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    "textoCompleto" => "<p class="elsevierStylePara">To the Editor&#58;</p><p class="elsevierStylePara">There are some reports in the literature pointing out that the progression of the diabetic nephropathy &#40;DN&#41; is slower in patients who take low protein diets&#46;<span class="elsevierStyleSup">1&#44;2</span> Macrobiotic diet is an extreme form of vegetarianism that had showed to be useful in the prevention and in the treatment of some tumors&#46; To date it has not been reported that this diet can slow down the progression of the DN&#46;</p><p class="elsevierStylePara">We present a 58 year-old Caucasian male&#44; with a history of high blood pressure since 1990 regularly controlled with antihypertensives drugs&#44; and of type 2 diabetes mellitus since 1998&#44; treated with insulin and with good metabolic control&#46; He was referred to the Nephrology Department in 2000 because of stage 2 chronic renal failure &#40;CRF&#41; and microalbuminuria secondary to DN&#46; He was being treated with irbesartan 300 mg&#47;day&#44; hydrochlorotiazide 12&#44;5 mg&#47;day&#44; nifedipine 60 mg&#47;day and salicylic acid 100 mg&#47;day&#46; During the follow up the renal function worsened lightly and he had normo-albuminuria&#46; In December of 2005 the following measurements were made&#58; bloodpressure 139&#47;87 mmHg&#44; weight 81 kg&#44; and height 180 cm&#46; The laboratory parameters were urea 61 mg&#47;dL&#44; creatinine 1&#46;7 mg&#47;dL&#44; creatinine clearance 44&#46;37 mL&#47;min&#44; microalbuminuria 11&#46;75 mug&#47;min and hemoglobin A1c 5&#46;5&#46; Other parameters were normal&#46; In January of 2006 the patient began a macrobiotic diet&#44; consisting of wholemeal cereals&#44; like barley and wheat&#44; see algae&#44; and vegetables&#46; He avoided eating meat&#44; milk or milk derivatives&#46; In October of 2006 he had blood pressure 138&#47;82 mmHg and weight 79 Kg&#46; Laboratory findings were urea 46 mg&#47;dL&#44; creatinine 1 mg&#47;dL&#44; creatinine clearance 81&#46;57 mL&#47;min&#44; microalbuminuria 29&#44;31 m&#47;min&#44; hemoglobin A1c 5&#46;9&#44; albumin 4&#46;2 g&#47;dL&#44; total proteins 6&#46;7 g&#47;dL&#44; total cholesterol 150 mg&#47;dL&#44; triglycerides 168 mg&#47;dL&#44; and the other parameters were normal&#46; These findings were similar in further analyses three and six months later&#46; He did not appear malnourished&#46; No changes in the treatment were prescribed and no other cause could be found to explain the improvement in renal function&#46;</p><p class="elsevierStylePara">Macrobiotic diet is an extreme form of vegetarianism combined with some thoughts derived from Buddhist Zen philosophy&#46; Eating and quality of food are thought to affect the health&#46;<span class="elsevierStyleSup">3</span> Macrobioticdiet emphasizes the use of organic products&#44; like cereals&#44; fruits&#44; algae&#44; vegetables&#44; fermented soy&#44; combined according to the principles of the balance between the yin and yang properties&#46;<span class="elsevierStyleSup">4</span> Some reports demonstrate the anti-tumoral effect&#44; particularly in breast tumors&#46; Women who make a macrobiotic diet apparently excrete a greater amount of estrogens in stool and urine&#44; have lower blood levels of estradiol and have lower risk of developing a breast carcinoma&#46;<span class="elsevierStyleSup">5&#44; 6</span> Some studies about the macrobiotic diet as treatment of different neoplasms&#44; like melanoma or pancreas cancer&#44; have been published&#46; An improvement of the clinical picture and of the quality of life of the patients was observed&#46;<span class="elsevierStyleSup">6&#44; 7</span></p><p class="elsevierStylePara">The effect of macrobiotic diet in diminishing cardiovascular risk has been reported&#46;<span class="elsevierStyleSup">8&#44; 9</span> An improvement in total cholesterol&#44; an increase in HDL-cholesterol and an improvement in blood pressure were demonstrated&#44; but no effect on the progression of the DN could be showed&#46;</p><p class="elsevierStylePara">The potential danger of the diet is that if strictly followed can cause malnourishment&#44; anemia due to vitamin B12 deficiency and scurvy&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The reported patient presented a - CRF secondary to DN of six years&#46; After 10 months of macrobiotic diet an improvement in renal function was observed&#44; without signs of malnourishment and no other cause could be found to explain this improvement&#46;</p>"
