was read the article
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"short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier survival curve.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nestor Toapanta, Zaira Castañeda, José Zúñiga, Juan León-Román, Natalia Ramos, María Azancot, María José Soler" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Nestor" "apellidos" => "Toapanta" ] 1 => array:2 [ "nombre" => "Zaira" "apellidos" => "Castañeda" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Zúñiga" ] 3 => array:2 [ "nombre" => "Juan" "apellidos" => "León-Román" ] 4 => array:2 [ "nombre" => "Natalia" "apellidos" => "Ramos" ] 5 => array:2 [ "nombre" => "María" "apellidos" => "Azancot" ] 6 => array:2 [ "nombre" => "María José" "apellidos" => "Soler" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699521001053" "doi" => "10.1016/j.nefro.2021.04.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521001053?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000354?idApp=UINPBA000064" "url" => "/20132514/0000004200000006/v1_202303262115/S2013251423000354/v1_202303262115/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2013251423000330" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2023.02.003" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "818" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2022;42:729-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Arterial thrombosis in a patient with nephrotic syndrome and antithrombin Cambrigde II" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "729" "paginaFinal" => "731" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trombosis arteriales en un paciente con síndrome nefrótico y antitrombina Cambrigde II" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1269 "Ancho" => 1514 "Tamanyo" => 133713 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Aortic thrombosis.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Axial computed tomography of the abdomen following administration of arterial-phase intravenous contrast, showing a 32<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>27-mm dilation of the infrarenal aorta, with a small 6-mm-thick intramural thrombus on the posterior left aspect (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana Esther Sirvent, Giomar Urzola-Rodríguez, Alicia Lorenzo, Ramiro Callejas-Martínez, Ana Saiz, Leonardo Calle-García, Álvaro Molina-Ordás, Astrid Rodríguez-Gómez, Carmen Martin-Varas, María José Fernández-Reyes-Luis" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Ana Esther" "apellidos" => "Sirvent" ] 1 => array:2 [ "nombre" => "Giomar" "apellidos" => "Urzola-Rodríguez" ] 2 => array:2 [ "nombre" => "Alicia" "apellidos" => "Lorenzo" ] 3 => array:2 [ "nombre" => "Ramiro" "apellidos" => "Callejas-Martínez" ] 4 => array:2 [ "nombre" => "Ana" "apellidos" => "Saiz" ] 5 => array:2 [ "nombre" => "Leonardo" "apellidos" => "Calle-García" ] 6 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Molina-Ordás" ] 7 => array:2 [ "nombre" => "Astrid" "apellidos" => "Rodríguez-Gómez" ] 8 => array:2 [ "nombre" => "Carmen" "apellidos" => "Martin-Varas" ] 9 => array:2 [ "nombre" => "María José" "apellidos" => "Fernández-Reyes-Luis" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699521000060" "doi" => "10.1016/j.nefro.2020.10.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521000060?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251423000330?idApp=UINPBA000064" "url" => "/20132514/0000004200000006/v1_202303262115/S2013251423000330/v1_202303262115/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Variation genetics and disease: The answer is in the clinical and in the family" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "731" "paginaFinal" => "733" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ana Isabel Morales-García, Carmen García-Rabaneda, Susana García-Linares, María Dolores Prados-Garrido, Rafael José Esteban-de la Rosa" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Ana Isabel" "apellidos" => "Morales-García" "email" => array:1 [ 0 => "amoralesg@senefro.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Carmen" "apellidos" => "García-Rabaneda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Susana" "apellidos" => "García-Linares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "María Dolores" "apellidos" => "Prados-Garrido" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Rafael José" "apellidos" => "Esteban-de la Rosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Clínico San Cecilio, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Variante genética y enfermedad: la respuesta está en la clínica y en la familia" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2940 "Ancho" => 2509 "Tamanyo" => 402779 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Genogram illustrating the familial segregation study.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We are in the midst of an upsurge in information about genetic variants associated with hereditary diseases thanks to mass sequencing and reduced costs. Being a carrier of a variant may not have pathological implications, and linking the changes found in the genome to clinical symptoms continues to be essential. We present a case that provides good proof of this.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The case in question involved a 47-year-old woman referred to the Nephrology Service by Primary Care physician for follow-up of autosomal dominant polycystic kidney disease (ADPKD). Her 17-year-old son was incidentally diagnosed with ADPKD according to the criteria of Pei et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in the context of abdominal pain. A genetic study was performed in the son to confirm the diagnosis due to the absence of a family background of the disease and the existence of normal ultrasound studies in all first-degree relatives. Three heterozygous variants were identified in the <span class="elsevierStyleItalic">PKD1</span> gene, hitherto undescribed and which were classified as being of uncertain significance. However, the <span class="elsevierStyleItalic">in silico</span> analyses rated them as pathogenic (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The patient was symptom-free, BP 110/60 mmHg, serum creatinine 0.68 mg/dL, with no urinary alterations and the kidney