was read the article
array:20 [ "pii" => "X201325140900363X" "issn" => "20132514" "doi" => "10.3265/Nefrologia.2009.29.5.5524.en.full" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2009;29:456" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4735 "formatos" => array:3 [ "EPUB" => 265 "HTML" => 3905 "PDF" => 565 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699509003632" "issn" => "02116995" "doi" => "10.3265/Nefrologia.2009.29.5.5524.en.full" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2009;29:456" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 13521 "formatos" => array:3 [ "EPUB" => 250 "HTML" => 12599 "PDF" => 672 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "El tiempo de isquemia fría corto optimiza los resultados de los trasplantes renales efectuados con donantes con criterios expandidos" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "456" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Short cold ischaemia time optimises transplant results for kidneys from expanded criteria donors" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "416527_figura1.jpg" "Alto" => 452 "Ancho" => 834 "Tamanyo" => 36649 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Gallego Valcarce, A. Ortega Cerrato, F. Llamas Fuentes, J. Masiá Mondéjar, G. Martínez Fernández, E. López Rubio, A. López Montes, J. Pérez Martínez, M. Martínez Villaescusa, C. Gómez Roldán" "autores" => array:10 [ 0 => array:2 [ "Iniciales" => "E." "apellidos" => "Gallego Valcarce" ] 1 => array:2 [ "Iniciales" => "A." "apellidos" => "Ortega Cerrato" ] 2 => array:2 [ "Iniciales" => "F." "apellidos" => "Llamas Fuentes" ] 3 => array:2 [ "Iniciales" => "J." "apellidos" => "Masiá Mondéjar" ] 4 => array:2 [ "Iniciales" => "G." "apellidos" => "Martínez Fernández" ] 5 => array:2 [ "Iniciales" => "E." "apellidos" => "López Rubio" ] 6 => array:2 [ "Iniciales" => "A." "apellidos" => "López Montes" ] 7 => array:2 [ "Iniciales" => "J." "apellidos" => "Pérez Martínez" ] 8 => array:2 [ "Iniciales" => "M." "apellidos" => "Martínez Villaescusa" ] 9 => array:2 [ "Iniciales" => "C." "apellidos" => "Gómez Roldán" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X201325140900363X" "doi" => "10.3265/Nefrologia.2009.29.5.5524.en.full" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325140900363X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699509003632?idApp=UINPBA000064" "url" => "/02116995/0000002900000005/v0_201502091404/X0211699509003632/v0_201502091404/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251409003672" "issn" => "20132514" "doi" => "10.3265/Nefrologia.2009.29.5.5448.en.full" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2009;29:421" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5160 "formatos" => array:3 [ "EPUB" => 273 "HTML" => 4279 "PDF" => 608 ] ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "The antiproteinuric effect of the blockage of the renin-angiotensin-aldosterone system (RAAS) in obese patients. Which treatment option is the most effective?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "421" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto antiproteinúrico del bloqueo del sistema renina-angiotensina-aldosterona (SRAA) en los pacientes obesos. ¿Cuál es la opción terapéutica más eficaz?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "41218078_t1_pag424.jpg" "Alto" => 349 "Ancho" => 827 "Tamanyo" => 65070 ] ] "descripcion" => array:1 [ "en" => "Patients' clinical characteristics" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Morales, A. Huerta, E. Gutiérrez, E. Gutiérrez Solís, J. Segura, M. Praga" "autores" => array:6 [ 0 => array:2 [ "Iniciales" => "E." "apellidos" => "Morales" ] 1 => array:2 [ "Iniciales" => "A." "apellidos" => "Huerta" ] 2 => array:2 [ "Iniciales" => "E." "apellidos" => "Gutiérrez" ] 3 => array:2 [ "Iniciales" => "E." "apellidos" => "Gutiérrez Solís" ] 4 => array:2 [ "Iniciales" => "J." "apellidos" => "Segura" ] 5 => array:2 [ "Iniciales" => "M." "apellidos" => "Praga" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699509003675" "doi" => "10.3265/Nefrologia.2009.29.5.5448.en.full" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699509003675?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251409003672?idApp=UINPBA000064" "url" => "/20132514/0000002900000005/v0_201502091625/X2013251409003672/v0_201502091625/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Short cold ischaemia time optimises transplant results for kidneys from expanded criteria donors" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "456" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "E. Gallego Valcarce, A. Ortega Cerrato, F. Llamas Fuentes, J. Masiá Mondéjar, G. Martínez Fernández, E. López Rubio, A. López Montes, J. Pérez Martínez, M. Martínez Villaescusa, C. Gómez Roldán" "autores" => array:10 [ 0 => array:4 [ "Iniciales" => "E." "apellidos" => "Gallego Valcarce" "email" => array:1 [ 0 => "egallegov@telefonica.