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Since 1999, comorbidity has been recorded as the presence of the most common risk factors (age, diabetes, cardiovascular disease, neoplastic disease, liver disease, dyslipidemia, etc.). From 2004, the Charlson index<span class="elsevierStyleSup">1,2</span> has also been included at the start of treatment as a measure of comorbidity.</p><p class="elsevierStylePara">All hospitals with PD in the Community of Andalusia have participated in the completion of this database:</p><p class="elsevierStylePara">- Almería: Torrecárdenas Hospital.<br></br>- Cádiz: Hospital of Puerto Real. Puerta del Mar Hospital. Hospital of Jerez de la Frontera.<br></br>- Córdoba: Reina Sofía Hospital.<br></br>- Granada: Virgen de las Nieves Hospital. San Cecilio Hospital.<br></br>- Huelva: Juan Ramón Jiménez Hospital.<br></br>- Jaén: Medical-Surgical Hospital.<br></br>- Málaga: Carlos Haya Hospital.<br></br>- Seville: Virgen del Rocío Hospital. Virgen de Macarena Hospital.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Data Processing</span></p><p class="elsevierStylePara">This report has been produced with the data from all adult patients (> 14 years old) who began treatment on PD within the period from January 1999 to December 2008, and who have stayed on this technique for more than one month. The treatment population of 2008 has been analysed with respect to the incidence, aetiology and evolution of peritonitis.</p><p class="elsevierStylePara">The statistical analysis (SPSS.15) has been carried out through the use of: central tendency and dispersion measures (means and standard deviation) for quantitative variables; frequencies for qualitative variables; contingency tables, hypothesis tests, chi squared and Student t-test, determination of relative risks (RR) and confidence intervals (CI) to 95% for inferential statistics; and Kaplan-Meier survival curves and log-rank test for curve comparison. Finally, a multivariate Cox model has been used to adjust risk proportional to the included comorbidities.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Demographic data</span></p><p class="elsevierStylePara">The total number of patients included in the technique from 1 January 1999 to 31 December 2008 was 1,173. In the last 5 years, the percentage of incident patients on PD has not changed significantly with respect to other renal replacement treatments (2004: 11.1%; 2005: 10.1%; 2006: 10%; 2007: 10.1%; 2008: 13.1%).</p><p class="elsevierStylePara">57% are men (n = 669) and 43%, women (n = 504). The average age is 56 years (SD = 17), ranging between 15 and 90 years old. Distribution by age is shown in Figure 1, where we emphasise that 40% of patients start PD in the 61 to 80 age range.</p><p class="elsevierStylePara">During 2008, 419 patients were treated, and as of 31 December, 318 remained in the program. In that year, 139 new patients started PD in Andalusia, following a gently rising trend in the study period (Figure 2).</p><p class="elsevierStylePara">Most of patients who begin PD have not had any other previous renal replacement treatment (73.74%, n = 865). Of the 308 remaining patients (26.26%), 286 (24.38% of the total) transferred from HD. Although this percentage of previous HD may be considered relatively high, only 108 (9.21% of the total) were on this technique for more than 90 days and, therefore, the technique could be considered temporary or preparatory to PD in the 178 remaining patients (15.1% of the total). Finally, it should be pointed out that 22 patients (1.88% of the total who began PD) came from the loss of a previous kidney graft.</p><p class="elsevierStylePara">The distribution of incident patients on PD by province per million inhabitants in the 1999-2008 period (pat./year/mill.) shows the following data in descending order: Cádiz: 34.5; Jaén: 27.8; Huelva: 16.5; Granada: 14.7; Seville: 14.4; Almería: 12.1; Córdoba and Málaga: 10.5 (Figure 3). The mean in Andalusia is 17.5 pat./year/mill.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Causes of renal failure</span></p><p class="elsevierStylePara">Causal nephropathy is shown in Figure 4. Glomerulonephritis and diabetes constitute the primary aetiologies of renal failure in this population, followed by non-filiated causes.