Mycophenolate mofetil in the treatment of lupus nephritis, in patients with failure, intolerance or relapses after treatment with steroids and cyclophosphamide
Micofenolato mofetil en el tratamiento de la nefritis lúpica en pacientes con fracaso, intolerancia o recidivas tras tratamiento con esteroides y ciclofosfamida
Santiago Suria González Nefrología Hospital Universitario Insular de Gran Canaria, María Dolores Checa Andrés Nefrología Hospital Universitario Insu
Read
7132
Timeswas read the article
2986
Total PDF
4146
Total HTML
Share statistics
array:21 [ "pii" => "X2013251407021586" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2007-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2007;27:459-65" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2888 "formatos" => array:3 [ "EPUB" => 201 "HTML" => 2031 "PDF" => 656 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699507021589" "issn" => "02116995" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2007-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2007;27:459-65" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 12450 "formatos" => array:3 [ "EPUB" => 285 "HTML" => 10836 "PDF" => 1329 ] ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Micofenolato mofetil en el tratamiento de la nefritis lúpica en pacientes con fracaso, intolerancia o recidivas tras tratamiento con esteroides y ciclofosfamida" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "459" "paginaFinal" => "465" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mycophenolate mofetil in the treatment of lupus nephritis, in patients with failure, intolerance or relapses after treatment with steroids and cyclophosphamide" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Santiago Suria González Nefrología Hospital Universitario Insular de Gran Canaria, María Dolores Checa Andrés Nefrología Hospital Universitario Insu" "autores" => array:1 [ 0 => array:1 [ "nombre" => "Santiago Suria González Nefrología Hospital Universitario Insular de Gran Canaria, María Dolores Checa Andrés Nefrología Hospital Universitario Insu" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251407021586" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021586?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507021589?idApp=UINPBA000064" "url" => "/02116995/0000002700000004/v0_201502091325/X0211699507021589/v0_201502091325/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251407021578" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2007-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2007;27:466-71" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2821 "formatos" => array:3 [ "EPUB" => 216 "HTML" => 1986 "PDF" => 619 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Either calcium carbonate or sevelamer decreases urinary oxalate excretion in chronic renal failure patients" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "466" "paginaFinal" => "471" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carbonato cálcico o sevelamer reducen la excreción urinaria de oxalato en pacientes con insuficiencia renal avanzada" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Caravaca, Ana Belén Ruiz, Jose María Escola, Román Hernández-Gallego, Isis Cerezo, Noemí Fernández, Sergio Barroso, María Vic" "autores" => array:1 [ 0 => array:1 [ "nombre" => "Francisco Caravaca, Ana Belén Ruiz, Jose María Escola, Román Hernández-Gallego, Isis Cerezo, Noemí Fernández, Sergio Barroso, María Vic" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699507021570" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507021570?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021578?idApp=UINPBA000064" "url" => "/20132514/0000002700000004/v0_201502091551/X2013251407021578/v0_201502091551/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251407021594" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2007-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2007;27:448-58" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2859 "formatos" => array:3 [ "EPUB" => 214 "HTML" => 2092 "PDF" => 553 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Effects of mycophenolate mofetil in renal failure acute ischemia in rats" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "448" "paginaFinal" => "458" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos del micofenolato mofetil en la insuficiencia renal aguda isquémica en ratas" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maribel Chávez-Velásquez, Héctor Pons, Marianela Medina, Yasmir Quiroz, Gustavo Parra, José Herrera" "autores" => array:1 [ 0 => array:1 [ "nombre" => "Maribel Chávez-Velásquez, Héctor Pons, Marianela Medina, Yasmir Quiroz, Gustavo Parra, José Herrera" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699507021597" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699507021597?