array:21 [
  "pii" => "X2013251407022024"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2007-12-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2007;27:694-703"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2974
    "formatos" => array:3 [
      "EPUB" => 255
      "HTML" => 2115
      "PDF" => 604
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699507022027"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2007-12-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2007;27:694-703"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6042
        "formatos" => array:3 [
          "EPUB" => 285
          "HTML" => 5104
          "PDF" => 653
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "titulo" => "Alteraciones en el metabolismo mineral óseo en pacientes con urolitiasis de repetición y polimorfismos del gen del receptor de la vitamina D. Resultados preliminares."
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "694"
            "paginaFinal" => "703"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Changes in bone mineral metabolism in patients with recurrent urolithiasis and vitamin D receptor gene polymorphisms. Preliminary results"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
            "autores" => array:1 [
              0 => array:1 [
                "nombre" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251407022024"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022024?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507022027?idApp=UINPBA000064"
      "url" => "/02116995/0000002700000006/v0_201502091324/X0211699507022027/v0_201502091324/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251407021989"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2007-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2007;27:704-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3212
      "formatos" => array:3 [
        "EPUB" => 247
        "HTML" => 2432
        "PDF" => 533
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "OUR EXPERIENCE IN PRIMARY HYPERALDOSTERONISM"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "704"
          "paginaFinal" => "709"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "NUESTRA EXPERIENCIA EN EL HIPERALDOSTERONISMO PRIMARIO"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sandra Gallego, Adelardo Covarsí, Juan Luengo*, Petri González, Miguel Angel Suarez, Ricardo Novillo"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "Sandra Gallego, Adelardo Covarsí, Juan Luengo*, Petri González, Miguel Angel Suarez, Ricardo Novillo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699507021981"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507021981?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021989?idApp=UINPBA000064"
    "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407021989/v0_201502091551/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X2013251407022149"
    "issn" => "20132514"
    "estado" => "S300"
    "fechaPublicacion" => "2007-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2007;27:689-93"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2681
      "formatos" => array:3 [
        "EPUB" => 257
        "HTML" => 2037
        "PDF" => 387
      ]
    ]
    "en" => array:6 [
      "idiomaDefecto" => true
      "titulo" => "Reality and future in the treatment of advanced chronic renal disease"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "689"
          "paginaFinal" => "693"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "REALIDAD Y FUTURO EN EL TRATAMIENTO DE LA ENFERMEDAD RENAL CRÓNICA AVANZADA (ERCA)."
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael Selgas, Jesús Aguilar, Juan Carlos Julián, Alejandro Toledo"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "Rafael Selgas, Jesús Aguilar, Juan Carlos Julián, Alejandro Toledo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:8 [
        "pii" => "X0211699507022141"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507022141?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022149?idApp=UINPBA000064"
    "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407022149/v0_201502091551/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Changes in bone mineral metabolism in patients with recurrent urolithiasis and vitamin D receptor gene polymorphisms. Preliminary results"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "694"
        "paginaFinal" => "703"
      ]
    ]
    "autores" => array:1 [
      0 => array:2 [
        "autoresLista" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
        "autores" => array:1 [
          0 => array:1 [
            "nombre" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alteraciones en el metabolismo mineral óseo en pacientes con urolitiasis de repetición y polimorfismos del gen del receptor de la vitamina D. Resultados preliminares."
