Genetics and environment: pathogenetic factors of vasculitis?
Genética y ambiente: ¿factores etiopatogéncos de las vasculitis?
Read
6384
Timeswas read the article
2068
Total PDF
4316
Total HTML
Share statistics
array:21 [ "pii" => "X2013251408004081" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:568" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3177 "formatos" => array:3 [ "EPUB" => 278 "HTML" => 2333 "PDF" => 566 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699508004084" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2008;28:568" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6431 "formatos" => array:3 [ "EPUB" => 288 "HTML" => 5783 "PDF" => 360 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Genética y ambiente: ¿factores etiopatogéncos de las vasculitis?" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "568" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Genetics and environment: pathogenetic factors of vasculitis?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "MANUEL HERAS BENITO, MARIA JOSE FERNANDEZ-REYES LUIS, ROSA SANCHEZ HERNANDEZ, ANA SAIZ" "autores" => array:4 [ 0 => array:2 [ "nombre" => "MANUEL" "apellidos" => "HERAS BENITO" ] 1 => array:2 [ "nombre" => "MARIA JOSE" "apellidos" => "FERNANDEZ-REYES LUIS" ] 2 => array:2 [ "nombre" => "ROSA" "apellidos" => "SANCHEZ HERNANDEZ" ] 3 => array:2 [ "nombre" => "ANA" "apellidos" => "SAIZ" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251408004081" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004081?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004084?idApp=UINPBA000064" "url" => "/02116995/0000002800000005/v0_201502091416/X0211699508004084/v0_201502091416/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251408004065" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:569-70" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5202 "formatos" => array:3 [ "EPUB" => 301 "HTML" => 4209 "PDF" => 692 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Hypokalemia, distal renal tubular acidosis, and Hashimoto's thyroiditis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "569" "paginaFinal" => "570" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hipokalemia, acidosis tubular distal y tiroiditis de Hashimoto" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bárbara Finn, Pablo Young, Julio E Bruetman, Mariano Forrester, Fernando Lombi, Vicente Campolo Girard, Horacio Pereyra, Hernán Trimarchi" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Finn" ] 1 => array:2 [ "nombre" => "Pablo" "apellidos" => "Young" ] 2 => array:2 [ "nombre" => "Julio" "apellidos" => "E Bruetman" ] 3 => array:2 [ "nombre" => "Mariano" "apellidos" => "Forrester" ] 4 => array:2 [ "nombre" => "Fernando" "apellidos" => "Lombi" ] 5 => array:2 [ "nombre" => "Vicente" "apellidos" => "Campolo Girard" ] 6 => array:2 [ "nombre" => "Horacio" "apellidos" => "Pereyra" ] 7 => array:2 [ "nombre" => "Hernán" "apellidos" => "Trimarchi" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508004068" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004068?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004065?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004065/v0_201502091635/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251408004073" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:568-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3299 "formatos" => array:3 [ "EPUB" => 292 "HTML" => 2454 "PDF" => 553 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Intracranyal hypertension as presentation of neurobrucellosis in a patient on hemodialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "568" "paginaFinal" => "569" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hipertensión endocraneal como presentación de una neurobrucellosis en un paciente de hemodiálisis." ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge Roig, Felipe Sarró, Mercè Borras, Elvira Fernández" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Roig" ] 1 => array:2 [ "nombre" => "Felipe" "apellidos" => "Sarró" ] 2 => array:2 [ "nombre" => "Mercè" "apellidos" => "Borras" ] 3 => array:2 [ "nombre" => "Elvira" "apellidos" => "Fernández" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508004076" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508004076?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004073?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004073/v0_201502091635/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Genetics and environment: pathogenetic factors of vasculitis?