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021594?idApp=UINPBA000064" "url" => "/20132514/0000002700000004/v0_201502091551/X2013251407021594/v0_201502091551/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Mycophenolate mofetil in the treatment of lupus nephritis, in patients with failure, intolerance or relapses after treatment with steroids and cyclophosphamide" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "459" "paginaFinal" => "465" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Santiago Suria González Nefrología Hospital Universitario Insular de Gran Canaria, María Dolores Checa Andrés Nefrología Hospital Universitario Insu" "autores" => array:1 [ 0 => array:1 [ "nombre" => "Santiago Suria González Nefrología Hospital Universitario Insular de Gran Canaria, María Dolores Checa Andrés Nefrología Hospital Universitario Insu" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Micofenolato mofetil en el tratamiento de la nefritis lúpica en pacientes con fracaso, intolerancia o recidivas tras tratamiento con esteroides y ciclofosfamida" ] ] "pdfFichero" => "P-E-S-A4550-EN.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec436242" "palabras" => array:5 [ 0 => "Lupus eritematoso sistémico" 1 => "Nefritis lúpica" 2 => "Micofenolato mofetil" 3 => "Esteroides" 4 => "Ciclofosfamida" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec436243" "palabras" => array:5 [ 0 => "Systemic lupus erythematosus" 1 => "Lupus nephritis" 2 => "Mycophenolate mofetil" 3 => "Steroids" 4 => "Cyclophosphamide" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Intravenous cyclophosphamide (IVCP) in combination with oral steroids (ST) is the most widely accepted therapy for severe lupus nephritis (LN); however, its side effects, lack of response and relapses, have led to other treatment alternatives. being sought. Mycophenolate mofetil (MMF) has been shown to be effective in these cases. We studied the course over 12 months of 28 patients with LN WHO class III(n=3), IV(n=22) or V(n=3), with 38,1 ± 11,4 tears of age, proteinuria 4,2 ± 2,6 g /24 hours and serum creatinine 1,4 ± 0,8 mg/dL, who, after being initially treated with ST and IVCP, showed no response(n=21), frequent relapses(n=6), or adverse side effects(n=1). All patients were treated with MMF in doses of 1000 to 2000 mg/day combined with ST or cyclosporine for one year. Four patients withdrew from treatment before the end of the follow-up. None of the patients who completed the study showed changes in hematologic parameters. Creatinine and creatinine clearance remained stable. Resulted in a significant improvement; serum albumine (3 ± 0,8 vs 3,9 ± 0,5 g/dL) p <0 01 and decreased of proteinuria 4 2 6 vs 1 8 g 24 hours p <0 05 complement fractions improvement significantly c3 and ch50 p <0 05 c4 p <0 01 antinuclear antibodies ana and anti-dna decreased significantly p <0 05 during follow-up a reduction in the st dose was achieved: 18 3 10 5 vs 1 4 mg 24h p <0 01 three mild side effects related to mmf were observed and only 1 case required discontinuation of treatment we concluded that is a useful drug in the control lupus nephritis which also allows for significant reduction dose st with minimal</0> </0> </0> </0> </0> </0>" ] "es" => array:1 [ "resumen" => "La asociación de Esteroides orales y Ciclofosfamida intravenosa en bolos, es la pauta terapéutica más aceptada en la Nefritis Lúpica severa. Los efectos secundarios, así como los casos de falta de respuesta y recidivas han hecho que se busquen otras alternativas terapéuticas. El Micofenolato Mofetil se ha mostrado eficaz en estos casos. Hemos estudiado la evolución, a lo largo de 12 meses, de 28 pacientes afectos de Nefritis Lúpica clase III(n=3), IV(n=22) y V(n=3), según la clasificación de la Organización Mundial de la Salud, con edad de 38,1 ± 11,4 años, todos presentaban proteinuria y en la mitad de ellos era mayor de 3,5 g/24 horas, la creatinina sérica fue 1,4 ± 0,8 mg/dL. Habiendo sido tratados inicialmente con esteroides y Ciclofosfamida intravenosa en bolos, habían presentado falta de respuesta(n=21), recidivas frecuentes(n=6), o efectos secundarios adversos(n=1). Todos ellos han sido tratados, durante 12 meses, con Micofenolato Mofetil con dosis de 1000 a 2000 mg/día asociado a esteroides o Ciclosporina durante un año. Cuatro pacientes abandonaron el tratamiento antes de finalizar el periodo. Observamos incremento