      ]
    ]
    "pdfFichero" => "P-E-S-A4945-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436105"
          "palabras" => array:1 [
            0 => "Palabras clave: Litiasis renal cálcica, hipercalciuria absortiva, hipercalciuria renal, densidad mineral ósea, polimorfismos del receptor de la vitami"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436106"
          "palabras" => array:6 [
            0 => "Key words: Calcium kidney stone disease"
            1 => "Absortive hypercalciuria"
            2 => "Renal hypercalciuria"
            3 => "Bone mineral density"
            4 => "Calcium intake"
            5 => "Vitamin D polymorphism"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "SUMMARY Bone health, within calcium kidney stone disease is a matter of controversy. On the other hand, some genetic studies have shown an association between some Vitamin D receptor polymorphisms and calcium kidney stone disease. Main objective: To study the possible association between calcium kidney stone disease with bone metabolism and some Vitamin D receptor polymorphisms. Patients and Methods: This is a case-control study, with seventy-two subjects of both genders divided into two groups: Group I: cases, composed by 51 patients suffering from calcium kidney stone disease. Twenty-four of them had no hypercalciuria, 16 had absortive hypercalciuria and 11 had renal hypercalciuria. Group II: controls, composed by 21 people, without either urolithiasis or hypercalciuria. We performed a complete study including biochemical markers of bone mineral remodelling, bone mineral density (BMD) was estimated both in the lumbar spine (L2-L4) and femoral neck, and also VDR polymorphism for the loci b, a and t. Results: Patients with urolithiasis had lower values of BMD both in the lumbar spine and femoral neck, compared to controls. Z-score were lower in the lumbar spine and femoral neck (p =0,045 y 0,031, respectively). Those patients with absorptive hypercalciuria had higher BMD in the femoral neck than those with renal hypercalciuria and non-hypercalciuria. Because they had more weight and height all the statistical study was performed alter adjusting by these two variables and statistical significance was then only stated between patients with hypercalciuria and without it. Patients with urolithiasis had higher values of 1,25 (OH)2 vitamin D (p=0,002), and lower of PTH (p=0,049), without any relationship to hypercalciuria and its subtypes. Seventy six percent of the patients had a daily calcium intake lower than 800 mg/day. The distribution of VDR alleles in patients with urolithiasis was similar to controls, although after grouping genotypes, a lower distribution of BB and tt polymorphisms were observed in patients suffering from urolithiasis. Conclusions: Calcium kidney stone disease by itself produces a decrease in BMD, more intense in femoral neck, independently the presence or absence of hypercalciuria. Patients suffering from urolitihiasis have higher values of 1,25 (OH)2 vitamin D than non-hypercalciuric patients and lower values of PTH probably due to a low dietary calcium intake. In our population studied there is no relationship between VDR polymorphisms and the presence of calcium kidney stone disease. Because the reduced number of patients of our study, more studies are needed to obtain definitely conclusions. "
      ]
      "es" => array:1 [
        "resumen" => "Existe controversia sobre la afectación ósea en la litiasis renal cálcica. Por otro lado, algunos estudios genéticos han encontrado asociación entre los polimorfismos del receptor de la vitamina D (VDR) y la urolitiasis. Objetivo principal: Relacionar la nefrolitiasis cálcica de repetición con el metabolismo óseo y los polimorfismos del gen del VDR. Material y métodos: Estudio de casos y controles, estando el grupo de casos formado por 51 pacientes con litiasis renal de repetición, que subdividimos en no hipercalciúricos (NHC, n = 27), hipercalciúricos absortivos (HCA, n = 10) e hipercalciúricos renales (HCR, n = 14)&#59; el grupo control, formado por 21 sujetos sin historia de litiasis renal ni hipercalciuria. Se les determinaron parámetros del metabolismo fosfo-cálcico, marcadores de remodelado óseo, densidad mineral ósea (DMO) en columna lumbar y en cuello femoral, y polimorfismos del gen del VDR para los loci b, a y t. Resultados: Los pacientes litiásicos presentaron frente a los controles una DMO inferior tanto en L2-L4 como en cuello femoral (Z-score, p = 0,045 y 0,031), niveles superiores de 1,25 (OH)2 vitamina D (p = 0,002) e inferiores de PTH (p = 0,049), y una menor ingesta cálcica (p < 0,001). Los HCA mostraron una mayor DMO frente a los NHC (sólo significativo en cuello femoral). Los pacientes con LRC no mostraron diferencias en las frecuencias genotípicas estudiadas frente a los controles. Al reagrupar los alelos, sólo se apreció una menor frecuencia del genotipo BB respecto al Bb-bb, y del tt frente al TT-Tt, en los pacientes litiásicos (p = 0,098 y p = 0,051, respectivamente). Conclusiones: La litiasis renal cálcica parece influir en la DMO de cuello femoral. Los pacientes litiásicos mostraron niveles elevados de 1,25 (OH)2 vitamina D, posiblemente relacionado con la baja dieta cálcica. Los genotipos homocigóticos BB y tt parecen ser menos frecuentes entre los pacientes con litiasis renal cálcica."
