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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">The development of acute renal failure &#40;ARF&#41; in patients with nephrotic syndrome is rare and usually associated to minimal changes nephropathy&#46;<span class="elsevierStyleSup">1</span> The pathogenesis is not clear and several mechanisms have been implicated&#46;<span class="elsevierStyleSup">2&#44; 3</span> The increase in the pressure within the tubules and the Bowman&#191;s space can play a role&#46; This is due both to interstitial edema and to intratubular obstruction because of accumulation of proteins<span class="elsevierStyleSup">4</span> and cellular detritus&#46;<span class="elsevierStyleSup">5</span> Hypovolemia is another mechanism implicated and is related to hypoalbuminemia and to the excessive use of diuretics&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">A 36 year-old male is presented with a history of nephrotic syndrome in complete remission since 2000&#46;</p><p class="elsevierStylePara">In 2004 he was evaluated in the Emergency Room because of edemas&#46; The laboratory findings revealed mild renal function impairment and mild proteinuria&#46; Diuretics were prescribed and the patient was referred to the outpatient clinic&#46; Eight days later he was again evaluated because of increasing edemas and he was admitted to the hospital&#46; The following laboratory findings were obtained&#58; urea 71&#44; Cr 1&#46;15&#44; cholesterol 423&#44; triglycerides 254 mg&#47;dL&#59; total proteins 4&#46;32&#44; albumin 2&#46;22g&#47;dL&#59; proteinuria 3&#46;1 g&#47;12-hours&#46; A new renal biopsy was performed and the patient was discharged&#46;</p><p class="elsevierStylePara">A week later the patients was again admitted with anasarca and oligo-anuria&#46; Serum level of urea was 287 and creatinine was 4&#46;1 mg&#47;dL&#46; Severe hypoalbuminemia was detected that prompted the administration of albumin&#46; The urine analysis revealed Na &#60; 10 mEq&#47;L and Cr &#62; 130 mg&#47;dL&#44; which supported the diagnosis of prerrenal renal failure&#46; Diuretics were withdrawn&#46; The patient developed anuria and a central catheter was placed to initiate hemodialysis&#46; Renal biopsy &#40;fig&#46; 1&#41; showed 8 glomeruli with mild sclerosis and capillary collapse within the vascular pole and others with capsular adhesions or capillary lumen collapse&#46; The interstitium and the tubules were normal&#46; The immunofluorescence pattern was granular mesangial IgM&#43; and C3 &#43;&#43;&#46; Adiagnosis of focal and segmentary glomerulosclerosis &#40;FSGS&#41; was made and three boluses of steroids were administrated followed by oral prednisone and cyclophosphamide&#46; When the patient was discharged he was in anuria and required periodic hemodialysis&#46;</p><p class="elsevierStylePara">Two days later the patient was again admitted to the hospital to evaluate renal function because he referred increasing diuresis that reached 7 L&#47;day&#46; On day 9 of hospital stay the laboratory parameters were as follows&#58; urea 32&#44; Cr 0&#46;8 mg&#47;dL&#59; proteinuria 2&#46;5 g&#47;24h&#59; CrCl 156 mL&#47;min&#46;</p><p class="elsevierStylePara">After 10 months of periodic follow up&#44; the proteinuria was negative and therefore treatment with steroids and cyclophosphamide could be discontinued&#46; The patient remained asymptomatic&#44; with no signs of nephropathy relapse&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">Some cases of ARF remission without steroidal administration have been reported&#46;<span class="elsevierStyleSup">7</span> However the treatment with high doses of prednisone &#40;1 mg&#47;kg&#47;day&#41; is considered necessary in case of nephrotic syndrome associated to FSGS and can induce complete remission in 35-45&#37; of the patients&#46;<span class="elsevierStyleSup">8</span> The effect of steroids on glomerular filtrate in ARF associated to nephrotic syndrome is unknown&#44; but they may prevent the tubular reabsorption of sodium and allow the complete recovery of filtration fraction<span class="elsevierStyleSup">9&#44; 10</span> as proteinuria decreases&#46; The judicious use of diuretics should maintain the diuresis&#44; avoiding a misbalance of pressures within the glomeruli and the potential progression to anuria&#46; Ultrafiltration hemodialysis is indicated in case of nephrotic syndrome due to FSGS with ARF&#44; which presents with oligo-anuria and accumulation of nitrogen products&#46; At the same time&#44; steroidal treatment should be initiated or their dose increased&#46; The resolution of ARF is in this way to be expected&#44; which may occur in a few weeks or months<span class="elsevierStyleSup">5&#44; 11</span> or dramatically&#44; as it happened in the reported case&#46;<br></br></p>"