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Effect of macrobiotic diet on the progression of diabetic nephropathy: a propos of a case
Efecto de la dieta macrobiótica sobre la progresión de la nefropatía diabética: a propósito de un caso
Olga Costero Fernándeza, F.. De Álvaroa, S.. Romeroa, R.. Selgasa
a Servicio de Nefrología, Hospital Universitario La Paz, Madrid, Madrid, España,
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    "textoCompleto" => "<p class="elsevierStylePara">To the Editor&#58;</p><p class="elsevierStylePara">There are some reports in the literature pointing out that the progression of the diabetic nephropathy &#40;DN&#41; is slower in patients who take low protein diets&#46;<span class="elsevierStyleSup">1&#44;2</span> Macrobiotic diet is an extreme form of vegetarianism that had showed to be useful in the prevention and in the treatment of some tumors&#46; To date it has not been reported that this diet can slow down the progression of the DN&#46;</p><p class="elsevierStylePara">We present a 58 year-old Caucasian male&#44; with a history of high blood pressure since 1990 regularly controlled with antihypertensives drugs&#44; and of type 2 diabetes mellitus since 1998&#44; treated with insulin and with good metabolic control&#46; He was referred to the Nephrology Department in 2000 because of stage 2 chronic renal failure &#40;CRF&#41; and microalbuminuria secondary to DN&#46; He was being treated with irbesartan 300 mg&#47;day&#44; hydrochlorotiazide 12&#44;5 mg&#47;day&#44; nifedipine 60 mg&#47;day and salicylic acid 100 mg&#47;day&#46; During the follow up the renal function worsened lightly and he had normo-albuminuria&#46; In December of 2005 the following measurements were made&#58; bloodpressure 139&#47;87 mmHg&#44; weight 81 kg&#44; and height 180 cm&#46; The laboratory parameters were urea 61 mg&#47;dL&#44; creatinine 1&#46;7 mg&#47;dL&#44; creatinine clearance 44&#46;37 mL&#47;min&#44; microalbuminuria 11&#46;75 mug&#47;min and hemoglobin A1c 5&#46;5&#46; Other parameters were normal&#46; In January of 2006 the patient began a macrobiotic diet&#44; consisting of wholemeal cereals&#44; like barley and wheat&#44; see algae&#44; and vegetables&#46; He avoided eating meat&#44; milk or milk derivatives&#46; In October of 2006 he had blood pressure 138&#47;82 mmHg and weight 79 Kg&#46; Laboratory findings were urea 46 mg&#47;dL&#44; creatinine 1 mg&#47;dL&#44; creatinine clearance 81&#46;57 mL&#47;min&#44; microalbuminuria 29&#44;31 m&#47;min&#44; hemoglobin A1c 5&#46;9&#44; albumin 4&#46;2 g&#47;dL&#44; total proteins 6&#46;7 g&#47;dL&#44; total cholesterol 150 mg&#47;dL&#44; triglycerides 168 mg&#47;dL&#44; and the other parameters were normal&#46; These findings were similar in further analyses three and six months later&#46; He did not appear malnourished&#46; No changes in the treatment were prescribed and no other cause could be found to explain the improvement in renal function&#46;</p><p class="elsevierStylePara">Macrobiotic diet is an extreme form of vegetarianism combined with some thoughts derived from Buddhist Zen philosophy&#46; Eating and quality of food are thought to affect the health&#46;<span class="elsevierStyleSup">3</span> Macrobioticdiet emphasizes the use of organic products&#44; like cereals&#44; fruits&#44; algae&#44; vegetables&#44; fermented soy&#44; combined according to the principles of the balance between the yin and yang properties&#46;<span class="elsevierStyleSup">4</span> Some reports demonstrate the anti-tumoral effect&#44; particularly