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407022024/v0_201502091551/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000006/v0_201502091551/X2013251407022024/v0_201502091551/en/P-E-S-A4945-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022024?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Changes in bone mineral metabolism in patients with recurrent urolithiasis and vitamin D receptor gene polymorphisms. Preliminary results
Alteraciones en el metabolismo mineral óseo en pacientes con urolitiasis de repetición y polimorfismos del gen del receptor de la vitamina D. Resultados preliminares.
Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen
Read
6130
Times
was read the article
2276
Total PDF
3854
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251407022024"
  "issn" => "20132514"
  "doi" => " "
  "estado" => "S300"
  "fechaPublicacion" => "2007-12-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2007;27:694-703"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2974
    "formatos" => array:3 [
      "EPUB" => 255
      "HTML" => 2115
      "PDF" => 604
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699507022027"
      "issn" => "02116995"
      "doi" => " "
      "estado" => "S300"
      "fechaPublicacion" => "2007-12-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2007;27:694-703"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6042
        "formatos" => array:3 [
          "EPUB" => 285
          "HTML" => 5104
          "PDF" => 653
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "titulo" => "Alteraciones en el metabolismo mineral óseo en pacientes con urolitiasis de repetición y polimorfismos del gen del receptor de la vitamina D. Resultados preliminares."
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "694"
            "paginaFinal" => "703"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Changes in bone mineral metabolism in patients with recurrent urolithiasis and vitamin D receptor gene polymorphisms. Preliminary results"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
            "autores" => array:1 [
              0 => array:1 [
                "nombre" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251407022024"
          "doi" => " "
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022024?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507022027?idApp=UINPBA000064"
      "url" => "/02116995/0000002700000006/v0_201502091324/X0211699507022027/v0_201502091324/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251407021989"
    "issn" => "20132514"
    "doi" => " "
    "estado" => "S300"
    "fechaPublicacion" => "2007-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2007;27:704-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3212
      "formatos" => array:3 [
        "EPUB" => 247
        "HTML" => 2432
        "PDF" => 533
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "OUR EXPERIENCE IN PRIMARY HYPERALDOSTERONISM"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "704"
          "paginaFinal" => "709"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "NUESTRA EXPERIENCIA EN EL HIPERALDOSTERONISMO PRIMARIO"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sandra Gallego, Adelardo Covarsí, Juan Luengo*, Petri González, Miguel Angel Suarez, Ricardo Novillo"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "Sandra Gallego, Adelardo Covarsí, Juan Luengo*, Petri González, Miguel Angel Suarez, Ricardo Novillo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699507021981"
        "doi" => " "
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507021981?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021989?idApp=UINPBA000064"
    "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407021989/v0_201502091551/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X2013251407022149"
    "issn" => "20132514"
    "estado" => "S300"
    "fechaPublicacion" => "2007-12-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2007;27:689-93"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2681
      "formatos" => array:3 [
        "EPUB" => 257
        "HTML" => 2037
        "PDF" => 387
      ]
    ]
    "en" => array:6 [
      "idiomaDefecto" => true
      "titulo" => "Reality and future in the treatment of advanced chronic renal disease"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "689"
          "paginaFinal" => "693"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "REALIDAD Y FUTURO EN EL TRATAMIENTO DE LA ENFERMEDAD RENAL CRÓNICA AVANZADA (ERCA)."
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael Selgas, Jesús Aguilar, Juan Carlos Julián, Alejandro Toledo"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "Rafael Selgas, Jesús Aguilar, Juan Carlos Julián, Alejandro Toledo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:8 [
        "pii" => "X0211699507022141"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507022141?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022149?idApp=UINPBA000064"
    "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407022149/v0_201502091551/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Changes in bone mineral metabolism in patients with recurrent urolithiasis and vitamin D receptor gene polymorphisms. Preliminary results"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "694"
        "paginaFinal" => "703"
      ]
    ]
    "autores" => array:1 [
      0 => array:2 [
        "autoresLista" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
        "autores" => array:1 [
          0 => array:1 [
            "nombre" => "Mª Jesús Moyano Franco, Mª Jesús Gómez de Tejada Romero, Raúl García Lozano, Rosa Moruno, Rosa Ortega, Vicente Martí, Rocío Sánchez Palen"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alteraciones en el metabolismo mineral óseo en pacientes con urolitiasis de repetición y polimorfismos del gen del receptor de la vitamina D. Resultados preliminares."
