HIV and dialysis: unfounde optimism or real change
HIV y diálisis: optimismo infundado o cambios reales
Read
7048
Timeswas read the article
2499
Total PDF
4549
Total HTML
Share statistics
array:21 [ "pii" => "X2013251408003897" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:479-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3726 "formatos" => array:3 [ "EPUB" => 277 "HTML" => 2843 "PDF" => 606 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X021169950800389X" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2008;28:479-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6682 "formatos" => array:3 [ "EPUB" => 307 "HTML" => 6014 "PDF" => 361 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "HIV y diálisis: optimismo infundado o cambios reales" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "479" "paginaFinal" => "482" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "HIV and dialysis: unfounde optimism or real change" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Bernis Carro" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Bernis Carro" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251408003897" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408003897?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950800389X?idApp=UINPBA000064" "url" => "/02116995/0000002800000005/v0_201502091416/X021169950800389X/v0_201502091416/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X201325140800391X" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:483-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3550 "formatos" => array:3 [ "EPUB" => 274 "HTML" => 2694 "PDF" => 582 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "The role of immunocompetent cell renal infiltration in the pathogenesis of arterial hypertension" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "483" "paginaFinal" => "492" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El papel de la infiltración renal de células inmunocompetentes en la patogenia de la hipertensión arterial" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bernardo Rodriguez-Iturbe" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Bernardo" "apellidos" => "Rodriguez-Iturbe" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508003912" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508003912?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325140800391X?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X201325140800391X/v0_201502091635/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251408003901" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2008-10-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2008;28:475-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4771 "formatos" => array:3 [ "EPUB" => 280 "HTML" => 3812 "PDF" => 679 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "The essential role of water treatment system (WTS) in the quality of water for hemodialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "475" "paginaFinal" => "478" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papel fundamental del Sistema de Tratamiento del Agua (STA) en la calidad del agua para hemodiálisis." ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rafael Pérez García" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Rafael" "apellidos" => "Pérez García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699508003904" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699508003904?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408003901?idApp=UINPBA000064" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408003901/v0_201502091635/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "HIV and dialysis: unfounde optimism or real change" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "479" "paginaFinal" => "482" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carmen Bernis Carro" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Carmen" "apellidos" => "Bernis Carro" "email" => array:1 [ 0 => "cbernis@senefro.