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    "textoCompleto" => "<p class="elsevierStylePara">The administration of fluids to the postsurgical patient is a routinary practice that is usually dictated by practices learned during specialized training and&#44; with the exception of children&#44; it usually is the same irrespective of age&#44; gender&#44; and body size of the patient&#46; Since the mortality secondary to fluid therapy is perceived by the clinician as being relatively low&#44; concerns are not generated nor clinical studies on whether volume or composition of the fluids administered may be improved or not&#46; For several years ago&#44; the clinician has been put on alert about the risk for hyponatremia associated to the administration of hypotonic solutions&#44; particularly at the post-surgical setting and in childbearing-aged women&#46;<span class="elsevierStyleSup">1</span> In a recent review<span class="elsevierStyleSup">2</span> Dr&#46; Moritz and Dr&#46; Ay&#250;s question the use of hypotonic solutions at the hospital setting since hospitalized patients&#44; especially post-surgical patients&#44; receive several stimuli for nonosmotic release of vasopressin&#44; so that the administration of fluids other than normal saline increases the risk for hyponatremia occurrence that may be fatal&#46; In the review here commented&#44; it is proposed to avoid any type of hypotonic solution in hospitalized patients&#46; Although there are data suggesting the severe hyponatremia is less likely to occur in patients having not received hypotonic solutions&#44; there are&#44; however&#44; no studies confirming that routinary administration of normal saline may be safer than hypotonic solutions&#46;</p><p class="elsevierStylePara">In the work by Caramelo et al&#46; published in this issue of NEFROLOG&#205;A&#44;<span class="elsevierStyleSup">3</span> the authors look deeper into this topic&#44; analyzing the reposition of water and electrolytes and its consequences in the internal milieu in 112 patients submitted to elective surgeries under general anesthesia&#46; In these patients&#44; the average volume of fluids administered was 4&#46;6 liters for the first 24 hours&#44; with a mean proportion of isotonic fluids&#47;water of approximately 2&#58;1&#44; that is to say&#44; a hypotonic combination&#46; Twentysix cases of either hyponatremia &#40;n &#61; 12&#44; Na&#43; &#60; 135&#41; or Na&#43; decrease &#62; 6 mmol&#47;L although without hyponatremic values &#40;n &#61; 14&#41; were detected&#46; These patients did not receive&#44; however&#44; higher amounts of free water than the remaining ones&#44; three patients even only received normal saline during fluid reposition&#46; The authors conclude that there is not a significant relationship between the type of fluids administered and hyponatremia occurrence&#44; and that the latter would be more related to the existence of renal impairment in free water clearance&#46;</p><p class="elsevierStylePara">These results suggest that the type of reposition used after surgery is neither the main nor the critical factor in the genesis of post-surgical hyponatremia&#46; Besides&#44; they highlight the arbitrariness with which fluids are administered in clinical practice&#46; In fact&#44; there still are important questions to which an appropriate answer cannot be found in the literature&#44; such as how much volume&#63; With what tonicity&#63; In what type of surgeries&#63;</p><p class="elsevierStylePara">Fluid reposition regimens currently used at post-surgery came up in the 1950s because of the need to maintain post-surgical fasting&#44; and have not substantially being modified to date&#46;<span class="elsevierStyleSup">4&#44; 5</span> These regimens were calculated according to estimations on daily needs of water and electrolytes and reposition of losses through drainages or fistulae&#46; They generally establish volumes of 2&#46;5-6 liters of fluids for the first 24 hours with sodium concentrations of 30-100 mmol&#47;L &#40;normal saline has a sodium concentration of 154 mmol&#47;L&#41;&#46; One liter of Ringer lactate &#40;&#91;Na&#43;&#93;&#58; 130 mmol&#47;L&#41; and 2&#46;5 liters of 5&#37; dextrose&#44; that is to say an overtly hypotonic solution is established as proper intake in some textbooks on electrolytes and acid-base balance&#46;<span class="elsevierStyleSup">6</span> Other textbooks&#44; such as the one by Kokko and Tannen&#44;<span