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    "titulo" => "Acute renal rejection is associated with induction of replicative senescence in CD8+ T lymphocytes"
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        "resumen" => "Durante el rechazo renal agudo las células T CD8+ son activadas de forma mantenida pudiendo desencadenar un proceso de senescencia replicativa. En este trabajo nosotros hemos evaluado varias características de senescencia replicativa como es : a) porcentaje de células T CD28-&#59; b) acortamiento telomérico, y c) producción de citoquinas proinflamatorias. Este estudio se realizó en 14 pacientes con rechazo renal agudo, 14 pacientes sin rechazo renal agudo y 8 controles sanos. Los resultados indicaron que los pacientes con rechazo renal agudo mostraban altos porcentajes de células T CD28-CD8+ en sangre periférica y biopsia renal. Estos pacientes mostraron telómeros cortos que se asociaban con el fenotipo CD28-. Además, los pacientes con rechazo renal agudo presentaban altas concentraciones de IL-10 e IFN-ã en plasma y orina. Nuestro estudio demuestra que las células T CD8+ de pacientes con rechazo renal agudo sufren un proceso de senescencia replicativa."
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        "resumen" => "Acute renal rejection repeatedly activates immunocompromised CD8 + T cells. Maintained activation of CD8 + T cells can induce a process of replicative senescence. In the present study, we will evaluate in CD8 lymphocytes from patients undergoing acute renal rejection characteristics of replicative senescence such as: a) low expression of CD28 molecule&#59; b) telomere shortening and c) increase production of proinflammatory cytokines. The study was carried out in CD8 + T cells from 14 patients transplanted without clinical evidences of acute renal rejection, 14 patients kidney transplanted with clinical and anatomopathological evidences of acute renal rejection, 8 healthy controls. The results shown that in peripheral blood and renal biopsy of patients with acute renal rejection there is a significant increment of the population of T cells CD28-CD8+, with short telomere length, as compared with healthy controls and patients without acute renal rejection. The presence of senescent cells was associated with high levels of IL-10 and IFN-Y in plasma and urine. In conclusion our study suggest that the CD8 + T cells of patients with acute renal rejection suffer a process of replicative senescence."
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