array:21 [
  "pii" => "X2013251408004237"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2008-12-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2008;28:627-32"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4356
    "formatos" => array:3 [
      "EPUB" => 254
      "HTML" => 3329
      "PDF" => 773
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X021169950800423X"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2008-12-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2008;28:627-32"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 12931
        "formatos" => array:3 [
          "EPUB" => 262
          "HTML" => 11745
          "PDF" => 924
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "titulo" => "Evolución de la nefropatía de Schönlein-Henoch en pacientes pediátricos. Factores pronósticos"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "627"
            "paginaFinal" => "632"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Outcome of Henoch-Schönlein nephropathy in pediatric patients. Prognostic factors"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jesús Lucas García, Olalla Álvarez Blanco, Maria Jose Sanahuja Ibáñez, Pedro Jose Ortega López, Isabel Zamora Martín"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Jesús"
                "apellidos" => "Lucas García"
              ]
              1 => array:2 [
                "nombre" => "Olalla"
                "apellidos" => "Álvarez Blanco"
              ]
              2 => array:2 [
                "nombre" => "Maria Jose"
                "apellidos" => "Sanahuja Ibáñez"
              ]
              3 => array:2 [
                "nombre" => "Pedro Jose"
                "apellidos" => "Ortega López"
              ]
              4 => array:2 [
                "nombre" => "Isabel"
                "apellidos" => "Zamora Martín"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251408004237"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004237?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800423X?idApp=UINPBA000064"
      "url" => "/02116995/0000002800000006/v0_201502091415/X021169950800423X/v0_201502091415/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251408004229"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:633-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4016
      "formatos" => array:3 [
        "EPUB" => 243
        "HTML" => 3240
        "PDF" => 533
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "How much should dialysis time be increased when catheters are used?"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "633"
          "paginaFinal" => "636"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "¿Cuánto tiempo es necesario aumentar la prescripción de hemodiálisis con la utilización de catéteres?"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Maduell, Manel Vera, Marta Arias, Néstor Fontseré, Miquel Blasco, Nuria Serra, Eduardo Bergadá, Aleix Cases, Josep M. Campistol"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            1 => array:2 [
              "nombre" => "Manel"
              "apellidos" => "Vera"
            ]
            2 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Arias"
            ]
            3 => array:2 [
              "nombre" => "Néstor"
              "apellidos" => "Fontseré"
            ]
            4 => array:2 [
              "nombre" => "Miquel"
              "apellidos" => "Blasco"
            ]
            5 => array:2 [
              "nombre" => "Nuria"
              "apellidos" => "Serra"
            ]
            6 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Bergadá"
            ]
            7 => array:2 [
              "nombre" => "Aleix"
              "apellidos" => "Cases"
            ]
            8 => array:2 [
              "nombre" => "Josep M."
              "apellidos" => "Campistol"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004221"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004221?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004229?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004229/v0_201502091634/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251408004245"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2008;28:621-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3442
      "formatos" => array:3 [
        "EPUB" => 223
        "HTML" => 2817
        "PDF" => 402
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Underestimation of renal risk in cardiology clinics. RICAR study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "621"
          "paginaFinal" => "626"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Infravaloración del riesgo renal en consultas de cardiología. Estudio RICAR"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V. Bertomeu Martínez, V. Bertomeu-González, J. Quiles, P. Morillas, J. R. González-Juanatey, L. Fácila, P. Mazón, C. Filozof"
          "autores" => array:8 [
            0 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Bertomeu Martínez"
            ]
            1 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Bertomeu-González"
            ]
            2 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Quiles"
            ]
            3 => array:2 [
              "Iniciales" => "P."
              "apellidos" => "Morillas"
            ]
            4 => array:2 [
              "Iniciales" => "J. R."
              "apellidos" => "González-Juanatey"
            ]
            5 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "Fácila"
            ]
            6 => array:2 [
              "Iniciales" => "P."
              "apellidos" => "Mazón"
            ]
            7 => array:2 [
              "Iniciales" => "C."
              "apellidos" => "Filozof"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004248"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004248?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004245?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004245/v0_201502091634/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Outcome of Henoch-Schönlein nephropathy in pediatric patients. Prognostic factors"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "627"
        "paginaFinal" => "632"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jesús Lucas García, Olalla Álvarez Blanco, Maria Jose Sanahuja Ibáñez, Pedro Jose Ortega López, Isabel Zamora Martín"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Jesús"
            "apellidos" => "Lucas García"
            "email" => array:1 [
              0 => "jelugar@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Olalla"
            "apellidos" => "&#193;lvarez Blanco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Maria Jose"
            "apellidos" => "Sanahuja Ib&#225;&#241;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Pedro Jose"
            "apellidos" => "Ortega L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Isabel"
            "apellidos" => "Zamora Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Unidad de Nefrología Pediátrica, H.U. La Fe, Valencia Valencia España, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Evoluci&#243;n de la nefropat&#237;a de Sch&#246;nlein-Henoch en pacientes pedi&#225;tricos&#46; Factores pron&#243;sticos"
      ]
    ]
    "textoCompleto" => "INTRODUCTION <br></br><br></br>Henoch-Sch&#246;nlein purpura is the most common leukocytoclastic vasculitis in children&#44; and is characterized by deposition of IgA immunoglobulins and IgA-containing immune complexes in the small blood vessels of different <br></br>tissues&#44; causing the symptoms typical of the disease&#46; The etiology and pathogenesis of this disease are currently <br></br>unknown&#46; Disease incidence is approximately 14&#47;100&#46;000 inhabitants&#47;year&#44;1&#44;2 and 75&#37; of cases occur in children aged 2 to 11 years&#46;2 <br></br><br></br>The most significant clinical findings include non-thrombocytopenic palpable purpura&#44; periarticular edema and swelling&#44; colic abdominal pain and gastrointestinal bleeding&#44; and nephritis&#46; The disease is usually preceded by a non-specific respiratory tract infection&#46; <br></br><br></br>Renal signs determine long-term prognosis&#44; and their prevalence ranges from 20&#37; and 60&#37; according to the different reports&#46;3 <br></br><br></br>The most common clinical sign of Henoch-Sch&#246;nlein nephropathy &#40;HSN&#41; is isolated microscopic hematuria&#44; often <br></br>associated to proteinuria&#46; <br></br><br></br>The presence of renal failure&#44; arterial hypertension&#44; nephrotic proteinuria&#44; and histological findings at the renal biopsy &#40;proportion of glomeruli with crescents&#41; has traditionally represented a poor prognostic factor&#46;4 <br></br><br></br>The proportion of patients who develop chronic end-stage renal disease &#40;ESRD&#41; differs depending on patient selection in the different reports&#46; ESRD eventually occurs in 1&#46;6&#37; of patients who only have isolated hematuria or proteinuria&#44; but in 19&#46;5&#37; of those with a nephrotic or nephritic syndrome&#46;2 <br></br><br></br>OBJECTIVE <br></br><br></br>Objectives of this study included&#58; to analyze the epidemiological&#44; clinical&#44; and laboratory data from patients diagnosed of Henoch-Sch&#246;nlein nephropathy in a third-level hospital&#59; &#40;2&#41; to determine the short- &#40;2 years&#41; and long-term &#40;5 years&#41; prognostic factors&#59; and &#40;3&#41; to estimate the renal survival curve&#46; <br></br><br></br>MATERIALS AND METHODS <br></br><br></br>Design <br></br>A retrospective&#44; analytical&#44; cohort clinical study&#46; <br></br><br></br>Patients <br></br>A review was made of the clinical histories of 100 patients diagnosed of Henoch-Sch&#246;nlein nephropathy and monitored by the pediatric nephrology unit of Hospital Universitario La Fe in Valencia from January 1&#44; 1975 to December 31&#44; 2006&#46; Age at disease onset ranged from 1 and 18 years&#46; Patients were diagnosed at our hospital or referred from other centers after diagnosis&#46; <br></br><br></br>Mean follow-up time was 5&#46;25 &#177; 0&#46;76 years &#40;range&#44; 0&#46;2-16&#46;4 years&#41;&#46; Ninety-three and 81 patients completed two and five years of follow-up