Large kidney due to levofloxacin
Nefromegalia por levofloxacino
Read
6662
Timeswas read the article
2096
Total PDF
4566
Total HTML
Share statistics
array:21 [ "pii" => "X2013251408004335" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-12-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:662-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3106 "formatos" => array:3 [ "EPUB" => 253 "HTML" => 2354 "PDF" => 499 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699508004338" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-12-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2008;28:662-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 18613 "formatos" => array:3 [ "EPUB" => 282 "HTML" => 17497 "PDF" => 834 ] ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Nefromegalia por levofloxacino" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "662" "paginaFinal" => "663" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Large kidney due to levofloxacin" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jesus Javier Castellanos Monedero, Jose Luis Rodriguez Garcia, Minerba Arambarri Segura, Agustin Carreño Parrilla, Julia Blanco" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Jesus Javier" "apellidos" => "Castellanos Monedero" ] 1 => array:2 [ "nombre" => "Jose Luis" "apellidos" => "Rodriguez Garcia" ] 2 => array:2 [ "nombre" => "Minerba" "apellidos" => "Arambarri Segura" ] 3 => array:2 [ "nombre" => "Agustin" "apellidos" => "Carreño Parrilla" ] 4 => array:2 [ "nombre" => "Julia" "apellidos" => "Blanco" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251408004335" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004335?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004338?idApp=UINPBA000064" "url" => "/02116995/0000002800000006/v0_201502091415/X0211699508004338/v0_201502091415/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251408004327" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-12-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:663-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3055 "formatos" => array:3 [ "EPUB" => 249 "HTML" => 2299 "PDF" => 507 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Emphysematous pyelonephritis in peritoneal dialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "663" "paginaFinal" => "664" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pielonefritis enfisematosa en diálisis peritoneal" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Paz Borrajo Prol, Cristina Perez Melón, Juan Santos Nores, Maria Camba Caride" "autores" => array:4 [ 0 => array:2 [ "nombre" => "María Paz" "apellidos" => "Borrajo Prol" ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "Perez Melón" ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Santos Nores" ] 3 => array:2 [ "nombre" => "Maria" "apellidos" => "Camba Caride" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X021169950800432X" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800432X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004327?idApp=UINPBA000064" "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004327/v0_201502091634/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251408004343" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-12-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:661-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2706 "formatos" => array:3 [ "EPUB" => 230 "HTML" => 2074 "PDF" => 402 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Improvement of intradialytic arrhytmias after combined conductivity and ultrafiltration profiling without secondary overhydration" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "661" "paginaFinal" => "662" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mejoría de arritmias intradilíticas tras aplicación de perfiles combinados de conductividad y ultrafiltración sin expansión de volumen secundaria" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alvaro Molina Ordás, Rosa Sánchez Hernández, María José Fernández- Reyes Luis, Manuel Heras Benito" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alvaro" "apellidos" => "Molina Ordás" ] 1 => array:2 [ "nombre" => "Rosa" "apellidos" => "Sánchez Hernández" ] 2 => array:2 [ "nombre" => "María José" "apellidos" => "Fernández- Reyes Luis" ] 3 => array:2 [ "nombre" => "Manuel" "apellidos" => "Heras Benito" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508004346" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004346?