class="elsevierStyleSup">7</span> also establish hypotonic reposition regimens&#44; although they underline the need for close supervision for the first 24 hours after surgery&#44; during which there is renal inability to eliminate free water due to non-osmotic release of vasopressin&#59; this release may be sustained up to one week after surgery&#46;</p><p class="elsevierStylePara">In the daily practice there exist high variability in fluids prescription&#44; both in their volume and in their composition&#46; A survey done among 200 surgeons from the United Kingdom<span class="elsevierStyleSup">8</span> showed that education on fluid therapy was insufficient&#44; the prescription being mainly done by training physicians&#44; being highly variable&#44; the most prescribed regimen being 1 liter of normal saline &#40;0&#46;9&#37;&#41; and 2 liters of 5&#37; dextrose&#46; In an analysis carried out by the Pharmacy Department of the &#171;12 de Octubre&#187; Hospital in Madrid&#44;<span class="elsevierStyleSup">9</span> the most used regimen was 1&#46;5 liters of normal saline and 1&#46;5 liters of dextrose&#46; In spite of this striking diversity of regimens&#44; as also reflected in the study by Caramelo et al&#46;&#44; it seems that the mortality secondary to electrolytic impairments during postsurgery is low&#44; or at least these impairments are not reported&#44; which reflects that in most of the cases the kidney response to hypotonic solutions overload is adequate&#44; and although there exists a net gain of free water it does not seem to have a clinical relevance&#46;</p><p class="elsevierStylePara">An important problem with post-surgery fluid therapy is that generic regimens are used in very different clinical conditions&#46; So that a surgery needing prolonged gastric drainage will have increased reposition requirements as compared with a gynecologic surgery without paralytic ileus&#46; During surgery itself&#44; there are fluid losses that should be estimated and replaced&#46; So&#44; in those surgeries in which the peritoneal cavity or the thorax are exposed for a long time&#44; it is estimated that 4&#46;5 mL&#47;kg of free water per hour of surgery are lost&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">Controlled studies allowing reaching any conclusion only exist in particular groups of patients&#46; Several controlled studies and one meta-analysis in minor ambulatory surgery and in laparoscopic surgery have shown that the administration of 20-40 mL&#47;kg of normal saline vs&#46; 1-15 mL&#47;kg before the surgery decrease dizziness&#44; thirst&#44; and vomiting after surgery&#46;<span class="elsevierStyleSup">11-14</span> There are fewer data in major surgery to reach conclusions&#46; In a Cochrane review from the year 2000&#44; in surgery of the abdominal aortic artery&#44;<span class="elsevierStyleSup">15</span> no significant differences were found between different fluid therapy regimens&#46; The authors conclude that more studies are required in order to establish additional conclusions&#46; In a controlled study on parenteral fluids regimens in patients submitted to hemicolectomy&#44;<span class="elsevierStyleSup">16</span> the administration of a restricted regimen of 2 liters&#47;day &#40;0&#46;5 liters of normal saline &#43; 1&#46;5 L of 5&#37; dextrose vs&#46; 3 liters &#40;1 liter of normal saline and 2 L of 5&#37; dextrose&#41; decreased perioperative complications and hospitalization days&#46; Surprisingly&#44; the group with a restricted regimen presented less hyponatremia episodes in spite of receiving lower sodium concentration &#40;37&#46;5 vs 51 mmol&#47;L&#41;&#44; which again reflects that the issue of post-surgical hyponatremia is probably more related with the volume of fluid administered and renal retention of free water than with the concentration of sodium administered&#46; In children&#44; the data available are in favor of administering normal saline as the reposition fluid&#44; for both surgeries and other circumstances requiring fluid therapy such as dehydration due to gastroenteritis&#46; A systematic review from the year 2006<span class="elsevierStyleSup">17</span> concludes that the experimental evidence in childhood is limited&#44; the studies having a heterogeneous design and low power&#44; although a higher risk for hyponatremia episodes is detected in children receiving hypotonic solutions&#44; which may be anticipated and prevented by the administration