respectively&#46; <br></br><br></br>Methods <br></br>Clinical and laboratory controls were conducted at least six months after HSN and every year in low risk cases&#44; where as in high risk patients control periodicity was individualized based on the severity of the condition&#46; <br></br><br></br>Clinical data collected at purpura diagnosis included presence or absence of a history of respiratory tract infection&#44; <br></br>spectrum of clinical signs&#44; and personal and family history of kidney disease&#46; Laboratory tests included plasma levels of immunoglobulins &#40;IgA&#41; and complement fractions C3 and C4&#46; At HSN diagnosis&#44; the following renal signs were recorded&#58; gross or microscopic hematuria&#44; proteinuria and its quantification&#44; plasma creatinine levels and glomerular filtration rate&#44; and blood pressure &#40;BP&#41;&#46; These data were collected at each of the follow-up visits&#46; <br></br><br></br>The number of purpura relapses was also recorded in each patient&#46; <br></br><br></br>Definition <br></br>Diagnostic criteria of Henoch-Sch&#246;nlein nephropathy meet the 1990 criteria of the American Collage of Rheumatologists &#40;ACR&#41;&#46; <br></br><br></br>Diagnostic criteria for HSN included the presence at any time during its course of any change in urinary sediment&#44; <br></br>either hematuria or proteinuria&#44; a nephrotic or nephritic syndrome&#44; as well as a decreased glomerular filtration rate&#44; <br></br>or arterial hypertension based on the percentile for height&#44; age&#44; and sex according to the reference parameters of the Task Force&#46;&#40;5&#41; <br></br><br></br>At the onset of nephropathy&#44; patients were classified in the different clinical stages using the clinical classification of <br></br>Meadow et al&#44; as modified by Counahan et al in 1997&#44; shown below&#58; <br></br><br></br>A&#58; Normal&#46; Normal physical examination&#44; BP&#44; urine analysis&#44; and glomerular filtration rate&#46; <br></br>B&#58; Minor urinary abnormalities&#46; Micro&#47;macrohematuria&#46; Non-nephrotic proteinuria&#46; <br></br>C&#58; Active kidney disease&#46; Glomerular filtration rate &#8805; 60 mL&#47;min&#47;1&#46;73 m2 or creatinine increase &#60; 25&#37; of the upper limit for age and sex&#46; Associated to nephrotic proteinuria &#40;&#8805; 40 mg&#47;m2&#47;h&#41; or AHT&#46; <br></br>D&#58; Renal failure&#46; Glomerular filtration rate &#60; 60 mL&#47;min&#47;1&#46;73 m2 or creatinine increase &#62; 25&#37; of the upper limit for age and sex&#46; Includes ESRD&#46; <br></br><br></br>Clinical stages are in turn subdivided into two categories designed as low risk &#40;Stage A and B&#41; and high risk &#40;Stage C and D&#41;&#46; <br></br><br></br>These stages were determined at diagnosis and in the short- &#40;2 years&#41; and long-term &#40;5 years&#41;&#46; <br></br><br></br>Indications for renal biopsy were&#44; in agreement with the unit protocol&#58; <br></br><br></br>a&#41; Acute nephritic syndrome&#58; hematuria&#44; hypertension&#44; oliguria&#44; and renal failure&#46; <br></br>a&#41; Established nephrotic syndrome &#40;time period longer than 15 days&#41;&#58; proteinuria in the nephrotic range and hypoalbuminemia&#46; <br></br>c&#41; Persistent proteinuria&#58; proteinuria in the nephrotic range &#40;&#62; 40 mg&#47;m2&#47;day&#41; for more than 1 month&#44; moderate proteinuria &#40;20-40 mg&#47;m2&#47;day&#41; for more than 3 months or significant proteinuria &#40;&#62; 4 mg&#47;m2&#47;day&#41; for more than 6 <br></br>months&#46; <br></br><br></br>The histological classification used was the one based on the International Study of Kidney Disease in Children <br></br>&#40;ISKDC&#41;&#58; <br></br><br></br>I&#58; Minimal glomerular lesions&#46; <br></br>II&#58; Pure mesangial proliferation&#46; <br></br>III&#58; Minimal glomerular lesions or mesangial proliferation with crescents&#47;segmental lesions in &#60; 50&#37; glomeruli&#46; <br></br>IV&#58; Stage III with crescents&#47;segmental lesions in 50&#37;-75&#37; glomeruli&#46; <br></br>V&#58; Stage III with crescents&#47;segmental lesions in &#62; 75&#37; glomeruli&#46; <br></br>VI&#58; Membranoproliferative or pseudomesangiocapillary lesions&#46; <br></br>Treatment indications and their results are not the purpose of this study&#46; <br></br><br></br>Statistics <br></br>Short- and long-term prognostic factors were established by a non-parametric univariate analysis using the gamma and Somers&#191; D test&#46; In this first analysis&#44; explanatory variables were age at onset of kidney disease&#44; sex&#44; number of purpura episodes&#44; hematuria&#44; proteinuria&#44; BP&#44; glomerular filtration rate&#44; and initial stage&#44; and the variable to be explained was the shortand long-term clinical stage&#46; <br></br><br></br>These same variables were subsequently evaluated using a multivariate hierarchical loglinear and logit analysis&#46; In this case&#44; the variable to be explained was the short- and longterm clinical stage&#44; that was grouped into two subsets&#44; lowrisk stages &#40;Stages A and B&#41; and high-risk stages &#40;Stages C and D&#41;&#46; <br></br><br></br>SPSS for Windows version 12&#46;00 software was used for statistical analysis&#46; A value of p &#60; 0&#46;05 was considered statistically significant&#46; <br></br><br></br>RESULTS <br></br><br></br>Epidemiological data <br></br>One hundred pediatric patients were studied between 1975 and 2006&#44; 53&#37; males and 47&#37; females &#40;1&#46;1&#58;1&#41;&#46; Mean age at purpura onset was 6&#46;95 &#177; 0&#46;58 years&#46; Mean age at HSN was 7&#46;14 &#177; 0&#46;57 years&#46; The interval between occurrence of purpura and nephropathy was 0&#46;22 years&#44; ranging from 0 and 6&#46;84 years&#46; Patients were divided into two groups based on the number of purpura relapses&#58; patients with more than 4 relapses &#40;30&#37;&#41; and patients with less than 4 relapses &#40;67&#37;&#41;&#46; <br></br><br></br>Clinical data <br></br>Virtually all study patients had the characteristic skin lesions at diagnosis of Henoch-Sch&#246;nlein purpura&#46; Fifty-seven percent of patients reported gastrointestinal symptoms and 40&#37; joint symptoms&#44; and HSN occurred at the onset of purpura in 67&#37; of patients&#46; Mention should be made of a case of HSN occurring 6&#46;84 years after diagnosis of purpura&#46; <br></br><br></br>Table I shows the renal signs at HSN diagnosis&#46; The most common renal sign was hematuria&#44; that was microscopic <br></br>in 57&#37; and gross in 35&#37; of patients&#46; Only 7 patients had no hematuria&#46; Proteinuria was found in 73&#37; of patients&#44; <br></br>and was associated to hematuria in most of them &#40;67&#37;&#41;&#46; Nephrotic proteinuria occurred in 27&#37; of patients&#44; with a mean value of 97&#46;49 mg&#47;m2&#47;h &#40;95&#37; CI&#44; 45&#46;30- 149&#46;69&#41;&#44; while non-nephrotic proteinuria was found in 46&#37; of patients&#44; with a mean value of 20 mg &#47;m2&#47;h &#40;95&#37; CI&#44; 15&#46;18-24&#46;81&#41;&#46; Nephrotic syndrome was present in 8&#37; of <br></br>patients at diagnosis&#44; and developed in two additional patients over time&#46; A pure nephrotic syndrome occurred in <br></br>8&#37; of patients&#44; and the combination of both nephrotic and nephritic syndromes in 3&#37;&#46; <br></br><br></br>Renal failure with a mean glomerular filtration rate of 63 mL&#47;min&#47;1&#46;73 m2 &#40;95&#37; CI&#44; 48&#46;82-77&#46;40&#41; was seen at disease onset in 11&#37; of patients&#46; <br></br><br></br>Fourteen percent of patients had BP values above the 95th percentile for age&#44; height&#44; and sex of the Task Force&#46; <br></br><br></br>Immunoglobulin IgA was increased in 37&#37; of patients&#44; while high complement levels only occurred in 3&#37; of patients&#46; <br></br><br></br>Clinical stages at diagnosis&#44; 2 years&#44; and 5 years of follow up are analyzed in Figure 1&#46; A decrease is seen in high-risk clinical stages at 2 and 5 years of follow-up at the expense of an increase in low-risk stages&#44; so that 50&#37; of patients had no disease evidence at 2 and 5 years of follow-up&#46; The proportion of patients with chronic end-stage renal disease at 5 years was 5&#37;&#46; <br></br><br></br>Histological data <br></br>Arenal biopsy was performed in 35&#37; of patients according to the previously stated unit criteria&#46; Repeat biopsies were taken in three patients&#46; Figure 2 shows biopsy results&#46; <br></br><br></br>Prognostic factors <br></br>Among the different variables explored in the univariate analysis as probable short- and long-term prognostic factors&#44; only a number of relapses higher than 4&#44; age over 8 years at the onset of nephropathy&#44; and the presence of a membranoproliferative lesion in the biopsy turned out to be poor prognostic factors &#40;table II&#41;&#46; <br></br><br></br>Special mention should be made of the highly significant correlation between the short- and long-term stage seen in our study &#40;p values of 0&#46;000 and 0&#46;000 according to the gamma and Somers&#191; D tests respectively&#41;&#46; Thus&#44; the clinical status at 2 years predicted for the status at 5 years of follow-up&#46; <br></br><br></br>The multivariate study &#40;table III&#41; showed that only the number of relapses remained as a short-term prognostic factor&#46; All other variables showed no short- and long-term statistical significance&#46; The smaller number of patients analyzed long-term may probably have had an influence on the lack of statistical significance in that period&#46; <br></br><br></br>Kaplan-Meier survival curves <br></br>Figure 3 shows the renal survival curve at 5 years of followup&#44; considering chronic end-stage renal failure as the final event&#46; <br></br><br></br>DISCUSSION <br></br><br></br>The morbidity and mortality of Henoch-Sch&#246;nlein purpura is dictated by renal involvement by the disease&#46; Henoch-Sch&#246;nlein nephropathy &#40;HSN&#41; is currently an uncommon cause of chronic end-stage renal disease &#40;ESRD&#41; in children&#44; accounting for 1&#46;2&#37; and 1&#46;7&#37; of patients entering an extrarenal clearance program in the US and Europe respectively&#46;6&#44;7 According to the 1990 Spanish registry of chronic kidney disease