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "A." "apellidos" => "Ortega Cerrato" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "F." "apellidos" => "Llamas Fuentes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "J." "apellidos" => "Masiá Mondéjar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "Iniciales" => "G." "apellidos" => "Martínez Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "Iniciales" => "E." "apellidos" => "López Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 6 => array:3 [ "Iniciales" => "A." "apellidos" => "López Montes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 7 => array:3 [ "Iniciales" => "J." "apellidos" => "Pérez Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 8 => array:3 [ "Iniciales" => "M." "apellidos" => "Martínez Villaescusa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 9 => array:3 [ "Iniciales" => "C." "apellidos" => "Gómez Roldán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Complejo Hospitalario Universitario de Albacete, Albacete, Albacete, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El tiempo de isquemia fría corto optimiza los resultados de los trasplantes renales efectuados con donantes con criterios expandidos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "41618078_t1_pag459.jpg" "Alto" => 637 "Ancho" => 827 "Tamanyo" => 116199 ] ] "descripcion" => array:1 [ "en" => "Characteristics of expanded criteria donors (ECD) and standard criteria donors (SCD). Characteristics of recipients." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">An ECD is defined as a donor of a kidney whose relative risk of failure is 1.7 times greater than that of a kidneyprovided by an ideal donor.<span class="elsevierStyleSup">1</span> ECD implants have an estimated survival rate of 92.3% at three months, 84.5% at one year, and 68% at three years, while standard criteria donor (SCD) kidney transplants have survival rates of 94.6, 90.6 and 79.4%, respectively, for the same time periods.<span class="elsevierStyleSup">2</span></p><p class="elsevierStylePara">Despite having a worse prognosis, the use of ECD kidneys has been completely justified ever since it was shown that the survival time for the recipient of this type of graft is greater than that of a person remaining on the waiting list<span class="elsevierStyleSup">3</span>. ECD organs are increasingly common, and their use is practically mandatory if we are to maintain the current transplant rates in order to satisfy the continuous and increasing demand for grafts.</p><p class="elsevierStylePara">With this in mind, we must adopt the measures that are necessary in order to optimise ECD transplant results.<span class="elsevierStyleSup">4 </span>To do so, we have proposed selecting recipients correctly and attempting to reduce damage during organ preservation.</p><p class="elsevierStylePara">Regarding the recipient selection aspect, these organs are not recommended for repeat transplants or for patients younger than 40,<span class="elsevierStyleSup">5</span> but are recommended for recipients with a low metabolic demand (the elderly and patients with a low body mass index) and for patients with little immunologic risk (low PRA score).<span class="elsevierStyleSup">6</span> There has even been a proposal to match up donors and recipients according to estimated survival profiles.<span class="elsevierStyleSup">7</span></p><p class="elsevierStylePara">There are two strategies for attempting to limit damage during preservation: preserving organs with machine perfusion<span class="elsevierStyleSup">8</span> or reducing cold ischaemia times (CIT).<span class="elsevierStyleSup">9</span></p><p class="elsevierStylePara"><span class="elsevierStyleSup"></span>Prolonged CIT is associated with delayed organ function, and both factors lead to increased rejection rate and hospitalisation time, worse renal function and a decreased long-term survival rate. CIT has also been described as an independent risk factor in organ survival with donors younger than 50 (SCDs).<span class="elsevierStyleSup">10</span> As a result, it seems reasonable to attempt to optimise the results of ECD organs using short CITs.</p><p class="elsevierStylePara">In this study, we will compare the evolution of transplanted ECD and SCD organs in a transplant programme that uses short CITs in order to reduce both the delay in graft function as well as the acute rejection rate, thus improving survival and renal function.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">MATERIAL AND METHODS</span></p><p class="elsevierStylePara">A prospective cohort study was performed using incident cases of kidney transplants performed on patients at a single centre between June 2003 and December 2007. All transplants involved adult recipients and donors, and none of the organs came from a living donor. The study excluded transplants performed with a CIT >15 hours. All of the recipients underwent follow-up for a minimum of one year after the transplant or until loss of the organ or death; data collection was completed in December 2008.</p><p class="elsevierStylePara">We used the following immunosuppressant protocol: until June 2005, triple immunosuppressant therapy with corticosteroids in decreasing doses, mycophenolate mofetil (MFM) and tacrolimus (TAC) with target levels between 10 and 15ng/ml during the first month. In June 2005, we added induction therapy with basiliximab in patients with low immunologic risk (PRA < 50%) and timoglobulin in hyperimmune patients (PRA > 50%). After induction therapy, target levels of TAC were lowered to 5-10ng/ml during the first post-transplant month. When digestive intolerance appeared in response to MMF, the drug was replaced with enteric-coated mycophenolic acid (EC-MPA). Immunosuppressants were not adjusted according to the donor type (ECD or SCD). In cases of suspected acute rejection, a kidney biopsy was performed and empirical treatment begun with 6-methylprednisolone bolus; where the diagnosis was not confirmed, the corticosteroids were discontinued. If the rejection was corticosteroid-resistant, it was treated with timoglobulin. Humoral rejection was treated with plasmapheresis and immunoglobulins. The biopsies were classified according to Banff-97 criteria.