Are IL2 receptor antagonist useful in high risk acute tubular necrosis kidney recipients?
RESPUESTA ESTRUCTURADA A PREGUNTAS CLÍNICAS (CAT: CRITICAL APPRAISAL TOPICS) : EN RECEPTORES CON ALTO RIESGO DE DESARROLLAR NECROSIS TUBULAR AGUDA (NTA) POST-TRASPLANTE ¿ES ÚTIL LA INDUCCIÓN CON ANTICUERPOS CONTRA EL RECEPTOR DE LA INTERLEUKINA DOS?
Ana Fernandez, Ana Royuela, Almudena Quintás, Zamora Javier
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To answer the first question we have come to information from registry and uni or multicenter studies. We have used the Irish normograme that included 16 clinical questions from donors, recipients and kidney transplant. We concluded that age of donors increases likelihood of delayed graft function. The second question is answered in the literature with information of a meta-analysis with 38 clinical studies. Of them 9 (1.380 patients) studied delayed graft function and are against placebo. The odds ratio for delayed graft function was 0.87(IC 95% 0,72 a 1,06). Therefore, at the moment, we can conclude that the utilization of antagonists of Il-2 receptors does not have protective effect to NTA." ] "es" => array:1 [ "resumen" => "Se plantea si los receptores añosos de donantes añosos tienen más incidencia de NTA y si el uso de antagonistas del receptor de la IL2 contribuiría a disminuir la incidencia de función renal retrasada. Para responder a la primera cuestión se ha acudido a datos publicados de registros y a estudios uni o multicéntricos y se ha seleccionado el normograma de Irish que integra 16 variables clínicas del donante, receptor y trasplante, y se concluye que la edad del donante aumenta la probabilidad de desarrollar NTA. La segunda cuestión está respondida en la literatura en un meta-análisis que incluye 38 ensayos clínicos. De estos solamente 9 estudios (1.380 pacientes) registran la incidencia de función renal retrasada y están realizados contra placebo. En este subgrupo el riesgo relativo de padecer función renal retrasada en pacientes en los que se utilizan anticuerpos contra el receptor de la IL-2 vs placebo no alcanzó la significación estadística (0,87 IC95% 0,72 a 1,06). Por lo que de momento y hasta nuevos análisis podemos concluir que la utilización de antagonistas del receptor de la IL2 no tiene efecto protector para la aparición de NTA." ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002700000005/v0_201502091551/X2013251407021668/v0_201502091551/en/main.assets" "Apartado" => null "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021668?idApp=UINPBA000064" ]
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ISSN: 20132514Original language: English
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