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Reason for selection of peritoneal dialysis</span></p><p class="elsevierStylePara">In 82% of patients, PD was freely chosen as renal replacement treatment. The remaining 18% opted for PD for medical reasons, predominantly due to vascular access problems (impossibility or exhaustion) and heart disease (Figure 5).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Transplant situation</span></p><p class="elsevierStylePara">33% of patients are included on the renal transplant waiting list. The main cause of exclusion from the list of the remaining 67% is advanced age and age-associated morbidity (Figure 6).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Catheter and peritoneal dialysis modalities</span></p><p class="elsevierStylePara">The most frequently implanted catheter was the Swan-Neck (52.4%), followed by the Tenckhoff straight, two-cuff catheter (25.2%) and single-cuff catheter (9.4%), the Toronto WH (4.6%) and others (8.3%). Implantation was performed surgically in 81% of cases and placement was predominantly paramedial (77.6%).</p><p class="elsevierStylePara">Continuous ambulatory peritoneal dialysis (CAPD) is the most used PD technique (57.9%). However, in recent years the percentage of patients included in automatic peritoneal dialysis techniques has been increasing considerably, reaching 47.5% of all patients in 2008 (Figure 7).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Peritonitis</span></p><p class="elsevierStylePara">This report presents a detailed analysis of peritonitis occurrences during 2008. A total of 170 cases were accounted for in that year, which, calculating the period of exposure to risk, corresponds to a rate of 0.50 episodes/patient/year, or expressed in another way, one peritonitis episode every 24 months. This is similar to the incidence figures of previous years (Figure 8).</p><p class="elsevierStylePara">Of the 170 peritonitis cases in 2008, a gram-positive germ grew in the culture of 54.6%, gram-negative in 27.6% and fungi in 1.2%. The peritonitis was polymicrobial in 4.8% of cases and no growth was detected (sterile peritonitis) or it was not recorded in 11.8% of cases. Peritonitis occurred with exit-site infection (ESI) in 7 cases (4.8%).</p><p class="elsevierStylePara">Evolution tended towards cure in the majority of cases (74.4%), relapse in 9.9% and removal of the catheter in 12.2%. In 6 cases the patient died in the following 4 week period (3.5%).</p><p class="elsevierStylePara">65 patients required hospitalisation due to this reason (45%), with a mean stay of 8.17 days (SD = 8.9 days; range, 1-60).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Causes for abandoning the program in the 1999-2008 period (Figure 9)</span></p><p class="elsevierStylePara">The total withdrawals from the PD program in Andalusia during the whole period were 855 patients, meaning that 318 were continuing on the technique as of 31 December 2008. The causes for abandonment were distributed almost equally in one third for patient death (35.6%), one third for kidney transplant (32.6%) and one third for transfer to haemodialysis (30.3%). Finally, 1.5% stopped the treatment due to recovery of kidney function.</p><p class="elsevierStylePara">Cardiovascular disease is the primary cause of death in patients included in PD in Andalusia (42%), followed by infections (18%).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Technique and patient survival</span></p><p class="elsevierStylePara">An inclusion criterium for the survival (SV) study was having been on the technique for at least one month. Withdrawals due to transplant, recovery of renal function or transfer to haemodialysis were considered follow-up losses, and the episode measured was withdrawal due to death. The overall actuarial survival curve shows the median SV of PD patients in Andalusia at 54 months (survival of 50% at 54 months). The mean is 60 months and 44% survival is observed at 5 years (Figure 10A).</p><p class="elsevierStylePara">We also calculated the gross annual mortality rate from 2003 to 2007 using the index that relates the deaths in each year to the total population exposed throughout that same year, with the following results: 2003, 10.3%; 2004, 12.2%; 2005, 8.9%; 2006, 7.4%, 2007, 7.1%.</p><p class="elsevierStylePara">SV of the PD technique (studied episode: transfer to haemodialysis) shows somewhat better results, with a median of 63.5 months and a mean of 67.5 months (Figure 10B).