Recovery of total innmunoglobulin and immunoglobulin subclasses in nephrotic syndrome: deflazacort vs methylprednisone
Recuperación de la inmnoglobulina total y sus subclases en el síndrome nefrótico: deflazacort vs metilprednisona.
Read
7147
Timeswas read the article
2037
Total PDF
5110
Total HTML
Share statistics
array:21 [ "pii" => "X2013251408004139" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:562-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3259 "formatos" => array:3 [ "EPUB" => 270 "HTML" => 2481 "PDF" => 508 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699508004131" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2008;28:562-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5923 "formatos" => array:3 [ "EPUB" => 298 "HTML" => 5242 "PDF" => 383 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Recuperación de la inmnoglobulina total y sus subclases en el síndrome nefrótico: deflazacort vs metilprednisona." "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "562" "paginaFinal" => "563" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Recovery of total innmunoglobulin and immunoglobulin subclasses in nephrotic syndrome: deflazacort vs methylprednisone" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Miguel Liern, StellaMaris Dieguez, Carlos Canepa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Miguel" "apellidos" => "Liern" ] 1 => array:2 [ "nombre" => "StellaMaris" "apellidos" => "Dieguez" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Canepa" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251408004139" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004139?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004131?idApp=UINPBA000064" "url" => "/02116995/0000002800000005/v0_201502091416/X0211699508004131/v0_201502091416/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251408004120" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:563-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4586 "formatos" => array:3 [ "EPUB" => 342 "HTML" => 3653 "PDF" => 591 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Rhabdomyolysis after correction of severe hyponatremia due to an attack of acute intermittent porphyria" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "563" "paginaFinal" => "564" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Rabdomiolisis tras la corrección de hiponatremia severa en una crisis de porfiria aguda intermitente" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mélida García-Martul, Luciano Santana-Cabrera, Zenaida Santos-Moyano, Manuel Sánchez-Palacios" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mélida" "apellidos" => "García-Martul" ] 1 => array:2 [ "nombre" => "Luciano" "apellidos" => "Santana-Cabrera" ] 2 => array:2 [ "nombre" => "Zenaida" "apellidos" => "Santos-Moyano" ] 3 => array:2 [ "nombre" => "Manuel" "apellidos" => "Sánchez-Palacios" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508004123" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004123?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004120?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004120/v0_201502091635/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251408004147" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:562-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3382 "formatos" => array:3 [ "EPUB" => 267 "HTML" => 2571 "PDF" => 544 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Renal function recovery on hemodialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "562" "paginaFinal" => "563" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Recuperación de función renal en hemodiálsis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Quiiñones Ortiz, Ana Suárez Laurés, Alfonso Pobes Martínez, Ramón Forascepi Roza" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Quiiñones Ortiz" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Suárez Laurés" ] 2 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Pobes Martínez" ] 3 => array:2 [ "nombre" => "Ramón" "apellidos" => "Forascepi Roza" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X021169950800414X" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800414X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004147?