in pediatric patients &#40;REPIR&#41;&#44; HSN causes 1&#46;4&#37; of ESRD cases&#46;8 <br></br><br></br>There are reports about the prognostic factors of nephropathy giving very disparate results&#46; The purpose of our study was to analyze&#44; in addition to the epidemiological and clinical data on nephropathy&#44; the short- and long-term prognostic factors of the disease&#44; as well as the renal survival curve&#46; The rationale for this study was the few publications available about long-term follow-up of patients with HSN&#46; <br></br><br></br>In our series&#44; the clinical signs of Henoch-Sch&#246;nlein purpura were similar to those reported in other publications&#46;9-11 Our study enrolled patients already diagnosed of HSN&#44; and was therefore not intended to assess its frequency in children with Henoch-Sch&#246;nlein purpura&#46; In this series&#44; kidney involvement was found at the time of purpura onset in 67&#37; of patients&#46; The nephrological clinical signs were also similar to those previously reported&#46; The most common finding was hematuria &#40;in 93&#37; of patients&#41;&#44; whereas associated hematuria and proteinuria were seen in 67&#37; of cases&#46; Nephrotic and nephritic syndromes occurred in 8&#37; of patients&#44; while its combination was only found in 3&#37; of cases&#46; Coppo et al&#44;12 however&#44; in a study on 219 patients with HSN&#44; reported minimal urinary abnormalities in 47&#37; of cases&#44; nephrotic syndrome in 25&#37;&#44; renal failure in 31&#37;&#44; and hypertension in 23&#37;&#46; Other <br></br>authors&#44; such as Kawasaki et al&#44;10 reported a series of cases similar to ours with 15&#37; of nephrotic syndrome&#44; 8&#37; of nephritic syndrome&#44; and 4&#37; of rapidly progressive glomerulonephritis&#46; Vila et al13 emphasized that hematuria with non-nephrotic proteinuria was the most common finding in a population of 764 patients with Henoch-Sch&#246;nlein purpura with a 20&#37; incidence of nephropathy&#46; <br></br><br></br>According to some publications&#44;2&#44;14 an initial follow-up period of Henoch-Sch&#246;nlein purpura of at least 6 months is recommended in order to detect urinary abnormalities&#46; In our series&#44; one patient experienced nephropathy 6&#46;84 years after disease onset&#46; This finding leads us to question the follow-up time of these patients&#44; as well as the etiology of their renal involvement&#46; <br></br><br></br>Clinical stages in our patients did not therefore differ from those reported in other series&#46; The spectrum of clinical signs&#44; and thus the clinical stages at disease onset&#44; are highly influenced by the type of center providing the data &#40;selection bias&#41;&#46; The clinical course is also variable depending on the patient group reported&#44; so that while ESRD eventually occurs in 12&#37;-19&#37; of patients in specialized centers&#44; the proportion in non-specialized centers is only 0&#37;-3&#37;&#46;7 Thus&#44; Chang et al11 reported a 100&#37; survival curve at 10 years&#44; similar to the 96&#37; reported by Kawasaki et al&#46;10 Coppo et al12 and Scharer et al7 published values of 75&#37; and 73&#37;&#44; respectively&#46; Our study <br></br>showed a 95&#37; survival curve at 5 years of follow-up&#46; <br></br><br></br>The most common histological finding in our biopsied patients was mesangial proliferation &#40;ISKDC stage II&#41;&#44; with <br></br>stage distribution being similar to that reported in other series&#46; 10&#44;13 The proportion of crescents and the chronicity index have been considered poor prognostic factors&#46;4&#44;7&#44;10 There are&#44; however&#44; other publications where biopsy findings did not have statistical significance as poor prognostic factors&#46;9&#44;12&#44;15 In our patients&#44; the presence of a stage VI &#40;membranopoliferative histological lesion&#41; was found to be a poor prognostic factor&#44; both in the short and long term&#44; in the univariate analysis&#46; The vast majority of publications on long-term follow-up of HSN studied prognostic factors at the end of follow-up&#44; with a highly variable observation period in each patient&#46; In the Coppo et al12 series including 219 patients &#40;136 adults and 86 children&#41; with a mean follow-up time of 4&#46;5 years&#44; a Cox <br></br>multivariate regression analysis suggested age and female sex&#44; as well as persistent proteinuria during follow-up&#44; as prognostic factors&#46; <br></br><br></br>Sharer et al7 analyzed the prognostic factors for progression of renal damage in a population of 200 children with Henoch- Sch&#246;nlein purpura with a 30&#37; incidence of nephropathy&#44; and reported as prognostic factors renal failure at diagnosis&#44; nephrotic syndrome&#44; and the severity of histological changes&#44; defined as the proportion of glomerular crescents&#46; By contrast&#44; age&#44; sex&#44; initial arterial hypertension&#44; and purpura recurrence were not prognostic factors&#46; <br></br><br></br>Sevgi Mir et al9 recently published a study on 114 patients with Henoch-Sch&#246;nlein purpura with a 58&#37; incidence of <br></br>nephropathy in which a significant correlation was established between the clinical signs &#40;Stages C and D&#41; at the onset of nephropathy and the short-term &#40;6 months&#41; and long-term &#40;mean&#44; 52 months&#44; with a minimum of 1 year&#41; clinical outcome&#46; Age&#44; sex&#44; glomerular filtration rate&#44; and arterial hypertension had no statistical significance in this study&#46; <br></br><br></br>In our series&#44; however&#44; the presence of a membranoproliferative lesion at histology&#44; age older than 8 years at onset of nephropathy&#44; and more than 4 relapses were both short- and long-term poor prognostic factors in the univariate analysis&#46; When these variables were analyzed with a multivariate analysis&#44; only the number of relapses continued to be a shortterm prognostic factor&#46; Probably&#44; no statistical significance was found for other factors because of sample size&#46; <br></br><br></br>Prognosis of HSN has traditionally been more unfavorable in adults as compared to children&#46; However&#44; in another study conducted by Coppo et al15 comparing the clinical course of HSN in adult and pediatric patients requiring a renal biopsy&#44; the authors concluded that the final outcome was similar in both groups&#44; with remission rates of 32&#37; in adults and 31&#46;6&#37; in children&#44; and occurrence of chronic kidney disease in 31&#46;6&#37; and 24&#46;5&#37; of children and adults respectively&#46; No significant differences were seen in the renal survival curve in adults and children at 5 and 10 years&#46; Poor prognostic factors in adults included renal failure&#44; proteinuria higher than 1&#46;5 g&#47;day&#44; and arterial hypertension&#44; while no such prognostic factors were found in children&#46; This study may have a selection bias&#46; <br></br><br></br>Finally&#44; we would like to emphasize the correlation between the clinical stages at 2 and 5 years &#40;p 0&#46;000&#41;&#44; so that the short-term clinical status predicts for the long-term clinical stage with a high degree of reliability&#46; However&#44; as recommended by some authors&#44;2&#44;16&#44;17 long-term clinical follow-up should be performed&#44; particularly in patients who have required a renal biopsy&#46; <br></br><br></br>These widely disparate results as regards prognostic factors suggest that Henoch-Sch&#246;nlein nephropathy is a disease with a very uncertain and variable prognosis&#46; Further multicenter&#44; collaborative studies recruiting larger patient samples that would allow us for a more potent statistical treatment are required&#46; <br></br><br></br>CONCLUSION <br></br><br></br>1&#41; The clinical and epidemiological characteristics are similar to those reported in the literature&#46; <br></br>2&#41; The renal survival curve in the reported series greatly depends on the hospital center providing the data&#59; in our <br></br>study&#44; a value of 95&#37; was found at 5 years of follow-up&#46; <br></br>3&#41; In the univariate analysis&#44; poor prognostic factors&#44; both in the short- and long-term&#44; were considered to be age older than 8 years at onset&#44; more than four purpura relapses&#44; and histological stage VI in the renal biopsy&#46; In the multivariate analysis&#44; only the number of relapses was considered to be a short-term prognostic factor&#46; <br></br>4&#41; Clinical status at 2 years predicts for clinical status at 5 years&#46; Long-term follow-up is nevertheless recommended&#46; <br></br><br></br>ACKNOWLEDGEMENT <br></br><br></br>We thank H&#233;ctor Perpi&#241;an Fabuel for statistical data processing&#46; <br></br>"
    "pdfFichero" => "P-E-S-A333-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440471"
          "palabras" => array:1 [
            0 => "Proliferaci&#243;n mesangial"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440473"
          "palabras" => array:1 [
            0 => "Sch&#246;nlein-Henoch"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440475"
          "palabras" => array:1 [
            0 => "Nefropat&#237;a"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440477"
          "palabras" => array:1 [
            0 => "P&#250;rpura"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440479"
          "palabras" => array:1 [
            0 => "Ni&#241;os"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440472"
          "palabras" => array:1 [
            0 => "Mesangial proliferation"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440474"
          "palabras" => array:1 [
            0 => "Henoch-Sch&#246;nlein"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440476"
          "palabras" => array:1 [
            0 => "Nephropathy"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440478"
          "palabras" => array:1 [
            0 => "Purpura"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440480"
          "palabras" => array:1 [