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Risk factors at start of technique and their influence on patient survival</span></p><p class="elsevierStylePara">Cardiovascular disease (defined as the presence of one or various of the following conditions: heart failure, ischaemic cardiopathy, cerebral vasculopathy or peripheral arteriopathy) was the most frequent risk factor, being present in 38.4% of patients who started PD, followed by diabetes mellitus (27%) and age of over 70 years (24.8%). If we analyze the Charlson index (taken in 707 patients; 60.3% of the total) we see that 41.7% have an index of less than 3, while 33.2% have a medium risk, with an index of 4 to 6, and 25% have a high risk (defined as an index of 7 or more) (Table 1).</p><p class="elsevierStylePara">A bivariate log-rank test was used to study the influence of these risk factors on patient survival: an age of more than 55 years at the start of PD (p < 0.001; Figure 11A), the presence of diabetes mellitus at that time (p < 0.001; Figure 11B), cardiovascular disease (p < 0.001; Figure 11C) or a higher Charlson index (p < 0.005; Figure 11D) are seen to be conditions for significantly worse survival.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Multivariate model</span></p><p class="elsevierStylePara">We used the Cox regression to evaluate the independence of the distinct risk factors to each other and their influence on survival. The significant factors were: <span class="elsevierStyleItalic">a</span>) age (treated as a continuous variable), with a Hazard Ratio (HR) of 1.040 (CI 95% of 1.029-1.050), that is, an increase in risk of 4% for each year older; <span class="elsevierStyleItalic">b</span>) cardiovascular disease (HR: 1.687; CI 95%: 1.290-2.205), and <span class="elsevierStyleItalic">c</span>) diabetes mellitus (HR: 1.905; CI 95%: 1.479-2.455) (Table 2).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION AND COMPARISON TO OTHER REGISTRIES</span></p><p class="elsevierStylePara">The use of PD in Andalusia is rare (incidence of 17.5 pat./year/mill. in the current report) if compared to the figures for haemodialysis (HD) in the same community and according to the dialysis and transplant report for 2005 from the Spanish Society of Nephrology (SEN in Spanish) (107 pat./year/mill.).<span class="elsevierStyleSup">3</span> This figure of incident patients per year and million inhabitants on PD is similar to the national mean, but lower than autonomous communities such as the Canary Islands, Cantabria and the Basque Country.<span class="elsevierStyleSup">3</span> However, there is a very heterogeneous distribution between provinces that is maintained over time in such a way that provinces like Cádiz and Jaén are above the national mean and in figures similar to the communities mentioned above.</p><p class="elsevierStylePara">Diabetes mellitus is the second cause of terminal chronic renal failure in PD in Andalusia, and would have been the first had glomerular disease not been considered as a separate entity. This is similar to the Spanish Registry published by the SEN for 2005.<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The percentage of patients included on the kidney transplant waiting list can be considered high and similar to that reported by other Spanish PD registries (Levante Registry). This percentage is higher in Andalusia than that of patients included in HD (data from the CKD Registry of the Community of Andalusia)<span class="elsevierStyleSup">4</span> and can be explained by the younger population with less comorbidity.</p><p class="elsevierStylePara">The rate of peritonitis in 2008 in Andalusia was 0.50 episodes/patient/year (one episode every 24 months/patient), a similar incidence to that of previous years. A stability is observed, with slight annual increases and decreases in this incidence in the study period (Figure 9). These rates are lower than the maximum admissible rate indicated by the International Peritoneal Dialysis Society Guidelines, which is one episode every 18 months (0.67 per year at risk).<span class="elsevierStyleSup">5</span> And although the rate of peritonitis depends on the characteristics of the treated population, it is still above what is considered the optimal rate of one episode every 40 to 50 months published by some authors.