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        "resumen" => "El fracaso renal agudo en el s&#237;ndrome nefr&#243;tico es poco frecuente y suele asociarse con una nefropat&#237;a de cambios m&#237;nimos&#46; Su etiopatogenia es oscura y se relaciona con una reducci&#243;n de la permeabilidad glomerular&#44; con necrosis tubular aguda o con un incremento de la presi&#243;n intrarrenal debido al edema intersticial&#46; Presentamos un var&#243;n de 36 a&#241;os con un s&#237;ndrome nefr&#243;tico por glomeruloesclerosis focal y segmentaria que desarroll&#243; un fracaso renal agudo an&#250;rico&#46; A pesar de reducir el edema con hemodi&#225;lisis fue tras iniciar tratamiento con esteroides e inmunosupresores cuando la diuresis se restableci&#243; y mejor&#243; r&#225;pidamente la funci&#243;n renal&#46; En la biopsia renal no se observaron datos de necrosis u obstrucci&#243;n tubular ni de edema intersticial&#44; por lo que atribuimos el fracaso renal agudo a una severa reducci&#243;n del coeficiente de ultrafiltraci&#243;n glomerular&#46;"
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Acute renal failure in a case of nephrotic syndrome secondary to focal and segmental glomerulosclerosis
Fracaso renal agudo en síndrome nefrótico secundario a glomeruloesclerosis focal y segmentaria
Manuel Polaina Rusilloa, F. J.. Borrego Utiela, I.. Ruiz Ávilaa, V.. Pérez Bañascoa
a Complejo Hospitalario de Jaén, Jaén, Jaén, España,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">INTRODUCTION</span></p><p class="elsevierStylePara">The development of acute renal failure &#40;ARF&#41; in patients with nephrotic syndrome is rare and usually associated to minimal changes nephropathy&#46;<span class="elsevierStyleSup">1</span> The pathogenesis is not clear and several mechanisms have been implicated&#46;<span class="elsevierStyleSup">2&#44; 3</span> The increase in the pressure within the tubules and the Bowman&#191;s space can play a role&#46; This is due both to interstitial edema and to intratubular obstruction because of accumulation of proteins<span class="elsevierStyleSup">4</span> and cellular detritus&#46;<span class="elsevierStyleSup">5</span> Hypovolemia is another mechanism implicated and is related to hypoalbuminemia and to the excessive use of diuretics&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">A 36 year-old male is presented with a history of nephrotic syndrome in complete remission since 2000&#46;</p><p class="elsevierStylePara">In 2004 he was evaluated in the Emergency Room because of edemas&#46; The laboratory findings revealed mild renal function impairment and mild proteinuria&#46; Diuretics were prescribed and the patient was referred to the outpatient clinic&#46; Eight days later he was again evaluated because of increasing edemas and he was admitted to the hospital&#46; The following laboratory findings were obtained&#58; urea 71&#44; Cr 1&#46;15&#44; cholesterol 423&#44; triglycerides 254 mg&#47;dL&#59; total proteins 4&#46;32&#44; albumin 2&#46;22g&#47;dL&#59; proteinuria 3&#46;1 g&#47;12-hours&#46; A new renal biopsy was performed and the patient was discharged&#46;</p><p class="elsevierStylePara">A week later the patients was again admitted with anasarca and oligo-anuria&#46; Serum level of urea was 287 and creatinine was 4&#46;1 mg&#47;dL&#46; Severe hypoalbuminemia was detected that prompted the administration of albumin&#46; The urine analysis revealed Na &#60; 10 mEq&#47;L and Cr &#62; 130 mg&#47;dL&#44; which supported the diagnosis of prerrenal renal failure&#46; Diuretics were withdrawn&#46; The patient developed anuria and a central catheter was placed to initiate hemodialysis&#46; Renal biopsy &#40;fig&#46; 1&#41; showed 8 glomeruli with mild sclerosis and capillary collapse within the vascular pole and others with capsular adhesions or capillary lumen collapse&#46; The interstitium and the tubules were normal&#46; The immunofluorescence pattern was granular mesangial IgM&#43; and C3 &#43;&#43;&#46; Adiagnosis of focal and segmentary glomerulosclerosis &#40;FSGS&#41; was made and three boluses of steroids were administrated followed by oral prednisone and cyclophosphamide&#46; When the patient was discharged he was in anuria and required periodic hemodialysis&#46;</p><p class="elsevierStylePara">Two days later the patient was again admitted to the hospital to evaluate renal function because he referred increasing diuresis that reached 7 L&#47;day&#46; On day 9 of hospital stay the laboratory parameters were as follows&#58; urea 32&#44; Cr 0&#46;8 mg&#47;dL&#59; proteinuria 2&#46;5 g&#47;24h&#59; CrCl 156 mL&#47;min&#46;</p><p class="elsevierStylePara">After 10 months of periodic follow up&#44; the proteinuria was negative and therefore treatment with steroids and cyclophosphamide could be discontinued&#46; The patient remained