            0 => "Children"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "RESUMEN Objetivo&#58; Analizar los datos epidemiol&#243;gicos&#44; cl&#237;nicos y anal&#237;ticos&#44; as&#237; como la curva de supervivencia renal y los factores pron&#243;sticos a corto y a largo plazo de ni&#241;os con nefropat&#237;a de Sch&#246;nlein-Henoch &#40;NSH&#41;&#46; Material y m&#233;todo&#58; Estudio cl&#237;nico de cohorte retrospectivo anal&#237;tico&#46; Se revisan las historias cl&#237;nicas de 100 ni&#241;os diagnosticados de NSH en el HIU La Fe entre 1975 y 2006&#46; Resultados&#58; La manifestaci&#243;n nefrol&#243;gica m&#225;s frecuente fue hematuria con proteinuria no nefr&#243;tica&#46; El 35&#37; de pacientes fueron biopsiados&#46; La histolog&#237;a m&#225;s frecuente fue la proliferaci&#243;n mesangial &#40;46&#37;&#41;&#46; Los estadios cl&#237;nicos al diagn&#243;stico fueron Estadio B&#58; 63&#37;&#44; Estadio C&#58; 33&#37;&#59; Estadio D&#58; 4&#37;&#46; Estadios cl&#237;nicos a los 5 a&#241;os&#58; Estadio A&#58; 49&#37;&#44; Estadio B&#58; 27&#37;&#44; Estadio C&#58; 0&#37; y Estadio D&#58; 5&#37;&#46; Trasplante renal&#58; 5&#37;&#46; Curva de supervivencia renal &#40;Kaplan Meier&#41; a 5 a&#241;os&#58; 95&#37;&#46; Factores pron&#243;sticos&#58; En el an&#225;lisis univariante se evidencia que tanto a corto como a largo plazo los factores de mal pron&#243;stico renal fueron la edad superior a 8 a&#241;os al debut&#44; el n&#250;mero de brotes de p&#250;rpura superior a 4 y la presencia de una estadio VI en la histolog&#237;a&#46; El an&#225;lisis multivariante muestra que a corto plazo &#250;nicamente el n&#250;mero de brotes es considerado factor pron&#243;stico&#46; Conclusi&#243;n&#58; Se pueden considerar como factores pron&#243;sticos&#44; tanto a corto como a largo plazo&#44; la edad al inicio de la enfermedad renal&#44; el n&#186; de brotes y la alteraci&#243;n histol&#243;gica&#46; Sin embargo&#44; en el an&#225;lisis multivariante &#250;nicamente el n&#186; de brotes constituye un factor pron&#243;stico a corto plazo&#46;"
      ]
      "en" => array:1 [
        "resumen" => "SUMMARY Objective&#58; To analyze epidemiological&#44; clinical and laboratory data&#44; renal survival curve and short-term &#40;2 years&#41; and long-term &#40;5 years&#41; prognostic factors in children with nephropathy secondary to Henoch-Sch&#246;nlein purpura &#40;HSP&#41;&#46; Materials and methods&#58; Retrospective analitic cohort study&#46; Clinical records of 100 children diagnosed with HSP at HIU La Fe from 1975-2006 were reviewed&#46; Statistical analysis was by univariate and multivariate analysis&#46; Results&#58; In 67&#37; of cases&#44; nephropathy coincided with onset of the disease and most commonly manifested hematuria with nonnephrotic proteinuria&#46; 35&#37; of patients were biopsied&#46; The most common histology was mesangial proliferation &#40;46&#37;&#41;&#46; Clinical stages at diagnosis were stage B&#58; 63&#37;&#44; stage C&#58; 33&#37;&#59; stage D&#58; 4&#37;&#46; Mean follow-up was 5&#46;25 &#177; 0&#46;76 years&#46; Renal data at 5 years&#58; Clinical stages&#58; stage A&#58; 49&#37;&#44; stage B&#58; 27&#37;&#44; stage C&#58; 0&#37;&#44; and stage D&#58; 5&#37;&#46; Renal transplant&#58; 5&#37;&#46; Renal survival curve &#40;Kaplan-Meier&#41; at 5 years&#58; 95&#37;&#46; Prognostic factors&#58; the univariate analysis showed that the prognostic factors of poor renal prognosis in both the short and long-term were age greater than 8 years&#44; number of purpura relapses greater than 4 and presence of stage VI histology&#46; The multivariate analysis showed that only the number of relapses was a short-term prognostic factor&#46; Conclusion&#58; 1&#41; The clinical and laboratory data reviewed were similar to those reported in the literature&#46; 2&#41; The renal survival curve at 5 years was 95&#37;&#46; 3&#41; Age&#44; number of relapses and histology were prognostic factors&#46; 4&#41; The multivariate analysis showed that only the number of relapses was a short-term prognostic factor&#46;"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:1 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bibliografía."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004237/v0_201502091634/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35441"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000006/v0_201502091634/X2013251408004237/v0_201502091634/en/P-E-S-A333-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004237?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Outcome of Henoch-Schönlein nephropathy in pediatric patients. Prognostic factors
Evolución de la nefropatía de Schönlein-Henoch en pacientes pediátricos. Factores pronósticos
Jesús Lucas Garcíaa, Olalla Álvarez Blancoa, Maria Jose Sanahuja Ibáñeza, Pedro Jose Ortega Lópeza, Isabel Zamora Martína
a Unidad de Nefrología Pediátrica, H.U. La Fe, Valencia Valencia España,
Read
8436
Times
was read the article
2649
Total PDF
5787
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251408004237"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2008-12-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:627-32"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4356
    "formatos" => array:3 [
      "EPUB" => 254
      "HTML" => 3329
      "PDF" => 773
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X021169950800423X"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2008-12-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2008;28:627-32"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 12931
        "formatos" => array:3 [
          "EPUB" => 262
          "HTML" => 11745
          "PDF" => 924
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "titulo" => "Evoluci&#243;n de la nefropat&#237;a de Sch&#246;nlein-Henoch en pacientes pedi&#225;tricos&#46; Factores pron&#243;sticos"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "627"
            "paginaFinal" => "632"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Outcome of Henoch-Sch&#246;nlein nephropathy in pediatric patients&#46; Prognostic factors"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jes&#250;s Lucas Garc&#237;a, Olalla &#193;lvarez Blanco, Maria Jose Sanahuja Ib&#225;&#241;ez, Pedro Jose Ortega L&#243;pez, Isabel Zamora Mart&#237;n"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Jes&#250;s"
                "apellidos" => "Lucas Garc&#237;a"
              ]
              1 => array:2 [
                "nombre" => "Olalla"
                "apellidos" => "&#193;lvarez Blanco"
              ]
              2 => array:2 [
                "nombre" => "Maria Jose"
                "apellidos" => "Sanahuja Ib&#225;&#241;ez"
              ]
              3 => array:2 [
                "nombre" => "Pedro Jose"
                "apellidos" => "Ortega L&#243;pez"
              ]
              4 => array:2 [
                "nombre" => "Isabel"
                "apellidos" => "Zamora Mart&#237;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251408004237"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004237?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800423X?idApp=UINPBA000064"
      "url" => "/02116995/0000002800000006/v0_201502091415/X021169950800423X/v0_201502091415/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251408004229"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:633-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4016
      "formatos" => array:3 [
        "EPUB" => 243
        "HTML" => 3240
        "PDF" => 533
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "How much should dialysis time be increased when catheters are used&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "633"
          "paginaFinal" => "636"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#191;Cu&#225;nto tiempo es necesario aumentar la prescripci&#243;n de hemodi&#225;lisis con la utilizaci&#243;n de cat&#233;teres&#63;"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Maduell, Manel Vera, Marta Arias, N&#233;stor Fontser&#233;, Miquel Blasco, Nuria Serra, Eduardo Bergad&#225;, Aleix Cases, Josep M&#46; Campistol"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            1 => array:2 [
              "nombre" => "Manel"
              "apellidos" => "Vera"
            ]
            2 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Arias"
            ]
            3 => array:2 [
              "nombre" => "N&#233;stor"
              "apellidos" => "Fontser&#233;"
            ]
            4 => array:2 [
              "nombre" => "Miquel"
              "apellidos" => "Blasco"
            ]
            5 => array:2 [
              "nombre" => "Nuria"
              "apellidos" => "Serra"
            ]
            6 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Bergad&#225;"
            ]
            7 => array:2 [
              "nombre" => "Aleix"
              "apellidos" => "Cases"
            ]
            8 => array:2 [
              "nombre" => "Josep M&#46;"
              "apellidos" => "Campistol"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004221"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004221?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004229?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004229/v0_201502091634/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251408004245"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2008-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2008;28:621-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3442
      "formatos" => array:3 [
        "EPUB" => 223
        "HTML" => 2817
        "PDF" => 402
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Underestimation of renal risk in cardiology clinics&#46; RICAR study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "621"
          "paginaFinal" => "626"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Infravaloraci&#243;n del riesgo renal en consultas de cardiolog&#237;a&#46; Estudio RICAR"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V. Bertomeu Mart&#237;nez, V. Bertomeu-Gonz&#225;lez, J. Quiles, P. Morillas, J. R. Gonz&#225;lez-Juanatey, L. F&#225;cila, P. Maz&#243;n, C. Filozof"
          "autores" => array:8 [
            0 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Bertomeu Mart&#237;nez"
            ]
            1 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Bertomeu-Gonz&#225;lez"
            ]
            2 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Quiles"
            ]
            3 => array:2 [
              "Iniciales" => "P."
