was read the article
array:21 [ "pii" => "X2013251408005556" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:466-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3548 "formatos" => array:3 [ "EPUB" => 297 "HTML" => 2776 "PDF" => 475 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699508005559" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2008;28:466-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7294 "formatos" => array:3 [ "EPUB" => 294 "HTML" => 6384 "PDF" => 616 ] ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Nefropatía IgA y anticoagulante lúpico: ¿una asociación casual?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "466" "paginaFinal" => "467" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "IgA nephropathy and lupus anticoagulant: an incidental association?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "MANUEL HERAS BENITO, MARIA JOSE FERNANDEZ-REYES LUIS, ROSA SANCHEZ HERNANDEZ, ROSA FISAC HERRERO" "autores" => array:4 [ 0 => array:2 [ "nombre" => "MANUEL" "apellidos" => "HERAS BENITO" ] 1 => array:2 [ "nombre" => "MARIA JOSE" "apellidos" => "FERNANDEZ-REYES LUIS" ] 2 => array:2 [ "nombre" => "ROSA" "apellidos" => "SANCHEZ HERNANDEZ" ] 3 => array:2 [ "nombre" => "ROSA" "apellidos" => "FISAC HERRERO" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251408005556" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408005556?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508005559?idApp=UINPBA000064" "url" => "/02116995/0000002800000004/v0_201502091416/X0211699508005559/v0_201502091417/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X201325140800553X" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:467-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3963 "formatos" => array:3 [ "EPUB" => 295 "HTML" => 3173 "PDF" => 495 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Primary antiphospholipid syndrome: dormant, not cured" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "467" "paginaFinal" => "469" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome antifosfolípido primario: dormido, no curado" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Caramelo, Ana Ramos, Simona Alexandru, Olga Sanchez Pernaute" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Caramelo" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Ramos" ] 2 => array:2 [ "nombre" => "Simona" "apellidos" => "Alexandru" ] 3 => array:2 [ "nombre" => "Olga" "apellidos" => "Sanchez Pernaute" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508005532" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508005532?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325140800553X?idApp=UINPBA000064" "url" => "/20132514/0000002800000004/v0_201502091636/X201325140800553X/v0_201502091636/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251408005564" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:464-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3606 "formatos" => array:3 [ "EPUB" => 268 "HTML" => 2720 "PDF" => 618 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Carcinoid tumor and hypernephroma coexisting in a patient with chronic renal failure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "464" "paginaFinal" => "466" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor carcinoide e hipernefroma: coexistencia en un paciente con insuficiencia renal crónica" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Montserrat Picazo Sánchez, Marc Cuxart Pérez, Ramon Sans Lorman" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Picazo Sánchez" ] 1 => array:2 [ "nombre" => "Marc" "apellidos" => "Cuxart Pérez" ] 2 => array:2 [ "nombre" => "Ramon" "apellidos" => "Sans Lorman" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508005567" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508005567?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408005564?idApp=UINPBA000064" "url" => "/20132514/0000002800000004/v0_201502091636/X2013251408005564/v0_201502091636/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "IgA nephropathy and lupus anticoagulant: an incidental association?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "466" "paginaFinal" => "467" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "MANUEL HERAS BENITO, MARIA JOSE FERNANDEZ-REYES LUIS, ROSA SANCHEZ HERNANDEZ, ROSA FISAC HERRERO" "autores" => array:4 [ 0 => array:4 [ "nombre" => "MANUEL" "apellidos" => "HERAS BENITO" "email" => array:1 [ 0 => "mheras@hgse.sacyl.