of isotonic solutions&#46;</p><p class="elsevierStylePara">Given the lack of robust evidence&#44; at least in adult patients&#44; about the type of fluid therapy to be administered during the post-surgical period and given the description of severe hyponatremia episodes&#44; some of them fatal&#44; the question to be answered is whether or not the use of only isotonic solutions is justified&#46; Until controlled studies analyzing this issue will not be available&#44; observational studies as the one published in this issue of NEFROLOG&#205;A deserve great interest&#46; Caramelo et al&#46; show how free water gain is not correlated with the tonicity of the fluids administered&#46; Other observational studies show how postsurgical complications are related with the volume of fluids and the amount of sodium administered and not with the fluids tonicity&#46; So&#44; in an analysis of 100 surgeries of the colon and rectum&#44;<span class="elsevierStyleSup">18</span> there were 44 complications&#44; of which 11 were cardiopulmonary&#46; The group having complications received higher amount of Na &#40;149 vs 115 mmol&#47;day&#41; and more volume &#40;2000 vs 1700 mL&#47; day&#41;&#46; In a similar prospective study on 106 patients submitted to laparotomy&#44;<span class="elsevierStyleSup">19</span> there were 55&#37; complications&#44; including 4 hypernatremia episodes&#44; <span class="elsevierStyleSup">17</span> hyponatremia episodes&#44; and 19 episodes of cardiac failure&#46; The risk for complications was very much higher &#40;67 vs 45&#37;&#41; in the group receiving more than 200 mmol of Na per day&#46; The importance of Na intake is essential in the elderly due to his&#47;her decreased cardiopulmonar capacity&#46; In an analysis from the year 1999 about hospital mortality in the elderly population from the United Kingdom<span class="elsevierStyleSup">20</span> it was concluded that errors in parenteral fluids prescription &#40;usually due to an excess&#41; represent the main preventable perioperative morbimortality cause in the elderly&#46;</p><p class="elsevierStylePara">Within this context&#44; the debate on tonicity still goes on&#46; To assume the recommendations proposed by Ay&#250;s et al&#46; to prevent post-surgical hyponatremia and giving only normal saline without controlling the volume and amount of sodium administered may generate higher morbidity due to volume overload than to hyponatremia itself&#44; which usually has little clinical relevance&#46; Besides&#44; and according to the results by Caramelo et al&#46;&#44; this is not a regimen allowing for the prevention of hyponatremia occurrence since some patients develop the phenomenon known as &#171;desalination &#187; or inappropriate natriuresis&#46;<span class="elsevierStyleSup">21</span></p><p class="elsevierStylePara">Until more information is available on the risks derived from the tonicity and fluid volume to be prescribed in the post-surgical setting&#44; it is judicious to establish strategies allowing preventing the complications&#44; which are as simple as&#58; regularly assessing the patient&#44; from both a clinical and laboratory perspective &#40;electrolytes in blood and urine during all the time that fluid therapy remains in order to adequate the tonicity of the reposition regimen&#41;&#44; and keeping a careful water balance&#44; with estimates of intakes and losses&#44; and avoiding unnecessary overhydration&#44; specially in children and the elderly&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">NOTE TO THE EDITOR&#58;</span> The topic discussed in the article by Dr&#46; Caramelo&#44;<span class="elsevierStyleSup">3 </span>being the object of this editorial&#44; is of great interest&#46; Despite the continuous use&#44; post-surgical fluid therapy constitutes a very little studied intervention&#44; sometimes with controversial opinions&#46; NEFROLOG&#205;A considers that it may be extremely useful to promote the debate on this issue&#44; so the Journal will try to get the opinion from experts on this topic&#46; From here we invite Spanish nephrologists having an opinion on the topic&#44; based on their own work or analysis of the literature&#44; to send us their opinions as a &#171;Letter to the Editor&#187;&#46; <br></br></p>"
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Post-surgery fluid therapy: the debate on tonicity is still open
Fluidoterapia postcirugía: El debate sobre la tonicidad continúa.
