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However, the prevalence of other glomerulopathies mediated by immunocomplexes has increased in the last years. We report on the glomerular diseases observed in HIV patients in our Hospital. Methods: A retrospective study of all patients with HIV infection and glomerular diseases diagnosed by renal biopsy. Results: We found 27 patients with the following glomerular diseases: membranoproliferative glomerulonephritis (MPGN) in 8 patients, non-collapsing focal segmental glomerulosclerosis (FSGS) in 7, IgA nephropaty (IgA N) in 6, collapsing glomerulosclerosis in 4 (HIVAN, and membranous nephropaty (MN) in 2. Most of patients were young white men. A high prevalence of coinfection with hepatitis C virus (HCV) (77.8%) and hepatitis B virus (HBV) (37%) was found. At diagnosis, most of patients (90%) had proteinuria, with nephrotic syndrome in 52% of them; 59% presented with acute renal failure. Nine patients (33%) showed malignant hypertension at diagnosis: this complication was particularly common among IgA N patients (4/6, 66%).Conclusion: In our Hospital, immunocomplex-mediated glomerulonephritis were more frequent than HIVAN among HIV-infected patients. HCV-associated MPGN was the most frequently detected glomerular disease. A high prevalence of malignant hypertension was observed at diagnosis, particularly among patients with IgAN. " ] "es" => array:1 [ "resumen" => "RESUMEN: La nefropatía asociada al VIH (HIVAN) es la causa más común de insuficiencia renal crónica en los pacientes VIH de raza negra. Sin embargo, en los últimos años la prevalencia de otras glomerulopatías asociadas a inmunocomplejos ha ido en aumento. Nuestro estudio describe la patología glomerular en los pacientes VIH de nuestro centro. Material y métodos: estudio retrospectivo de pacientes VIH con afectación glomerular confirmada mediante biopsia renal. Resultados: Se detectaron 27 pacientes en los que se habían diagnosticado las siguientes glomerulopatías: glomerulonefritis membranoproliferativa (GNMP) en 8, glomeruloesclerosis focal y segmentaria no colapsante (GSF) en 7, nefropatía mesangial IgA (GNIgA) en 6, glomeruloesclerosis colapsante (HIVAN) en 4 y glomerulonefritis membranosa (GNM) en 2. La mayoría de los casos eran varones jóvenes de raza blanca. Destaca una alta coinfección con el virus de la hepatitis C (VHC) (77.8%) y con el virus de la hepatitis B (VHB) (37 %). En el momento del diagnóstico la mayoría de los pacientes presentaba proteinuria (96%), con síndrome nefrótico en el 52% de los casos, y un 59% presentaba un deterioro agudo de la función renal. Nueve pacientes (33%) presentaron HTA maligna al diagnóstico, siendo particularmente frecuente esta complicación entre los pacientes con GNIgA (4/6, 66%). Conclusiones: las glomerulopatías más frecuentes en nuestra población VIH son las asociadas a inmunocomplejos, sobre todo la GNMP asociada a la infección por el VHC. La HTA maligna tiene una alta incidencia en los pacientes VIH, más marcada en los pacientes con nefropatía mesangial IgA. " ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002700000004/v0_201502091551/X2013251407021609/v0_201502091551/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000004/v0_201502091551/X2013251407021609/v0_201502091551/en/P-E-S-A4677-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021609?idApp=UINPBA000064" ]
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