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "MARIA JOSE" "apellidos" => "FERNANDEZ-REYES LUIS" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "ROSA" "apellidos" => "SANCHEZ HERNANDEZ" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "ROSA" "apellidos" => "FISAC HERRERO" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "SERVICIO DE NEFROLOGIA Hospital General de Segovia, Segovia, Segovia, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "SERVICIO DE HEMATOLOGIA, Hospital General de Segovia, Segovia, Segovia, España, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nefropatía IgA y anticoagulante lúpico: ¿una asociación casual?" ] ] "textoCompleto" => "To the editor: IgA nephropathy is the most common chronic primary glomerulonephritis, leading to progressive renal failure in at least one third of patients.1 No association of this disease with the lupus anticoagulant (LA) has been found in the literature. The occurrence of IgA nephropathy in two sisters, one of whom had LA, is reported. <br></br><br></br>CASE 1 <br></br><br></br>A 26-year-old female patient with a history of acne and recurrent urinary tract infection. She was studied for <br></br>gross hematuria after upper respiratory tract infections. Physical examination was normal. Laboratory test results <br></br>included: creatinine 1.4 mg/dL, hematocrit 25%, prothrombin activity 87%, APTT 44.7 seconds , fibrinogen <br></br>434 mg/dL. Immunological test results included: IgG 1260 mg/dL (N: 751-1560), IgA 667 mg/dL (N:82-453), <br></br>IgM 190 mg/dL (N: 46-304), C3 88 mg/dl (N: 79-152), C4 27.8 mg/dl (N: 16- 38), negative ANA. Urine sediment <br></br>showed 6-10 RBCs/field. Proteinuria in a 24-hour sample was 3 g/day. A renal pathology study confirmed the <br></br>existence of IgA nephropathy. As the patient had a prolonged cephalin time, a hypercoagulability study was performed, showing a positive result for IgM anticardiolipin antibodies, 50.7 MPL/mL (N < 11). <br></br><br></br>CASE 2 <br></br><br></br>A 29-year-old female patient with personal and clinical history similar to her sister (case 1). Physical examination <br></br>was normal. Results of laboratory blood tests included: Creatinine 1 mg/dL. Normal complete blood count. Coagulation: Prothrombin activity 84%, APTT 39.5 sec. Negative LA and anticardiolipin antibodies. Immunological <br></br>tests showed the following values: IgG 1470 mg/dL, IgA 388 mg/dL, IgM 417 mg/dL, C3 100 mg/dL, C4 28.6 mg/dL. ASLO, ANA, and anti-DNA antibodies were negative. Urine sediment showed more than 40 RBCs/field. No protein <br></br>was found in a 24-hour urine sample. Renal biopsy confirmed the existence of nephropathy with IgA mesangial <br></br>deposits. <br></br><br></br>DISCUSSION <br></br><br></br>IgA nephropathy is characterized by IgA mesangial deposits associated to a proliferative mesangial glomerulonephritis. Its pathogenesis is not fully known, but there is increasing evidence of the formation of immune complexes containing IgA that would be deposited in mesangium and would induce glomerular damage.2 <br></br><br></br>The primary antiphospholipid syndrome (PAPS) is characterized by recurrent thrombosis, multiorgan damage, and abortion, as well as the presence of LA and/or anticardiolipin antibodies. <br></br><br></br>LAs are antibodies directed against plasma proteins such as b2-glycoprotein I, prothrombin, or annexin V.3,4 In <br></br>case 1, a basic coagulation study detected a prolonged cephalin time, and a subsequent hypercoagulability study <br></br>was positive for LA anticardiolipin antibodies, but there were no associated clinical signs consistent with PAPS. <br></br><br></br>Association of LA and anticardiolipin antibodies with various autoimmune and rheumatic diseases (SLE, scleroderma, psoriatic arthritis¿) has been reported in the literature,5 but there are no reports of an association with IgA nephropathy, except in cases having, in addition to LA, the clinical signs of PAPS.6 It is also possible that this patient initially had or may have subsequently developed a Schönlein-Henoch glomerulonephritis or a lupus nephropathy. <br></br><br></br>These are both conditions with mesangial IgA deposits that pathologists are sometimes unable to differentiate from pure mesangial glomerulonephritis. In the reported cases, the finding of LA alone, without other signs of PAPS, in only one of the sisters (with the same nephropathy and the same clinical sign of hematuria following upper respiratory tract infections) raises the question whether this association was incidental or its occurrence was related to a common immune pathogenetic mechanism. " "pdfFichero" => "P-E-S-A400-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La nefropatía Ig A es la glomerulonefritis primaria crónica más frecuente, que conduce a la insuficiencia renal progresiva en al menos un tercio de los pacientes 1. En la literatura no hemos encontrado ninguna asociación de esta enfermedad con el anticoagulante lupico (AL). Describimos una nefropatía Ig A en dos hermanas, detectando en una de ellas la presencia de AL. " ] "en" => array:1 [ "resumen" => "To the editor: IgA nephropathy is the most common chronic primary glomerulonephritis, leading to progressive renal failure in at least one third of patients.1 No association of this disease with the lupus anticoagulant (LA) has been found in the literature. The occurrence of IgA nephropathy in two sisters, one of whom had LA, is reported." