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        "resumen" => "Background: The nitric oxide synthase (NOS3) G894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism. We tested for a significant contribution to blood pressure values for the NOS3 G894T and 4a/b gene polymorphisms and whether those changes could explain the modulating effect on tHcy concentrations. Patients and methods: We analyzed 158 healthy men. The NOS3 gene polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment analysis (G894T) and by PCR (4a/b). Total homocysteine concentrations were evaluated by the fluorescence polarization immunoassay method. Results: In our population we did not obtain a significant contribution of the G894T to blood pressure variations. However, tHcy mean concentration values differed according G894T genotypes (P = 0.01). Interestingly, we did not obtain a significant modulating effect on tHcy concentrations according to 4a/b genotypes although the 4a/b genotype distribution was statistically associated with blood pressure variations. Conclusion: Our results showed a modulating effect of the NOS3 4a/b gene variant on tHcy concentrations that is at least partially provoked by discrete blood pressure increments. Nevertheless, our multivariate analysis did not show a statistical significant role for the NOS3 G894T gene polymorphism on tHcy concentrations."
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Arterial blood pressure variations: homocysteine and nitric oxide synthase gene polymorphisms (NOS3)
Presión arterial, homocisteína y variantes polimórficas del gen de la óxido nítrico sintasa (NOS3)
F.J. Rodríguez Esparragón, J.C. Rodríguez Pérez, A. Macías Reyes, Y. Hernández Trujillo, M. González Leiza, A. Caballero Hidalgo
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    "titulo" => "Arterial blood pressure variations: homocysteine and nitric oxide synthase gene polymorphisms (NOS3)"
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        "titulo" => "Presión arterial, homocisteína y variantes polimórficas del gen de la óxido nítrico sintasa (NOS3)"
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        "resumen" => "Background: The nitric oxide synthase (NOS3) G894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism. We tested for a significant contribution to blood pressure values for the NOS3 G894T and 4a/b gene polymorphisms and whether those changes could explain the modulating effect on tHcy concentrations. Patients and methods: We analyzed 158 healthy men. The NOS3 gene polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment analysis (G894T) and by PCR (4a/b). Total homocysteine concentrations were evaluated by the fluorescence polarization immunoassay method. Results: In our population we did not obtain a significant contribution of the G894T to blood pressure variations. However, tHcy mean concentration values differed according G894T genotypes (P = 0.01). Interestingly, we did not obtain a significant modulating effect on tHcy concentrations according to 4a/b genotypes although the 4a/b genotype distribution was statistically associated with blood pressure variations. Conclusion: Our results showed a modulating effect of the NOS3 4a/b gene variant on tHcy concentrations that is at least partially provoked by discrete blood pressure increments. Nevertheless, our multivariate analysis did not show a statistical significant role for the NOS3 G894T gene polymorphism on tHcy concentrations."
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        "resumen" => "Fundamento y objetivo: El polimorfismo G894T en el gen humano NOS3 se ha sugerido como un determinante genético que contribuye a modular las variaciones de las concentraciones de homocisteína (tHcy) a través de un efecto indirecto sobre el catabolismo del folato. Nos planteamos estudiar la contribución de las variantes NOS3 G894T y 4a/b a las variaciones de presión arterial y la contribución de estas variaciones a la modulación de concentraciones de tHcy. Pacientes y métodos: Analizamos 158 hombres sanos. Los genotipos de los polimorfismos NOS3 se determinaron mediante amplificación por reacción en cadena de la polimerasa (PCR) y posterior digestión enzimática (G894T) y por PCR (4a/b). Las concentraciones de tHcy mediante inmunofluorescencia polarizada. Resultados: En nuestra población la variante G894T no parece contribuir de forma significativa a las variaciones de presión arterial, pero obtuvimos una gradación de concentraciones de tHcy en función de los genotipos G894T (P = 0,01). No obtuvimos un efecto modulador significativo sobre los niveles de tHcy para la variante 4a/b, si bien su contribución a la variación de cifras de presión arterial resultó estadísticamente significativa. Conclusiones: Nuestros resultados muestran un efecto modulador de la variante 4a/b en el gen NOS3 sobre la variación de concentraciones de tHcy que se produce, parcialmente y a expensas de incrementos de valores de presión arterial. En análisis multivariante, el papel del polimorfismo G894T del gen NOS3 sobre la modulación de las concentraciones de tHcy, no resultó sin embargo estadísticamente relevante."
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Article information
ISSN: 20132514
Original language: English
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