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004343?idApp=UINPBA000064" "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004343/v0_201502091634/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Large kidney due to levofloxacin" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "662" "paginaFinal" => "663" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Jesus Javier Castellanos Monedero, Jose Luis Rodriguez Garcia, Minerba Arambarri Segura, Agustin Carreño Parrilla, Julia Blanco" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Jesus Javier" "apellidos" => "Castellanos Monedero" "email" => array:1 [ 0 => "castellanosvela@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Jose Luis" "apellidos" => "Rodriguez Garcia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Minerba" "apellidos" => "Arambarri Segura" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 3 => array:3 [ "nombre" => "Agustin" "apellidos" => "Carreño Parrilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 4 => array:3 [ "nombre" => "Julia" "apellidos" => "Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad-Real, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital General de Ciudad-Real, Ciudad-Real, Ciudad-Real, España, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario San Carlos, Madrid, Madrid, España, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nefromegalia por levofloxacino" ] ] "textoCompleto" => "To the editor: Tubulointerstitial nephritis was first described by Councilman1 in 1898. It is an infrequent clinical-pathological entity with an estimated incidence of 8-14% among patients subjected to biopsy for acute renal failure of indeterminate origin.2 The triggering factors of this disease comprise neoplasms, drugs and infections. We present the case of a patient who manifested with acute tubulointerstitial nephritis and a large kidney (nephromegaly) secondary to levofloxacin. <br></br><br></br>CLINICAL CASE <br></br><br></br>The clinical case corresponds to a 67-year-old male. His personal history included allergy to nicotinamide, ischemic <br></br>heart disease (requiring three coronary stents, with follow-up comprising 6 catheterizations ¿ the last performed one year before admission) and dilated myocardiopathy secondary to the latter. His usual treatment consisted <br></br>of pantoprazole 40 mg/24 h, carvedilol 25 mg/12 h, aspirin 100 mg/24 h, amlodipine 5 mg/24 h, isosorbide <br></br>dinitrate 20 mg/8 h, and simvastatin 20 mg/24 h. <br></br><br></br>The patient reported to the Emergency Service with right-flank abdominal pain irradiating to the hypogastrium, <br></br>and accompanied by vomiting and fever. Physical examination revealed positive right-side fist-percussion as <br></br>sole significant finding. The emergency complementary tests showed creatinine 4 mg/dl, leukocytosis (16,000/μl) and urine sediment with leukocyturia. The chest and abdominal X-rays showed no anomalies. The study was completed with abdominal ultrasound, which revealed an enlarged right (15 cm) (fig. 1) and left kidney (14.5 cm) ¿ the latter organ also showing two cortical cysts. Based on the above data, admission to the Nephrology ward was decided, and a more complete evaluation with laboratory tests was made ¿ the immune and tumor marker parameters proving negative. The blood and urine cultures were also negative. Fluid therapy and broad-spectrum antibiotic treatment was prescribed, resulting in clinical and analytical improvement (creatinine 1.6 mg/dl); hospital