Effects of mycophenolate mofetil in renal failure acute ischemia in rats
Efectos del micofenolato mofetil en la insuficiencia renal aguda isquémica en ratas
Maribel Chávez-Velásquez, Héctor Pons, Marianela Medina, Yasmir Quiroz, Gustavo Parra, José Herrera
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=> "xpalclavsec436240" "palabras" => array:1 [ 0 => "Insuficiencia Renal Aguda, Inmunosupresión, Sistema Inmunitario, Linfocitos T, Micofenolato Mofetil" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec436241" "palabras" => array:1 [ 0 => "Index Words: renal failure acute, immunosupression, Immune System, lymphocytes T, mycophenolate mofetil" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Abstract. Mycophenolate mofetil (MMF) is a purine synthesis inhibitor commonly used as immunosupresive agent in transplantation. Kidney grafts undergo more or less prolonged cold ischemia after harvesting which results in variable degrees of ischemia reperfusion injury. To determine whether the inhibition of early events of cellular infiltration may influence the severity of damage induced by ischemic acute renal failure, 45 Sprague Dawley rats were given MMF at a dose of 20mg/kg/day (MMF-rats) by gavage 2 days before (pre-MMF group, n=15) or after (post-MMF group, n=15) clamping the left renal artery for 40 minutes followed by rigt-sided nephrectomy. (control group, n=15) received vehicle. Serum Creatinine (Screat) was measured daily in all groups. On the 2nd post-ischemic day Screat was significantly lower (p=0.001) in pre-MMF group compared with post-MMF group and control group (4 +/- 2mg/dl post-MMF group vs 1.7 +/- 1.2 mg/dl pre-MMF group, control group 5+/-2, p < 0.05). Kidney biopsies shown that the histologic damage was 54 +/- 28% in post-MMF group vs 34+/- 22% in pre-MMF group and 61 +/- 25% in control group (pre-MMF vs post-MMF, p NS). On the 5th day post-ischemic, MMF-rats showed more severe tubulointerstitial necrosis (pre-MMF group: 17 +/- 20 %, post-MMF group: 33 +/- 27%) than controls (4 +/- 5%). The severity of ATN was significantly higher in post-MMF group compared with controls (p=0.01). Tubulointersticial T-lymphocyte (T CD 5) and monocyte (ED 1) infiltration evaluated on the 2nd post-ischemic day was less intense in group I (T CD5: 3 +/- 3, ED 1: 10 +/- 9, cel/mm2) compared to post-MMF group (T CD 5: 10 +/- 4, ED 1: 55 +/- 40) and to control group (T CD 5: 10+/- 4, ED 1: 64 +/- 46). However, on the 5th post-ischemia day, ED 1 infiltration was significantly higher in post-MMF group (24 +/- 18%) compared to pre-MMF group (5 +/- 5, p NS) and also in pre-MMF group vs control group (31 +/- 33, p < 0.05). Our results suggest that MMF given before a renal ischemic insult may reduce the severity of histologic damage resulting from ischemia reperfusion injury." ] "es" => array:1 [ "resumen" => "Resumen. El micofenolato mofetil (MMF) es un inhibidor de la síntesis de las purinas comúnmente usado como inmunosupresor. Previo al trasplante, el riñón es sometidos a períodos variables de isquemia, resultando en daño tisular por isquemia-reperfusión. Para determinar si la inhibición de infiltración celular temprana están implicados en la evolución de la IRA isquemica, esta se indujo en ratas Sprague Dawley por oclusión del pedículo renal izquierdo durante 40 minutos con nefrectomía derecha, se le administró MMF (20mg/Kg/día por gavage) 2 días previos a la isquemia (MMF-pre, n=15), post-isquemia (MMF-post, n=15) o vehículo (control, n=15). La creatinina sérica (CS) fue medida diariamente en todos los grupos. Al segundo día postisquemia la CS fue significativamente mas baja en el grupo MMF-pre con respecto al grupo MMF-post y control. El análisis histológico reveló que el daño histológico fue (34 +/- 22 en el MMF-pre vs 54 +/- 28% MMF-post, p NS). Al quinto día las ratas pre-tratadas y post-tratadas con MMF presentaron mayor necrosis tubulointersticial que en el control (17 +/- 20 vs 33 +/- 27, en el control 4 +/- 5%). La infiltración de linfocitos T y monocitos (CD5 y ED 1 respectivamente) fue menor en animales pre-tratados con MMF, mientras en el grupo post-tratado y control fue mayor al segundo y quinto día. Así, en el intersticio a los 2 días, las células T CD5 fueron 10 +/- 4cel/ mm2 en el MMF-post vs 3 +/- 3 en el MMF-pre (p < 0.01), en el control 10 +/- 4. A los 5 días no hubo diferencias significativas entre los grupos. Las células ED1 fueron 55 +/- 40 cel/ mm2 en el MMF-post vs 10 +/- 9 en e MMF-pre, en el grupo control 64 +/- 46. (p <0 05 a los 5 días se mantuvo menor infiltración en el mmf-pre - cel mm2 vs 24 18 mmf-post grupo control 31 33 estos resultados sugieren que tratamiento con mmf previo la inducción de isquemia-reperfusión puede mejorar daño renal temprano 2</0>" ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002700000004/v0_201502091551/X2013251407021594/v0_201502091551/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000004/v0_201502091551/X2013251407021594/v0_201502091551/en/P-E-S-A4366-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021594?idApp=UINPBA000064" ]
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