</p><p class="elsevierStylePara">An ECD is defined as any donor older than 60 years or between 50 and 59 years with at least two of the following conditions: a history of hypertension, death due to stroke and creatinine above 1.5mg/dl prior to organ removal.<span class="elsevierStyleSup">1</span> According to this definition, the recipients are classified in two groups according to the type of donor providing the organ: those receiving an organ from a standard criteria donor and those with an expanded criteria donor.</p><p class="elsevierStylePara">The variables in the study were collected prospectively, and data from both donors and recipients were collected in addition to data on transplant evolution.</p><p class="elsevierStylePara">The following donor information was collected: age, sex, weight, history of hypertension, cause of death, creatinine level prior to kidney removal and estimated glomerular filtration rate (eGFR) calculated with the Cockcroft-Gault formula.<span class="elsevierStyleSup">11</span> Additionally, the transplant prognosis was rated according to the Nyberg score.<span class="elsevierStyleSup">12</span></p><p class="elsevierStylePara">For recipients, the following information was collected: age, sex, the cause of the chronic kidney disease, body mass index, type of dialysis and its duration, number of transplant being received, number of incompatibilities between donor and recipient, the PRA score at the time of transplant and the maximum peak in historical serum levels, considering patients with PRA > 50% to be hyperimmune. CIT was counted from clamping time in the donor up to unclamping time in the recipient.</p><p class="elsevierStylePara">The initial evolution of the transplants included the record of surgical complications: Arterial or venous thrombosis, haemorrhage requiring secondary surgery, urological fistulae, stenosis of the ureter leading to deterioration of renal function, and lymphoceles that produced secondary complications due to their size or location. Patients were classified in four groups according to evolution of renal function over the immediate post-op period: no primary function (NPF), delayed graft function (DGF), delayed graft function without dialysis (DGF-WOD) and immediate renal function (IRF). The NPF group included those with a lack of function at any time, due to any cause. The DGF group included all patients who underwent dialysis during the first week following the transplant. The DGF-WOD and IRF groups were defined according to the creatinine reduction rate.<span class="elsevierStyleSup">13,14</span> Where the rate exceeded 30%, the patient was included in the IRF group, and where it was less, in the DGF-WOD group. In addition, we recorded the number of days required in order for the creatinine to drop below 3mg/dl, and the creatinine level and eGFR calculated by the MDRD-4<span class="elsevierStyleSup">15</span> formula on the sixth day following the transplant.</p><p class="elsevierStylePara">Upon discharge, we recorded the number of days admitted, the proteinuria, creatinine, eGFR calculated by the MDRD-4 formula and the tacrolimus levels.</p><p class="elsevierStylePara">During follow-up, analytical data for all patients was recorded prospectively at 3, 6 and 12 months, and annually thereafter. The organ function stability was calculated for the first year (eGFR at 12 months - eGFR at 6 months) as well as any acute rejection episodes. All cases of kidney loss and exitus were also recorded throughout the follow-up.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Statistical analysis</span></p><p class="elsevierStylePara">We initially performed a descriptive analysis of the study variables by comparing the normality of the quantitative variable distributions using the Kolmogorov-Smirnov test. Following this, we carried out a comparative bivariate analysis using parametric tests (Student-t test and Chisquared with Fisher¿s exact probability test) or nonparametric tests (Mann-Whitney U test) as applicable. In addition, we used the log-rank test to compare survival curves.  Statistical significance was established for p values < 0.05. Statistical analysis was carried out using SPSS software, version 15.0 (SPSS Inc., Chicago IL, USA).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">RESULTS</span></p><p class="elsevierStylePara">Of the 87 transplants performed during the study period, 13 were excluded for having a CIT of more than 15 hours (only three with SCDs): eight organs were sent from other centers (CIT 21.3 ± 3.2 hours) and five were from our center (CIT 16.8 ± 1.2 hours). Of the 74 remaining patients (mean CIT 9.1 ± 3.6 hours), 50 received SCD organs and 24 received ECD organs.</p><p class="elsevierStylePara">Demographic data for ECDs and SCDs, as well as the characteristics of the recipients of either type of organ are shown in table 1. Compared with SCDs, ECDs were significantly older, more frequently hypertensive, and a larger percentage died from a cerebrovascular event. Although creatinine levels in ECDs were lower than in SCDs, their eGFR calculated by the Cockcroft-Gault formula was significantly less.</p><p class="elsevierStylePara">All of the ECD organ transplants had a Nyberg score<span class="elsevierStyleSup">12</span> of more than 20 points. 87.5% of these transplants belonged to group C (between 20 and 29 points) and 12.5% belonged to group D (more than 30 points). All SCD organ transplants scored below 20 points. Of these, 58% belonged to group B (between 10 and 19 points) and 42% belonged to group A (between 0 and 9 points).