<span class="elsevierStyleSup">6,7</span></p><p class="elsevierStylePara">The most frequent reasons for leaving the technique are distributed almost evenly in thirds and correspond to patient death, renal transplant and technique failure. This distribution in patient withdrawal coincides with that reported previously by other authors<span class="elsevierStyleSup">.8,9</span></p><p class="elsevierStylePara">The overall survival of PD patients in Andalusia is 44% at 5 years (mean of 60 months and median of 54 months); this overall survival is similar to that published by the majority of Spanish<span class="elsevierStyleSup">10</span> and other European countries<span class="elsevierStyleSup">11,12</span> registries and is above registries in the USA.<span class="elsevierStyleSup">13</span> and the Australia–New Zealand registry (ANZDATA).<span class="elsevierStyleSup">14</span> However, mortality is significantly influenced by some of the characteristics of the treated population such as age and comorbidity,<span class="elsevierStyleSup">15</span> which we have also studied.</p><p class="elsevierStylePara">Firstly, the gross annual mortality rate of the Andalusian PD population was calculated with the aim of comparing it to those published by the SEN’s Spanish Registry of Dialysis and Transplant,<span class="elsevierStyleSup">16</span> observing similar values between PD in Andalusia and SEN, with a tendency to lesser mortality in the last 5 years (Figure 12).</p><p class="elsevierStylePara">The annual mortality rates of PD (Andalusia and SEN) are lower than those reported by the SEN for HD in the same periods. However, these analyses are not adjusted to comorbidity, and this difference may be explained by the lower age and lesser comorbidity of patients on PD.</p><p class="elsevierStylePara">In this study a multivariate adjustment has been made through the construction of a Cox regression model to evaluate the influence of comorbidity and age on the survival of PD patients in Andalusia. In our population, as previously described by other authors,<span class="elsevierStyleSup">17-19</span> the principal independent factors for the patient’s prognosis are age and comorbidity derived from cardiovascular disease and diabetes mellitus present before the start of renal replacement treatment.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">We are grateful to the technicians of the Regional Transplant Coordination Office of Andalusia, especially to César Remón García, computer technician with INDRA, for his collaboration in the programming and maintenance of the Database.</p><p class="elsevierStylePara"><a href="grande/1020618078_f1_pag47.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f1_pag47.jpg" alt="Distribution by age group (1999-2008)."></img></a></p><p class="elsevierStylePara">Figure 1. Distribution by age group (1999-2008).</p><p class="elsevierStylePara"><a href="grande/1020618078_f2_pag48.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f2_pag48.jpg" alt="Evolution of annual entrants in the period 1999-2008."></img></a></p><p class="elsevierStylePara">Figure 2. Evolution of annual entrants in the period 1999-2008.</p><p class="elsevierStylePara"><a href="grande/1020618078_f3_pag48.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f3_pag48.jpg" alt="Distribution by province, referring to entries by province per year and million inhabitants."></img></a></p><p class="elsevierStylePara">Figure 3. Distribution by province, referring to entries by province per year and million inhabitants.</p><p class="elsevierStylePara"><a href="grande/1020618078_f4_pag48.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f4_pag48.jpg" alt="Causal nephropathy (n = 1,163 [99.3%])."></img></a></p><p class="elsevierStylePara">Figure 4. Causal nephropathy (n = 1,163 [99.3%]).</p><p class="elsevierStylePara"><a href="grande/1020618078_f5_pag48.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f5_pag48.jpg" alt="Reason for choosing PD."></img></a></p><p class="elsevierStylePara">Figure 5. Reason for choosing PD.</p><p class="elsevierStylePara"><a href="grande/1020618078_f6_pag49.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f6_pag49.jpg" alt="Transplant situation."></img></a></p><p class="elsevierStylePara">Figure 6. Transplant situation.</p><p class="elsevierStylePara"><a href="grande/1020618078_f7_pag49.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f7_pag49.jpg" alt="Annual percentage of patients on automatic peritoneal dialysis (APD)."></img></a></p><p class="elsevierStylePara">Figure 7. Annual percentage of patients on automatic peritoneal dialysis (APD).</p><p class="elsevierStylePara"><a href="grande/1020618078_f8_pag49.