Cefepime-induced encephalopathy in patients with renal failure
ENCEFALOPATÍA POR CEFEPIMA EN PACIENTES CON INSUFICIENCIA RENAL.
Read
8512
Timeswas read the article
1902
Total PDF
6610
Total HTML
Share statistics
array:21 [ "pii" => "X2013251409005061" "issn" => "20132514" "doi" => "10.3265/Nefrologia.2009.29.2.4911.en.full" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2009;29:181" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3494 "formatos" => array:3 [ "EPUB" => 216 "HTML" => 2826 "PDF" => 452 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699509005064" "issn" => "02116995" "doi" => "10.3265/Nefrologia.2009.29.2.4911.en.full" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2009;29:181" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8072 "formatos" => array:3 [ "EPUB" => 233 "HTML" => 7354 "PDF" => 485 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "ENCEFALOPATÍA POR CEFEPIMA EN PACIENTES CON INSUFICIENCIA RENAL." "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "181" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cefepime-induced encephalopathy in patients with renal failure" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Martín Herrera, Macarena Navarro" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Martín Herrera" ] 1 => array:2 [ "nombre" => "Macarena" "apellidos" => "Navarro" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251409005061" "doi" => "10.3265/Nefrologia.2009.29.2.4911.en.full" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251409005061?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699509005064?idApp=UINPBA000064" "url" => "/02116995/0000002900000002/v0_201502091411/X0211699509005064/v0_201502091411/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251409005053" "issn" => "20132514" "doi" => "10.3265/Nefrologia.2009.29.2.4918.en.full" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2009;29:181-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3593 "formatos" => array:3 [ "EPUB" => 224 "HTML" => 2817 "PDF" => 552 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Ileal intussusception by carcinoid tumour in patients with chronic renal failure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "181" "paginaFinal" => "182" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Intususcepción ileal por tumor carcinoide en paciente con insuficiencia renal crónica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "21818078_f1_p182.jpg" "Alto" => 178 "Ancho" => 260 "Tamanyo" => 8666 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana Isabel Gómez Sotelo, Beatriz Pérez Cabrera, Cristina González Puga, Antonio Palomeque Jimenez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ana Isabel" "apellidos" => "Gómez Sotelo" ] 1 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Pérez Cabrera" ] 2 => array:2 [ "nombre" => "Cristina" "apellidos" => "González Puga" ] 3 => array:2 [ "nombre" => "Antonio" "apellidos" => "Palomeque Jimenez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699509005056" "doi" => "10.3265/Nefrologia.2009.29.2.4918.en.full" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699509005056?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251409005053?idApp=UINPBA000064" "url" => "/20132514/0000002900000002/v0_201502091631/X2013251409005053/v0_201502091631/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X201325140900507X" "issn" => "20132514" "doi" => "10.3265/NEFROLOGIA.2009.29.2.4889.EN.FULL" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2009;29:180-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3243 "formatos" => array:3 [ "EPUB" => 238 "HTML" => 2563 "PDF" => 442 ] ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "CMV disease resistant to Ganciclovir. Should valganciclovir plasma levels be monitored in high risk patients?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "180" "paginaFinal" => "181" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad por CMV resistente a ganciclovir ¿Está indicado monitorizar niveles plasmáticos de valganciclovir en pacientes de alto riesgo ?