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital de la Princesa Madrid, Madrid, España, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "HIV y diálisis: optimismo infundado o cambios reales" ] ] "textoCompleto" => "HIV disease is a health catastrophe.1 There are approximately 34 million people affected, with 2.5 million new infections and 2.1 million deaths every year.2 In countries with access to treatment, introduction of highly active antiretroviral therapy (HAART) has greatly improved survival.3 This treatment appears to have a long-term influence to decrease kidney disease, but for the time being, improved survival has resulted in an increase in the number of HIV-infected patients with ESRD who require dialysis.4 <br></br><br></br>In Spain, HIV patients account for 1.1% of all patients on dialysis. Sixty percent of these have HCV coinfection and 7% HBV coinfection, 86% are receiving HAART, the predominant procedure is hemodialysis, and 20% could meet transplant requirements.5,6 Quality of dialysis and safety measures against HIV and other viral infections have recently been addressed in a consensus document.7 <br></br><br></br>Survival on dialysis has improved after the HAART era. However, some authors have noted that this improvement <br></br>is smaller than would be expected if data from the population with no renal failure were extrapolated.8 Ahuja9 assessed 6166 HIV-positive patients dialyzed in the United States from 1990 to 1999 and found an improvement <br></br>in one-year survival from 56% to 74%. Macrea10 found that survival doubled in the Afro-American population. However, an ongoing study in Afro-Americans in Baltimore11 found no change. <br></br><br></br>Survival analysis in dialyzed HIV patients is complex. Recognized risk factors include age, Afro-American ascent, <br></br>CD4 count, disease stage, HCV coinfection, albumin levels, HAART treatment,8-15 and persistent drug addiction.16 While biopsied patients are unfortunately few, the type of renal lesion also has an influence on ESRD occurrence and patient survival, with the HIVAN type having the worst prognosis.17 <br></br><br></br>Adequate nutrition with albumin normalization maintains immune function and decreases complications, disease <br></br>progression, and mortality.18 Two meta-analyses recently reviewed the potential role of supplementation with <br></br>macro and micronutrients, but reported no conclusive results.19,20 Assessment of weight and BMI changes is considered important in HIV, and decreases are associated to a poorer prognosis.21 In patients on dialysis, weight changes are particularly complex to analyze, and evaluation with nPCR and impedance would be required.22,23 <br></br><br></br>Adequate, up-to-date antiretroviral treatment is possibly the greatest determinant of survival.3,4,24 Continuous advent of new drugs and characteristics of the population on dialysis make this treatment difficult, but a recent review on the subject is available.25 <br></br><br></br>The high number of dialyzed HIV patients without HAART treatment has recently been stressed.11,26 Patients theoretically receiving HAART but with a dosage poorly adapted to dialysis, usually with very low doses, represent <br></br>another problem.27 <br></br><br></br>As regards the type of procedure, hemodialysis (HD) has predominately been used, but comparisons to peritoneal <br></br>dialysis (PD)28,12 appear to show similar results. In a study on 6053 HIV patients dialyzed in the United States from 1995 to 1999 (88% on HD and 12% on PD), the same survival was found.28 A more recent study in which two small groups of HIV patients were followed up reported survival rates of 100%, 83%, and 50% at 1, 2, and 3 years respectively in PD patients; the respective values in HD patients were 75%, 33%, and 33%, and adjusted differences were not significant. 12 Both procedures therefore provide good results, and selection of one of them should therefore be made based on patient characteristics and preferences. <br></br><br></br>The greatest diversity in published data is found in complications in HIV patients on dialysis as compared to HIV-negative patients. Most old and many recent studies report a greater incidence of catheter infections, peritonitis, severe infections, and hospitalizations and a lower survival in HIVpositive as compared to HIV-negative <br></br>patients.8-10,14 However, some recent reports contradict these data. The French experience13 reported the same survival in hemodialysis for HIV patients than for the general population (89% at 2 years). In this issue, Rivera et al29 report their experience