Roberto Alcázar Arroyoa
a Unidad de Nefrología, Hospital de Fuenlabrada, Madrid, Madrid, España,
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    "textoCompleto" => "<p class="elsevierStylePara">The administration of fluids to the postsurgical patient is a routinary practice that is usually dictated by practices learned during specialized training and&#44; with the exception of children&#44; it usually is the same irrespective of age&#44; gender&#44; and body size of the patient&#46; Since the mortality secondary to fluid therapy is perceived by the clinician as being relatively low&#44; concerns are not generated nor clinical studies on whether volume or composition of the fluids administered may be improved or not&#46; For several years ago&#44; the clinician has been put on alert about the risk for hyponatremia associated to the administration of hypotonic solutions&#44; particularly at the post-surgical setting and in childbearing-aged women&#46;<span class="elsevierStyleSup">1</span> In a recent review<span class="elsevierStyleSup">2</span> Dr&#46; Moritz and Dr&#46; Ay&#250;s question the use of hypotonic solutions at the hospital setting since hospitalized patients&#44; especially post-surgical patients&#44; receive several stimuli for nonosmotic release of vasopressin&#44; so that the administration of fluids other than normal saline increases the risk for hyponatremia occurrence that may be fatal&#46; In the review here commented&#44; it is proposed to avoid any type of hypotonic solution in hospitalized patients&#46; Although there are data suggesting the severe hyponatremia is less likely to occur in patients having not received hypotonic solutions&#44; there are&#44; however&#44; no studies confirming that routinary administration of normal saline may be safer than hypotonic solutions&#46;</p><p class="elsevierStylePara">In the work by Caramelo et al&#46; published in this issue of NEFROLOG&#205;A&#44;<span class="elsevierStyleSup">3</span> the authors look deeper into this topic&#44; analyzing the reposition of water and electrolytes and its consequences in the internal milieu in 112 patients submitted to elective surgeries under general anesthesia&#46; In these patients&#44; the average volume of fluids administered was 4&#46;6 liters for the first 24 hours&#44; with a mean proportion of isotonic fluids&#47;water of approximately 2&#58;1&#44; that is to say&#44; a hypotonic combination&#46; Twentysix cases of either hyponatremia &#40;n &#61; 12&#44; Na&#43; &#60; 135&#41; or Na&#43; decrease &#62; 6 mmol&#47;L although without hyponatremic values &#40;n &#61; 14&#41; were detected&#46; These patients did not receive&#44; however&#44; higher amounts of free water than the remaining ones&#44; three patients even only received normal saline during fluid reposition&#46; The authors conclude that there is not a significant relationship between the type of fluids administered and hyponatremia occurrence&#44; and that the latter would be more related to the existence of renal impairment in free water clearance&#46;</p><p class="elsevierStylePara">These results suggest that the type of reposition used after surgery is neither the main nor the critical factor in the genesis of post-surgical hyponatremia&#46; Besides&#44; they highlight the arbitrariness with which fluids are administered in clinical practice&#46; In fact&#44; there still are important questions to which an appropriate answer cannot be found in the literature&#44; such as how much volume&#63; With what tonicity&#63; In what type of surgeries&#63;</p><p class="elsevierStylePara">Fluid reposition regimens currently used at post-surgery came up in the 1950s because of the need to maintain post-surgical fasting&#44; and have not substantially being modified to date&#46;<span class="elsevierStyleSup">4&#44; 5</span> These regimens were calculated according to estimations on daily needs of water and electrolytes and reposition of losses through drainages or fistulae&#46; They generally establish volumes of 2&#46;5-6 liters of fluids for the first 24 hours with sodium concentrations of 30-100 mmol&#47;L &#40;normal saline has a sodium concentration of 154 mmol&#47;L&#41;&#46; One liter of Ringer lactate &#40;&#91;Na&#43;&#93;&#58; 130 mmol&#47;L&#41; and 2&#46;5 liters of 5&#37; dextrose&#44; that is to say an overtly hypotonic solution is established as proper intake in some textbooks on electrolytes and acid-base balance&#46;<span class="elsevierStyleSup">6</span> Other textbooks&#44; such as the one by Kokko and Tannen&#44;<span