              "apellidos" => "Morillas"
            ]
            4 => array:2 [
              "Iniciales" => "J. R."
              "apellidos" => "Gonz&#225;lez-Juanatey"
            ]
            5 => array:2 [
              "Iniciales" => "L."
              "apellidos" => "F&#225;cila"
            ]
            6 => array:2 [
              "Iniciales" => "P."
              "apellidos" => "Maz&#243;n"
            ]
            7 => array:2 [
              "Iniciales" => "C."
              "apellidos" => "Filozof"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699508004248"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004248?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004245?idApp=UINPBA000064"
    "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004245/v0_201502091634/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Outcome of Henoch-Sch&#246;nlein nephropathy in pediatric patients&#46; Prognostic factors"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "627"
        "paginaFinal" => "632"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jes&#250;s Lucas Garc&#237;a, Olalla &#193;lvarez Blanco, Maria Jose Sanahuja Ib&#225;&#241;ez, Pedro Jose Ortega L&#243;pez, Isabel Zamora Mart&#237;n"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Jes&#250;s"
            "apellidos" => "Lucas Garc&#237;a"
            "email" => array:1 [
              0 => "jelugar&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Olalla"
            "apellidos" => "&#193;lvarez Blanco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Maria Jose"
            "apellidos" => "Sanahuja Ib&#225;&#241;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Pedro Jose"
            "apellidos" => "Ortega L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Isabel"
            "apellidos" => "Zamora Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Unidad de Nefrología Pediátrica, H.U. La Fe, Valencia Valencia España, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Evoluci&#243;n de la nefropat&#237;a de Sch&#246;nlein-Henoch en pacientes pedi&#225;tricos&#46; Factores pron&#243;sticos"
      ]
    ]
    "textoCompleto" => "INTRODUCTION <br></br><br></br>Henoch-Sch&#246;nlein purpura is the most common leukocytoclastic vasculitis in children&#44; and is characterized by deposition of IgA immunoglobulins and IgA-containing immune complexes in the small blood vessels of different <br></br>tissues&#44; causing the symptoms typical of the disease&#46; The etiology and pathogenesis of this disease are currently <br></br>unknown&#46; Disease incidence is approximately 14&#47;100&#46;000 inhabitants&#47;year&#44;1&#44;2 and 75&#37; of cases occur in children aged 2 to 11 years&#46;2 <br></br><br></br>The most significant clinical findings include non-thrombocytopenic palpable purpura&#44; periarticular edema and swelling&#44; colic abdominal pain and gastrointestinal bleeding&#44; and nephritis&#46; The disease is usually preceded by a non-specific respiratory tract infection&#46; <br></br><br></br>Renal signs determine long-term prognosis&#44; and their prevalence ranges from 20&#37; and 60&#37; according to the different reports&#46;3 <br></br><br></br>The most common clinical sign of Henoch-Sch&#246;nlein nephropathy &#40;HSN&#41; is isolated microscopic hematuria&#44; often <br></br>associated to proteinuria&#46; <br></br><br></br>The presence of renal failure&#44; arterial hypertension&#44; nephrotic proteinuria&#44; and histological findings at the renal biopsy &#40;proportion of glomeruli with crescents&#41; has traditionally represented a poor prognostic factor&#46;4 <br></br><br></br>The proportion of patients who develop chronic end-stage renal disease &#40;ESRD&#41; differs depending on patient selection in the different reports&#46; ESRD eventually occurs in 1&#46;6&#37; of patients who only have isolated hematuria or proteinuria&#44; but in 19&#46;5&#37; of those with a nephrotic or nephritic syndrome&#46;2 <br></br><br></br>OBJECTIVE <br></br><br></br>Objectives of this study included&#58; to analyze the epidemiological&#44; clinical&#44; and laboratory data from patients diagnosed of Henoch-Sch&#246;nlein nephropathy in a third-level hospital&#59; &#40;2&#41; to determine the short- &#40;2 years&#41; and long-term &#40;5 years&#41; prognostic factors&#59; and &#40;3&#41; to estimate the renal survival curve&#46; <br></br><br></br>MATERIALS AND METHODS <br></br><br></br>Design <br></br>A retrospective&#44; analytical&#44; cohort clinical study&#46; <br></br><br></br>Patients <br></br>A review was made of the clinical histories of 100 patients diagnosed of Henoch-Sch&#246;nlein nephropathy and monitored by the pediatric nephrology unit of Hospital Universitario La Fe in Valencia from January 1&#44; 1975 to December 31&#44; 2006&#46; Age at disease onset ranged from 1 and 18 years&#46; Patients were diagnosed at our hospital or referred from other centers after diagnosis&#46; <br></br><br></br>Mean follow-up time was 5&#46;25 &#177; 0&#46;76 years &#40;range&#44; 0&#46;2-16&#46;4 years&#41;&#46; Ninety-three and 81 patients completed two and five years of follow-up respectively&#46; <br></br><br></br>Methods <br></br>Clinical and laboratory controls were conducted at least six months after HSN and every year in low risk cases&#44; where as in high risk patients control periodicity was individualized based on the severity of the condition&#46; <br></br><br></br>Clinical data collected at purpura diagnosis included presence or absence of a history of respiratory tract infection&#44; <br></br>spectrum of clinical signs&#44; and personal and family history of kidney disease&#46; Laboratory tests included plasma levels of immunoglobulins &#40;IgA&#41; and complement fractions C3 and C4&#46; At HSN diagnosis&#44; the following renal signs were recorded&#58; gross or microscopic hematuria&#44; proteinuria and its quantification&#44; plasma creatinine levels and glomerular filtration rate&#44; and blood pressure &#40;BP&#41;&#46; These data were collected at each of the follow-up visits&#46; <br></br><br></br>The number of purpura relapses was also recorded in each patient&#46; <br></br><br></br>Definition <br></br>Diagnostic criteria of Henoch-Sch&#246;nlein nephropathy meet the 1990 criteria of the American Collage of Rheumatologists &#40;ACR&#41;&#46; <br></br><br></br>Diagnostic criteria for HSN included the presence at any time during its course of any change in urinary sediment&#44; <br></br>either hematuria or proteinuria&#44; a nephrotic or nephritic syndrome&#44; as well as a decreased glomerular filtration rate&#44; <br></br>or arterial hypertension based on the percentile for height&#44; age&#44; and sex according to the reference parameters of the Task Force&#46;&#40;5&#41; <br></br><br></br>At the onset of nephropathy&#44; patients were classified in the different clinical stages using the clinical classification of <br></br>Meadow et al&#44; as modified by Counahan et al in 1997&#44; shown below&#58; <br></br><br></br>A&#58; Normal&#46; Normal physical examination&#44; BP&#44; urine analysis&#44; and glomerular filtration rate&#46; <br></br>B&#58; Minor urinary abnormalities&#46; Micro&#47;macrohematuria&#46; Non-nephrotic proteinuria&#46; <br></br>C&#58; Active kidney disease&#46; Glomerular filtration rate &#8805; 60 mL&#47;min&#47;1&#46;73 m2 or creatinine increase &#60; 25&#37; of the upper limit for age and sex&#46; Associated to nephrotic proteinuria &#40;&#8805; 40 mg&#47;m2&#47;h&#41; or AHT&#46; <br></br>D&#58; Renal failure&#46; Glomerular filtration rate &#60; 60 mL&#47;min&#47;1&#46;73 m2 or creatinine increase &#62; 25&#37; of the upper limit for age and sex&#46; Includes ESRD&#46; <br></br><br></br>Clinical stages are in turn subdivided into two categories designed as low risk &#40;Stage A and B&#41; and high risk &#40;Stage C and D&#41;&#46; <br></br><br></br>These stages were determined at diagnosis and in the short- &#40;2 years&#41; and long-term &#40;5 years&#41;&#46; <br></br><br></br>Indications for renal biopsy were&#44; in agreement with the unit protocol&#58; <br></br><br></br>a&#41; Acute nephritic syndrome&#58; hematuria&#44; hypertension&#44; oliguria&#44; and