was read the article
array:21 [ "pii" => "X2013251410033729" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10218" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:131-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4193 "formatos" => array:3 [ "EPUB" => 297 "HTML" => 3302 "PDF" => 594 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699510033721" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2010.Jan.10218" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2010;30:131-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 11608 "formatos" => array:3 [ "EPUB" => 292 "HTML" => 10524 "PDF" => 792 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Los riesgos de la digoxina en el anciano" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "131" "paginaFinal" => "132" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The risk of digoxin in the elderly" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "10218108_10218_t1.jpg" "Alto" => 316 "Ancho" => 1135 "Tamanyo" => 41275 ] ] "descripcion" => array:1 [ "es" => "Cumplimiento de factores de riesgo de intoxicación digitálica de la función renal antes y después del tratamiento" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Suárez Laurés, A. Pobes Martínez, Luis Quiñones Ortiz, R. Forascepi" "autores" => array:4 [ 0 => array:2 [ "Iniciales" => "A." "apellidos" => "Suárez Laurés" ] 1 => array:2 [ "Iniciales" => "A." "apellidos" => "Pobes Martínez" ] 2 => array:2 [ "nombre" => "Luis" "apellidos" => "Quiñones Ortiz" ] 3 => array:2 [ "Iniciales" => "R." "apellidos" => "Forascepi" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251410033729" "doi" => "10.3265/Nefrologia.pre2010.Jan.10218" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033729?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510033721?idApp=UINPBA000064" "url" => "/02116995/0000003000000001/v0_201502091336/X0211699510033721/v0_201502091337/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251410033745" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10220" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:132-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3158 "formatos" => array:3 [ "EPUB" => 243 "HTML" => 2419 "PDF" => 496 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Ten years' experience of an Intensive and Continuous Theoretical/Practical Training Course in Peritoneal Dialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "132" "paginaFinal" => "133" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diez años de experiencia del Curso Intensivo Teórico- Práctico de Formación Continuada en Diálisis Peritoneal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Covadonga Hevia Ojanguren, M.A. Bajo Rubio, A. Cirugeda García, A. Fernández Perpén, G. del Peso Gilsanz, J.A. Sánchez Tomero, R. Selgas Gutiérrez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Covadonga" "apellidos" => "Hevia Ojanguren" ] 1 => array:2 [ "Iniciales" => "M.A." "apellidos" => "Bajo Rubio" ] 2 => array:2 [ "Iniciales" => "A." "apellidos" => "Cirugeda García" ] 3 => array:2 [ "Iniciales" => "A." "apellidos" => "Fernández Perpén" ] 4 => array:2 [ "Iniciales" => "G." "apellidos" => "del Peso Gilsanz" ] 5 => array:2 [ "Iniciales" => "J.A." "apellidos" => "Sánchez Tomero" ] 6 => array:2 [ "Iniciales" => "R." "apellidos" => "Selgas Gutiérrez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699510033748" "doi" => "10.3265/Nefrologia.pre2010.Jan.10220" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510033748?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033745?idApp=UINPBA000064" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033745/v0_201502091609/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251410033933" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2010.Jan.10217" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2010;30:127-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5156 "formatos" => array:3 [ "EPUB" => 277 "HTML" => 4225 "PDF" => 654 ] ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Extended hemoperfusion in the treatment of acute carbamazepine