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        "resumen" => "Numerosos estudios han demostrado que los niveles plasmáticos de cistatina C (CisC) son más precisos que los niveles de creatinina (Cr) en la estimación del filtrado glomerlar (FG). Este hecho parece particularmente cierto en casos de disfunción renal leve-moderada, aunque es menos conocida su precisión en casos de insuficiencia renal avanzada. El objetivo de este estudio fue determinar la precisión de la CisC plasmática para estimar el FG en pacientes con enfermedad renal crónica avanzada. Se estudiaron 94 pacientes (57 mujeres) con insuficiencia renal avanzada. La edad media fue 61 ± 16 años. Ningún paciente presentaba alteraciones funcionales tiroideas o estaba en tratamiento con corticoides. Se midió el FG mediante Tc99mDTPA, determinando simultáneamente las concentraciones plasmáticas de Cr (reacción cinética modificada de Jaffé), y CisC (inmunonefelometría). Los niveles de Cr y CisC se correlacionaron con el FG, y se analizó la influencia del sexo, edad y diagnóstico de diabetes en los residuales de estas correlaciones. El valor predictivo tanto de la Cr como de la CisC para diagnosticar un FG < 15 ml/min/1,73 m2 fue analizado mediante curvas ROC, determinando las áreas bajo las curvas y sus significaciones estadísticas. El FG medio fue 16,49 ± 4,65 ml/min/1,73 m2. Las concentraciones medias de Cr y CisC fueron respectivamente: 4,19 ± 1,19 mg/L y 3,44 ± 0,73 mg/L. Tanto la Cr como la CisC se correlacionaron significativamente con el FG (R = 0,49&#59; p < 0,0001 y R = 0,52&#59; p < 0,0001 respectivamente). La edad y sexo influyeron en la correlación entre Cr y FG, pero no en la correlación entre CisC y FG. El área bajo la curva de predicción para un FG < 15 ml/min/1,73 m2 con la Cr fue 0,675 (p = 0,004), mientras que con la CisC fue 0,633 (p = 0,030). En conclusión, las concentraciones séricas de CisC son igual de imprecisas que las de Cr para la estimación del FG en la enfermedad renal crónica avanzada."
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Cystatin C as a renal function estimator in advanced chronic renal failure stages
CISTATINA C COMO ESTIMADOR DE LA FUNCIÓN RENAL EN ESTADIOS AVANZADOS DE ENFERMEDAD RENAL CRÓNICA
M.V. Martín, S Barroso, O Herráez, F de Sande, F Caravaca
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      "titulo" => "Albuminuria and cardiovascular risk: results of the KORAL-CARDIO study"
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          "titulo" => "Albuminuria y riesgo cardiovascular. Estudio Koral-Cardio"
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          "autoresLista" => "J.R. González-Juanatey, Eduardo Alegría Ezquerra, José Luis Zamorano Gómez, Vicente Bertomeu González, Olga Velasco Guijarro, Inmaculada"
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    "titulo" => "Cystatin C as a renal function estimator in advanced chronic renal failure stages"
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            "nombre" => "M.V. Martín, S Barroso, O Herráez, F de Sande, F Caravaca"
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        "titulo" => "CISTATINA C COMO ESTIMADOR DE LA FUNCIÓN RENAL EN ESTADIOS AVANZADOS DE ENFERMEDAD RENAL CRÓNICA"
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        "resumen" => "Numerosos estudios han demostrado que los niveles plasmáticos de cistatina C (CisC) son más precisos que los niveles de creatinina (Cr) en la estimación del filtrado glomerlar (FG). Este hecho parece particularmente cierto en casos de disfunción renal leve-moderada, aunque es menos conocida su precisión en casos de insuficiencia renal avanzada. El objetivo de este estudio fue determinar la precisión de la CisC plasmática para estimar el FG en pacientes con enfermedad renal crónica avanzada. Se estudiaron 94 pacientes (57 mujeres) con insuficiencia renal avanzada. La edad media fue 61 ± 16 años. Ningún paciente presentaba alteraciones funcionales tiroideas o estaba en tratamiento con corticoides. Se midió el FG mediante Tc99mDTPA, determinando simultáneamente las concentraciones plasmáticas de Cr (reacción cinética modificada de Jaffé), y CisC (inmunonefelometría). Los niveles de Cr y CisC se correlacionaron con el FG, y se analizó la influencia del sexo, edad y diagnóstico de diabetes en los residuales de estas correlaciones. El valor predictivo tanto de la Cr como de la CisC para diagnosticar un FG < 15 ml/min/1,73 m2 fue analizado mediante curvas ROC, determinando las áreas bajo las curvas y sus significaciones estadísticas. El FG medio fue 16,49 ± 4,65 ml/min/1,73 m2. Las concentraciones medias de Cr y CisC fueron respectivamente: 4,19 ± 1,19 mg/L y 3,44 ± 0,73 mg/L. Tanto la Cr como la CisC se correlacionaron significativamente con el FG (R = 0,49&#59; p < 0,0001 y R = 0,52&#59; p < 0,0001 respectivamente). La edad y sexo influyeron en la correlación entre Cr y FG, pero no en la correlación entre CisC y FG. El área bajo la curva de predicción para un FG < 15 ml/min/1,73 m2 con la Cr fue 0,675 (p = 0,004), mientras que con la CisC fue 0,633 (p = 0,030). En conclusión, las concentraciones séricas de CisC son igual de imprecisas que las de Cr para la estimación del FG en la enfermedad renal crónica avanzada."
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        "resumen" => "Serum cystatin C (CysC) has been shown to be more accurate than serum creatinine (Cr) in estimating renal function, especially in patients with mild moderate chronic renal failure. However, it is unknown whether CysC provides or not any advantage over Cr in severe chronic renal failure. The aim of this study was to establish the accuracy of CysC in estimating the glomerular filtration rate (GFR) in advanced chronic renal failure patients. The study group consisted of 94 patients (57 females, mean age 61 ± 16 years) with advanced chronic renal failure. None of them had thyroid dysfunction or was on corticoid treatment. GFR was measured by Tc99mDTPA, and simultaneously, serum CysC (particle enhanced immunonephelometry) and Cr (modified Jaffe's kinetic reaction) were also determined. Serum Cr and CysC levels were correlated with GFR, and the influences of age, sex and diabetes on these correlations were analyzed. The predictive value of CysC and Cr to estimate a GFR less than 15 ml/min/1.73 m2 was analyzed by measuring the crea-under-the-curve (AUC) with Receiver-Operating Characteristics (ROC) plots. The mean GFR was 16.49 ± 4.65 ml/min/1.73 m2. The mean concentrations of Cr and CysC were 4.19 ± 1.19 mg/L and 3.44 ± 0.73 mg/L, respectively. Both Cr and CysC correlated significantly with GFR (R = 0.49, p < 0.0001 and R = 0.52, p < 0.0001, respectively). Age and sex influenced on the correlation between Cr and GFR, but these demographic characteristics did not influence on the correlation between CysC and GFR. The AUC for the prediction of a GFR less than 15 ml/min/1.73 m2 with serum Cr was 0.675 (p = 0.004), while with CysC was 0.633 (p = 0.030). In conclusion, both serum Cr and CysC are highly inaccurate markers of renal function in advanced chronic renal failure patients."
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Article information
ISSN: 20132514
Original language: English
DOI:
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