renal failure&#46; <br></br>a&#41; Established nephrotic syndrome &#40;time period longer than 15 days&#41;&#58; proteinuria in the nephrotic range and hypoalbuminemia&#46; <br></br>c&#41; Persistent proteinuria&#58; proteinuria in the nephrotic range &#40;&#62; 40 mg&#47;m2&#47;day&#41; for more than 1 month&#44; moderate proteinuria &#40;20-40 mg&#47;m2&#47;day&#41; for more than 3 months or significant proteinuria &#40;&#62; 4 mg&#47;m2&#47;day&#41; for more than 6 <br></br>months&#46; <br></br><br></br>The histological classification used was the one based on the International Study of Kidney Disease in Children <br></br>&#40;ISKDC&#41;&#58; <br></br><br></br>I&#58; Minimal glomerular lesions&#46; <br></br>II&#58; Pure mesangial proliferation&#46; <br></br>III&#58; Minimal glomerular lesions or mesangial proliferation with crescents&#47;segmental lesions in &#60; 50&#37; glomeruli&#46; <br></br>IV&#58; Stage III with crescents&#47;segmental lesions in 50&#37;-75&#37; glomeruli&#46; <br></br>V&#58; Stage III with crescents&#47;segmental lesions in &#62; 75&#37; glomeruli&#46; <br></br>VI&#58; Membranoproliferative or pseudomesangiocapillary lesions&#46; <br></br>Treatment indications and their results are not the purpose of this study&#46; <br></br><br></br>Statistics <br></br>Short- and long-term prognostic factors were established by a non-parametric univariate analysis using the gamma and Somers&#191; D test&#46; In this first analysis&#44; explanatory variables were age at onset of kidney disease&#44; sex&#44; number of purpura episodes&#44; hematuria&#44; proteinuria&#44; BP&#44; glomerular filtration rate&#44; and initial stage&#44; and the variable to be explained was the shortand long-term clinical stage&#46; <br></br><br></br>These same variables were subsequently evaluated using a multivariate hierarchical loglinear and logit analysis&#46; In this case&#44; the variable to be explained was the short- and longterm clinical stage&#44; that was grouped into two subsets&#44; lowrisk stages &#40;Stages A and B&#41; and high-risk stages &#40;Stages C and D&#41;&#46; <br></br><br></br>SPSS for Windows version 12&#46;00 software was used for statistical analysis&#46; A value of p &#60; 0&#46;05 was considered statistically significant&#46; <br></br><br></br>RESULTS <br></br><br></br>Epidemiological data <br></br>One hundred pediatric patients were studied between 1975 and 2006&#44; 53&#37; males and 47&#37; females &#40;1&#46;1&#58;1&#41;&#46; Mean age at purpura onset was 6&#46;95 &#177; 0&#46;58 years&#46; Mean age at HSN was 7&#46;14 &#177; 0&#46;57 years&#46; The interval between occurrence of purpura and nephropathy was 0&#46;22 years&#44; ranging from 0 and 6&#46;84 years&#46; Patients were divided into two groups based on the number of purpura relapses&#58; patients with more than 4 relapses &#40;30&#37;&#41; and patients with less than 4 relapses &#40;67&#37;&#41;&#46; <br></br><br></br>Clinical data <br></br>Virtually all study patients had the characteristic skin lesions at diagnosis of Henoch-Sch&#246;nlein purpura&#46; Fifty-seven percent of patients reported gastrointestinal symptoms and 40&#37; joint symptoms&#44; and HSN occurred at the onset of purpura in 67&#37; of patients&#46; Mention should be made of a case of HSN occurring 6&#46;84 years after diagnosis of purpura&#46; <br></br><br></br>Table I shows the renal signs at HSN diagnosis&#46; The most common renal sign was hematuria&#44; that was microscopic <br></br>in 57&#37; and gross in 35&#37; of patients&#46; Only 7 patients had no hematuria&#46; Proteinuria was found in 73&#37; of patients&#44; <br></br>and was associated to hematuria in most of them &#40;67&#37;&#41;&#46; Nephrotic proteinuria occurred in 27&#37; of patients&#44; with a mean value of 97&#46;49 mg&#47;m2&#47;h &#40;95&#37; CI&#44; 45&#46;30- 149&#46;69&#41;&#44; while non-nephrotic proteinuria was found in 46&#37; of patients&#44; with a mean value of 20 mg &#47;m2&#47;h &#40;95&#37; CI&#44; 15&#46;18-24&#46;81&#41;&#46; Nephrotic syndrome was present in 8&#37; of <br></br>patients at diagnosis&#44; and developed in two additional patients over time&#46; A pure nephrotic syndrome occurred in <br></br>8&#37; of patients&#44; and the combination of both nephrotic and nephritic syndromes in 3&#37;&#46; <br></br><br></br>Renal failure with a mean glomerular filtration rate of 63 mL&#47;min&#47;1&#46;73 m2 &#40;95&#37; CI&#44; 48&#46;82-77&#46;40&#41; was seen at disease onset in 11&#37; of patients&#46; <br></br><br></br>Fourteen percent of patients had BP values above the 95th percentile for age&#44; height&#44; and sex of the Task Force&#46; <br></br><br></br>Immunoglobulin IgA was increased in 37&#37; of patients&#44; while high complement levels only occurred in 3&#37; of patients&#46; <br></br><br></br>Clinical stages at diagnosis&#44; 2 years&#44; and 5 years of follow up are analyzed in Figure 1&#46; A decrease is seen in high-risk clinical stages at 2 and 5 years of follow-up at the expense of an increase in low-risk stages&#44; so that 50&#37; of patients had no disease evidence at 2 and 5 years of follow-up&#46; The proportion of patients with chronic end-stage renal disease at 5 years was 5&#37;&#46; <br></br><br></br>Histological data <br></br>Arenal biopsy was performed in 35&#37; of patients according to the previously stated unit criteria&#46; Repeat biopsies were taken in three patients&#46; Figure 2 shows biopsy results&#46; <br></br><br></br>Prognostic factors <br></br>Among the different variables explored in the univariate analysis as probable short- and long-term prognostic factors&#44; only a number of relapses higher than 4&#44; age over 8 years at the onset of nephropathy&#44; and the presence of a membranoproliferative lesion in the biopsy turned out to be poor prognostic factors &#40;table II&#41;&#46; <br></br><br></br>Special mention should be made of the highly significant correlation between the short- and long-term stage seen in our study &#40;p values of 0&#46;000 and 0&#46;000 according to the gamma and Somers&#191; D tests respectively&#41;&#46; Thus&#44; the clinical status at 2 years predicted for the status at 5 years of follow-up&#46; <br></br><br></br>The multivariate study &#40;table III&#41; showed that only the number of relapses remained as a short-term prognostic factor&#46; All other variables showed no short- and long-term statistical significance&#46; The smaller number of patients analyzed long-term may probably have had an influence on the lack of statistical significance in that period&#46; <br></br><br></br>Kaplan-Meier survival curves <br></br>Figure 3 shows the renal survival curve at 5 years of followup&#44; considering chronic end-stage renal failure as the final event&#46; <br></br><br></br>DISCUSSION <br></br><br></br>The morbidity and mortality of Henoch-Sch&#246;nlein purpura is dictated by renal involvement by the disease&#46; Henoch-Sch&#246;nlein nephropathy &#40;HSN&#41; is currently an uncommon cause of chronic end-stage renal disease &#40;ESRD&#41; in children&#44; accounting for 1&#46;2&#37; and 1&#46;7&#37; of patients entering an extrarenal clearance program in the US and Europe respectively&#46;6&#44;7 According to the 1990 Spanish registry of chronic kidney disease in pediatric patients &#40;REPIR&#41;&#44; HSN causes 1&#46;4&#37; of ESRD cases&#46;8 <br></br><br></br>There are reports about the prognostic factors of nephropathy giving very disparate results&#46; The purpose of our study was to analyze&#44; in addition to the epidemiological and clinical data on nephropathy&#44; the short- and long-term prognostic factors of the disease&#44; as well as the renal survival curve&#46; The rationale for this study was the few publications available about long-term follow-up of patients with HSN&#46; <br></br><br></br>In our series&#44; the clinical signs of Henoch-Sch&#246;nlein purpura were similar to those reported in other publications&#46;9-11 Our study enrolled patients already diagnosed of HSN&#44; and was therefore not intended to assess its frequency in children with Henoch-Sch&#246;nlein purpura&#46; In this series&#44; kidney involvement was