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "568" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "MANUEL HERAS BENITO, MARIA JOSE FERNANDEZ-REYES LUIS, ROSA SANCHEZ HERNANDEZ, ANA SAIZ" "autores" => array:4 [ 0 => array:4 [ "nombre" => "MANUEL" "apellidos" => "HERAS BENITO" "email" => array:1 [ 0 => "mheras@hgse.sacyl.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "MARIA JOSE" "apellidos" => "FERNANDEZ-REYES LUIS" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "ROSA" "apellidos" => "SANCHEZ HERNANDEZ" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "ANA" "apellidos" => "SAIZ" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital General de Segovia, Segovia, Segovia, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Ramón y Cajal, Madrid, Madrid, España, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Genética y ambiente: ¿factores etiopatogéncos de las vasculitis?" ] ] "textoCompleto" => "To the editor: Etiopathogenesis of vasculitis is not fully understood, and environmental factors have been implicated in genetically predisposed individuals.1,2 The histological renal expression of systemic vasculitis is apauci-immune  necrotizing  glomerulonephritis  (PNG).3 Two cases of familial vasculitis  in  two  brothers  living in  a  rural  environment  are  reported here. <br></br><br></br>CASE 1 <br></br>A 63-year-old male,  a  shepherd  living in a rural environment. He consulted in 1988  for  an  impaired  general  status, and  laboratory  tests  revealed  oliguric acute  renal  failure. Histological  analysis of  renal biopsy  found a necrotizing vasculitis with extracapillary proliferative  glomerulonephritis.  The  patient was  treated  with  corticosteroids  and oral cyclophosphamide. No renal function  improvement  occurred,  and  renal replacement therapy was required until the patient died in 2003. <br></br><br></br>CASE 2 <br></br>A 72-year-old male, a farmer living in a rural  environment.  In  April  2004  he complained  of  cough,  expectoration, fatigue,  and  anorexia.  His  family  history  revealed  that  the  patient  reported as  case  1 was  his  brother. His  parents had  died  at  an  advanced  age,  and  he had two sisters with type 2 diabetes mellitus, one of them with a history of pulmonary tuberculosis. <br></br><br></br>Based on his personal history,  clinical  signs,  and  renal  function  impairment,  a  renal  biopsy  was  performed, <br></br>which confirmed  the presence of PNG in  the  setting  of  a  systemic  vasculitis associated  to  P-ANCA (positive  anti-MPO, titer 442 U/mL). <br></br><br></br>DISCUSSION <br></br>Pauci-immune necrotizing glomerulonephritis with extracapillary proliferation  is  the  renal  pathological  expression of systemic vasculitis. This group of diseases is characterized by inflammation  of  small  and  medium-sized <br></br>blood vessels, and includes Wegener¿s granulomatosis  (WG),  microscopic polyangeitis  (MPA),  Churg-Strauss <br></br>syndrome, or vasculitis  limited  to  the kidney.3 <br></br><br></br>Their etiopathogenesis is unknown. Occurrence of  these diseases  in  several members of a same family has suggested  that genetic  factors could contribute  to  its  occurrence.1 We  report two cases of PNG as a renal manifestation  of  systemic  vasculitis  in  two brothers. In case 2, the disease started when  the  first  patient  had  already died. The presence on the same disease  in  two  brothers  could  support  the genetic component in the etiopathogenesis of vasculitis. <br></br><br></br>Some  researchers have  attempted  to find  associations  of  vasculitis  with HLA genes.1 Recent studies found a positive association with HLA DR1, particularly in patients with WG, and negative  associations  with  HLA DR3, <br></br>particularly  in  Churg-Strauss  granulomatosis and polyarteritis nodosa.1, 4 Our patient  had  the  haplotype A1, B8 B35 Cw4 Cw7 DR3 and DR5 DQ2. Case 1 haplotype  is  unknown  because  the  patient died before the second patient experienced the disease. <br></br><br></br>It has also been suggested that environmental  factors  could  contribute  to disease  development  in  genetically <br></br>predisposed  individuals.2 Patients  reported  here  lived  in  a  rural  environment,  and  some  environmental  component may possibly have contributed to  occurrence  of  the  same  disease  in both patients. <br></br><br></br>In  conclusion,  these  two  cases  of PNG as an expression of systemic vasculitis in two brothers living in a similar environment could support the suggested  hypothesis  of  an  influence  of environmental factors on the etiopathogenesis of vasculitis in genetically predisposed individuals. " "pdfFichero" => "P-E-S-A373-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La