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004147/v0_201502091635/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Recovery of total innmunoglobulin and immunoglobulin subclasses in nephrotic syndrome: deflazacort vs methylprednisone" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "562" "paginaFinal" => "563" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Miguel Liern, StellaMaris Dieguez, Carlos Canepa" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Miguel" "apellidos" => "Liern" "email" => array:1 [ 0 => "jliern@ yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "StellaMaris" "apellidos" => "Dieguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Carlos" "apellidos" => "Canepa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrologia, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Buenos Aires, Argentina " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Recuperación de la inmnoglobulina total y sus subclases en el síndrome nefrótico: deflazacort vs metilprednisona." ] ] "textoCompleto" => "<p class="elsevierStylePara">To the editor: Hypogammaglobulinemia in nephrotic syndrome (NS) is a condition attributable to increased catabolism and urinary loss of immunoglobulins.1,2<br></br><br></br>Patients with NS have an increased risk of infection, primarily caused by capsulated germs (pneumococci, Hemophilus influenzae).3,4 There is evidence suggesting that IgG2 are antibodies protecting against pneumococci.<br></br><br></br>Our purpose was to study recovery of the different immunoglobulin subclasses in patients with NS treated with methylprednisone and deflazacort during remission and relapse.<br></br><br></br>PATIENTS AND METHODS<br></br><br></br>Eleven patients with a mean age of 48 months (range, 16-52 months) were studied. An interventional, single blind, clinical study, randomized for treatment start and with treatment crossover after the first relapse, was designed.<br></br><br></br>Methylprednisone (MPD) was given at 48 mg/m2/day for 6 weeks, followed by 2/3 of the dose every other day for<br></br>the next 6 weeks.<br></br><br></br>The equivalent dose of deflazacort (DFZ) was 72 mg/m2/day (maximum 90 mg/day), with the same therapeutic scheme.<br></br><br></br>Blood samples were taken at relapse and 40 days after remission was achieved to measure total IgG and its subclasses by the radial immunodiffusion method.<br></br><br></br>RESULTS<br></br><br></br>Mean times on remission were 7.8 ± 0.36 days with MPD and 8.3 ± 0.22 days with DFZ.<br></br><br></br>Mean times to relapse were 85 ± 3.8 days with MPD and 102 ± 4.19 days with DFZ.<br></br><br></br>Both total IgG and IgG1 similarly recovered with both corticosteroids, but IgG2 and IgG3 only significantly increased with DFZ. Percent recovery of IgG and its subclasses was asymmetric during remission. <br></br><br></br>IgG1  showed  the  greatest  recovery, while  IgG2  reached  50%  of  normal value. The  same  imbalance was  found with both treatments.<br></br><br></br>While this was not considered as an objective, it may be stated that the incidence rate of infection by capsulated germs was not significant with both corticosteroids (p0.12) and that less adverse effects occurred when DFZ was used (hypertrichosis, Cushingoid appearance, ocular hypertension, hyperglycemia).<br></br><br></br>CONCLUSIONS<br></br><br></br>We found an imbalance in recovery of IgG subclasses during remission of NS treated with both corticosteroids, but a better recovery of such levels was achieved with DFZ. </p>" "pdfFichero" => "P-E-S-A368-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La hipogamaglobulinemia en el síndrome nefrótico (SN) es una alteración atribuible a un aumento de su catabolismo y a la perdida urinaria de las inmunoglobulinas (1,2) " ] "en" => array:1 [ "resumen" => "To the editor: Hypogammaglobulinemia in nephrotic syndrome (NS) is a condition attributable to increased catabolism and urinary loss of immunoglobulins.1,2 " ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Longsworth IG, Mac Innes D.A. An electrophoretic study of nephrotic sera and urine. J.Exp>Med 1998; 71:77-82" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "2.Vivi-Anne Oxelius IgG Subclass levels in infancy and childhood Act Pediatr Scand 1979; 68:23-27" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Lowy Y, Brezin