class="elsevierStyleSup">7</span> also establish hypotonic reposition regimens&#44; although they underline the need for close supervision for the first 24 hours after surgery&#44; during which there is renal inability to eliminate free water due to non-osmotic release of vasopressin&#59; this release may be sustained up to one week after surgery&#46;</p><p class="elsevierStylePara">In the daily practice there exist high variability in fluids prescription&#44; both in their volume and in their composition&#46; A survey done among 200 surgeons from the United Kingdom<span class="elsevierStyleSup">8</span> showed that education on fluid therapy was insufficient&#44; the prescription being mainly done by training physicians&#44; being highly variable&#44; the most prescribed regimen being 1 liter of normal saline &#40;0&#46;9&#37;&#41; and 2 liters of 5&#37; dextrose&#46; In an analysis carried out by the Pharmacy Department of the &#171;12 de Octubre&#187; Hospital in Madrid&#44;<span class="elsevierStyleSup">9</span> the most used regimen was 1&#46;5 liters of normal saline and 1&#46;5 liters of dextrose&#46; In spite of this striking diversity of regimens&#44; as also reflected in the study by Caramelo et al&#46;&#44; it seems that the mortality secondary to electrolytic impairments during postsurgery is low&#44; or at least these impairments are not reported&#44; which reflects that in most of the cases the kidney response to hypotonic solutions overload is adequate&#44; and although there exists a net gain of free water it does not seem to have a clinical relevance&#46;</p><p class="elsevierStylePara">An important problem with post-surgery fluid therapy is that generic regimens are used in very different clinical conditions&#46; So that a surgery needing prolonged gastric drainage will have increased reposition requirements as compared with a gynecologic surgery without paralytic ileus&#46; During surgery itself&#44; there are fluid losses that should be estimated and replaced&#46; So&#44; in those surgeries in which the peritoneal cavity or the thorax are exposed for a long time&#44; it is estimated that 4&#46;5 mL&#47;kg of free water per hour of surgery are lost&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">Controlled studies allowing reaching any conclusion only exist in particular groups of patients&#46; Several controlled studies and one meta-analysis in minor ambulatory surgery and in laparoscopic surgery have shown that the administration of 20-40 mL&#47;kg of normal saline vs&#46; 1-15 mL&#47;kg before the surgery decrease dizziness&#44; thirst&#44; and vomiting after surgery&#46;<span class="elsevierStyleSup">11-14</span> There are fewer data in major surgery to reach conclusions&#46; In a Cochrane review from the year 2000&#44; in surgery of the abdominal aortic artery&#44;<span class="elsevierStyleSup">15</span> no significant differences were found between different fluid therapy regimens&#46; The authors conclude that more studies are required in order to establish additional conclusions&#46; In a controlled study on parenteral fluids regimens in patients submitted to hemicolectomy&#44;<span class="elsevierStyleSup">16</span> the administration of a restricted regimen of 2 liters&#47;day &#40;0&#46;5 liters of normal saline &#43; 1&#46;5 L of 5&#37; dextrose vs&#46; 3 liters &#40;1 liter of normal saline and 2 L of 5&#37; dextrose&#41; decreased perioperative complications and hospitalization days&#46; Surprisingly&#44; the group with a restricted regimen presented less hyponatremia episodes in spite of receiving lower sodium concentration &#40;37&#46;5 vs 51 mmol&#47;L&#41;&#44; which again reflects that the issue of post-surgical hyponatremia is probably more related with the volume of fluid administered and renal retention of free water than with the concentration of sodium administered&#46; In children&#44; the data available are in favor of administering normal saline as the reposition fluid&#44; for both surgeries and other circumstances requiring fluid therapy such as dehydration due to gastroenteritis&#46; A systematic review from the year 2006<span class="elsevierStyleSup">17</span> concludes that the experimental evidence in childhood is limited&#44; the studies having a heterogeneous design and low power&#44; although a higher risk for hyponatremia episodes is detected in children receiving hypotonic solutions&#44; which may be anticipated and prevented by the administration of isotonic solutions&#46;</p><p class="elsevierStylePara">Given the lack of