intoxication" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "130" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento con hemoperfusión prolongada en la intoxicación aguda por carbamazepina" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1021718078_f1_pag129.jpg" "Alto" => 311 "Ancho" => 403 "Tamanyo" => 11462 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ramón Peces Serrano, S. Azorín, C. Peces, R. Selgas" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ramón" "apellidos" => "Peces Serrano" ] 1 => array:2 [ "Iniciales" => "S." "apellidos" => "Azorín" ] 2 => array:2 [ "Iniciales" => "C." "apellidos" => "Peces" ] 3 => array:2 [ "Iniciales" => "R." "apellidos" => "Selgas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699510033936" "doi" => "10.3265/Nefrologia.pre2010.Jan.10217" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699510033936?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033933?idApp=UINPBA000064" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033933/v0_201502091609/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "The risk of digoxin in the elderly" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "131" "paginaFinal" => "132" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "A. Suárez Laurés, A. Pobes Martínez, Luis Quiñones Ortiz, R. Forascepi" "autores" => array:4 [ 0 => array:3 [ "Iniciales" => "A." "apellidos" => "Suárez Laurés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "A." "apellidos" => "Pobes Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:4 [ "nombre" => "Luis" "apellidos" => "Quiñones Ortiz" "email" => array:1 [ 0 => "luysquio@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "R." "apellidos" => "Forascepi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Cabueñes, Gijón, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Los riesgos de la digoxina en el anciano" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1021818078_t1_pag131.jpg" "Alto" => 151 "Ancho" => 547 "Tamanyo" => 16521 ] ] "descripcion" => array:1 [ "en" => "Compliance of risk factors of digitalis toxicity in kidney function before and after treatment" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara">The elderly represent 17% of the population and 70% of drug expenditure. Adverse drug events account for between 7.2 and 14% of hospital admissions for these patients in internal medicine in Spain.<span class="elsevierStyleSup">1</span> Over the last decades this consumption has increased from 3 to 4-8.2 drugs/day,<span class="elsevierStyleSup">2</span> and it has been shown that the quantity of drugs ingested is related to adverse effects. The prevalence of hidden kidney disease in old age, and internal changes in patients due to the pathology of multiple medication has led to an increase in iatrogenic events. The following case of digitalis intoxication is submitted as an example of this.</p><p class="elsevierStylePara">An 82-year old woman with a history of heart failure episodes, with a previous serum Cr reference of 1.2mg/dL, arrived at an emergency ward in a mentally confused state. Multiply medicated, with an unknown dose of digoxin, plus diuretics, anticoagulants, etc., and no access to medical attention in the previous 4 months. On examination there were signs of moderate dehydration, psychomotor agitation, with a blood pressure of 120/60mmHg and a heart rate of 34 beats/min. At the emergency unit, biochemistry values were: Hct 42%, Hb 11g/dl, urea 199, Cr 4.8, K 6.8, digoxinaemia 5.4, pH 7.29, HCO 18. Chest radiograph, abdominal ultrasound and CT head scans were unremarkable. ECG: nodal rhythm of 34 per minute. She was given emergency haemodialysis without ultrafiltration, controlling the hyperkalaemia without any changes in the ECG. She was not considered in need for admission to the intensive care unit, nor were any other measures taken, such as insertion of a pacemaker or administration of digoxin antibody. For 48 hours the cardiovascular and neurological status of the patient remained unchanged, with subsequent resolution of the whole process after rehydration, digoxin levels normalised, with recovery of urine output and mental state.