      ]
    ]
    "pdfFichero" => "P-E-S-A4945-EN.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec436105"
          "palabras" => array:1 [
            0 => "Palabras clave: Litiasis renal cálcica, hipercalciuria absortiva, hipercalciuria renal, densidad mineral ósea, polimorfismos del receptor de la vitami"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec436106"
          "palabras" => array:6 [
            0 => "Key words: Calcium kidney stone disease"
            1 => "Absortive hypercalciuria"
            2 => "Renal hypercalciuria"
            3 => "Bone mineral density"
            4 => "Calcium intake"
            5 => "Vitamin D polymorphism"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "SUMMARY Bone health, within calcium kidney stone disease is a matter of controversy. On the other hand, some genetic studies have shown an association between some Vitamin D receptor polymorphisms and calcium kidney stone disease. Main objective: To study the possible association between calcium kidney stone disease with bone metabolism and some Vitamin D receptor polymorphisms. Patients and Methods: This is a case-control study, with seventy-two subjects of both genders divided into two groups: Group I: cases, composed by 51 patients suffering from calcium kidney stone disease. Twenty-four of them had no hypercalciuria, 16 had absortive hypercalciuria and 11 had renal hypercalciuria. Group II: controls, composed by 21 people, without either urolithiasis or hypercalciuria. We performed a complete study including biochemical markers of bone mineral remodelling, bone mineral density (BMD) was estimated both in the lumbar spine (L2-L4) and femoral neck, and also VDR polymorphism for the loci b, a and t. Results: Patients with urolithiasis had lower values of BMD both in the lumbar spine and femoral neck, compared to controls. Z-score were lower in the lumbar spine and femoral neck (p =0,045 y 0,031, respectively). Those patients with absorptive hypercalciuria had higher BMD in the femoral neck than those with renal hypercalciuria and non-hypercalciuria. Because they had more weight and height all the statistical study was performed alter adjusting by these two variables and statistical significance was then only stated between patients with hypercalciuria and without it. Patients with urolithiasis had higher values of 1,25 (OH)2 vitamin D (p=0,002), and lower of PTH (p=0,049), without any relationship to hypercalciuria and its subtypes. Seventy six percent of the patients had a daily calcium intake lower than 800 mg/day. The distribution of VDR alleles in patients with urolithiasis was similar to controls, although after grouping genotypes, a lower distribution of BB and tt polymorphisms were observed in patients suffering from urolithiasis. Conclusions: Calcium kidney stone disease by itself produces a decrease in BMD, more intense in femoral neck, independently the presence or absence of hypercalciuria. Patients suffering from urolitihiasis have higher values of 1,25 (OH)2 vitamin D than non-hypercalciuric patients and lower values of PTH probably due to a low dietary calcium intake. In our population studied there is no relationship between VDR polymorphisms and the presence of calcium kidney stone disease. Because the reduced number of patients of our study, more studies are needed to obtain definitely conclusions. "
      ]
      "es" => array:1 [
        "resumen" => "Existe controversia sobre la afectación ósea en la litiasis renal cálcica. Por otro lado, algunos estudios genéticos han encontrado asociación entre los polimorfismos del receptor de la vitamina D (VDR) y la urolitiasis. Objetivo principal: Relacionar la nefrolitiasis cálcica de repetición con el metabolismo óseo y los polimorfismos del gen del VDR. Material y métodos: Estudio de casos y controles, estando el grupo de casos formado por 51 pacientes con litiasis renal de repetición, que subdividimos en no hipercalciúricos (NHC, n = 27), hipercalciúricos absortivos (HCA, n = 10) e hipercalciúricos renales (HCR, n = 14)&#59; el grupo control, formado por 21 sujetos sin historia de litiasis renal ni hipercalciuria. Se les determinaron parámetros del metabolismo fosfo-cálcico, marcadores de remodelado óseo, densidad mineral ósea (DMO) en columna lumbar y en cuello femoral, y polimorfismos del gen del VDR para los loci b, a y t. Resultados: Los pacientes litiásicos presentaron frente a los controles una DMO inferior tanto en L2-L4 como en cuello femoral (Z-score, p = 0,045 y 0,031), niveles superiores de 1,25 (OH)2 vitamina D (p = 0,002) e inferiores de PTH (p = 0,049), y una menor ingesta cálcica (p < 0,001). Los HCA mostraron una mayor DMO frente a los NHC (sólo significativo en cuello femoral). Los pacientes con LRC no mostraron diferencias en las frecuencias genotípicas estudiadas frente a los controles. Al reagrupar los alelos, sólo se apreció una menor frecuencia del genotipo BB respecto al Bb-bb, y del tt frente al TT-Tt, en los pacientes litiásicos (p = 0,098 y p = 0,051, respectivamente). Conclusiones: La litiasis renal cálcica parece influir en la DMO de cuello femoral. Los pacientes litiásicos mostraron niveles elevados de 1,25 (OH)2 vitamina D, posiblemente relacionado con la baja dieta cálcica. Los genotipos homocigóticos BB y tt parecen ser menos frecuentes entre los pacientes con litiasis renal cálcica."