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f8_pag49.jpg" alt="Incidence of peritonitis per year."></img></a></p><p class="elsevierStylePara">Figure 8. Incidence of peritonitis per year.</p><p class="elsevierStylePara"><a href="grande/1020618078_f9_pag50.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f9_pag50.jpg" alt="Abandonment of the technique and causes."></img></a></p><p class="elsevierStylePara">Figure 9. Abandonment of the technique and causes.</p><p class="elsevierStylePara"><a href="grande/1020618078_f10_pag50.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f10_pag50.jpg" alt="Overall survival of patients (A) and technique (B) in PD in Andalusia. Period 1999-2008."></img></a></p><p class="elsevierStylePara">Figure 10. Overall survival of patients (A) and technique (B) in PD in Andalusia. Period 1999-2008.</p><p class="elsevierStylePara"><a href="grande/1020618078_t1_pag51.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_t1_pag51.jpg" alt="Risk factors at start of PD"></img></a></p><p class="elsevierStylePara">Table 1. Risk factors at start of PD</p><p class="elsevierStylePara"><a href="grande/1020618078_f11_pag51.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f11_pag51.jpg" alt="Influence of risk factors on patient survival (log-rank test)."></img></a></p><p class="elsevierStylePara">Figure 11. Influence of risk factors on patient survival (log-rank test).</p><p class="elsevierStylePara"><a href="grande/1020618078_t2_pag51.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_t2_pag51.jpg" alt="Cox multivariate regression model"></img></a></p><p class="elsevierStylePara">Table 2. Cox multivariate regression model</p><p class="elsevierStylePara"><a href="grande/1020618078_f12_pag52.jpg" class="elsevierStyleCrossRefs"><img src="1020618078_f12_pag52.jpg" alt="Comparison of gross annual mortality rates: HD, PD and TX according to the Spanish Registry of the SEN and of PD in Andalusia."></img></a></p><p class="elsevierStylePara">Figure 12. Comparison of gross annual mortality rates: HD, PD and TX according to the Spanish Registry of the SEN and of PD in Andalusia.</p>" "pdfFichero" => "P1-E43-S1796-A10206-EN.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:6 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437723" "palabras" => array:1 [ 0 => "Supervivencia técnica" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437725" "palabras" => array:1 [ 0 => "Supervivencia de los pacientes" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437727" "palabras" => array:1 [ 0 => "Peritonitis" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437729" "palabras" => array:1 [ 0 => "Prevalencia" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437731" "palabras" => array:1 [ 0 => "Incidencia" ] ] 5 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec437733" "palabras" => array:1 [ 0 => "Registro de diálisis peritoneal" ] ] ] "en" => array:6 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437724" "palabras" => array:1 [ 0 => "Technique survival" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437726" "palabras" => array:1 [ 0 => "Patient survival" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437728" "palabras" => array:1 [ 0 => "Peritonitis" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437730" "palabras" => array:1 [ 0 => "Prevalence rate" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437732" "palabras" => array:1 [ 0 => "Incidence rate" ] ] 5 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437734" "palabras" => array:1 [ 0 => "Registry peritoneal dialysis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStylePara">In this study we show the results derived from the processing of the data of the Registry of the patients on peritoneal dialysis that initiated renal replacement therapy in Andalucía between January of 1999 and December of 2008. All the information comes from the base of the Registry of Renal Patients of the Andalucia´s Health Service. The results show demographic data, distribution by provinces, etiology of the end stage renal disease, reason for election of the peritoneal dialysis, inclusion or not in list of renal transplant, catheter data, withdraws and their causes, and peritonitis data of 2008. We also analyze in the report, from 1999-2008: anual incidence, diabetes, automatic peritoneal dialysis and peritonitis incidence. Finally we have studied patient and technique survival and factors affecting mortality on peritoneal dialysis, the initial comorbid conditions and its impact in the patient´s survival.