found at the time of purpura onset in 67&#37; of patients&#46; The nephrological clinical signs were also similar to those previously reported&#46; The most common finding was hematuria &#40;in 93&#37; of patients&#41;&#44; whereas associated hematuria and proteinuria were seen in 67&#37; of cases&#46; Nephrotic and nephritic syndromes occurred in 8&#37; of patients&#44; while its combination was only found in 3&#37; of cases&#46; Coppo et al&#44;12 however&#44; in a study on 219 patients with HSN&#44; reported minimal urinary abnormalities in 47&#37; of cases&#44; nephrotic syndrome in 25&#37;&#44; renal failure in 31&#37;&#44; and hypertension in 23&#37;&#46; Other <br></br>authors&#44; such as Kawasaki et al&#44;10 reported a series of cases similar to ours with 15&#37; of nephrotic syndrome&#44; 8&#37; of nephritic syndrome&#44; and 4&#37; of rapidly progressive glomerulonephritis&#46; Vila et al13 emphasized that hematuria with non-nephrotic proteinuria was the most common finding in a population of 764 patients with Henoch-Sch&#246;nlein purpura with a 20&#37; incidence of nephropathy&#46; <br></br><br></br>According to some publications&#44;2&#44;14 an initial follow-up period of Henoch-Sch&#246;nlein purpura of at least 6 months is recommended in order to detect urinary abnormalities&#46; In our series&#44; one patient experienced nephropathy 6&#46;84 years after disease onset&#46; This finding leads us to question the follow-up time of these patients&#44; as well as the etiology of their renal involvement&#46; <br></br><br></br>Clinical stages in our patients did not therefore differ from those reported in other series&#46; The spectrum of clinical signs&#44; and thus the clinical stages at disease onset&#44; are highly influenced by the type of center providing the data &#40;selection bias&#41;&#46; The clinical course is also variable depending on the patient group reported&#44; so that while ESRD eventually occurs in 12&#37;-19&#37; of patients in specialized centers&#44; the proportion in non-specialized centers is only 0&#37;-3&#37;&#46;7 Thus&#44; Chang et al11 reported a 100&#37; survival curve at 10 years&#44; similar to the 96&#37; reported by Kawasaki et al&#46;10 Coppo et al12 and Scharer et al7 published values of 75&#37; and 73&#37;&#44; respectively&#46; Our study <br></br>showed a 95&#37; survival curve at 5 years of follow-up&#46; <br></br><br></br>The most common histological finding in our biopsied patients was mesangial proliferation &#40;ISKDC stage II&#41;&#44; with <br></br>stage distribution being similar to that reported in other series&#46; 10&#44;13 The proportion of crescents and the chronicity index have been considered poor prognostic factors&#46;4&#44;7&#44;10 There are&#44; however&#44; other publications where biopsy findings did not have statistical significance as poor prognostic factors&#46;9&#44;12&#44;15 In our patients&#44; the presence of a stage VI &#40;membranopoliferative histological lesion&#41; was found to be a poor prognostic factor&#44; both in the short and long term&#44; in the univariate analysis&#46; The vast majority of publications on long-term follow-up of HSN studied prognostic factors at the end of follow-up&#44; with a highly variable observation period in each patient&#46; In the Coppo et al12 series including 219 patients &#40;136 adults and 86 children&#41; with a mean follow-up time of 4&#46;5 years&#44; a Cox <br></br>multivariate regression analysis suggested age and female sex&#44; as well as persistent proteinuria during follow-up&#44; as prognostic factors&#46; <br></br><br></br>Sharer et al7 analyzed the prognostic factors for progression of renal damage in a population of 200 children with Henoch- Sch&#246;nlein purpura with a 30&#37; incidence of nephropathy&#44; and reported as prognostic factors renal failure at diagnosis&#44; nephrotic syndrome&#44; and the severity of histological changes&#44; defined as the proportion of glomerular crescents&#46; By contrast&#44; age&#44; sex&#44; initial arterial hypertension&#44; and purpura recurrence were not prognostic factors&#46; <br></br><br></br>Sevgi Mir et al9 recently published a study on 114 patients with Henoch-Sch&#246;nlein purpura with a 58&#37; incidence of <br></br>nephropathy in which a significant correlation was established between the clinical signs &#40;Stages C and D&#41; at the onset of nephropathy and the short-term &#40;6 months&#41; and long-term &#40;mean&#44; 52 months&#44; with a minimum of 1 year&#41; clinical outcome&#46; Age&#44; sex&#44; glomerular filtration rate&#44; and arterial hypertension had no statistical significance in this study&#46; <br></br><br></br>In our series&#44; however&#44; the presence of a membranoproliferative lesion at histology&#44; age older than 8 years at onset of nephropathy&#44; and more than 4 relapses were both short- and long-term poor prognostic factors in the univariate analysis&#46; When these variables were analyzed with a multivariate analysis&#44; only the number of relapses continued to be a shortterm prognostic factor&#46; Probably&#44; no statistical significance was found for other factors because of sample size&#46; <br></br><br></br>Prognosis of HSN has traditionally been more unfavorable in adults as compared to children&#46; However&#44; in another study conducted by Coppo et al15 comparing the clinical course of HSN in adult and pediatric patients requiring a renal biopsy&#44; the authors concluded that the final outcome was similar in both groups&#44; with remission rates of 32&#37; in adults and 31&#46;6&#37; in children&#44; and occurrence of chronic kidney disease in 31&#46;6&#37; and 24&#46;5&#37; of children and adults respectively&#46; No significant differences were seen in the renal survival curve in adults and children at 5 and 10 years&#46; Poor prognostic factors in adults included renal failure&#44; proteinuria higher than 1&#46;5 g&#47;day&#44; and arterial hypertension&#44; while no such prognostic factors were found in children&#46; This study may have a selection bias&#46; <br></br><br></br>Finally&#44; we would like to emphasize the correlation between the clinical stages at 2 and 5 years &#40;p 0&#46;000&#41;&#44; so that the short-term clinical status predicts for the long-term clinical stage with a high degree of reliability&#46; However&#44; as recommended by some authors&#44;2&#44;16&#44;17 long-term clinical follow-up should be performed&#44; particularly in patients who have required a renal biopsy&#46; <br></br><br></br>These widely disparate results as regards prognostic factors suggest that Henoch-Sch&#246;nlein nephropathy is a disease with a very uncertain and variable prognosis&#46; Further multicenter&#44; collaborative studies recruiting larger patient samples that would allow us for a more potent statistical treatment are required&#46; <br></br><br></br>CONCLUSION <br></br><br></br>1&#41; The clinical and epidemiological characteristics are similar to those reported in the literature&#46; <br></br>2&#41; The renal survival curve in the reported series greatly depends on the hospital center providing the data&#59; in our <br></br>study&#44; a value of 95&#37; was found at 5 years of follow-up&#46; <br></br>3&#41; In the univariate analysis&#44; poor prognostic factors&#44; both in the short- and long-term&#44; were considered to be age older than 8 years at onset&#44; more than four purpura relapses&#44; and histological stage VI in the renal biopsy&#46; In the multivariate analysis&#44; only the number of relapses was considered to be a short-term prognostic factor&#46; <br></br>4&#41; Clinical status at 2 years predicts for clinical status at 5 years&#46; Long-term follow-up is nevertheless recommended&#46; <br></br><br></br>ACKNOWLEDGEMENT <br></br><br></br>We thank H&#233;ctor Perpi&#241;an Fabuel for statistical data processing&#46; <br></br>"
    "pdfFichero" => "P-E-S-A333-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440471"
          "palabras" => array:1 [
            0 => "Proliferaci&#243;n mesangial"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440473"
          "palabras" => array:1 [
