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        "resumen" => "ABSTRACT: The aim of this paper is to analyze the ways of appearance, clinical characteristics, diagnosis and treatment related to patients suffering from primary hyperaldosteronism (HA1º) in external nephrology consultation since their opening. METHODOLOGY: a retrospective study was carried out, checking out all HA1º diagnosed patients of clinical records from 1981-2005. RESULTS: 35 patients were diagnosed, with an average age of 50 and a predominance of men (82%). The main reason for starting the HA1º study was persistent hypertension&#59; other reasons were hypertension and hypopotassemia (34%). Sixteen of the cases were adenomas (7 classic adenomas and 9 renin-dependents) and fourteen of them were hyperplasia (10 bilateral hyperplasias and 4 primary adrenals hyperplasia). Five cases were excluded because they were waiting for complementary tests. For location diagnosis, gammagrafía I131cholesterol was the test showing more agreement with final diagnosis, and then RMN and TAC. In eight of the cases, an adrenal vein sampling was made. Ten of sixteen adenomas suffered a surgery performance. The result showed standardization of tensional levels, without any treatment in 60% of the cases. The rest of them are currently treated with spironolactone under an appropriate tensional control. Gynecomastia was the most usual adverse effect found. CONCLUSION: Contrary to other published papers, we found out a male predominance in our database. A similar incidence of adenomas e hyperplasias was obtained. The most usual way of appearance was persistent hypertension to treatment. Adenomas surgery does not imply healing results, though it achieves a better tensional levels control, using less drugs and diminishing aldosterone levels. It implies a descent in myocardic and vascular toxicity. "
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OUR EXPERIENCE IN PRIMARY HYPERALDOSTERONISM
NUESTRA EXPERIENCIA EN EL HIPERALDOSTERONISMO PRIMARIO
Sandra Gallego, Adelardo Covarsí, Juan Luengo*, Petri González, Miguel Angel Suarez, Ricardo Novillo
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    "titulo" => "OUR EXPERIENCE IN PRIMARY HYPERALDOSTERONISM"
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        "resumen" => "ABSTRACT: The aim of this paper is to analyze the ways of appearance, clinical characteristics, diagnosis and treatment related to patients suffering from primary hyperaldosteronism (HA1º) in external nephrology consultation since their opening. METHODOLOGY: a retrospective study was carried out, checking out all HA1º diagnosed patients of clinical records from 1981-2005. RESULTS: 35 patients were diagnosed, with an average age of 50 and a predominance of men (82%). The main reason for starting the HA1º study was persistent hypertension&#59; other reasons were hypertension and hypopotassemia (34%). Sixteen of the cases were adenomas (7 classic adenomas and 9 renin-dependents) and fourteen of them were hyperplasia (10 bilateral hyperplasias and 4 primary adrenals hyperplasia). Five cases were excluded because they were waiting for complementary tests. For location diagnosis, gammagrafía I131cholesterol was the test showing more agreement with final diagnosis, and then RMN and TAC. In eight of the cases, an adrenal vein sampling was made. Ten of sixteen adenomas suffered a surgery performance. The result showed standardization of tensional levels, without any treatment in 60% of the cases. The rest of them are currently treated with spironolactone under an appropriate tensional control. Gynecomastia was the most usual adverse effect found. CONCLUSION: Contrary to other published papers, we found out a male predominance in our database. A similar incidence of adenomas e hyperplasias was obtained. The most usual way of appearance was persistent hypertension to treatment. Adenomas surgery does not imply healing results, though it achieves a better tensional levels control, using less drugs and diminishing aldosterone levels. It implies a descent in myocardic and vascular toxicity. "
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        "resumen" => "Objetivo: Analizar las formas de presentación, características clínicas, diagnóstico y tratamiento de los pacientes diagnosticados de hiperaldosteronismo primario (HA1º) en la consulta externa de nefrología desde su apertura. Método: Se realizó un estudio retrospectivo revisando todas las historias clínicas de pacientes diagnosticados de HA1º desde 1981-2005. Resultados: Se diagnosticaron un total de 35 pacientes con una edad media de 50 años con predominio de varones (82%). El motivo principal de inicio de estudio de HA1º fue la hipertensión arterial (HTA) rebelde, seguido de hipertensión más hipopotasemia(34%). Dieciséis casos eran adenomas (7 adenomas clásicos y 9 renino-dependientes) y 14 hiperplasias (10 hiperplasias bilaterales y 4 hiperplasias adrenales primarias). Cinco casos fueron excluidos del estudio por encontrarse en el momento de realización del estudio pendientes de pruebas complementarias. Para diagnóstico de localización la prueba que mostró más concordancia con el diagnóstico final fue la gammgrafía I-131colesterol seguida de la RMN y la TAC. En 8 casos se realizó muestreo venoso suprarrenal. Fueron intervenidos 10 de los 16 adenomas con resultado de normalización de cifras tensionales sin tratamiento en el 60% de ellos. El resto de los casos se encuentran en tratamiento con espironolactona con adecuado control tensional. El efecto adverso más frecuente fue la ginecomastia. Conclusión: En contra de lo publicado en la literatura, en nuestra serie observamos un claro predominio de varones. Obtuvimos una similar incidencia de adenomas e hiperplasias. La forma de presentación más frecuente fue la hipertensión arterial rebelde al tratamiento. La opción quirúrgica de los adenomas no significa un resultado curativo, pero sí un mejor control de las cifras tensionales con menos fármacos y una disminución de los niveles de aldosterona con el consiguiente descenso de la toxicidad miocárdica y vascular."
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Article information
ISSN: 20132514
Original language: English
DOI:
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Idiomas
Nefrología (English Edition)