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000002700000006/v0_201502091551/X2013251407022024/v0_201502091551/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000006/v0_201502091551/X2013251407022024/v0_201502091551/en/P-E-S-A4945-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407022024?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
DOI:
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 9 14
2024 October 31 53 84
2024 September 49 45 94
2024 August 52 77 129
2024 July 32 30 62
2024 June 44 33 77
2024 May 58 37 95
2024 April 34 31 65
2024 March 40 23 63
2024 February 41 39 80
2024 January 38 30 68
2023 December 29 21 50
2023 November 29 28 57
2023 October 32 46 78
2023 September 18 30 48
2023 August 31 22 53
2023 July 39 37 76
2023 June 46 28 74
2023 May 59 34 93
2023 April 22 21 43
2023 March 46 17 63
2023 February 23 17 40
2023 January 26 25 51
2022 December 30 31 61
2022 November 35 23 58
2022 October 25 48 73
2022 September 35 24 59
2022 August 41 43 84
2022 July 25 36 61
2022 June 27 23 50
2022 May 32 31 63
2022 April 33 30 63
2022 March 36 40 76
2022 February 27 38 65
2022 January 29 31 60
2021 December 31 33 64
2021 November 25 31 56
2021 October 31 42 73
2021 September 25 31 56
2021 August 20 34 54
2021 July 35 35 70
2021 June 23 17 40
2021 May 27 45 72
2021 April 39 34 73
2021 March 36 23 59
2021 February 22 45 67
2021 January 22 16 38
2020 December 13 23 36
2020 November 21 13 34
2020 October 12 15 27
2020 September 12 9 21
2020 August 29 13 42
2020 July 21 6 27
2020 June 16 22 38
2020 May 21 18 39
2020 April 22 15 37
2020 March 25 13 38
2020 February 25 24 49
2020 January 28 21 49
2019 December 29 23 52
2019 November 17 20 37
2019 October 7 19 26
2019 September 19 17 36
2019 August 3 16 19
2019 July 17 22 39
2019 June 6 9 15
2019 May 16 20 36
2019 April 28 43 71
2019 March 15 18 33
2019 February 13 19 32
2019 January 11 12 23
2018 December 31 35 66
2018 November 31 16 47
2018 October 40 17 57
2018 September 38 19 57
2018 August 23 16 39
2018 July 23 11 34
2018 June 17 17 34
2018 May 27 14 41
2018 April 26 11 37
2018 March 21 7 28
2018 February 23 7 30
2018 January 26 4 30
2017 December 34 11 45
2017 November 24 6 30
2017 October 17 6 23
2017 September 32 7 39
2017 August 16 5 21
2017 July 20 11 31
2017 June 18 15 33
2017 May 15 17 32
2017 April 22 17 39
2017 March 17 11 28
2017 February 12 15 27
2017 January 17 4 21
2016 December 35 3 38
2016 November 30 5 35
2016 October 39 2 41
2016 September 64 2 66
2016 August 89 9 98
2016 July 96 9 105
2016 June 78 0 78
2016 May 95 0 95
2016 April 66 0 66
2016 March 53 0 53
2016 February 73 0 73
2016 January 81 0 81
2015 December 88 0 88
2015 November 84 0 84
2015 October 75 0 75
2015 September 56 0 56
2015 August 66 0 66
2015 July 59 0 59
2015 June 35 0 35
2015 May 55 0 55
2015 April 6 0 6
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?