ultrasound was completely normal. A genetic study was performed, identifying the heterozygous variants <span class="elsevierStyleItalic">c.3999C > G</span> and <span class="elsevierStyleItalic">c.5068 G > A</span> in the <span class="elsevierStyleItalic">PKD1</span> gene, previously identified in her son. In view of this situation, a new kidney ultrasound was performed, which again presented no pathological findings, whereby an abdominal resonance was performed in which neither was any abnormality found (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Genetic studies were conducted on the father and sister of the index case in the context of a segregation study and no variant was identified (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><p id="par0020" class="elsevierStylePara elsevierViewall">The son inherited both variants in the <span class="elsevierStyleItalic">PKD1</span> gene through his mother and presented another one (<span class="elsevierStyleItalic">c.7261A > C</span>), suspected as possibly de novo. This variant has not been described and produces, at protein level, changing a threonine for a proline in position 2421, and the <span class="elsevierStyleItalic">in silico</span> analysis assigned a pathogenic nature to it.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Despite the advances in genetics, ADPKD is still diagnosed clinically at this point in time. Genetic studies make it possible to explain diagnoses, although in some cases they may lead to confusion. The interpretation of genetic studies is by no means simple and requires training. Clinicians will have to become increasingly more familiar with the specific nomenclature of these studies and with searching for variants in the international databases set up for sharing knowledge about these variants. Genetics cannot be separated from clinical practice and from the study of families, because this could lead to an unsuitable appraisal of the results, as exemplified by this clinical case. The limitations of genetic studies and what may be expected of them should be explained in consultations. Being a carrier of one or several genetic variants in a specific gene is not synonymous with disease. Moreover, ADPKD is characterised by major intrafamilial variability, whereby, and even if the genetic variant is shared, a disease may evolve very differently between different individuals due to mechanisms as yet unknown.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> However, despite these limitations, until now, genetic studies play a major clinical role in the management of ADPKD and are essential in being able to make an early diagnosis of the disease. There is still a certain degree of controversy as to what the most adequate time for screening the children of affected patients is, since there is still no curative treatment, although neither is there any doubt that patients who carry hereditary diseases are entitled to a proper genetic assessment.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> The autosomal dominant polycystic kidney disease (GEEPAD) study group has demonstrated that in 60% of cases ADPKD is diagnosed at a mean age of 34 years and after the birth of the first child.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The only way to make an early diagnosis of ADPKD is to classify all families properly and perform genetic studies. Building family trees, conducting sequential genetic and segregation studies, when necessary, must also be addressed by nephrologists. Changing from an individual to a familial approach is essential to the proper management of this and other hereditary kidney diseases.</p><p id="par0035" class="elsevierStylePara elsevierViewall">This clinical case highlights the need to combine clinical experience and genetics. This challenge will enjoy increasingly greater presence in daily healthcare work and is a change that we must adapt to.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2940 "Ancho" => 2509 "Tamanyo" => 402779 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Genogram illustrating the familial segregation study.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ht: heterozygosis; ND: not described.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gene \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">cDNA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Protein \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exon \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Genotype \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bases \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">In silico</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">PKD1</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">c.3999C > G</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p.Gly1333Gly \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ht \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transversion substitution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Human Splicing Finder</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">PKD1</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">c.5068 G > A</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p.Ala1690Thr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ht \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transition substitution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Polyphen: pathogenic</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">PKD1</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">c.7261A > C</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p.Thr2421Pro \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ht \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transversion substitution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Polyphen: pathogenic</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3134354.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Variants identified in the <span class="elsevierStyleItalic">PKD1</span> gene in the son.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unified criteria for ultrasonographic diagnosis of ADPKD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. 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Year/Month | Html | Total | |
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