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStylePara">En este estudio presentamos todos los resultados derivados del procesamiento de los datos del registro de los pacientes de diálisis peritoneal que iniciaron tratamiento sustitutivo en Andalucía entre enero de 1999 y diciembre de 2008. Toda la información procede del Sistema de Información de la Coordinación Autonómica de Trasplante de Andalucía (SICATA). Se presentan datos demográficos, distribución por provincias, las causas de insuficiencia renal y motivo de elección de la diálisis peritoneal como técnica de tratamiento renal sustitutivo, la situación con respecto al trasplante, datos en relación con el catéter y técnica de diálisis peritoneal, las salidas del programa y sus causas, las peritonitis del año 2008, su evolución y resultado de los cultivos. Presentamos también en el informe datos evolutivos 1999-2008 en cuanto a inclusiones, diabetes, tratamiento con diálisis peritoneal automática e incidencia de peritonitis. Analizamos, por otra parte, la supervivencia global de los pacientes y de la técnica diálisis peritoneal, la comorbilidad al inicio del tratamiento y su impacto en la supervivencia.</p>" ] ] "multimedia" => array:14 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f1_pag47.jpg" "Alto" => 334 "Ancho" => 401 "Tamanyo" => 18322 ] ] "descripcion" => array:1 [ "en" => "Distribution by age group (1999-2008)." ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f2_pag48.jpg" "Alto" => 243 "Ancho" => 401 "Tamanyo" => 23377 ] ] "descripcion" => array:1 [ "en" => "Evolution of annual entrants in the period 1999-2008." ] ] 2 => array:8 [ "identificador" => "fig3" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f3_pag48.jpg" "Alto" => 261 "Ancho" => 401 "Tamanyo" => 18934 ] ] "descripcion" => array:1 [ "en" => "Distribution by province, referring to entries by province per year and million inhabitants." ] ] 3 => array:8 [ "identificador" => "fig4" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f4_pag48.jpg" "Alto" => 341 "Ancho" => 401 "Tamanyo" => 21374 ] ] "descripcion" => array:1 [ "en" => "Causal nephropathy (n = 1,163 [99.3%])." ] ] 4 => array:8 [ "identificador" => "fig5" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f5_pag48.jpg" "Alto" => 301 "Ancho" => 401 "Tamanyo" => 17682 ] ] "descripcion" => array:1 [ "en" => "Reason for choosing PD." ] ] 5 => array:8 [ "identificador" => "fig6" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f6_pag49.jpg" "Alto" => 286 "Ancho" => 401 "Tamanyo" => 15672 ] ] "descripcion" => array:1 [ "en" => "Transplant situation." ] ] 6 => array:8 [ "identificador" => "fig7" "etiqueta" => "Fig. 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f7_pag49.jpg" "Alto" => 261 "Ancho" => 401 "Tamanyo" => 22275 ] ] "descripcion" => array:1 [ "en" => "Annual percentage of patients on automatic peritoneal dialysis (APD)." ] ] 7 => array:8 [ "identificador" => "fig8" "etiqueta" => "Fig. 8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f8_pag49.jpg" "Alto" => 282 "Ancho" => 402 "Tamanyo" => 24401 ] ] "descripcion" => array:1 [ "en" => "Incidence of peritonitis per year." ] ] 8 => array:8 [ "identificador" => "fig9" "etiqueta" => "Fig. 9" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f9_pag50.jpg" "Alto" => 317 "Ancho" => 402 "Tamanyo" => 20319 ] ] "descripcion" => array:1 [ "en" => "Abandonment of the technique and causes." ] ] 9 => array:8 [ "identificador" => "fig10" "etiqueta" => "Fig. 10" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f10_pag50.jpg" "Alto" => 688 "Ancho" => 399 "Tamanyo" => 34035 ] ] "descripcion" => array:1 [ "en" => "Overall survival of patients (A) and technique (B) in PD in Andalusia. Period 1999-2008." ] ] 10 => array:8 [ "identificador" => "fig11" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_t1_pag51.jpg" "Alto" => 440 "Ancho" => 400 "Tamanyo" => 21078 ] ] "descripcion" => array:1 [ "en" => "Risk factors at start of PD" ] ] 11 => array:8 [ "identificador" => "fig12" "etiqueta" => "Fig. 11" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f11_pag51.jpg" "Alto" => 349 "Ancho" => 400 "Tamanyo" => 26190 ] ] "descripcion" => array:1 [ "en" => "Influence of risk factors on patient survival (log-rank test)." ] ] 12 => array:8 [ "identificador" => "fig13" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_t2_pag51.jpg" "Alto" => 114 "Ancho" => 826 "Tamanyo" => 27389 ] ] "descripcion" => array:1 [ "en" => "Cox multivariate regression model" ] ] 13 => array:8 [ "identificador" => "fig14" "etiqueta" => "Fig. 12" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1020618078_f12_pag52.jpg" "Alto" => 256 "Ancho" => 400 "Tamanyo" => 23307 ] ] "descripcion" => array:1 [ "en" => "Comparison of gross annual mortality rates: HD, PD and TX according to the Spanish Registry of the SEN and of PD in Andalusia." ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Fried L, Bernardini J, Piraino B. 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"contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033835/v0_201502091608/en/main.assets" "Apartado" => array:4 [ "identificador" => "35446" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Special Originals" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003000000001/v0_201502091608/X2013251410033835/v0_201502091608/en/P1-E43-S1796-A10206-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033835?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
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2024 November | 4 | 5 | 9 |
2024 October | 52 | 47 | 99 |
2024 September | 52 | 33 | 85 |
2024 August | 81 | 47 | 128 |
2024 July | 41 | 19 | 60 |
2024 June | 64 | 41 | 105 |
2024 May | 52 | 27 | 79 |
2024 April | 46 | 38 | 84 |
2024 March | 29 | 25 | 54 |
2024 February | 35 | 33 | 68 |
2024 January | 29 | 25 | 54 |
2023 December | 21 | 30 | 51 |
2023 November | 30 | 32 | 62 |
2023 October | 26 | 40 | 66 |
2023 September | 41 | 33 | 74 |
2023 August | 30 | 20 | 50 |
2023 July | 44 | 43 | 87 |
2023 June | 41 | 20 | 61 |
2023 May | 39 | 32 | 71 |
2023 April | 32 | 19 | 51 |
2023 March | 37 | 15 | 52 |
2023 February | 26 | 28 | 54 |
2023 January | 31 | 23 | 54 |
2022 December | 50 | 33 | 83 |
2022 November | 45 | 22 | 67 |
2022 October | 38 | 41 | 79 |
2022 September | 36 | 41 | 77 |
2022 August | 37 | 45 | 82 |
2022 July | 35 | 41 | 76 |
2022 June | 31 | 27 | 58 |
2022 May | 27 | 30 | 57 |
2022 April | 32 | 35 | 67 |
2022 March | 28 | 40 | 68 |
2022 February | 35 | 32 | 67 |
2022 January | 36 | 33 | 69 |
2021 December | 29 | 38 | 67 |
2021 November | 33 | 28 | 61 |
2021 October | 31 | 40 | 71 |
2021 September | 21 | 34 | 55 |
2021 August | 24 | 24 | 48 |
2021 July | 31 | 27 | 58 |
2021 June | 22 | 20 | 42 |
2021 May | 31 | 19 | 50 |
2021 April | 76 | 38 | 114 |
2021 March | 38 | 28 | 66 |
2021 February | 38 | 15 | 53 |
2021 January | 14 | 17 | 31 |
2020 December | 15 | 16 | 31 |
2020 November | 27 | 9 | 36 |
2020 October | 27 | 11 | 38 |
2020 September | 24 | 1 | 25 |
2020 August | 30 | 9 | 39 |
2020 July | 25 | 10 | 35 |
2020 June | 24 | 20 | 44 |
2020 May | 25 | 10 | 35 |
2020 April | 27 | 10 | 37 |
2020 March | 22 | 14 | 36 |
2020 February | 27 | 15 | 42 |
2020 January | 41 | 18 | 59 |
2019 December | 30 | 13 | 43 |
2019 November | 19 | 20 | 39 |
2019 October | 13 | 10 | 23 |
2019 September | 15 | 13 | 28 |
2019 August | 13 | 11 | 24 |
2019 July | 22 | 16 | 38 |
2019 June | 29 | 12 | 41 |
2019 May | 26 | 12 | 38 |
2019 April | 88 | 39 | 127 |
2019 March | 37 | 20 | 57 |
2019 February | 50 | 21 | 71 |
2019 January | 44 | 15 | 59 |
2018 December | 104 | 28 | 132 |
2018 November | 282 | 20 | 302 |
2018 October | 199 | 14 | 213 |
2018 September | 128 | 21 | 149 |
2018 August | 46 | 9 | 55 |
2018 July | 39 | 11 | 50 |
2018 June | 56 | 12 | 68 |
2018 May | 52 | 10 | 62 |
2018 April | 78 | 9 | 87 |
2018 March | 45 | 20 | 65 |
2018 February | 74 | 4 | 78 |
2018 January | 35 | 8 | 43 |
2017 December | 85 | 10 | 95 |
2017 November | 40 | 5 | 45 |
2017 October | 42 | 5 | 47 |
2017 September | 28 | 8 | 36 |
2017 August | 34 | 7 | 41 |
2017 July | 37 | 6 | 43 |
2017 June | 43 | 16 | 59 |
2017 May | 55 | 6 | 61 |
2017 April | 44 | 5 | 49 |
2017 March | 40 | 7 | 47 |
2017 February | 49 | 11 | 60 |
2017 January | 55 | 12 | 67 |
2016 December | 84 | 10 | 94 |
2016 November | 79 | 5 | 84 |
2016 October | 137 | 17 | 154 |
2016 September | 148 | 4 | 152 |
2016 August | 248 | 5 | 253 |
2016 July | 199 | 9 | 208 |
2016 June | 152 | 0 | 152 |
2016 May | 143 | 0 | 143 |
2016 April | 99 | 0 | 99 |
2016 March | 75 | 0 | 75 |
2016 February | 89 | 0 | 89 |
2016 January | 114 | 0 | 114 |
2015 December | 97 | 0 | 97 |
2015 November | 75 | 0 | 75 |
2015 October | 81 | 0 | 81 |
2015 September | 95 | 0 | 95 |
2015 August | 74 | 0 | 74 |
2015 July | 80 | 0 | 80 |
2015 June | 30 | 0 | 30 |
2015 May | 46 | 0 | 46 |
2015 April | 5 | 0 | 5 |