robust evidence&#44; at least in adult patients&#44; about the type of fluid therapy to be administered during the post-surgical period and given the description of severe hyponatremia episodes&#44; some of them fatal&#44; the question to be answered is whether or not the use of only isotonic solutions is justified&#46; Until controlled studies analyzing this issue will not be available&#44; observational studies as the one published in this issue of NEFROLOG&#205;A deserve great interest&#46; Caramelo et al&#46; show how free water gain is not correlated with the tonicity of the fluids administered&#46; Other observational studies show how postsurgical complications are related with the volume of fluids and the amount of sodium administered and not with the fluids tonicity&#46; So&#44; in an analysis of 100 surgeries of the colon and rectum&#44;<span class="elsevierStyleSup">18</span> there were 44 complications&#44; of which 11 were cardiopulmonary&#46; The group having complications received higher amount of Na &#40;149 vs 115 mmol&#47;day&#41; and more volume &#40;2000 vs 1700 mL&#47; day&#41;&#46; In a similar prospective study on 106 patients submitted to laparotomy&#44;<span class="elsevierStyleSup">19</span> there were 55&#37; complications&#44; including 4 hypernatremia episodes&#44; <span class="elsevierStyleSup">17</span> hyponatremia episodes&#44; and 19 episodes of cardiac failure&#46; The risk for complications was very much higher &#40;67 vs 45&#37;&#41; in the group receiving more than 200 mmol of Na per day&#46; The importance of Na intake is essential in the elderly due to his&#47;her decreased cardiopulmonar capacity&#46; In an analysis from the year 1999 about hospital mortality in the elderly population from the United Kingdom<span class="elsevierStyleSup">20</span> it was concluded that errors in parenteral fluids prescription &#40;usually due to an excess&#41; represent the main preventable perioperative morbimortality cause in the elderly&#46;</p><p class="elsevierStylePara">Within this context&#44; the debate on tonicity still goes on&#46; To assume the recommendations proposed by Ay&#250;s et al&#46; to prevent post-surgical hyponatremia and giving only normal saline without controlling the volume and amount of sodium administered may generate higher morbidity due to volume overload than to hyponatremia itself&#44; which usually has little clinical relevance&#46; Besides&#44; and according to the results by Caramelo et al&#46;&#44; this is not a regimen allowing for the prevention of hyponatremia occurrence since some patients develop the phenomenon known as &#171;desalination &#187; or inappropriate natriuresis&#46;<span class="elsevierStyleSup">21</span></p><p class="elsevierStylePara">Until more information is available on the risks derived from the tonicity and fluid volume to be prescribed in the post-surgical setting&#44; it is judicious to establish strategies allowing preventing the complications&#44; which are as simple as&#58; regularly assessing the patient&#44; from both a clinical and laboratory perspective &#40;electrolytes in blood and urine during all the time that fluid therapy remains in order to adequate the tonicity of the reposition regimen&#41;&#44; and keeping a careful water balance&#44; with estimates of intakes and losses&#44; and avoiding unnecessary overhydration&#44; specially in children and the elderly&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">NOTE TO THE EDITOR&#58;</span> The topic discussed in the article by Dr&#46; Caramelo&#44;<span class="elsevierStyleSup">3 </span>being the object of this editorial&#44; is of great interest&#46; Despite the continuous use&#44; post-surgical fluid therapy constitutes a very little studied intervention&#44; sometimes with controversial opinions&#46; NEFROLOG&#205;A considers that it may be extremely useful to promote the debate on this issue&#44; so the Journal will try to get the opinion from experts on this topic&#46; From here we invite Spanish nephrologists having an opinion on the topic&#44; based on their own work or analysis of the literature&#44; to send us their opinions as a &#171;Letter to the Editor&#187;&#46; <br></br></p>"
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Article information
ISSN: 20132514
Original language: English
DOI:
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2015 October 85 0 85
2015 September 72 0 72
2015 August 72 0 72
2015 July 62 0 62
2015 June 43 0 43
2015 May 55 0 55
2015 April 5 0 5
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?