</p><p class="elsevierStylePara">We did not find any significant differences between the recipients of the ECD organs and recipients of the SCD organs. We should point out that although ECD organ recipients were older, the difference was not statistically significant (p = 0.052).</p><p class="elsevierStylePara">The evolution of both recipient groups is described in table 2. We did not find any significant differences in the percentage of surgical complications. Neither were there any differences in the percentage of patients classified as NPF, DGF, DGF-WOD or IRF for the two groups.</p><p class="elsevierStylePara">In the first month following the transplant, four patients in the ECD group were treated for suspected acute rejection (15.4%), which was proven by a renal biopsy in two patients (8.3%): one was a case of acute humoral rejection in a hyperimmune patient and the other, a case of cellular rejection (Banff-97 classification IIA); both reverted with treatment. In the SCD group, six patients (12%) were initially treated with corticosteroid boli due to suspected acute rejection; the biopsy ruled out the suspected diagnosis in five cases, and the other patient presented a borderline rejection.</p><p class="elsevierStylePara">The hospital stay durations were similar in both groups, and during this time renal function in recipients of SCD organs was significantly better than that of ECD organ recipients.</p><p class="elsevierStylePara">Evolution of renal function was significantly better in SCD recipients. Since the discharge date, eGFR calculated by MDRD-4 has been significantly better in SCD organ recipients than in ECD organ recipients, and this difference has been present throughout the entire follow-up (figure 1). However, organ function stability throughout the first year has been similar for both groups, and has been above zero even among ECD organ receptors (which indicates an improvement in eGFR between the 6 and 12 month marks), while in SCD organ recipients, it was below zero (suggesting a certain decrease in eGFR).</p><p class="elsevierStylePara">In the SCD group, two patients presented NPF in the organ due to vascular problems during surgery, and another lost the organ three months after the transplant due to the recurrence of a glomerular disease. No other transplant was lost and none of the patients died; survival rates at 12, 24 and 36 months were 100% for patients and 94% for organs. In the ECD group, one patient presented NPF, which was attributed to problems during organ preservation; no other graft was lost and none of the patients died, so survival rates at 12, 24 and 36 months were 100% for patients and 95.8% for grafts. Therefore, there were no differences for renal survival at 12, 24 and 36 months (log-rank, p = 0.749) between the recipients of ECD and SCD organs. There were also no differences in patient survival between the two groups during the same period of time.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Discussion</span></p><p class="elsevierStylePara">Our findings indicate that it is possible to obtain excellent results with ECD organs when using short CITs, and that these results can be similar to those for SCD organs, also with short CITs. However, in our experience, it is not possible to use ECD grafts and achieve a renal function comparable to that provided by SCD organs. The fact that both patient groups have similar renal survival rates could be related to the renal function stability that we reached between 6 and 12 months, considering that this parameter has been related to the survival of organs from older donors.<span class="elsevierStyleSup">16</span></p><p class="elsevierStylePara">Prolonged cold ischaemia favours a delay in graft function,<span class="elsevierStyleSup">17,18</span> and this delay is a risk factor for the survival of renal transplants.<span class="elsevierStyleSup">19</span> Furthermore, ischaemic damage is a determining factor for the appearance of acute rejection.<span class="elsevierStyleSup">20 </span>Experimental models for kidney transplants have shown that prolonged ischaemia and advanced donor age are closely related to organ malfunction.<span class="elsevierStyleSup">21</span> Due to these reasons, the tendency in the last few years has been to shorten CIT times for ECD organs in order to improve transplant results. Europe¿s Eurotransplant Senior Programme, which applies the concept of ¿old for old¿, has reduced CIT and obtained excellent results (mean CITs of 10.6 ± 3.9 hours).<span class="elsevierStyleSup">22</span> CITs have also been reduced in the USA by applying the UNOS criteria for ECD organs.<span class="elsevierStyleSup">23</span> In this study, our CIT for ECD organs was 9.3 ± 2.5 hours. With this CIT, we achieved an NPF rate of 4.2%, a DGF rate of 16.7%, a 25% rate of initial surgical complications and an 8.3% rate of acute rejection in the first month. These results are similar to those obtained by the Eurotransplant Senior Programme<span class="elsevierStyleSup">22</span> with similar CITs. These results are not as good as those obtained with SCD organs and similar CITs (8.3 ± 3.3 hours), but they are not significantly lower: Compare with an NPF rate of 4%, a DGF rate of 10%, a 16% rate of surgical complications and a 2% rate of acute rejection proven by biopsy (although this was actually a single case of borderline rejection).