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "EUGENIA SOLA, ENCARNACION VEGA, CRISTINA GUTIERREZ, VERONICA LOPEZ, MERCEDES CABELLO, DOLORES BURGOS, MIGUEL GONZALEZ MOLINA, JUAN SILES" "autores" => array:8 [ 0 => array:2 [ "nombre" => "EUGENIA" "apellidos" => "SOLA" ] 1 => array:2 [ "nombre" => "ENCARNACION" "apellidos" => "VEGA" ] 2 => array:2 [ "nombre" => "CRISTINA" "apellidos" => "GUTIERREZ" ] 3 => array:2 [ "nombre" => "VERONICA" "apellidos" => "LOPEZ" ] 4 => array:2 [ "nombre" => "MERCEDES" "apellidos" => "CABELLO" ] 5 => array:2 [ "nombre" => "DOLORES" "apellidos" => "BURGOS" ] 6 => array:2 [ "nombre" => "MIGUEL" "apellidos" => "GONZALEZ MOLINA" ] 7 => array:2 [ "nombre" => "JUAN" "apellidos" => "SILES" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699509005072" "doi" => "10.3265/NEFROLOGIA.2009.29.2.4889.EN.FULL" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699509005072?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325140900507X?idApp=UINPBA000064" "url" => "/20132514/0000002900000002/v0_201502091631/X201325140900507X/v0_201502091631/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Cefepime-induced encephalopathy in patients with renal failure" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "181" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carmen Martín Herrera, Macarena Navarro" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Carmen" "apellidos" => "Martín Herrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Macarena" "apellidos" => "Navarro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => " Hospitales Universitarios Virgen del Rocío Sevilla, Sevilla, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "ENCEFALOPATÍA POR CEFEPIMA EN PACIENTES CON INSUFICIENCIA RENAL." ] ] "textoCompleto" => "<p class="elsevierStylePara">Dear Editor,</p><p class="elsevierStylePara">Cefepime is a fourth-generation cephalosporin that is widely used in hospital settings.<span class="elsevierStyleSup">1 </span>Since its approval, isolated cases of encephalopathy have been reported in patients with both normal<span class="elsevierStyleSup">2</span> and impaired kidney function.<span class="elsevierStyleSup">3,4</span> Nonetheless, the information about the clinical manifestations and the prognosis of this adverse reaction is scarce. Therefore, we believe it is important to report seven cases of cefepime-induced encephalopathy in patients with kidney failure. These cases corresponded to 4 males and 3 females with an average age of 63 years. All of the patients had acute or chronic renal failure when cefepime was prescribed. The average value of creatinine at the beginning of treatment was 3.6mg/dl and the initial dose of cefepime was 2.75g/day; in five patients the dose was adjusted for the degree of kidney function. The average time period between beginning of treatment and symptoms was 5.4 days. The most common clinical manifestations were a decreased level of consciousness (71.4%) and myoclonus (71.4%). The EEG was pathological in the six cases where it was carried out, demonstrating a nonconvulsive epileptic status in three, slowed global activity with repetitive paroxysm in two, and diffuse affectation with a predominance of triphasic waves in one. The CT scan and the spinal tap were normal in all cases. After diagnosing the encephalopathy, treatment with cefepime was discontinued. Three of the patients received dialysis. Three patients improved (42.9%), one of whom required haemodialysis. The 4 remaining patients (57.1%) died from the encephalopathy.</p><p class="elsevierStylePara">The use of cefepime in patients with kidney failure, even at adjusted doses, may cause serious encephalopathy, and thus its administration should be avoided or used with close monitoring. The appearance of alterations in the level of consciousness and the myoclonus should alert us to the appearance of a nonconvulsive status that requires an EEG as it is the most useful diagnostic test. Haemodialysis does not seem to modify the clinical outcome.</p>" "pdfFichero" => "P-E-S-A217-EN.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "1.-Sánchez-Bailén MJ, Navarro Ciruelos N, Rovira García-Marrón R y Anglés Coll. Encefalopatía asociada a la administración de cefepime en uuna paciente con shock séptico e insuficiencia renal. Rev Clin Esp 2004, 204(9): 501-4." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "2.- Maganti R, Jolin D, Rishi D, Biswas A. Nonconvulsive statuus epilecticus due to cefepime in a patient with normal renal function. Epilepsy&Behavior 2006, 8: 312-314." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "3.