C, Neauport-Sautes C, Theze J, Fridman WH. Isotype regulation of antibody production :T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors Proc Natl Acad Sci USA 2003; Apr;80(8):2323-7 <a href="http://www.ncbi.nlm.nih.gov/pubmed/6220409" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "4 Lowy Y, Theze J, Regulation of IgG1 and IgG2 subclass expression by adjuvant-activated splenic suppresser T-cell Cell.immunol 1999;Apr 1;91(2):467-76" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004139/v0_201502091635/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000005/v0_201502091635/X2013251408004139/v0_201502091635/en/P-E-S-A368-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004139?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 8 | 15 |
| 2024 October | 42 | 33 | 75 |
| 2024 September | 59 | 16 | 75 |
| 2024 August | 71 | 61 | 132 |
| 2024 July | 50 | 20 | 70 |
| 2024 June | 52 | 32 | 84 |
| 2024 May | 62 | 35 | 97 |
| 2024 April | 66 | 27 | 93 |
| 2024 March | 55 | 25 | 80 |
| 2024 February | 61 | 37 | 98 |
| 2024 January | 61 | 27 | 88 |
| 2023 December | 40 | 19 | 59 |
| 2023 November | 42 | 33 | 75 |
| 2023 October | 48 | 33 | 81 |
| 2023 September | 39 | 23 | 62 |
| 2023 August | 40 | 28 | 68 |
| 2023 July | 39 | 28 | 67 |
| 2023 June | 69 | 26 | 95 |
| 2023 May | 69 | 26 | 95 |
| 2023 April | 32 | 19 | 51 |
| 2023 March | 31 | 18 | 49 |
| 2023 February | 40 | 22 | 62 |
| 2023 January | 30 | 26 | 56 |
| 2022 December | 42 | 24 | 66 |
| 2022 November | 47 | 28 | 75 |
| 2022 October | 35 | 33 | 68 |
| 2022 September | 34 | 37 | 71 |
| 2022 August | 42 | 29 | 71 |
| 2022 July | 34 | 46 | 80 |
| 2022 June | 27 | 28 | 55 |
| 2022 May | 46 | 37 | 83 |
| 2022 April | 66 | 36 | 102 |
| 2022 March | 80 | 41 | 121 |
| 2022 February | 29 | 32 | 61 |
| 2022 January | 70 | 33 | 103 |
| 2021 December | 51 | 33 | 84 |
| 2021 November | 41 | 34 | 75 |
| 2021 October | 53 | 39 | 92 |
| 2021 September | 38 | 36 | 74 |
| 2021 August | 42 | 36 | 78 |
| 2021 July | 50 | 31 | 81 |
| 2021 June | 34 | 25 | 59 |
| 2021 May | 52 | 27 | 79 |
| 2021 April | 64 | 32 | 96 |
| 2021 March | 58 | 25 | 83 |
| 2021 February | 60 | 20 | 80 |
| 2021 January | 42 | 22 | 64 |
| 2020 December | 34 | 17 | 51 |
| 2020 November | 41 | 17 | 58 |
| 2020 October | 26 | 14 | 40 |
| 2020 September | 22 | 11 | 33 |
| 2020 August | 46 | 6 | 52 |
| 2020 July | 34 | 9 | 43 |
| 2020 June | 33 | 18 | 51 |
| 2020 May | 51 | 10 | 61 |
| 2020 April | 32 | 21 | 53 |
| 2020 March | 48 | 10 | 58 |
| 2020 February | 34 | 23 | 57 |
| 2020 January | 31 | 22 | 53 |
| 2019 December | 37 | 24 | 61 |
| 2019 November | 33 | 21 | 54 |
| 2019 October | 7 | 10 | 17 |
| 2019 September | 21 | 18 | 39 |
| 2019 August | 16 | 17 | 33 |
| 2019 July | 25 | 21 | 46 |
| 2019 June | 16 | 8 | 24 |
| 2019 May | 19 | 13 | 32 |
| 2019 April | 34 | 24 | 58 |
| 2019 March | 13 | 14 | 27 |
| 2019 February | 16 | 10 | 26 |
| 2019 January | 26 | 15 | 41 |
| 2018 December | 44 | 33 | 77 |
| 2018 November | 103 | 20 | 123 |
| 2018 October | 66 | 17 | 83 |
| 2018 September | 56 | 12 | 68 |
| 2018 August | 42 | 19 | 61 |
| 2018 July | 41 | 13 | 54 |
| 2018 June | 32 | 18 | 50 |
| 2018 May | 21 | 16 | 37 |
| 2018 April | 33 | 2 | 35 |
| 2018 March | 34 | 9 | 43 |
| 2018 February | 29 | 6 | 35 |
| 2018 January | 30 | 8 | 38 |
| 2017 December | 29 | 10 | 39 |
| 2017 November | 27 | 4 | 31 |
| 2017 October | 35 | 6 | 41 |
| 2017 September | 28 | 10 | 38 |
| 2017 August | 26 | 5 | 31 |
| 2017 July | 28 | 8 | 36 |
| 2017 June | 20 | 7 | 27 |
| 2017 May | 31 | 7 | 38 |
| 2017 April | 23 | 9 | 32 |
| 2017 March | 24 | 4 | 28 |
| 2017 February | 14 | 4 | 18 |
| 2017 January | 16 | 5 | 21 |
| 2016 December | 27 | 7 | 34 |
| 2016 November | 23 | 4 | 27 |
| 2016 October | 56 | 6 | 62 |
| 2016 September | 93 | 4 | 97 |
| 2016 August | 94 | 3 | 97 |
| 2016 July | 110 | 2 | 112 |
| 2016 June | 111 | 0 | 111 |
| 2016 May | 125 | 0 | 125 |
| 2016 April | 53 | 0 | 53 |
| 2016 March | 59 | 0 | 59 |
| 2016 February | 59 | 0 | 59 |
| 2016 January | 67 | 0 | 67 |
| 2015 December | 89 | 0 | 89 |
| 2015 November | 61 | 0 | 61 |
| 2015 October | 64 | 0 | 64 |
| 2015 September | 53 | 0 | 53 |
| 2015 August | 59 | 0 | 59 |
| 2015 July | 52 | 0 | 52 |
| 2015 June | 34 | 0 | 34 |
| 2015 May | 47 | 0 | 47 |
| 2015 April | 5 | 0 | 5 |
Show all
