Stress oxidative analysis in patients on hemodiafiltration on-line
ANÁLISIS DEL ESTRÉS OXIDATIVO EN PACIENTES EN HEMODIAFILTRACION EN LINEA
Eduardo Torregrosa de Juan, Julio Hernández Jaras, Juan Sastre Belloch, Ramón Pons Prades, Hector García Calvo, Consuelo Calvo Gordo, Mª
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However, the traditional risk factors are not the only one explanation. Nowadays, there are new risk factors becoming, and one of these is the oxidative stress. Besides today we know that when these patients receive haemodialysis are being exposed to an additional oxidative stress. The aim of this study was to mesure and to compare the degree of oxidative stress in two groups of patients on different dialysis techniques: a)On-Line Haemodiafiltration three times / week (OL-HDF). b)Daily Om-Line haemodiafiltration ( six times / week ) ( dOL-HDF) We studied 9 patients with chronic renal disease stage 5 on hemodialysis. They all were men, with a medium age of 72,5 ± 6 years. Five patiens were on dOL-HDFand four on tOL-HDF. Glutathione (GSH) concentration of patients on dOL-HDF before dialysis was 742± 153 nmol/ml and post-dialysis de 878± 223. Blood GSSG concentration before and after dialysis was 34± 14 nmol/ml y 137± 74 nmol/ml (p < 0,03). GSSG/GSH ratio pre-dialysis was 58±10 and post-dialysis 169±65 ( p < 0,03). In OL-HDF group GSSG concentration and the ratio GSSG/GSH also increased in a significative way from 99±45 nmol/ml to 179±66 nmol/ml, and from 161± 99 to 337±143 ( p <0 05 we also found differences in pcr concentrations between both groups 3 1 4 g l dol-hdf and 8 75 5 hdf ol p < 0,05). We did not find differences between xatine-oxidase activity before and after hemodialysis and between groups. In conclusion, patient with terminal chronic renal disease on OL-HDF receive an additional load of oxidative stress, as the increase in GSSG/GSH ratio in both groups shows. However patients on dHDF-OL shows low ratios GSSG/GSH post-hemodialysis and low pCR concentrations, and maybe this could be explained because daily on line haemodiafiltration improves purification of inflammatory mediators. Clue words: Hemodialysis, oxidative stress, glutathione, gssg/gsh ratio, xantine oxidasa </0>" ] "es" => array:1 [ "resumen" => "Los pacientes afectos de enfermedad renal crónica presentan una elevada morbimortalidad debido a enfermedades cardiovasculares. Sin embargo, la elevada presencia de estas enfermedades no puede explicarse únicamente por los factores de riesgo tradicionales. En la actualidad, se considera la existencia de factores de riesgo emergentes, entre los que se encuentra el estrés oxidativo. Además se sabe que cuando reciben tratamiento con hemodiálisis, se ven sometidos a un estrés oxidativo adicional. El objetivo de este trabajo ha sido analizar y comparar el grado de estrés oxidativo en dos grupos de pacientes urémicos dializados con diferentes técnicas dialíticas: a. Hemodiafiltración on-line 3 veces/semana (HDFOL). b. Hemodiafiltración on-line diaria 6 veces semana(HDFOLD). Se estudiaron 9 pacientes afectos de enfermedad renal crónica terminal (Estadio 5), todos ellos varones con una edad media de 72,5 ± 6 años. Cinco pacientes pertenecían al grupo de HDFOLD y cuatro al grupo de HDFOL tres veces por semana. Los pacientes del grupo de HDF-OLD presentaban las siguientes concentraciones de glutatión reducido (GSH) en sangre, pre-diálisis de 742 ± 153 nmol/ml y post-diálisis de 878 ± 223, sin detectarse diferencias significativas entre ambos. Las concentraciones pre y post-diálisis de glutatión oxidado (GSSG) en sangre eran de 34 ± 14 nmol/ml y 137 ± 74 nmol/ml respectivamente (p < 0,03). Los cocientes GSSG/GSH obtenidos fueron: pre-diálisis de 58 ± 10 y post-diálisis 169 ± 65, con diferencias entre ambos valores (p < 0,03). Los pacientes del grupo HDF-OL 3 veces/semana también presentaron un incremento significativo de la concentración de GSSG y del ratio GSSG/GSH tras la sesión de diálisis, de 99 ± 45 nmol/ml a 179 ± 66 nmol/ml y de 161 ± 99 y a 337 ± 143, respectivamente (p < 0,05). La mediana de los valores de proteína C reactiva eran de 4,12 g/l en el grupo HDFOLD y 7,7 g/l en grupo de HDFOL (p < 0,05). No encontramos diferencias estadisticas en la actividad de la xantina oxidasa entre grupos ni tras la sesión de hemodiálisis. En resumen, podemos concluir que los pacientes afectos de enfermedad renal crónica terminal que reciben tratamiento sustitutivo se encuentran sometidos a un estrés oxidativo adicional, como muestra el incremento en los ratios GSSG/GSH en ambos grupos. Sin embargo los pacientes en el grupo HDFOLD presentan cocientes GSSG/GSH post-hemodiálisis y valores de PCR inferiores, lo que sugiere que la hemodiálisis diaria podría mejorar la depuración de medidores inflamatorios." ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002700000005/v0_201502091551/X2013251407021676/v0_201502091551/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000005/v0_201502091551/X2013251407021676/v0_201502091551/en/P-E-S-A4910-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021676?idApp=UINPBA000064" ]
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