asymptomatic&#44; with no signs of nephropathy relapse&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">Some cases of ARF remission without steroidal administration have been reported&#46;<span class="elsevierStyleSup">7</span> However the treatment with high doses of prednisone &#40;1 mg&#47;kg&#47;day&#41; is considered necessary in case of nephrotic syndrome associated to FSGS and can induce complete remission in 35-45&#37; of the patients&#46;<span class="elsevierStyleSup">8</span> The effect of steroids on glomerular filtrate in ARF associated to nephrotic syndrome is unknown&#44; but they may prevent the tubular reabsorption of sodium and allow the complete recovery of filtration fraction<span class="elsevierStyleSup">9&#44; 10</span> as proteinuria decreases&#46; The judicious use of diuretics should maintain the diuresis&#44; avoiding a misbalance of pressures within the glomeruli and the potential progression to anuria&#46; Ultrafiltration hemodialysis is indicated in case of nephrotic syndrome due to FSGS with ARF&#44; which presents with oligo-anuria and accumulation of nitrogen products&#46; At the same time&#44; steroidal treatment should be initiated or their dose increased&#46; The resolution of ARF is in this way to be expected&#44; which may occur in a few weeks or months<span class="elsevierStyleSup">5&#44; 11</span> or dramatically&#44; as it happened in the reported case&#46;<br></br></p>"
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          "palabras" => array:1 [
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:1 [
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            0 => "Glomeruloesclerosis focal y segmentaria"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:1 [
            0 => "Nephrotic syndrome"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:1 [
            0 => "Acute renal failure"
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        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec438758"
          "palabras" => array:1 [
            0 => "Focal and segmental glomeruloesclerosis"
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        "resumen" => "El fracaso renal agudo en el s&#237;ndrome nefr&#243;tico es poco frecuente y suele asociarse con una nefropat&#237;a de cambios m&#237;nimos&#46; Su etiopatogenia es oscura y se relaciona con una reducci&#243;n de la permeabilidad glomerular&#44; con necrosis tubular aguda o con un incremento de la presi&#243;n intrarrenal debido al edema intersticial&#46; Presentamos un var&#243;n de 36 a&#241;os con un s&#237;ndrome nefr&#243;tico por glomeruloesclerosis focal y segmentaria que desarroll&#243; un fracaso renal agudo an&#250;rico&#46; A pesar de reducir el edema con hemodi&#225;lisis fue tras iniciar tratamiento con esteroides e inmunosupresores cuando la diuresis se restableci&#243; y mejor&#243; r&#225;pidamente la funci&#243;n renal&#46; En la biopsia renal no se observaron datos de necrosis u obstrucci&#243;n tubular ni de edema intersticial&#44; por lo que atribuimos el fracaso renal agudo a una severa reducci&#243;n del coeficiente de ultrafiltraci&#243;n glomerular&#46;"
      ]
      "en" => array:1 [
        "resumen" => "Nephrotic syndrome is infrequently complicated with appearance of acute renal failure and minimal change disease is the glomerulopathy more usually involved&#46; Pathogenesis is unclear and three possible mechanisms it has been proposed to explain the decrease of glomerular filtration rate&#58; a severe reduction of glomerular permeability&#44; the presence of acute tubular necrosis or an increased intrarrenal pressure related with interstitial oedema&#46; Here we present a 36 years-old-male with a nephrotic syndrome caused by focal and segmental glomerulosclerosis who developed an anuric acute renal failure&#46; Renal function did not change despite oedema removal with haemodialysis and only after corticosteroid and cyclophosphamide therapy introduction we observed a rapid recovery of urinary output and resolution of acute renal failure&#46; Renal biopsy did not show signs of tubular damage or obstruction with proteins nor significant interstitial oedema&#46; Therefore&#44; in this case we think acute renal failure was caused by a severe reduction in glomerular ultrafiltration rate and steroids were the effective treatment that allowed recovery of renal function&#46;"
      ]
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                0 => array:3 [
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              "identificador" => "bib3"
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              "identificador" => "bib4"
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Article information
ISSN: 20132514
Original language: English
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