discharge was thus decided. The patient was posteriorly readmitted with this same clinical presentation on two further occasions, with the clinical diagnosis of acute pyelonephritis refractory to medical treatment. During the admissions, the study was completed with blood cultures, urine cultures, and gallium gammagraphy. In view of the persistence of the bilateral nephromegaly, the possibility of amyloidosis was discarded by a rectal and abdominal adipose tissue biopsy, which proved negative. Tuberculosis was likewise ruled out by negative Mantoux tests and specific cultures. A bone marrow aspirate to evaluate possible myeloma was also negative. Thus, due to the suspicion of disease circumscribed to the kidneys, a renal biopsy was performed, revealing a diffuse interstitial inflammatory infiltrate composed of T lymphocytes, numerous plasma cells and few β lymphocytes. These findings were compatible with acute tubulointerstitial nephritis, as a result of which treatment with prednisone was started. <br></br><br></br>DISCUSSION <br></br><br></br>The quinolones are broad spectrum antibiotics that are easy to use and which possess absorption and bioavailability <br></br>characteristics that make them one of the most widely used antibiotic groups. In this group it has been shown that ciprofloxacin3 is able to cause acute tubulointerstitial nephritis, and there are also isolated reports implicating the rest of the drugs belonging to this same group. Levofloxacin is a third-generation quinolone with a broad spectrum <br></br>of action and with the same side effects as the rest of the quinolones. Its association to acute tubulointerstitial nephritis is very infrequent; a Medline search spanning the period between 1998 and March 2008 revealed only four <br></br>cases of renal failure induced by levofloxacin4- 7, and none of them were accompanied by nephromegaly. <br></br><br></br>Our case represented a diagnostic challenge due to the suspicion of acute pyelonephritis during the entire clinical <br></br>course. Only in the light of the torpid evolution of events did we attempt to rule out other possible etiologies characterized by large kidney, renal failure and fever. Thus, having discarded hereditary causes of nephromegaly, we evaluated non-hereditary disorders such as amyloidosis, Gaucher¿s disease, mycoses, tuberculosis, AIDS, renal oncocytomatosis, angiofollicular ganglionic hyperplasia, myeloma, primary renal lymphoma, secondary renal lymphoma and acute leukemia.8 After ruling out some of these etiologies from the start, we examined the more plausible possibilities such as lymphoma, leukemia, myeloma, tuberculosis and amyloidosis. Since positive results were not obtained, a renal biopsy was decided, which revealed the above mentioned alterations. After corticoid <br></br>therapy with initial doses of 60 mg/kg of prednisone followed by slow withdrawal, kidney function was seen to normalize, with a reduction in kidney size (right 12.6 cm and left 13 cm), on occasion of the last ultrasound control (fig. 1). <br></br>" "pdfFichero" => "P-E-S-A347-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "Sr Editor: La nefritis tubulointerticial fue descrita por Councilman1 en 1898. Es una entidad clínico-patológica poco frecuente , se estima una incidencia de 8-14%, en los pacientes biopsiados por Insuficiencia Renal Aguda de causa no aclarada2. Las causas desencadenantes de esta enfermedad son las neoplasias, los fármacos y las infecciones. Presentamos el caso clínico de un paciente que debutó con nefritis tubulointerticial aguda y nefromegalia, secundario a levofloxacino. " ] "en" => array:1 [ "resumen" => "To the editor: Tubulointerstitial nephritis was first described by Councilman1 in 1898. It is an infrequent clinical-pathological entity with an estimated incidence of 8-14% among patients subjected to biopsy for acute renal failure of indeterminate origin.2 The triggering factors of this disease comprise neoplasms, drugs and infections. We present the case of a patient who manifested with acute tubulointerstitial nephritis and a large kidney (nephromegaly) secondary to levofloxacin. " ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004335/v0_201502091634/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000006/v0_201502091634/X2013251408004335/v0_201502091634/en/P-E-S-A347-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004335?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 11 | 16 |