</p><p class="elsevierStylePara">The renal function provided by the ECD organs is acceptable, although significantly less than that provided by SCD organs under the same conditions. This difference is apparent from the first week after the transplant and is still present after one year. We must take into account that the SCD group¿s evolution is very good, with a 2% acute rejection rate and only a 4% DGF rate if we exclude patients whose DGF was due to surgical complications. We believe this is what has resulted in creatinine levels of 1.22 ± 0.4mg/dl and an eGFR (MDRD-4) of 65.8 ± 14.9ml/min one year after the transplant. We calculated glomerular filtration rate with the MDRD-4 formula, which is the most precise estimate according to some studies.<span class="elsevierStyleSup">24,25</span> However, if we use the Cockcroft-Gault formula, at one year after transplant the SCD group has an eGFR of 76.7 ± 17.6ml/min, which is higher than that obtained in other studies over the same period of time and using similar immunosuppressant methods.<span class="elsevierStyleSup">26</span></p><p class="elsevierStylePara">One year after transplant, ECD organs present creatinine levels of 1.5 ± 0.4mg/dl and an eGFR calculated by MDRD-4 of 49.4 ± 12.5ml/min (61.4 ± 17.6ml/min by Cockcroft- Gault). This renal function is better than that obtained in other studies of ECD organs.<span class="elsevierStyleSup">6,16,22,27</span> Better renal function in ECD organ receptors has been described at one year of evolution when the CIT is less than 12 hours, compared with CITs ranging from 12 to 24 hours. However, this improvement only becomes noticeable when the ECD belong to group C on the Nyberg scale (scoring between 20 and 29 points). Our ECD organ recipients mostly belong to group C (87.5%), which probably explains their favourable evolution with short CITs. The concept of ECD implies a binary distinction between donor classes: either ECD or SCD. So, the same definition includes patients with an ample spectrum of risks having to do with losing the graft and a risk level between 1.7 and 2.691 of that of the ideal donor. This enormous difference must be reflected in the different evolutions and responses to the conditions that we impose in a transplant situation, and may generate large disparities in study results according to the type of ECD organ that is included.28 As a result, it seems necessary to develop more precise classification systems, as some have suggested.<span class="elsevierStyleSup">29,30</span></p><p class="elsevierStylePara">Renal survival in the ECD organ group was good: 95.8%. These good results may have been predictable, since it has been shown that in a rejection-free population, the age of the donor and the DGF rate are determining factors for graft survival;<span class="elsevierStyleSup">31</span> in our ECD group, the incidence rates for acute rejection and DGF were relatively low. In addition, we have attained a good level of renal function stability between the 6 and 12-month marks, even showing some eGFR improvement, which could be very important to these kidneys¿ long-term survival.<span class="elsevierStyleSup">16</span> Furthermore, we should not forget that one of the best parameters for predicting graft survival is the creatinine level one year after the transplant,<span class="elsevierStyleSup">32 </span>and our ECD organ recipients had creatinine levels of 1.5 ± 0.4mg/dl at the one-year mark.</p><p class="elsevierStylePara">This study has certain limitations. It is a single-centre cohort study, with a limited number of patients and it still has a short evolution time, which is why we did not apply regression methods. We have not been able to make any comparisons with a significant number of transplant patients with an organ CIT > 15 hours, since we have very few patients of this description. However, we feel that our results indicate that efforts should be made to reduce CITS in order to improve transplant results, and that these efforts should be maximised in the case of ECD organs. In this way, we will be able to optimise results from this graft type and offer recipients the best possible scenario for both initial evolution and for graft survival and renal function.</p><p class="elsevierStylePara">In conclusion, the use of short cold ischaemia times enable us to transplant kidneys from expanded criteria donors with a low incidence rate of delayed graft function and acute rejection, which also results in good survival rates and a good medium-term renal function. It also enables us to obtain a very stable renal function, which may be a determining factor for excellent longterm survival.<br></br></p><p class="elsevierStylePara"><a href="grande/41618078_t1_pag459.jpg" class="elsevierStyleCrossRefs"><img src="41618078_t1_pag459.jpg" alt="Characteristics of expanded criteria donors (ECD) and standard criteria donors (SCD). Characteristics of recipients."></img></a></p><p class="elsevierStylePara">Table 1. Characteristics of expanded criteria donors (ECD) and standard criteria donors (SCD). Characteristics of recipients.</p><p class="elsevierStylePara"><a href="grande/41618078_t2_pag460.jpg" class="elsevierStyleCrossRefs"><img src="41618078_t2_pag460.jpg" alt="Evolution of ECD and SCT transplant recipients"></img></a></p><p class="elsevierStylePara">Table 2. Evolution of ECD and SCT transplant recipients</p><p class="elsevierStylePara"><a href="grande/41618078_f1_pag461.jpg" class="elsevierStyleCrossRefs"><img src="41618078_f1_pag461.jpg"></img></a></p><p class="elsevierStylePara">Figure 1. </p>" "pdfFichero" => "P-E-S-A416-EN.