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Gavela, A. Ávila, A. Sancho, P. Molina, J. E. Fernández Nájera, J. Crespo and Ll. M. Pallardó" "autores" => array:1 [ 0 => array:1 [ "nombre" => "E. Gavela, A. Ávila, A. Sancho, P. Molina, J. E. Fernández Nájera, J. Crespo and Ll. M. Pallardó" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699506019956" "doi" => " " "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699506019956?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251406019953?idApp=UINPBA000064" "url" => "/20132514/0000002600000004/v0_201502091552/X2013251406019953/v0_201502091552/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251406020003" "issn" => "20132514" "doi" => " " "estado" => "S300" "fechaPublicacion" => "2006-08-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2006;26:461-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3813 "formatos" => array:3 [ "EPUB" => 219 "HTML" => 2731 "PDF" => 863 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Temperature of the dialysis bath and hemodialysis tolerance" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "461" "paginaFinal" => "468" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "TEMPERATURA DEL BAÑO Y TOLERANCIA A LA HEMODIALISIS" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. 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BEYOND BETA2-MICROGLOBULIN" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "469" "paginaFinal" => "475" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Maduell, J.J. Sánchez-Canel, J.A.Blasco, V. Navarro, A. Rius, E. Torregrosa, M. T. Pin, C. Cruz, J.A. Ferrero" "autores" => array:1 [ 0 => array:1 [ "nombre" => "F. Maduell, J.J. Sánchez-Canel, J.A.Blasco, V. Navarro, A. Rius, E. Torregrosa, M. T. Pin, C. Cruz, J.A. Ferrero" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "DEPURACIÓN DE GRANDES MOLÉCULAS. MÁS ALLÁ DE LA BETA2-MICROGLOBULINA" ] ] "pdfFichero" => "P-E-S-A1224-EN.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec436497" "palabras" => array:1 [ 0 => "alfa1-microglobulina, hemodiafiltración en línea, hemodiálisis alto flujo, mioglobina, prolactina" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La capacidad depurativa de toxinas urémicas depende en gran medida de los dializadores y de la modalidad de tratamiento dialítico. La hemodiálisis de bajo flujo tan sólo depura solutos con un peso molecular inferior a 5.000 Da. La diálisis de alto flujo representa una forma de hemodiafiltración de bajo volumen ya que tanto el filtrado interno como el retrofiltrado se producen en el dializador. Las técnicas de hemodiafiltración con elevados volúmenes de reposición son los que consiguen mayor depuración tanto de pequeñas como de medias y grandes moléculas. El objetivo del estudio fue valorar la depuración de moléculas grandes, superiores a la β2-microglobulina en hemodiálisis de alto flujo y hemodiafiltración on-line con infusión postdilucional, en pacientes que seguían un esquema de tres sesiones semanales y otros con hemodiálisis diaria. Se estudiaron 24 pacientes, 15 hombres y 9 mujeres en programa estable de hemodiálisis, doce en régimen estándar de 4 a 5 horas 3 sesiones semanales y doce de 2 a 2 1/2 horas 6 veces por semana. Todos se dializaron con monitor 4008 (Fresenius). Cada paciente recibió tres sesiones con hemodiálisis de alto flujo (HD) y tres sesiones con hemodiafiltración on-line (HDF-OL), manteniendo el resto de parámetros habituales. Dos sesiones con cada dializador (polisulfona HF80, polietersulfona Arylane H9 y nueva polisulfona APS 900). Se determinó la concentración pre y postdiálisis de urea, creatinina, β2-microglobulina (β2-m), mioglobina, prolactina (PRL) y α1−microglobulina (α1−m). No hubo diferencias importantes en la depuración de urea y la creatinina. La depuración de β2-m fue del 68% con HD y del 81% con HDF-OL, sin apenas diferencias entre los tres dializadores. La mioglobina y PRL presentaron un patrón de depuración similar, con una mayor depuración en HD con los dializadores de nueva generación (60% con Arylane y 59% con APS) respecto a la polisulfona clásica (22% con HF80). La reducción de α1−m en HD fue del 6% y en HDF-OL del 22%. Con HDF-OL y APS 900 se obtuvo una depuración del 35,4%, muy superior con el resto de modalidades y dializadores. En conclusión, los cambios introducidos en los dializadores de nueva generación han facilitado una mayor depuración de toxinas urémicas de tamaño superior a la β2-m, especialmente en la modalidad de HD. Es importante cuantificar la capacidad depurativa y en cada modalidad de tratamiento para una adecuada elección y comparación de los dializadores." ] "en" => array:1 [ "resumen" => "The uremic toxin removal capacity mainly depends on dialyzer and hemodialysis modes. The low-flux hemodialysis only removes solutes having molecular weights less than 5.000 Da. High-flux hemodyalisis represents a form of low-volume hemodiafiltration because of the internal filtration and back-filtration that can take place within a dialyzer. Hemodiafiltration with large volumes of replacement fluid seems to be the best technique for removing all small, medium-sized and large molecules. The objective of our study was to evaluate the large molecules removal bigger than β2-microglobuline on high flux haemodialysis and on-line hemodiafiltration with postdilutional infusion, in patients with three times a week dialysis and on short daily dialysis. We studied 24 patients, 15 males y 9 females stable on haemodialysis programme, twelve on standard four to five hours three times a week dialysis and twelve on 2 to 2 1/2 hours six times a week dialysis. All patients were dialysed with Fresenius 4008 monitor, three sessions on high flux haemodialysis (HD) and three sessions on on-line hemodiafiltration (OL-HDF). Two sessions with each filter were performed (polisulfone HF80, polyethersulfone Arylane H9 and new polisulfone APS 900). Pre and postdialysis concentrations of urea, creatinine, ( β2-microglobulin ( β2- m), myoglobin, prolactin and α1−microglobulin (α1-m) were measured. There was no difference in urea and creatinine small molecules removal. β2m removal was 68% on HD and 81% on OL-HDF. Myoglobin and prolactin present a similar removal pattern, a higher removal with new filters (60% with Arylane and 59% with APS) in comparison with clasical polisulfone (22% with HF80). The mean α1-m reduction rate on HD was 6% and on OL-HDF 22%. OL-HDF with APS 900 filter was the most remove technique (35.4%), significatively higher than the other modes and filters. We can conclude that the new filters generation reach a better uremic toxins removal, specially in large molecules higher than β2-m and on HD modality." ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000002600000004/v0_201502091552/X2013251406020160/v0_201502091552/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/20132514/0000002600000004/v0_201502091552/X2013251406020160/v0_201502091552/en/P-E-S-A1224-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251406020160?idApp=UINPBA000064" ]
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