| 2024 October | 40 | 28 | 68 |
| 2024 September | 47 | 27 | 74 |
| 2024 August | 54 | 52 | 106 |
| 2024 July | 45 | 33 | 78 |
| 2024 June | 57 | 46 | 103 |
| 2024 May | 40 | 38 | 78 |
| 2024 April | 46 | 27 | 73 |
| 2024 March | 26 | 25 | 51 |
| 2024 February | 29 | 38 | 67 |
| 2024 January | 30 | 20 | 50 |
| 2023 December | 23 | 27 | 50 |
| 2023 November | 52 | 29 | 81 |
| 2023 October | 57 | 33 | 90 |
| 2023 September | 67 | 33 | 100 |
| 2023 August | 44 | 34 | 78 |
| 2023 July | 32 | 30 | 62 |
| 2023 June | 30 | 20 | 50 |
| 2023 May | 71 | 33 | 104 |
| 2023 April | 64 | 24 | 88 |
| 2023 March | 52 | 25 | 77 |
| 2023 February | 61 | 27 | 88 |
| 2023 January | 92 | 53 | 145 |
| 2022 December | 43 | 36 | 79 |
| 2022 November | 23 | 25 | 48 |
| 2022 October | 28 | 31 | 59 |
| 2022 September | 37 | 34 | 71 |
| 2022 August | 32 | 40 | 72 |
| 2022 July | 21 | 37 | 58 |
| 2022 June | 35 | 31 | 66 |
| 2022 May | 36 | 29 | 65 |
| 2022 April | 31 | 38 | 69 |
| 2022 March | 35 | 33 | 68 |
| 2022 February | 36 | 29 | 65 |
| 2022 January | 31 | 30 | 61 |
| 2021 December | 35 | 42 | 77 |
| 2021 November | 24 | 35 | 59 |
| 2021 October | 41 | 39 | 80 |
| 2021 September | 39 | 35 | 74 |
| 2021 August | 27 | 24 | 51 |
| 2021 July | 43 | 35 | 78 |
| 2021 June | 26 | 21 | 47 |
| 2021 May | 30 | 29 | 59 |
| 2021 April | 41 | 39 | 80 |
| 2021 March | 37 | 25 | 62 |
| 2021 February | 54 | 20 | 74 |
| 2021 January | 32 | 17 | 49 |
| 2020 December | 22 | 8 | 30 |
| 2020 November | 35 | 12 | 47 |
| 2020 October | 41 | 23 | 64 |
| 2020 September | 30 | 8 | 38 |
| 2020 August | 31 | 13 | 44 |
| 2020 July | 26 | 5 | 31 |
| 2020 June | 21 | 19 | 40 |
| 2020 May | 39 | 12 | 51 |
| 2020 April | 43 | 11 | 54 |
| 2020 March | 28 | 13 | 41 |
| 2020 February | 33 | 17 | 50 |
| 2020 January | 31 | 22 | 53 |
| 2019 December | 41 | 20 | 61 |
| 2019 November | 37 | 17 | 54 |
| 2019 October | 16 | 10 | 26 |
| 2019 September | 36 | 18 | 54 |
| 2019 August | 20 | 7 | 27 |
| 2019 July | 25 | 17 | 42 |
| 2019 June | 23 | 12 | 35 |
| 2019 May | 25 | 4 | 29 |
| 2019 April | 49 | 27 | 76 |
| 2019 March | 15 | 17 | 32 |
| 2019 February | 12 | 20 | 32 |
| 2019 January | 15 | 17 | 32 |
| 2018 December | 55 | 33 | 88 |
| 2018 November | 88 | 14 | 102 |
| 2018 October | 68 | 10 | 78 |
| 2018 September | 39 | 10 | 49 |
| 2018 August | 26 | 11 | 37 |
| 2018 July | 27 | 12 | 39 |
| 2018 June | 33 | 10 | 43 |
| 2018 May | 31 | 13 | 44 |
| 2018 April | 36 | 2 | 38 |
| 2018 March | 21 | 6 | 27 |
| 2018 February | 36 | 8 | 44 |
| 2018 January | 20 | 4 | 24 |
| 2017 December | 38 | 14 | 52 |
| 2017 November | 22 | 8 | 30 |
| 2017 October | 22 | 5 | 27 |
| 2017 September | 36 | 9 | 45 |
| 2017 August | 28 | 2 | 30 |
| 2017 July | 42 | 15 | 57 |
| 2017 June | 21 | 4 | 25 |
| 2017 May | 27 | 9 | 36 |
| 2017 April | 28 | 6 | 34 |
| 2017 March | 15 | 11 | 26 |
| 2017 February | 14 | 7 | 21 |
| 2017 January | 15 | 7 | 22 |
| 2016 December | 29 | 4 | 33 |
| 2016 November | 23 | 8 | 31 |
| 2016 October | 27 | 18 | 45 |
| 2016 September | 62 | 8 | 70 |
| 2016 August | 92 | 4 | 96 |
| 2016 July | 87 | 8 | 95 |
| 2016 June | 70 | 0 | 70 |
| 2016 May | 90 | 0 | 90 |
| 2016 April | 57 | 0 | 57 |
| 2016 March | 74 | 0 | 74 |
| 2016 February | 75 | 0 | 75 |
| 2016 January | 78 | 0 | 78 |
| 2015 December | 76 | 0 | 76 |
| 2015 November | 70 | 0 | 70 |
| 2015 October | 54 | 0 | 54 |
| 2015 September | 44 | 0 | 44 |
| 2015 August | 68 | 0 | 68 |
| 2015 July | 35 | 0 | 35 |
| 2015 June | 37 | 0 | 37 |
| 2015 May | 49 | 0 | 49 |
| 2015 April | 6 | 0 | 6 |
Show all