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec439613" "palabras" => array:1 [ 0 => "Trasplante renal" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec439615" "palabras" => array:1 [ 0 => "Retraso en la función del injerto" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec439617" "palabras" => array:1 [ 0 => "Preservación en frío" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec439619" "palabras" => array:1 [ 0 => "Tiempo de isquemia fría" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec439621" "palabras" => array:1 [ 0 => "Donante con criterios expandidos" ] ] ] "en" => array:5 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439614" "palabras" => array:1 [ 0 => "Kidney transplantation" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439616" "palabras" => array:1 [ 0 => "Delayed graft function" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439618" "palabras" => array:1 [ 0 => "Cold preservation" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439620" "palabras" => array:1 [ 0 => "Cold ischemia time" ] ] 4 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec439622" "palabras" => array:1 [ 0 => "Expanded criteria donors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStylePara">Introducción: Los resultados de los trasplantes efectuados con donantes con criterios expandidos (DCE) son inferiores a los obtenidos con donantes con criterios estándar (DCS). Para optimizar su evolución, se podría reducir su tiempo de isquemia fría (TIF) reduciendo su daño de preservación. Comparamos los resultados obtenidos al aplicar TIF <15 horas tanto a DCE como a DCS. Material y métodos: Realizamos un estudio unicéntrico, de cohortes, prospectivo, de casos incidentes de trasplante renal de cadáver entre junio de 2003 y diciembre de 2007. El tiempo mínimo de seguimiento fue de 12 meses. Comparamos los datos de los donantes, de los receptores y de la evolución de los trasplantes efectuados con DCE frente a los de los DCS. Resultados: El TIF para los DCE (N = 24) y para los DCS (N = 50) fue, respectivamente, de 9,3 ± 2,5 y 8,3 ± 3,3 horas (p = 0,18). No encontramos diferencias significativas entre los receptores de DCE y DCS en cuanto a: no función primaria del injerto 4,2 vs. 4%, retardo en la función del injerto 16,7 vs. 10%, complicaciones quirúrgicas 25 vs. 16% y rechazos agudos 8,3 vs. 2%. El filtrado glomerular estimado al año para los DCS fue de 65,8 ± 14,9 ml/min y para los DCE de 49,4 ± 12,5 ml/min (p <0,0001). La supervivencia renal al año fue del 95,8% para los receptores de DCE y del 94% para los DCS (p = 0,75). Conclusiones: La aplicación de TIF cortos a los DCE permite conseguir una evolución similar a la de los DCS, aunque su función renal sea en todo momento inferior.</p>" ] "en" => array:1 [ "resumen" => "Introduction: Outcome of renal transplant from expanded criteria donors (ECD) is usually inferior than those from standard criteria donors (SCD) and may be improved decreasing cold ischemia time (CIT) and minimizing preservation injury. We compare the results obtained with CIT <15 hours in kidney transplants from ecd vs scd subjects and methods: prospective single center study of performed since june 2003 to december 2007 minimum follow-up period was 12 months data donors receptors transplant outcome are compared results: cit mean sd 9 3 2 5 n="50)," 8 those p we did not find significant differences among recipients grafts regarding: primary non-function 4 respectively delayed graft function 16 7 10 surgical complications 25 or acute rejection episodes glomerular filtration rate at one year 65 14 ml min 49 <0 0001 one year graft survival was 95 8 in ecd recipients and 94 scd p="0.75)." conclusions: short cit kidney transplant from leads to similar outcome than that obtained although renal function is inferior grafts</0> </15>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "41618078_t1_pag459.jpg" "Alto" => 637 "Ancho" => 827 "Tamanyo" => 116199 ] ] "descripcion" => array:1 [ "en" => "Characteristics of expanded criteria donors (ECD) and standard criteria donors (SCD). Characteristics of recipients." ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Tab. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "41618078_t2_pag460.jpg" "Alto" => 511 "Ancho" => 827 "Tamanyo" => 103973 ] ] "descripcion" => array:1 [ "en" => "Evolution of ECD and SCT transplant recipients" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "41618078_f1_pag461.jpg" "Alto" => 443 "Ancho" => 825 "Tamanyo" => 38132 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Port FK, Bragg-Gresham JL, Metzger RA, Dykstra DM, Gillespie BW, Young EW, et al. Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors. Transplantation 2002;74:1281-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12451266" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rosengard BR, Feng S, Alfrey EJ, Zaroff JG, Emond JC, Henry ML, et al. Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor. Am J Transplant 2002;2:701-11. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12243491" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ojo AO, Hanson JA, Meier-Kriesche H, Okechukwu CN, Wolfe RA, Leichtman AB, et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001;12:589-97. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11181808" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Audard V, Matignon M, Dahan K, Lang P, Grimbert P. Renal transplantation from extended criteria cadaveric donors: problems and perspectives overview. Transplant Int 2008;21:11-7." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Pascual J, Zamora J, Pirsch JD. A Systematic Review of Kidney Transplantation From Expanded Criteria Donors. Am J Kidney Dis 2008;52:553-86. " "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Stratta RJ, Rohr MS, Sundberg AK, Farney AC, Hartmann EL, Moore PS, et al. Intermediate term outcomes with expanded criteria deceased donors in kidney transplantation: A spectrum or specter of quality? Ann Surg 2006;243:594-601. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16632993" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Baskin-Bey ES, Nyberg SL. Matching graft to recipient by predicted survival: can this be acceptable strategy to improve utilization of deceased donor kidneys? Transplant Rew 2008;22:167-70." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation N Engl J Med 2009;360:7-19. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19118301" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Carter JT, Chan S, Roberts JP, Feng S. Expanded criteria donor kidney allocation: Marked decrease in cold ischemia and delayed graft function at a single center. Am J Transplant 2005;5:2745-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16212636" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hernández D, Estupiñán S, Pérez G, Rufino M, González-Posada JM, Luis D, et al. Impact of cold ischemia time on renal allograft outcome using kidneys from young donors. Transplant Int 2008;21:955-62." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Cockcroft D, Gault M. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1244564" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Nyberg SL, Baskin-Bey ES, Kremers W, Prieto M,Henry ML, Stegall MD. Improving the prediction of donor kidney quality: Deceased donor score and resistive indices. Transplantation 2005;80:925-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16249740" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Govani MV, Kwon O, Batiuk TD, Milgrom ML, Filo RS. Creatinine reduction ratio and 24-hour creatinine excretion on posttransplant day two: simple and objective tools to define graft function. J Am Soc Nephrol 2002;13:1645-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12039994" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rodrigo E, Ruiz JC, Piñera C, Fernández-Fresnedo G, Escallada R, Palomar R, et al. Creatinine reduction ratio on post-transplant day two as criterion in defining delayed graft function. Am J Transplant 2004;4:1163-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15196076" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Levey AS, Greenne T, Kusej J. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 2000;11:155." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Woo YM, Gill JS, Johnson N, Pereira BJ, Hariharan S. The advanced age deceased kidney donor: current outcomes and future opportunities. Kidney Int 2005;67:2407-14. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15882286" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997;63:968-74. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9112349" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Quiroga I, McShane P, Koo DD, Gray D, Friend PJ, Fuggle S, et al. Major effects of delayed graft function and cold ischaemia time on renal allograft survival. Nephrol Dial Transplant2006;21:1689-96." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Shoskes DA, Cecka JM. Deleterious effects of delayed graft function in cadaveric renal transplant recipients independent of acute rejection. Transplantation 1998;66:1697-701. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9884262" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Mikhalski D, Wissing KM, Ghisdal L, Broeders N, Touly M, Hoang AD, et al. Cold ischemia is a major determinant of acute rejection and renal graft survival in the modern era of immunosuppression. Transplantation 2008;85(7):S3-S9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18401260" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Tullius SG, Reutzel-Selke A, Egermann F, Nieminen-Kelhä M, Jonas S, Bechstein WO, et al. Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction. J Am Soc Nephrol 2000;11:1317-24. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10864589" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Bentas W, Jones J, Karaoguz A, Tilp U, Probst M, Scheuermann E, et al. Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme. Nephrol Dial Transplant 2008;23:2043-51. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18203840" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sung RS, Guidinger MK, Lake CD, McBride MA, Greenstein SM, Delmonico FL, et al. Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transplantation 2005;79:1257-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15880081" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Poggio ED, Wang X, Weinstein DM, Issa N, Dennis vW, Braun WE, et al. Assessing glomerular filtration rate by estimation equations in kidney transplant recipients. Am J Transplant 2006;6:100-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16433763" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ibrahim HN, Rogers T, Tello A, Matas A. The performance of three serum creatinine-based formulas in estimating GFR in former kidney donors. Am J Transplant 2006;6:1479-85. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16686774" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ekberg H, Tedesco-Silva H, Demirbas A, Vítko S, Nashan B, Gürkan A, et al.; ELITE-Symphony Study. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007;357:2562-75. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18094377" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Nyberg SL, Matas AJ, Kremers WK, Thostenson JD, Larson TS, Prieto M, et al. Improved scoring system to assess adult donors for cadaver renal transplantation. Am J Transplant 2003;3:715-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12780563" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Schold JD, Kaplan B, Baliga RS, Meier-Kriesche HU. The broad spectrum of quality in deceased donor kidneys. Am J Transplant 2005;5:757-65. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15760399" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Anglicheau D, Loupy A, Lefaucheur C, Pessione F, Létourneau I, Côté I, et al. A simple clinico-histopathological composite scoring system is highly predictive of graft outcomes in marginal donors. Am J Transplant 2008;8:2325-34. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18785957" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Munivenkatappa RB, Schweitzer EJ, Papadimitriou JC, Drachenberg CB, Thom KA, Perencevich EN, et al. The Maryland aggregate pathology index: a deceased donor kidney biopsy scoring system for predicting graft failure. Am J Transplant 2008;8:2316-24. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18801024" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Moreso F, Serón D, Gil-Vernet S, Riera L, Fulladosa X, Ramos R, et al. Donor age and delayed graft function as predictors of renal allograft survival in rejection-free patients. Nephrol Dial Transplant 1999;14:930-5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10328472" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hariharan S, McBride MA, Cherikh WS, Tolleris CB, Bresnahan BA, Johnson CP. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002;6:2311-8." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002900000005/v0_201502091625/X201325140900363X/v0_201502091625/en/main.assets" "Apartado" => array:4 [ "identificador" => "35441" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originals" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002900000005/v0_201502091625/X201325140900363X/v0_201502091625/en/P-E-S-A416-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325140900363X?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 3 | 6 |
2024 October | 52 | 60 | 112 |
2024 September | 38 | 33 | 71 |
2024 August | 56 | 79 | 135 |
2024 July | 49 | 30 | 79 |
2024 June | 59 | 36 | 95 |
2024 May | 68 | 31 | 99 |
2024 April | 54 | 34 | 88 |
2024 March | 45 | 24 | 69 |
2024 February | 36 | 32 | 68 |
2024 January | 44 | 27 | 71 |
2023 December | 49 | 25 | 74 |
2023 November | 28 | 29 | 57 |
2023 October | 45 | 28 | 73 |
2023 September | 54 | 28 | 82 |
2023 August | 62 | 18 | 80 |
2023 July | 37 | 36 | 73 |
2023 June | 91 | 28 | 119 |
2023 May | 71 | 32 | 103 |
2023 April | 58 | 19 | 77 |
2023 March | 85 | 14 | 99 |
2023 February | 63 | 27 | 90 |
2023 January | 36 | 20 | 56 |
2022 December | 59 | 25 | 84 |
2022 November | 48 | 22 | 70 |
2022 October | 44 | 52 | 96 |
2022 September | 66 | 33 | 99 |
2022 August | 49 | 50 | 99 |
2022 July | 36 | 44 | 80 |
2022 June | 48 | 27 | 75 |
2022 May | 53 | 34 | 87 |
2022 April | 75 | 36 | 111 |
2022 March | 63 | 45 | 108 |
2022 February | 44 | 34 | 78 |
2022 January | 45 | 44 | 89 |
2021 December | 60 | 41 | 101 |
2021 November | 38 | 43 | 81 |
2021 October | 46 | 46 | 92 |
2021 September | 42 | 37 | 79 |
2021 August | 23 | 32 | 55 |
2021 July | 41 | 28 | 69 |
2021 June | 20 | 30 | 50 |
2021 May | 32 | 38 | 70 |
2021 April | 70 | 42 | 112 |
2021 March | 67 | 16 | 83 |
2021 February | 63 | 21 | 84 |
2021 January | 65 | 26 | 91 |
2020 December | 56 | 30 | 86 |
2020 November | 57 | 13 | 70 |
2020 October | 55 | 18 | 73 |
2020 September | 49 | 15 | 64 |
2020 August | 55 | 4 | 59 |
2020 July | 52 | 10 | 62 |
2020 June | 47 | 8 | 55 |
2020 May | 57 | 15 | 72 |
2020 April | 56 | 20 | 76 |
2020 March | 50 | 11 | 61 |
2020 February | 68 | 26 | 94 |
2020 January | 64 | 24 | 88 |
2019 December | 72 | 24 | 96 |
2019 November | 53 | 22 | 75 |
2019 October | 46 | 5 | 51 |
2019 September | 78 | 28 | 106 |
2019 August | 48 | 19 | 67 |
2019 July | 50 | 20 | 70 |
2019 June | 58 | 8 | 66 |
2019 May | 64 | 8 | 72 |
2019 April | 96 | 26 | 122 |
2019 March | 38 | 16 | 54 |
2019 February | 49 | 16 | 65 |
2019 January | 30 | 18 | 48 |
2018 December | 49 | 34 | 83 |
2018 November | 86 | 12 | 98 |
2018 October | 76 | 14 | 90 |
2018 September | 65 | 7 | 72 |
2018 August | 33 | 12 | 45 |
2018 July | 31 | 8 | 39 |
2018 June | 39 | 18 | 57 |
2018 May | 37 | 14 | 51 |
2018 April | 25 | 9 | 34 |
2018 March | 35 | 9 | 44 |
2018 February | 33 | 4 | 37 |
2018 January | 27 | 6 | 33 |
2017 December | 38 | 5 | 43 |
2017 November | 29 | 8 | 37 |
2017 October | 32 | 6 | 38 |
2017 September | 31 | 11 | 42 |
2017 August | 33 | 9 | 42 |
2017 July | 32 | 6 | 38 |
2017 June | 40 | 11 | 51 |
2017 May | 43 | 25 | 68 |
2017 April | 31 | 11 | 42 |
2017 March | 29 | 17 | 46 |
2017 February | 32 | 11 | 43 |
2017 January | 29 | 13 | 42 |
2016 December | 78 | 9 | 87 |
2016 November | 97 | 9 | 106 |
2016 October | 132 | 6 | 138 |
2016 September | 161 | 4 | 165 |
2016 August | 215 | 5 | 220 |
2016 July | 168 | 7 | 175 |
2016 June | 126 | 0 | 126 |
2016 May | 137 | 0 | 137 |
2016 April | 100 | 0 | 100 |
2016 March | 102 | 0 | 102 |
2016 February | 109 | 0 | 109 |
2016 January | 124 | 0 | 124 |
2015 December | 108 | 0 | 108 |
2015 November | 105 | 0 | 105 |
2015 October | 87 | 0 | 87 |
2015 September | 87 | 0 | 87 |
2015 August | 63 | 0 | 63 |
2015 July | 85 | 0 | 85 |
2015 June | 43 | 0 | 43 |
2015 May | 53 | 0 | 53 |
2015 April | 14 | 0 | 14 |