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Galla JH. Ig A nephropathy. Kidney Int 47 (2): 377-387, 1995. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7723227" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sinniah R, Gan HC, Yoon KH. Primary antiphospholipid antibody syndrome and mesangial Ig A glomerulonephritis. Am J Nephrol 21 (2): 134-140, 2001. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11359021" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002800000004/v0_201502091636/X2013251408005556/v0_201502091636/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000004/v0_201502091636/X2013251408005556/v0_201502091636/en/P-E-S-A400-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408005556?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 9 | 12 | 21 |
2024 October | 48 | 46 | 94 |
2024 September | 46 | 31 | 77 |
2024 August | 56 | 60 | 116 |
2024 July | 46 | 38 | 84 |
2024 June | 57 | 36 | 93 |
2024 May | 67 | 25 | 92 |
2024 April | 45 | 40 | 85 |
2024 March | 38 | 26 | 64 |
2024 February | 51 | 33 | 84 |
2024 January | 30 | 29 | 59 |
2023 December | 33 | 24 | 57 |
2023 November | 44 | 29 | 73 |
2023 October | 48 | 29 | 77 |
2023 September | 48 | 22 | 70 |
2023 August | 38 | 23 | 61 |
2023 July | 61 | 21 | 82 |
2023 June | 28 | 25 | 53 |
2023 May | 30 | 25 | 55 |
2023 April | 36 | 16 | 52 |
2023 March | 34 | 23 | 57 |
2023 February | 25 | 30 | 55 |
2023 January | 25 | 23 | 48 |
2022 December | 43 | 27 | 70 |
2022 November | 36 | 25 | 61 |
2022 October | 39 | 23 | 62 |
2022 September | 31 | 28 | 59 |
2022 August | 46 | 36 | 82 |
2022 July | 32 | 43 | 75 |
2022 June | 20 | 32 | 52 |
2022 May | 30 | 29 | 59 |
2022 April | 40 | 28 | 68 |
2022 March | 31 | 35 | 66 |
2022 February | 32 | 42 | 74 |
2022 January | 35 | 31 | 66 |
2021 December | 29 | 42 | 71 |
2021 November | 29 | 31 | 60 |
2021 October | 38 | 40 | 78 |
2021 September | 60 | 32 | 92 |
2021 August | 40 | 54 | 94 |
2021 July | 38 | 42 | 80 |
2021 June | 27 | 17 | 44 |
2021 May | 38 | 27 | 65 |
2021 April | 50 | 35 | 85 |
2021 March | 54 | 27 | 81 |
2021 February | 49 | 17 | 66 |
2021 January | 32 | 20 | 52 |
2020 December | 26 | 17 | 43 |
2020 November | 46 | 20 | 66 |
2020 October | 40 | 18 | 58 |
2020 September | 30 | 4 | 34 |
2020 August | 42 | 11 | 53 |
2020 July | 22 | 9 | 31 |
2020 June | 28 | 9 | 37 |
2020 May | 35 | 8 | 43 |
2020 April | 26 | 13 | 39 |
2020 March | 38 | 11 | 49 |
2020 February | 30 | 20 | 50 |
2020 January | 33 | 12 | 45 |
2019 December | 42 | 18 | 60 |
2019 November | 47 | 15 | 62 |
2019 October | 24 | 14 | 38 |
2019 September | 29 | 16 | 45 |
2019 August | 13 | 16 | 29 |
2019 July | 14 | 20 | 34 |
2019 June | 28 | 8 | 36 |
2019 May | 31 | 6 | 37 |
2019 April | 70 | 25 | 95 |
2019 March | 31 | 23 | 54 |
2019 February | 27 | 15 | 42 |
2019 January | 20 | 7 | 27 |
2018 December | 69 | 26 | 95 |
2018 November | 81 | 17 | 98 |
2018 October | 65 | 14 | 79 |
2018 September | 55 | 14 | 69 |
2018 August | 42 | 7 | 49 |
2018 July | 41 | 11 | 52 |
2018 June | 37 | 10 | 47 |
2018 May | 35 | 14 | 49 |
2018 April | 44 | 9 | 53 |
2018 March | 36 | 9 | 45 |
2018 February | 38 | 12 | 50 |
2018 January | 40 | 10 | 50 |
2017 December | 51 | 9 | 60 |
2017 November | 25 | 7 | 32 |
2017 October | 36 | 3 | 39 |
2017 September | 21 | 13 | 34 |
2017 August | 28 | 6 | 34 |
2017 July | 25 | 9 | 34 |
2017 June | 31 | 5 | 36 |
2017 May | 39 | 6 | 45 |
2017 April | 33 | 6 | 39 |
2017 March | 24 | 4 | 28 |
2017 February | 28 | 2 | 30 |
2017 January | 25 | 5 | 30 |
2016 December | 44 | 4 | 48 |
2016 November | 29 | 2 | 31 |
2016 October | 73 | 17 | 90 |
2016 September | 66 | 1 | 67 |
2016 August | 106 | 5 | 111 |
2016 July | 115 | 9 | 124 |
2016 June | 96 | 0 | 96 |
2016 May | 117 | 0 | 117 |
2016 April | 79 | 0 | 79 |
2016 March | 58 | 0 | 58 |
2016 February | 77 | 0 | 77 |
2016 January | 73 | 0 | 73 |
2015 December | 76 | 0 | 76 |
2015 November | 58 | 0 | 58 |
2015 October | 70 | 0 | 70 |
2015 September | 56 | 0 | 56 |
2015 August | 59 | 0 | 59 |
2015 July | 65 | 0 | 65 |
2015 June | 38 | 0 | 38 |
2015 May | 42 | 0 | 42 |
2015 April | 5 | 0 | 5 |