in breast tumors&#46; Women who make a macrobiotic diet apparently excrete a greater amount of estrogens in stool and urine&#44; have lower blood levels of estradiol and have lower risk of developing a breast carcinoma&#46;<span class="elsevierStyleSup">5&#44; 6</span> Some studies about the macrobiotic diet as treatment of different neoplasms&#44; like melanoma or pancreas cancer&#44; have been published&#46; An improvement of the clinical picture and of the quality of life of the patients was observed&#46;<span class="elsevierStyleSup">6&#44; 7</span></p><p class="elsevierStylePara">The effect of macrobiotic diet in diminishing cardiovascular risk has been reported&#46;<span class="elsevierStyleSup">8&#44; 9</span> An improvement in total cholesterol&#44; an increase in HDL-cholesterol and an improvement in blood pressure were demonstrated&#44; but no effect on the progression of the DN could be showed&#46;</p><p class="elsevierStylePara">The potential danger of the diet is that if strictly followed can cause malnourishment&#44; anemia due to vitamin B12 deficiency and scurvy&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">The reported patient presented a - CRF secondary to DN of six years&#46; After 10 months of macrobiotic diet an improvement in renal function was observed&#44; without signs of malnourishment and no other cause could be found to explain this improvement&#46;</p>"
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Article information
ISSN: 20132514
Original language: English
DOI:
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2024 October 60 51 111
2024 September 77 27 104
2024 August 84 61 145
2024 July 51 27 78
2024 June 59 30 89
2024 May 82 52 134
2024 April 56 39 95
2024 March 68 26 94
2024 February 61 48 109
2024 January 66 36 102
2023 December 64 32 96
2023 November 44 27 71
2023 October 86 38 124
2023 September 44 19 63
2023 August 38 27 65
2023 July 50 28 78
2023 June 57 21 78
2023 May 83 28 111
2023 April 85 24 109
2023 March 78 30 108
2023 February 57 23 80
2023 January 39 23 62
2022 December 46 36 82
2022 November 38 31 69
2022 October 46 47 93
2022 September 48 34 82
2022 August 68 37 105
2022 July 29 36 65
2022 June 48 27 75
2022 May 70 35 105
2022 April 86 39 125
2022 March 62 57 119
2022 February 45 36 81
2022 January 71 57 128
2021 December 59 34 93
2021 November 27 43 70
2021 October 74 49 123
2021 September 70 44 114
2021 August 57 47 104
2021 July 70 56 126
2021 June 52 26 78
2021 May 73 37 110
2021 April 151 58 209
2021 March 108 39 147
2021 February 86 24 110
2021 January 78 15 93
2020 December 51 16 67
2020 November 59 20 79
2020 October 39 20 59
2020 September 40 9 49
2020 August 57 17 74
2020 July 68 15 83
2020 June 55 20 75
2020 May 67 17 84
2020 April 48 23 71
2020 March 74 19 93
2020 February 54 23 77
2020 January 84 22 106
2019 December 75 24 99
2019 November 66 18 84
2019 October 50 8 58
2019 September 64 14 78
2019 August 61 17 78
2019 July 59 33 92
2019 June 66 11 77
2019 May 56 14 70
2019 April 78 24 102
2019 March 48 12 60
2019 February 34 14 48
2019 January 36 24 60
2018 December 87 38 125
2018 November 129 17 146
2018 October 134 16 150
2018 September 65 25 90
2018 August 49 17 66
2018 July 49 20 69
2018 June 45 20 65
2018 May 63 13 76
2018 April 44 7 51
2018 March 65 10 75
2018 February 55 3 58
2018 January 51 9 60
2017 December 59 9 68
2017 November 34 4 38
2017 October 34 8 42
2017 September 35 8 43
2017 August 36 8 44
2017 July 33 12 45
2017 June 28 5 33
2017 May 40 18 58
2017 April 38 6 44
2017 March 25 11 36
2017 February 21 4 25
2017 January 16 2 18
2016 December 46 3 49
2016 November 56 7 63
2016 October 82 12 94
2016 September 127 2 129
2016 August 205 6 211
2016 July 169 0 169
2016 June 126 0 126
2016 May 139 0 139
2016 April 106 0 106
2016 March 64 0 64
2016 February 69 0 69
2016 January 98 0 98
2015 December 86 0 86
2015 November 64 0 64
2015 October 75 0 75
2015 September 60 0 60
2015 August 63 0 63
2015 July 50 0 50
2015 June 37 0 37
2015 May 38 0 38
2015 April 5 0 5
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