etiopatogenia de las vasculitis no es del todo bien conocida, involucrándose la participación de factores ambientales en individuos genéticamente predispuestos 1,2. La expresión histológica renal de la vasculitis sistémicas es una glomerulonefritis necrotizante pauciinmune (GNP) 3. Nosotros describimos dos casos de vasculitis familiar en dos hermanos procedentes de medio rural. " ] "en" => array:1 [ "resumen" => "To the editor: Etiopathogenesis of vasculitis is not fully understood, and environmental factors have been implicated in genetically predisposed individuals.1,2 The histological renal expression of systemic vasculitis is apauci-immune necrotizing glomerulonephritis (PNG).3 Two cases of familial vasculitis in two brothers living in a rural environment are reported here. " ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408004081/v0_201502091635/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000005/v0_201502091635/X2013251408004081/v0_201502091635/en/P-E-S-A373-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408004081?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 9 | 16 |
| 2024 October | 40 | 28 | 68 |
| 2024 September | 46 | 21 | 67 |
| 2024 August | 64 | 47 | 111 |
| 2024 July | 30 | 26 | 56 |
| 2024 June | 55 | 41 | 96 |
| 2024 May | 52 | 32 | 84 |
| 2024 April | 40 | 29 | 69 |
| 2024 March | 42 | 26 | 68 |
| 2024 February | 28 | 29 | 57 |
| 2024 January | 26 | 26 | 52 |
| 2023 December | 31 | 20 | 51 |
| 2023 November | 40 | 30 | 70 |
| 2023 October | 52 | 26 | 78 |
| 2023 September | 59 | 27 | 86 |
| 2023 August | 46 | 28 | 74 |
| 2023 July | 56 | 22 | 78 |
| 2023 June | 37 | 18 | 55 |
| 2023 May | 78 | 33 | 111 |
| 2023 April | 49 | 16 | 65 |
| 2023 March | 57 | 19 | 76 |
| 2023 February | 68 | 17 | 85 |
| 2023 January | 26 | 18 | 44 |
| 2022 December | 38 | 31 | 69 |
| 2022 November | 30 | 25 | 55 |
| 2022 October | 29 | 44 | 73 |
| 2022 September | 35 | 23 | 58 |
| 2022 August | 40 | 37 | 77 |
| 2022 July | 32 | 38 | 70 |
| 2022 June | 27 | 32 | 59 |
| 2022 May | 35 | 34 | 69 |
| 2022 April | 25 | 35 | 60 |
| 2022 March | 46 | 36 | 82 |
| 2022 February | 24 | 34 | 58 |
| 2022 January | 29 | 32 | 61 |
| 2021 December | 43 | 33 | 76 |
| 2021 November | 23 | 37 | 60 |
| 2021 October | 23 | 38 | 61 |
| 2021 September | 32 | 36 | 68 |
| 2021 August | 24 | 32 | 56 |
| 2021 July | 30 | 39 | 69 |
| 2021 June | 14 | 20 | 34 |
| 2021 May | 27 | 35 | 62 |
| 2021 April | 32 | 30 | 62 |
| 2021 March | 31 | 22 | 53 |
| 2021 February | 37 | 33 | 70 |
| 2021 January | 27 | 20 | 47 |
| 2020 December | 12 | 19 | 31 |
| 2020 November | 26 | 11 | 37 |
| 2020 October | 16 | 16 | 32 |
| 2020 September | 14 | 12 | 26 |
| 2020 August | 34 | 8 | 42 |
| 2020 July | 16 | 8 | 24 |
| 2020 June | 17 | 17 | 34 |
| 2020 May | 40 | 12 | 52 |
| 2020 April | 16 | 18 | 34 |
| 2020 March | 23 | 12 | 35 |
| 2020 February | 18 | 16 | 34 |
| 2020 January | 24 | 21 | 45 |
| 2019 December | 27 | 31 | 58 |
| 2019 November | 21 | 24 | 45 |
| 2019 October | 10 | 15 | 25 |
| 2019 September | 18 | 17 | 35 |
| 2019 August | 11 | 11 | 22 |
| 2019 July | 15 | 24 | 39 |
| 2019 June | 15 | 11 | 26 |
| 2019 May | 13 | 16 | 29 |
| 2019 April | 28 | 18 | 46 |
| 2019 March | 13 | 12 | 25 |
| 2019 February | 20 | 13 | 33 |
| 2019 January | 15 | 15 | 30 |
| 2018 December | 70 | 33 | 103 |
| 2018 November | 54 | 17 | 71 |
| 2018 October | 56 | 12 | 68 |
| 2018 September | 43 | 14 | 57 |
| 2018 August | 43 | 18 | 61 |
| 2018 July | 38 | 17 | 55 |
| 2018 June | 33 | 14 | 47 |
| 2018 May | 23 | 14 | 37 |
| 2018 April | 41 | 4 | 45 |
| 2018 March | 32 | 11 | 43 |
| 2018 February | 34 | 4 | 38 |
| 2018 January | 35 | 8 | 43 |
| 2017 December | 41 | 12 | 53 |
| 2017 November | 26 | 6 | 32 |
| 2017 October | 30 | 11 | 41 |
| 2017 September | 27 | 10 | 37 |
| 2017 August | 17 | 8 | 25 |
| 2017 July | 30 | 9 | 39 |
| 2017 June | 26 | 3 | 29 |
| 2017 May | 35 | 10 | 45 |
| 2017 April | 20 | 12 | 32 |
| 2017 March | 22 | 26 | 48 |
| 2017 February | 12 | 9 | 21 |
| 2017 January | 15 | 3 | 18 |
| 2016 December | 30 | 10 | 40 |
| 2016 November | 46 | 8 | 54 |
| 2016 October | 45 | 9 | 54 |
| 2016 September | 90 | 7 | 97 |
| 2016 August | 125 | 3 | 128 |
| 2016 July | 113 | 5 | 118 |
| 2016 June | 82 | 0 | 82 |
| 2016 May | 91 | 0 | 91 |
| 2016 April | 65 | 0 | 65 |
| 2016 March | 55 | 0 | 55 |
| 2016 February | 51 | 0 | 51 |
| 2016 January | 58 | 0 | 58 |
| 2015 December | 94 | 0 | 94 |
| 2015 November | 60 | 0 | 60 |
| 2015 October | 51 | 0 | 51 |
| 2015 September | 52 | 0 | 52 |
| 2015 August | 53 | 0 | 53 |
| 2015 July | 39 | 0 | 39 |
| 2015 June | 35 | 0 | 35 |
| 2015 May | 49 | 0 | 49 |
| 2015 April | 5 | 0 | 5 |
Show all
