</span> (C = 3.6 ± 1.7; STZ = 8.82 ± 0.47; STZ + PPS = 8.63 ± 0.54). Electron microscope observation revealed typical renal lesions described in experimental diabetes (STZ group). PPS administration prevents the tubular basement membrane thickening and the loss of cytoarchitecture induced by experimental diabetes. Our data demonstrate that long-term administration of PPS has a favourable effect on morphological and functional abnormalities in kidneys of diabetic rats and suggests a potential therapeutic use for this compound.</span></p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStylePara">Se ha comunicado una disminución de los valores de glicosaminoglicanos (GAG) en el riñón y otros órganos en modelos experimentales de diabetes y en humanos. La administración a largo plazo de heparina y otros GAG previene las alteraciones morfológicas y funcionales del riñón en ratas diabéticas. Evaluamos el efecto del pentosán polisulfato de sodio (PPSNa), un mucopolisacárido semisintético similar a los GAG y de baja actividad anticoagulante, sobre la función renal y los cambios estructurales en ratas diabéticas. La diabetes fue inducida a ratas Sprague-Dawley mediante la administración i.v. de estreptozotocina (STZ). Los animales fueron distribuidos al azar en tres grupos (C = control, STZ y STZ + PPSNa = pretratados con 15 mg/kg/día de PPSNa s.c.). Después de 3 meses se tomaron muestras de sangre y de orina de 24 horas; los animales fueron sacrificados y los riñones extraídos mediante microdisección para el análisis morfométrico. Los animales del grupo STZ presentaron un incremento importante de la excreción de albúmina en orina (C = 0,26 ± 0,03 frente a STZ = 7,75 ± 1,8 mg/24 h), que fue parcialmente revertido por el pretratamiento con PPSNa (3,7 ± 0,7 mg/24 h), sin afectar al control metabólico, HbA<span class="elsevierStyleInf">1c</span> (C = 3,6 ± 1,7; STZ = 8,82 ± 0,47; STZ + PPSNa = 8,63 ± 0,54). En las micrografías electrónicas se observan las lesiones renales habituales descritas en la diabetes experimental (grupo STZ). La administración de PPSNa previene el engrosamiento de la membrana basal tubular y la pérdida de la citoarquitectura inducida por la diabetes. Nuestros resultados demuestran que la administración de PPSNa previene parcialmente el daño renal en este modelo experimental y sugieren un potencial uso terapéutico de este compuesto.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "\u{A0}" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Gambaro G, Cavazzana A, Luzi P, Piccoli A, Borsatti A, Crepaldi G, et al.\u{A0}Glycosaminoglycans prevents morphological renal alterations and albuminuria in diabetic rats.\u{A0}Kidney Int 1992;42:285-91. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1328749" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Gambaro G, Venturini A, Noonam D, Fries W, Re G, Garbisa S, et al.\u{A0}Treatment with a glycosaminoglycans formulation ameliorates experimental diabetic nephropaty. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 16 | 23 |
| 2024 October | 58 | 58 | 116 |
| 2024 September | 63 | 42 | 105 |
| 2024 August | 69 | 86 | 155 |
| 2024 July | 60 | 56 | 116 |
| 2024 June | 56 | 65 | 121 |
| 2024 May | 75 | 59 | 134 |
| 2024 April | 49 | 44 | 93 |
| 2024 March | 48 | 34 | 82 |
| 2024 February | 29 | 35 | 64 |
| 2024 January | 45 | 35 | 80 |