-Chatelier D, Jourdan M, Mangalaboyi J. and cols. Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure. Intensive Care Med 2002, 28: 214-217. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11907668" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "4.-Barbey F, Bugnon D, Wauters JP. Neurotoxicity of Cefepime in Uremic Patients. Ann Intern Med, 2001, 135: 1011. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11730416" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002900000002/v0_201502091631/X2013251409005061/v0_201502091631/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002900000002/v0_201502091631/X2013251409005061/v0_201502091631/en/P-E-S-A217-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251409005061?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 7 | 15 |
| 2024 October | 71 | 30 | 101 |
| 2024 September | 77 | 25 | 102 |
| 2024 August | 99 | 46 | 145 |
| 2024 July | 72 | 27 | 99 |
| 2024 June | 103 | 38 | 141 |
| 2024 May | 70 | 38 | 108 |
| 2024 April | 65 | 22 | 87 |
| 2024 March | 70 | 27 | 97 |
| 2024 February | 73 | 30 | 103 |
| 2024 January | 56 | 35 | 91 |
| 2023 December | 52 | 24 | 76 |
| 2023 November | 69 | 28 | 97 |
| 2023 October | 94 | 36 | 130 |
| 2023 September | 98 | 26 | 124 |
| 2023 August | 80 | 26 | 106 |
| 2023 July | 85 | 24 | 109 |
| 2023 June | 117 | 17 | 134 |
| 2023 May | 85 | 33 | 118 |
| 2023 April | 79 | 13 | 92 |
| 2023 March | 82 | 22 | 104 |
| 2023 February | 62 | 18 | 80 |
| 2023 January | 64 | 18 | 82 |
| 2022 December | 85 | 27 | 112 |
| 2022 November | 103 | 25 | 128 |
| 2022 October | 81 | 27 | 108 |
| 2022 September | 66 | 27 | 93 |
| 2022 August | 170 | 41 | 211 |
| 2022 July | 99 | 36 | 135 |
| 2022 June | 72 | 34 | 106 |
| 2022 May | 52 | 38 | 90 |
| 2022 April | 56 | 39 | 95 |
| 2022 March | 66 | 47 | 113 |
| 2022 February | 48 | 41 | 89 |
| 2022 January | 46 | 29 | 75 |
| 2021 December | 55 | 40 | 95 |
| 2021 November | 47 | 34 | 81 |
| 2021 October | 49 | 45 | 94 |
| 2021 September | 55 | 26 | 81 |
| 2021 August | 39 | 29 | 68 |
| 2021 July | 58 | 30 | 88 |
| 2021 June | 29 | 19 | 48 |
| 2021 May | 38 | 22 | 60 |
| 2021 April | 84 | 47 | 131 |
| 2021 March | 63 | 19 | 82 |
| 2021 February | 77 | 17 | 94 |
| 2021 January | 43 | 13 | 56 |
| 2020 December | 35 | 4 | 39 |
| 2020 November | 45 | 6 | 51 |
| 2020 October | 33 | 14 | 47 |
| 2020 September | 34 | 11 | 45 |
| 2020 August | 49 | 5 | 54 |
| 2020 July | 48 | 11 | 59 |
| 2020 June | 58 | 4 | 62 |
| 2020 May | 44 | 10 | 54 |
| 2020 April | 41 | 12 | 53 |
| 2020 March | 63 | 8 | 71 |
| 2020 February | 57 | 11 | 68 |
| 2020 January | 65 | 16 | 81 |
| 2019 December | 49 | 12 | 61 |
| 2019 November | 50 | 18 | 68 |
| 2019 October | 39 | 12 | 51 |
| 2019 September | 63 | 23 | 86 |
| 2019 August | 32 | 11 | 43 |
| 2019 July | 36 | 21 | 57 |
| 2019 June | 27 | 5 | 32 |
| 2019 May | 32 | 7 | 39 |
| 2019 April | 78 | 23 | 101 |
| 2019 March | 30 | 7 | 37 |
| 2019 February | 32 | 20 | 52 |
| 2019 January | 40 | 12 | 52 |
| 2018 December | 72 | 25 | 97 |
| 2018 November | 54 | 11 | 65 |
| 2018 October | 52 | 7 | 59 |
| 2018 September | 39 | 9 | 48 |
| 2018 August | 32 | 10 | 42 |
| 2018 July | 34 | 7 | 41 |
| 2018 June | 19 | 10 | 29 |
| 2018 May | 33 | 10 | 43 |
| 2018 April | 24 | 6 | 30 |
| 2018 March | 28 | 5 | 33 |
| 2018 February | 35 | 5 | 40 |
| 2018 January | 27 | 9 | 36 |
| 2017 December | 33 | 8 | 41 |
| 2017 November | 23 | 5 | 28 |
| 2017 October | 36 | 12 | 48 |
| 2017 September | 38 | 18 | 56 |
| 2017 August | 52 | 11 | 63 |
| 2017 July | 50 | 7 | 57 |
| 2017 June | 32 | 8 | 40 |
| 2017 May | 38 | 5 | 43 |
| 2017 April | 23 | 7 | 30 |
| 2017 March | 22 | 6 | 28 |
| 2017 February | 33 | 12 | 45 |
| 2017 January | 14 | 15 | 29 |
| 2016 December | 37 | 5 | 42 |
| 2016 November | 34 | 7 | 41 |
| 2016 October | 62 | 7 | 69 |
| 2016 September | 57 | 1 | 58 |
| 2016 August | 74 | 4 | 78 |
| 2016 July | 107 | 5 | 112 |
| 2016 June | 116 | 0 | 116 |
| 2016 May | 114 | 0 | 114 |
| 2016 April | 67 | 0 | 67 |
| 2016 March | 67 | 0 | 67 |
| 2016 February | 61 | 0 | 61 |
| 2016 January | 71 | 0 | 71 |
| 2015 December | 89 | 0 | 89 |
| 2015 November | 83 | 0 | 83 |
| 2015 October | 79 | 0 | 79 |
| 2015 September | 54 | 0 | 54 |
| 2015 August | 65 | 0 | 65 |
| 2015 July | 52 | 0 | 52 |
| 2015 June | 34 | 0 | 34 |
| 2015 May | 43 | 0 | 43 |
| 2015 April | 9 | 0 | 9 |
Show all