in treatment of HIV patients using peritoneal dialysis. Their results were particularly good, with no differences in hospitalization or number of peritonitis episodes as compared to negative patients and 1, 2, and 3-year survival rates of 100%, 62%, and 50%, similar to the rates reported in another recent population.12 <br></br><br></br>In HD, the ideal access would be a native arteriovenous fistula. No differences in infections have been seen in this subgroup as compared to HIV-negative patients with AVF.30 An analysis of bacteremia in patients with implanted <br></br>catheters found a greater incidence in HIV patients of infections caused by Gram-positive organisms and multiple <br></br>germs requiring hospital admission, but no differences in Gram-negative infections.31 <br></br><br></br>A final aspect is the increase in the causes of death not directly related to HIV, such as liver disease related to <br></br>coinfection by HCV, or cardiovascular disease in which antiretroviral medication has been implicated32-35 and that raises new preventive priorities.36-37 <br></br><br></br>The outlook allows for being optimistic because favorable changes have occurred in dialysis results in HIV. There are, however, widely different mortality results, possibly as an expression of subpopulations with different risk factors. Prospective studies with a comparative cohort are lacking. In this regard, we hope that the collaboration <br></br>started between the SEN and GESIDA for a prospective study with a comparative cohort in Spain will clarify some <br></br>issues. <br></br><br></br>Treatment of HIV patients with renal insufficiency is a challenge that nephrologists must address looking for multidisciplinary support to achieve an adequate HAART, a good nutrition, and a special attention to HCVinduced <br></br>liver disease, without forgetting the emerging cardiovascular morbidity. " "pdfFichero" => "P-E-S-A352-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La enfermedad por HIV es una catástrofe sanitaria (1).Existen unos 34 millones de afectados con 2.5 millones de nuevos infectados/año y 2.1 millones de muertos anuales. (2). En los países con acceso al tratamiento la introducción de la terapia antiviral de alta efectividad (TARVAE) ha mejorado mucho la supervivencia (3) Este tratamiento parece influir a largo plazo en la disminución de la nefropatía, pero de momento el resultado de la mejoría de la supervivencia ha sido el aumento de los pacientes HIV con IRC que precisan diálisis (4). " ] "en" => array:1 [ "resumen" => "HIV disease is a health catastrophe.1 There are approximately 34 million people affected, with 2.5 million new infections and 2.1 million deaths every year.2 In countries with access to treatment, introduction of highly active antiretroviral therapy (HAART) has greatly improved survival.3 This treatment appears to have a long-term influence to decrease kidney disease, but for the time being, improved survival has resulted in an increase in the number of HIV-infected patients with ESRD who require dialysis.4 " ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "1-DeCoockk K De Lay P:HIV/AIDS: a global disaster. Lancet2008;372:2" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "2.- HIV/AIDS estimates and the quest for universal access Lancet 2008; 371:2068-69" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "3 Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998; 338(13):853-60." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "6- Mazuecos A, Pascual J, Gómez E, Sola E, Cofán F, López F, Puig-Hooper CE, Baltar JM, González-Molina M, Oppenheimer F, Marcén R, Rivero M. Trasplante renal en pacientes con infección HIV en España. Nefrologia. 2006;26(1):113-20." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "10- Macrae J Friedman AL, Eggers P: Improved survival in HIV infected African-americans with ESRD.Clin Nephrol 2005; 64:124-8" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "25-Berns J, Kasbekar N: Highly active antiretroviral therapy and the kidney: an update on antiretroviral medications for nephrologists. Clin J Am Soc Nephrol 2006; 1:117-29" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "33- Crane HM, Van Rompaey SE, Kitahata MM. Antiretroviral medications associated with elevated blood pressure among patients receiving highly active antiretroviral therapy. AIDS. 2006 Apr 24;20(7):1019-26." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "34- Bergersen BM. Cardiovascular risk in patients with HIV Infection: impact of a antiretroviral therapy. Drugs. 2006;66(15):1971-87." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002800000005/v0_201502091635/X2013251408003897/v0_201502091635/en/main.assets" "Apartado" => array:4 [ "identificador" => "35428" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorial Comments" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002800000005/v0_201502091635/X2013251408003897/v0_201502091635/en/P-E-S-A352-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251408003897?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 9 | 19 |
| 2024 October | 35 | 53 | 88 |
| 2024 September | 44 | 58 | 102 |
| 2024 August | 56 | 89 | 145 |
| 2024 July | 33 | 47 | 80 |
| 2024 June | 40 | 53 | 93 |
| 2024 May | 43 | 49 | 92 |
| 2024 April | 45 | 35 | 80 |
| 2024 March | 37 | 26 | 63 |
| 2024 February | 43 | 43 | 86 |
| 2024 January | 28 | 34 | 62 |
| 2023 December | 34 | 38 | 72 |
| 2023 November | 31 | 37 | 68 |
| 2023 October | 38 | 45 | 83 |
| 2023 September | 33 | 34 | 67 |
| 2023 August | 25 | 40 | 65 |
| 2023 July | 34 | 52 | 86 |
| 2023 June | 29 | 41 | 70 |
| 2023 May | 33 | 42 | 75 |
| 2023 April | 24 | 24 | 48 |
| 2023 March | 29 | 29 | 58 |
| 2023 February | 20 | 18 | 38 |
| 2023 January | 30 | 26 | 56 |
| 2022 December | 42 | 30 | 72 |
| 2022 November | 36 | 34 | 70 |
| 2022 October | 30 | 44 | 74 |
| 2022 September | 28 | 50 | 78 |
| 2022 August | 38 | 42 | 80 |
| 2022 July | 26 | 54 | 80 |
| 2022 June | 34 | 35 | 69 |
| 2022 May | 17 | 38 | 55 |
| 2022 April | 22 | 35 | 57 |
| 2022 March | 40 | 51 | 91 |
| 2022 February | 23 | 35 | 58 |
| 2022 January | 28 | 45 | 73 |
| 2021 December | 40 | 52 | 92 |
| 2021 November | 27 | 45 | 72 |
| 2021 October | 32 | 33 | 65 |
| 2021 September | 23 | 36 | 59 |
| 2021 August | 18 | 34 | 52 |
| 2021 July | 34 | 27 | 61 |
| 2021 June | 16 | 22 | 38 |
| 2021 May | 19 | 27 | 46 |
| 2021 April | 40 | 35 | 75 |
| 2021 March | 47 | 28 | 75 |
| 2021 February | 26 | 13 | 39 |
| 2021 January | 26 | 17 | 43 |
| 2020 December | 11 | 12 | 23 |
| 2020 November | 22 | 9 | 31 |
| 2020 October | 11 | 12 | 23 |
| 2020 September | 17 | 7 | 24 |
| 2020 August | 26 | 7 | 33 |
| 2020 July | 17 | 4 | 21 |
| 2020 June | 28 | 17 | 45 |
| 2020 May | 29 | 6 | 35 |
| 2020 April | 18 | 20 | 38 |
| 2020 March | 31 | 11 | 42 |
| 2020 February | 23 | 14 | 37 |
| 2020 January | 35 | 20 | 55 |
| 2019 December | 28 | 25 | 53 |
| 2019 November | 33 | 30 | 63 |
| 2019 October | 9 | 9 | 18 |
| 2019 September | 22 | 18 | 40 |
| 2019 August | 17 | 12 | 29 |
| 2019 July | 18 | 22 | 40 |
| 2019 June | 16 | 8 | 24 |
| 2019 May | 21 | 11 | 32 |
| 2019 April | 53 | 29 | 82 |
| 2019 March | 16 | 15 | 31 |
| 2019 February | 18 | 13 | 31 |
| 2019 January | 35 | 16 | 51 |
| 2018 December | 49 | 39 | 88 |
| 2018 November | 56 | 23 | 79 |
| 2018 October | 52 | 16 | 68 |
| 2018 September | 60 | 20 | 80 |
| 2018 August | 47 | 21 | 68 |
| 2018 July | 35 | 13 | 48 |
| 2018 June | 34 | 14 | 48 |
| 2018 May | 34 | 16 | 50 |
| 2018 April | 29 | 9 | 38 |
| 2018 March | 33 | 10 | 43 |
| 2018 February | 25 | 6 | 31 |
| 2018 January | 23 | 6 | 29 |
| 2017 December | 30 | 12 | 42 |
| 2017 November | 26 | 5 | 31 |
| 2017 October | 32 | 9 | 41 |
| 2017 September | 36 | 14 | 50 |
| 2017 August | 27 | 9 | 36 |
| 2017 July | 36 | 12 | 48 |
| 2017 June | 21 | 16 | 37 |
| 2017 May | 49 | 11 | 60 |
| 2017 April | 42 | 8 | 50 |
| 2017 March | 22 | 19 | 41 |
| 2017 February | 22 | 6 | 28 |
| 2017 January | 14 | 5 | 19 |
| 2016 December | 62 | 10 | 72 |
| 2016 November | 52 | 9 | 61 |
| 2016 October | 59 | 18 | 77 |
| 2016 September | 107 | 7 | 114 |
| 2016 August | 139 | 2 | 141 |
| 2016 July | 104 | 3 | 107 |
| 2016 June | 88 | 0 | 88 |
| 2016 May | 133 | 0 | 133 |
| 2016 April | 83 | 0 | 83 |
| 2016 March | 86 | 0 | 86 |
| 2016 February | 100 | 0 | 100 |
| 2016 January | 117 | 0 | 117 |
| 2015 December | 107 | 0 | 107 |
| 2015 November | 101 | 0 | 101 |
| 2015 October | 66 | 0 | 66 |
| 2015 September | 72 | 0 | 72 |
| 2015 August | 58 | 0 | 58 |
| 2015 July | 50 | 0 | 50 |
| 2015 June | 34 | 0 | 34 |
| 2015 May | 47 | 0 | 47 |
| 2015 April | 10 | 0 | 10 |
Show all