| 2023 December | 41 | 30 | 71 |
| 2023 November | 46 | 45 | 91 |
| 2023 October | 40 | 52 | 92 |
| 2023 September | 45 | 38 | 83 |
| 2023 August | 85 | 21 | 106 |
| 2023 July | 54 | 49 | 103 |
| 2023 June | 55 | 23 | 78 |
| 2023 May | 52 | 44 | 96 |
| 2023 April | 19 | 21 | 40 |
| 2023 March | 40 | 32 | 72 |
| 2023 February | 34 | 20 | 54 |
| 2023 January | 33 | 36 | 69 |
| 2022 December | 48 | 33 | 81 |
| 2022 November | 46 | 42 | 88 |
| 2022 October | 32 | 47 | 79 |
| 2022 September | 41 | 38 | 79 |
| 2022 August | 54 | 53 | 107 |
| 2022 July | 24 | 49 | 73 |
| 2022 June | 33 | 38 | 71 |
| 2022 May | 37 | 39 | 76 |
| 2022 April | 30 | 40 | 70 |
| 2022 March | 35 | 50 | 85 |
| 2022 February | 33 | 44 | 77 |
| 2022 January | 31 | 35 | 66 |
| 2021 December | 41 | 43 | 84 |
| 2021 November | 28 | 53 | 81 |
| 2021 October | 36 | 47 | 83 |
| 2021 September | 29 | 38 | 67 |
| 2021 August | 47 | 38 | 85 |
| 2021 July | 44 | 34 | 78 |
| 2021 June | 27 | 17 | 44 |
| 2021 May | 37 | 36 | 73 |
| 2021 April | 64 | 57 | 121 |
| 2021 March | 47 | 54 | 101 |
| 2021 February | 53 | 30 | 83 |
| 2021 January | 37 | 22 | 59 |
| 2020 December | 31 | 22 | 53 |
| 2020 November | 35 | 14 | 49 |
| 2020 October | 27 | 25 | 52 |
| 2020 September | 28 | 9 | 37 |
| 2020 August | 45 | 10 | 55 |
| 2020 July | 36 | 13 | 49 |
| 2020 June | 25 | 27 | 52 |
| 2020 May | 43 | 19 | 62 |
| 2020 April | 30 | 18 | 48 |
| 2020 March | 34 | 11 | 45 |
| 2020 February | 26 | 28 | 54 |
| 2020 January | 42 | 28 | 70 |
| 2019 December | 54 | 32 | 86 |
| 2019 November | 37 | 30 | 67 |
| 2019 October | 13 | 12 | 25 |
| 2019 September | 26 | 32 | 58 |
| 2019 August | 21 | 16 | 37 |
| 2019 July | 36 | 24 | 60 |
| 2019 June | 30 | 26 | 56 |
| 2019 May | 43 | 22 | 65 |
| 2019 April | 72 | 53 | 125 |
| 2019 March | 34 | 25 | 59 |
| 2019 February | 30 | 22 | 52 |
| 2019 January | 32 | 22 | 54 |
| 2018 December | 72 | 35 | 107 |
| 2018 November | 101 | 22 | 123 |
| 2018 October | 55 | 25 | 80 |
| 2018 September | 53 | 11 | 64 |
| 2018 August | 32 | 17 | 49 |
| 2018 July | 32 | 15 | 47 |
| 2018 June | 37 | 18 | 55 |
| 2018 May | 40 | 17 | 57 |
| 2018 April | 38 | 12 | 50 |
| 2018 March | 35 | 15 | 50 |
| 2018 February | 33 | 11 | 44 |
| 2018 January | 25 | 13 | 38 |
| 2017 December | 52 | 18 | 70 |
| 2017 November | 34 | 22 | 56 |
| 2017 October | 26 | 14 | 40 |
| 2017 September | 32 | 5 | 37 |
| 2017 August | 28 | 13 | 41 |
| 2017 July | 34 | 14 | 48 |
| 2017 June | 33 | 17 | 50 |
| 2017 May | 44 | 16 | 60 |
| 2017 April | 36 | 15 | 51 |
| 2017 March | 25 | 13 | 38 |
| 2017 February | 23 | 9 | 32 |
| 2017 January | 19 | 11 | 30 |
| 2016 December | 59 | 6 | 65 |
| 2016 November | 76 | 8 | 84 |
| 2016 October | 101 | 9 | 110 |
| 2016 September | 143 | 8 | 151 |
| 2016 August | 194 | 7 | 201 |
| 2016 July | 206 | 11 | 217 |
| 2016 June | 152 | 0 | 152 |
| 2016 May | 163 | 0 | 163 |
| 2016 April | 128 | 0 | 128 |
| 2016 March | 103 | 0 | 103 |
| 2016 February | 136 | 0 | 136 |
| 2016 January | 137 | 0 | 137 |
| 2015 December | 147 | 0 | 147 |
| 2015 November | 103 | 0 | 103 |
| 2015 October | 103 | 0 | 103 |
| 2015 September | 74 | 0 | 74 |
| 2015 August | 78 | 0 | 78 |
| 2015 July | 63 | 0 | 63 |
| 2015 June | 34 | 0 | 34 |
| 2015 May | 63 | 0 | 63 |
| 2015 April | 7 | 0 | 7 |
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