</p><p class="elsevierStylePara">This case had several risk factors that increased the risk of drug and digoxin intoxication (Table 1), with the drug being responsible for the symptoms.</p><p class="elsevierStylePara">In order to evaluate kidney function when administering this drug in the elderly, more factors than the serum creatinine values should be taken into account.<span class="elsevierStyleSup">3</span> It is likely that this patient had hidden kidney disease. Our obligation as nephrologists is to carry out emergency dialysis, due to the presence of oliguric acute kidney injury after a pump failure with hyperkalaemia, obviously, not to decrease digoxin levels. The final outcome was satisfactory without any more aggressive measures being taken due to the history and age of the patient.</p><p class="elsevierStylePara">Digitalis toxicity is present in 0.4% of hospital admissions, with a toxicity of 10-18% in old peoples’ homes, leading to a 34% morbidity and mortality of 1%. This toxicity may be chronic, sometimes accidental and also due to attempted suicide.<span class="elsevierStyleSup">4</span> Situations (e.g. kidney disease) or drugs that increase their levels (verapamil and  amiodarone, among others) can lead to  intoxication. Moreover, as is known, hyperkalaemia, acidosis and hypercalcaemia enhance the effect.</p><p class="elsevierStylePara">Apart from the known clinical condition, hyperkalaemia requires a special mention as a prognostic factor and indicator of treatment. This may result in not only decreased excretion due to kidney disease, but a dysfunction of the Na-K-ATPase due to the digitalis effect. This would be a first order prognostic marker because it faithfully reflects the magnitude of the deleterious effect, and it is an indication for treatment with digoxin antibody (K > 5mEq/dL). Intravenous calcium administration to correct the electrocardiographic effect mediated by hyperkalaemia must be avoided, due to the risk of further increasing intracellular calcium linked to digitalis toxicity.</p><p class="elsevierStylePara">In another sense, arrhythmia therapy indications, among others, should be addressed by the relevant specialty, and we must practically confine ourselves to the repeated administration of atropine, if necessary, as there is a parasympathetic hyperactivity that can influence the placement of pacemakers, performing gastric lavage, etc. The use of digoxin antibodies seems far more efficient and faster, although in kidney disease a rebound effect may occur after initial administration.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara"><a href="grande/1021818078_t1_pag131.jpg" class="elsevierStyleCrossRefs"><img src="1021818078_t1_pag131.jpg" alt="Compliance of risk factors of digitalis toxicity in kidney function before and after treatment"></img></a></p><p class="elsevierStylePara">Table 1. Compliance of risk factors of digitalis toxicity in kidney function before and after treatment</p>" "pdfFichero" => "P1-E43-S1792-A10218-EN.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "1021818078_t1_pag131.jpg" "Alto" => 151 "Ancho" => 547 "Tamanyo" => 16521 ] ] "descripcion" => array:1 [ "en" => "Compliance of risk factors of digitalis toxicity in kidney function before and after treatment" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Alcalde P, Dapena MD, Nieto MD, Fontecha BJ. Ingreso hospitalario atribuible a efectos adversos a medicamentos. Rev Esp Geriatr Gerontol 2001;36:340-4." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Blasco F, Martínez López de Letona J, Pérez Maestu R,Villares P, Ponce J. Estudio piloto sobre el consumo defármacos en ancianos que ingresan en un hospital. An Med Intern 2004;21:69-71." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Cepeda Piorno J, Pobes Martínez de Salinas A, González García ME, Fernández Rodríguez E. Utilidad de la ecuación MDRD para detectar insuficiencia renal oculta y disminuir el riesgo de sobredosificación digitálica. Nefrologia 2009;29(2):150-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19396321" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Antman EM, Wenger TL, Butler VP, et al. Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation 1990;81:1744. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2188752" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Mehta RN, Mehta NJ, Gulati A. Late rebound digoxin toxicity after digoxinspecific antibody Fab fragments therapy in anuric patient. J Emerg Med 2002;22:203. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11858929" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003000000001/v0_201502091608/X2013251410033729/v0_201502091609/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003000000001/v0_201502091608/X2013251410033729/v0_201502091609/en/P1-E43-S1792-A10218-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251410033729?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 11 | 4 | 15 |
2024 October | 88 | 31 | 119 |
2024 September | 112 | 26 | 138 |
2024 August | 94 | 51 | 145 |
2024 July | 86 | 28 | 114 |
2024 June | 98 | 40 | 138 |
2024 May | 102 | 30 | 132 |
2024 April | 96 | 29 | 125 |
2024 March | 73 | 20 | 93 |
2024 February | 51 | 40 | 91 |
2024 January | 77 | 34 | 111 |
2023 December | 45 | 28 | 73 |
2023 November | 112 | 37 | 149 |
2023 October | 110 | 25 | 135 |
2023 September | 102 | 27 | 129 |
2023 August | 66 | 22 | 88 |
2023 July | 62 | 31 | 93 |
2023 June | 41 | 21 | 62 |
2023 May | 53 | 34 | 87 |
2023 April | 54 | 24 | 78 |
2023 March | 83 | 20 | 103 |
2023 February | 73 | 20 | 93 |
2023 January | 134 | 32 | 166 |
2022 December | 60 | 30 | 90 |
2022 November | 52 | 26 | 78 |
2022 October | 42 | 45 | 87 |
2022 September | 60 | 31 | 91 |
2022 August | 58 | 41 | 99 |
2022 July | 33 | 55 | 88 |
2022 June | 49 | 23 | 72 |
2022 May | 63 | 46 | 109 |
2022 April | 50 | 36 | 86 |
2022 March | 58 | 46 | 104 |
2022 February | 47 | 32 | 79 |
2022 January | 59 | 34 | 93 |
2021 December | 53 | 39 | 92 |
2021 November | 52 | 40 | 92 |
2021 October | 110 | 36 | 146 |
2021 September | 55 | 33 | 88 |
2021 August | 78 | 34 | 112 |
2021 July | 78 | 29 | 107 |
2021 June | 44 | 17 | 61 |
2021 May | 51 | 33 | 84 |
2021 April | 129 | 63 | 192 |
2021 March | 82 | 30 | 112 |
2021 February | 59 | 13 | 72 |
2021 January | 54 | 15 | 69 |
2020 December | 36 | 15 | 51 |
2020 November | 41 | 7 | 48 |
2020 October | 47 | 18 | 65 |
2020 September | 24 | 16 | 40 |
2020 August | 54 | 6 | 60 |
2020 July | 30 | 13 | 43 |
2020 June | 41 | 9 | 50 |
2020 May | 50 | 9 | 59 |
2020 April | 80 | 24 | 104 |
2020 March | 40 | 10 | 50 |
2020 February | 62 | 29 | 91 |
2020 January | 42 | 15 | 57 |
2019 December | 64 | 20 | 84 |
2019 November | 53 | 24 | 77 |
2019 October | 60 | 11 | 71 |
2019 September | 77 | 23 | 100 |
2019 August | 40 | 14 | 54 |
2019 July | 45 | 25 | 70 |
2019 June | 46 | 11 | 57 |
2019 May | 45 | 12 | 57 |
2019 April | 70 | 20 | 90 |
2019 March | 42 | 26 | 68 |
2019 February | 20 | 14 | 34 |
2019 January | 28 | 16 | 44 |
2018 December | 65 | 39 | 104 |
2018 November | 127 | 18 | 145 |
2018 October | 91 | 8 | 99 |
2018 September | 55 | 16 | 71 |
2018 August | 34 | 18 | 52 |
2018 July | 46 | 9 | 55 |
2018 June | 48 | 14 | 62 |
2018 May | 58 | 18 | 76 |
2018 April | 66 | 4 | 70 |
2018 March | 29 | 20 | 49 |
2018 February | 61 | 8 | 69 |
2018 January | 30 | 9 | 39 |
2017 December | 49 | 17 | 66 |
2017 November | 25 | 3 | 28 |
2017 October | 28 | 6 | 34 |
2017 September | 25 | 9 | 34 |
2017 August | 23 | 12 | 35 |
2017 July | 27 | 18 | 45 |
2017 June | 27 | 4 | 31 |
2017 May | 29 | 11 | 40 |
2017 April | 20 | 7 | 27 |
2017 March | 25 | 22 | 47 |
2017 February | 23 | 9 | 32 |
2017 January | 18 | 13 | 31 |
2016 December | 43 | 9 | 52 |
2016 November | 51 | 7 | 58 |
2016 October | 82 | 4 | 86 |
2016 September | 88 | 2 | 90 |
2016 August | 121 | 4 | 125 |
2016 July | 127 | 7 | 134 |
2016 June | 128 | 0 | 128 |
2016 May | 110 | 0 | 110 |
2016 April | 81 | 0 | 81 |
2016 March | 93 | 0 | 93 |
2016 February | 76 | 0 | 76 |
2016 January | 85 | 0 | 85 |
2015 December | 117 | 0 | 117 |
2015 November | 83 | 0 | 83 |
2015 October | 53 | 0 | 53 |
2015 September | 73 | 0 | 73 |
2015 August | 61 | 0 | 61 |
2015 July | 39 | 0 | 39 |
2015 June | 35 | 0 | 35 |
2015 May | 54 | 0 | 54 |
2015 April | 15 | 0 | 15 |