            0 => "Sch&#246;nlein-Henoch"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440475"
          "palabras" => array:1 [
            0 => "Nefropat&#237;a"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440477"
          "palabras" => array:1 [
            0 => "P&#250;rpura"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec440479"
          "palabras" => array:1 [
            0 => "Ni&#241;os"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440472"
          "palabras" => array:1 [
            0 => "Mesangial proliferation"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440474"
          "palabras" => array:1 [
            0 => "Henoch-Sch&#246;nlein"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440476"
          "palabras" => array:1 [
            0 => "Nephropathy"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440478"
          "palabras" => array:1 [
            0 => "Purpura"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec440480"
          "palabras" => array:1 [
            0 => "Children"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "RESUMEN Objetivo&#58; Analizar los datos epidemiol&#243;gicos&#44; cl&#237;nicos y anal&#237;ticos&#44; as&#237; como la curva de supervivencia renal y los factores pron&#243;sticos a corto y a largo plazo de ni&#241;os con nefropat&#237;a de Sch&#246;nlein-Henoch &#40;NSH&#41;&#46; Material y m&#233;todo&#58; Estudio cl&#237;nico de cohorte retrospectivo anal&#237;tico&#46; Se revisan las historias cl&#237;nicas de 100 ni&#241;os diagnosticados de NSH en el HIU La Fe entre 1975 y 2006&#46; Resultados&#58; La manifestaci&#243;n nefrol&#243;gica m&#225;s frecuente fue hematuria con proteinuria no nefr&#243;tica&#46; El 35&#37; de pacientes fueron biopsiados&#46; La histolog&#237;a m&#225;s frecuente fue la proliferaci&#243;n mesangial &#40;46&#37;&#41;&#46; Los estadios cl&#237;nicos al diagn&#243;stico fueron Estadio B&#58; 63&#37;&#44; Estadio C&#58; 33&#37;&#59; Estadio D&#58; 4&#37;&#46; Estadios cl&#237;nicos a los 5 a&#241;os&#58; Estadio A&#58; 49&#37;&#44; Estadio B&#58; 27&#37;&#44; Estadio C&#58; 0&#37; y Estadio D&#58; 5&#37;&#46; Trasplante renal&#58; 5&#37;&#46; Curva de supervivencia renal &#40;Kaplan Meier&#41; a 5 a&#241;os&#58; 95&#37;&#46; Factores pron&#243;sticos&#58; En el an&#225;lisis univariante se evidencia que tanto a corto como a largo plazo los factores de mal pron&#243;stico renal fueron la edad superior a 8 a&#241;os al debut&#44; el n&#250;mero de brotes de p&#250;rpura superior a 4 y la presencia de una estadio VI en la histolog&#237;a&#46; El an&#225;lisis multivariante muestra que a corto plazo &#250;nicamente el n&#250;mero de brotes es considerado factor pron&#243;stico&#46; Conclusi&#243;n&#58; Se pueden considerar como factores pron&#243;sticos&#44; tanto a corto como a largo plazo&#44; la edad al inicio de la enfermedad renal&#44; el n&#186; de brotes y la alteraci&#243;n histol&#243;gica&#46; Sin embargo&#44; en el an&#225;lisis multivariante &#250;nicamente el n&#186; de brotes constituye un factor pron&#243;stico a corto plazo&#46;"
      ]
      "en" => array:1 [
        "resumen" => "SUMMARY Objective&#58; To analyze epidemiological&#44; clinical and laboratory data&#44; renal survival curve and short-term &#40;2 years&#41; and long-term &#40;5 years&#41; prognostic factors in children with nephropathy secondary to Henoch-Sch&#246;nlein purpura &#40;HSP&#41;&#46; Materials and methods&#58; Retrospective analitic cohort study&#46; Clinical records of 100 children diagnosed with HSP at HIU La Fe from 1975-2006 were reviewed&#46; Statistical analysis was by univariate and multivariate analysis&#46; Results&#58; In 67&#37; of cases&#44; nephropathy coincided with onset of the disease and most commonly manifested hematuria with nonnephrotic proteinuria&#46; 35&#37; of patients were biopsied&#46; The most common histology was mesangial proliferation &#40;46&#37;&#41;&#46; Clinical stages at diagnosis were stage B&#58; 63&#37;&#44; stage C&#58; 33&#37;&#59; stage D&#58; 4&#37;&#46; Mean follow-up was 5&#46;25 &#177; 0&#46;76 years&#46; Renal data at 5 years&#58; Clinical stages&#58; stage A&#58; 49&#37;&#44; stage B&#58; 27&#37;&#44; stage C&#58; 0&#37;&#44; and stage D&#58; 5&#37;&#46; Renal transplant&#58; 5&#37;&#46; Renal survival curve &#40;Kaplan-Meier&#41; at 5 years&#58; 95&#37;&#46; Prognostic factors&#58; the univariate analysis showed that the prognostic factors of poor renal prognosis in both the short and long-term were age greater than 8 years&#44; number of purpura relapses greater than 4 and presence of stage VI histology&#46; The multivariate analysis showed that only the number of relapses was a short-term prognostic factor&#46; Conclusion&#58; 1&#41; The clinical and laboratory data reviewed were similar to those reported in the literature&#46; 2&#41; The renal survival curve at 5 years was 95&#37;&#46; 3&#41; Age&#44; number of relapses and histology were prognostic factors&#46; 4&#41; The multivariate analysis showed that only the number of relapses was a short-term prognostic factor&#46;"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:1 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bibliografía."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002800000006/v0_201502091634/X2013251408004237/v0_201502091634/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35441"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originals"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000006/v0_201502091634/X2013251408004237/v0_201502091634/en/P-E-S-A333-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004237?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
DOI:
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 10 16
2024 October 40 44 84
2024 September 56 46 102
2024 August 57 63 120
2024 July 48 45 93
2024 June 76 42 118
2024 May 75 56 131
2024 April 56 38 94
2024 March 53 28 81
2024 February 30 37 67
2024 January 25 34 59
2023 December 25 26 51
2023 November 33 37 70
2023 October 104 41 145
2023 September 79 37 116
2023 August 39 28 67
2023 July 47 42 89
2023 June 37 25 62
2023 May 46 25 71
2023 April 38 21 59
2023 March 39 20 59
2023 February 27 19 46
2023 January 22 20 42
2022 December 40 27 67
2022 November 33 25 58
2022 October 29 36 65
2022 September 38 31 69
2022 August 43 33 76
2022 July 29 41 70
2022 June 44 29 73
2022 May 34 42 76
2022 April 45 41 86
2022 March 56 41 97
2022 February 73 42 115
2022 January 86 32 118
2021 December 45 43 88
2021 November 40 31 71
2021 October 65 68 133
2021 September 33 42 75
2021 August 32 30 62
2021 July 44 34 78
2021 June 32 31 63
2021 May 28 43 71
2021 April 71 50 121
2021 March 44 42 86
2021 February 38 47 85
2021 January 28 19 47
2020 December 17 17 34
2020 November 31 15 46
2020 October 21 12 33
2020 September 29 25 54
2020 August 30 12 42
2020 July 40 15 55
2020 June 45 40 85
2020 May 34 16 50
2020 April 50 20 70
2020 March 39 13 52
2020 February 36 24 60
2020 January 46 27 73
2019 December 42 18 60
2019 November 63 23 86
2019 October 41 14 55
2019 September 54 21 75
2019 August 31 21 52
2019 July 38 39 77
2019 June 33 32 65
2019 May 33 30 63
2019 April 100 58 158
2019 March 41 24 65
2019 February 31 18 49
2019 January 49 32 81
2018 December 70 28 98
2018 November 59 16 75
2018 October 50 21 71
2018 September 56 15 71
2018 August 36 19 55
2018 July 45 11 56
2018 June 33 18 51
2018 May 34 13 47
2018 April 34 11 45
2018 March 41 12 53
2018 February 33 9 42
2018 January 34 6 40
2017 December 47 11 58
2017 November 29 19 48
2017 October 31 10 41
2017 September 30 12 42
2017 August 40 15 55
2017 July 39 8 47
2017 June 39 14 53
2017 May 39 12 51
2017 April 40 13 53
2017 March 18 7 25
2017 February 25 12 37
2017 January 12 12 24
2016 December 27 8 35
2016 November 30 17 47
2016 October 56 16 72
2016 September 67 7 74
2016 August 167 9 176
2016 July 142 18 160
2016 June 116 0 116
2016 May 101 0 101
2016 April 101 0 101
2016 March 86 0 86
2016 February 117 0 117
2016 January 123 0 123
2015 December 117 0 117
2015 November 102 0 102
2015 October 87 0 87
2015 September 77 0 77
2015 August 94 0 94
2015 July 68 0 68
2015 June 45 0 45
2015 May 63 0 63
2015 April 5 0 5
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?