de albúmina sérica 3 ± 0,8 vs 3,9 ± 0,5 g/dL), p <0 01 descenso de la proteinuria en 24 horas 4 2 6 vs 1 8 g p <0 05 las fracciones del complemento mejoraron c3 y ch50 p <0 05 c4 p <0 01 los anticuerpos anti nucleares y dna descendieron de forma significativa p <0 05 a lo largo del seguimiento se logro una reducción de la dosis esteroides: 18 3 10 5 vs 1 4 mg 24h p <0 01 se observaron 3 acontecimientos adversos leves relacionados con el mmf y solo 1 caso precisó suspensión del tratamiento concluimos que micofenolato mofetil es un fármaco útil en control de la nefritis lúpica permite además una reducción significativa dosis esteroides mínimos efectos secundarios</0> </0> </0> </0> </0> </0>" ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002700000004/v0_201502091551/X2013251407021586/v0_201502091551/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002700000004/v0_201502091551/X2013251407021586/v0_201502091551/en/P-E-S-A4550-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251407021586?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 15 | 21 |
| 2024 October | 41 | 122 | 163 |
| 2024 September | 55 | 111 | 166 |
| 2024 August | 65 | 176 | 241 |
| 2024 July | 36 | 95 | 131 |
| 2024 June | 55 | 105 | 160 |
| 2024 May | 47 | 55 | 102 |
| 2024 April | 45 | 47 | 92 |
| 2024 March | 32 | 43 | 75 |
| 2024 February | 36 | 47 | 83 |
| 2024 January | 40 | 39 | 79 |
| 2023 December | 62 | 36 | 98 |
| 2023 November | 47 | 53 | 100 |
| 2023 October | 24 | 64 | 88 |
| 2023 September | 26 | 49 | 75 |
| 2023 August | 55 | 54 | 109 |
| 2023 July | 41 | 78 | 119 |
| 2023 June | 102 | 51 | 153 |
| 2023 May | 93 | 57 | 150 |
| 2023 April | 74 | 37 | 111 |
| 2023 March | 72 | 25 | 97 |
| 2023 February | 19 | 20 | 39 |
| 2023 January | 22 | 30 | 52 |
| 2022 December | 33 | 35 | 68 |
| 2022 November | 28 | 24 | 52 |
| 2022 October | 26 | 51 | 77 |
| 2022 September | 33 | 28 | 61 |
| 2022 August | 29 | 33 | 62 |
| 2022 July | 34 | 46 | 80 |
| 2022 June | 23 | 39 | 62 |
| 2022 May | 26 | 31 | 57 |
| 2022 April | 32 | 38 | 70 |
| 2022 March | 36 | 52 | 88 |
| 2022 February | 35 | 35 | 70 |
| 2022 January | 30 | 36 | 66 |
| 2021 December | 35 | 37 | 72 |
| 2021 November | 27 | 34 | 61 |
| 2021 October | 27 | 45 | 72 |
| 2021 September | 45 | 36 | 81 |
| 2021 August | 23 | 25 | 48 |
| 2021 July | 26 | 34 | 60 |
| 2021 June | 26 | 19 | 45 |
| 2021 May | 29 | 20 | 49 |
| 2021 April | 57 | 44 | 101 |
| 2021 March | 40 | 21 | 61 |
| 2021 February | 29 | 15 | 44 |
| 2021 January | 38 | 20 | 58 |
| 2020 December | 12 | 14 | 26 |
| 2020 November | 23 | 8 | 31 |
| 2020 October | 17 | 11 | 28 |
| 2020 September | 21 | 7 | 28 |
| 2020 August | 20 | 10 | 30 |
| 2020 July | 24 | 9 | 33 |
| 2020 June | 22 | 13 | 35 |
| 2020 May | 30 | 15 | 45 |
| 2020 April | 36 | 21 | 57 |
| 2020 March | 34 | 8 | 42 |
| 2020 February | 37 | 17 | 54 |
| 2020 January | 48 | 15 | 63 |
| 2019 December | 15 | 17 | 32 |
| 2019 November | 22 | 9 | 31 |
| 2019 October | 18 | 4 | 22 |
| 2019 September | 13 | 18 | 31 |
| 2019 August | 18 | 10 | 28 |
| 2019 July | 11 | 17 | 28 |
| 2019 June | 11 | 7 | 18 |
| 2019 May | 14 | 25 | 39 |
| 2019 April | 44 | 21 | 65 |
| 2019 March | 8 | 11 | 19 |
| 2019 February | 4 | 14 | 18 |
| 2019 January | 14 | 10 | 24 |
| 2018 December | 30 | 27 | 57 |
| 2018 November | 28 | 11 | 39 |
| 2018 October | 41 | 19 | 60 |
| 2018 September | 36 | 5 | 41 |
| 2018 August | 19 | 15 | 34 |
| 2018 July | 18 | 28 | 46 |
| 2018 June | 15 | 16 | 31 |
| 2018 May | 20 | 14 | 34 |
| 2018 April | 10 | 16 | 26 |
| 2018 March | 10 | 10 | 20 |
| 2018 February | 13 | 20 | 33 |
| 2018 January | 11 | 11 | 22 |
| 2017 December | 14 | 24 | 38 |
| 2017 November | 8 | 21 | 29 |
| 2017 October | 9 | 28 | 37 |
| 2017 September | 11 | 14 | 25 |
| 2017 August | 10 | 19 | 29 |
| 2017 July | 11 | 12 | 23 |
| 2017 June | 16 | 28 | 44 |
| 2017 May | 15 | 20 | 35 |
| 2017 April | 10 | 16 | 26 |
| 2017 March | 12 | 17 | 29 |
| 2017 February | 5 | 20 | 25 |
| 2017 January | 8 | 13 | 21 |
| 2016 December | 27 | 11 | 38 |
| 2016 November | 35 | 7 | 42 |
| 2016 October | 73 | 9 | 82 |
| 2016 September | 63 | 6 | 69 |
| 2016 August | 93 | 4 | 97 |
| 2016 July | 103 | 7 | 110 |
| 2016 June | 87 | 0 | 87 |
| 2016 May | 95 | 0 | 95 |
| 2016 April | 85 | 0 | 85 |
| 2016 March | 70 | 0 | 70 |
| 2016 February | 82 | 0 | 82 |
| 2016 January | 62 | 0 | 62 |
| 2015 December | 91 | 0 | 91 |
| 2015 November | 79 | 0 | 79 |
| 2015 October | 76 | 0 | 76 |
| 2015 September | 45 | 0 | 45 |
| 2015 August | 80 | 0 | 80 |
| 2015 July | 45 | 0 | 45 |
| 2015 June | 42 | 0 | 42 |
| 2015 May | 50 | 0 | 50 |
| 2015 April | 5 | 0 | 5 |
Show all
