Letter to the Editor
Author's reply
Réplica a la carta al Editor
Read
5390
Timeswas read the article
1561
Total PDF
3829
Total HTML
Share statistics
array:24 [ "pii" => "S2013251420301255" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2020.11.002" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "661" "copyright" => "Sociedad Española de Nefrología" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2020;40:569" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:20 [ "pii" => "S201325142030119X" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2019.09.006" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "673" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2020;40:570-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "New aspects in epidemiological surveillance in relation to viral diseases in haemodialysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "570" "paginaFinal" => "571" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nuevos aspectos en la vigilancia epidemiológica en relación a las enfermedades virales en hemodiálisis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bárbara Cancho Castellano, Rosa María Ruiz-Calero Cendrero, María Victoria Martín Hidalgo-Barquero, Rosa Díaz Campillejo, Cristina López Arnaldo, Nicolás Roberto Robles Pérez-Monteoliva" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Cancho Castellano" ] 1 => array:2 [ "nombre" => "Rosa María" "apellidos" => "Ruiz-Calero Cendrero" ] 2 => array:2 [ "nombre" => "María Victoria" "apellidos" => "Martín Hidalgo-Barquero" ] 3 => array:2 [ "nombre" => "Rosa" "apellidos" => "Díaz Campillejo" ] 4 => array:2 [ "nombre" => "Cristina" "apellidos" => "López Arnaldo" ] 5 => array:2 [ "nombre" => "Nicolás Roberto" "apellidos" => "Robles Pérez-Monteoliva" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699519301900" "doi" => "10.1016/j.nefro.2019.09.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301900?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325142030119X?idApp=UINPBA000064" "url" => "/20132514/0000004000000005/v1_202012090755/S201325142030119X/v1_202012090755/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2013251420301188" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2019.07.001" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "657" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2020;40:566-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Thyroid plasmapheresis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "566" "paginaFinal" => "568" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Plasmaféresis tiroidea" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1882 "Ancho" => 2928 "Tamanyo" => 286264 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evolution chart.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge Rojo Álvaro, Concepción Conchillo Fernández, Leire Agea Díaz, Ismene Bilbao Garay, Cristina García Delgado, José Molina del Río, Miguel María Goena Iglesias" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Rojo Álvaro" ] 1 => array:2 [ "nombre" => "Concepción" "apellidos" => "Conchillo Fernández" ] 2 => array:2 [ "nombre" => "Leire" "apellidos" => "Agea Díaz" ] 3 => array:2 [ "nombre" => "Ismene" "apellidos" => "Bilbao Garay" ] 4 => array:2 [ "nombre" => "Cristina" "apellidos" => "García Delgado" ] 5 => array:2 [ "nombre" => "José Molina" "apellidos" => "del Río" ] 6 => array:2 [ "nombre" => "Miguel María" "apellidos" => "Goena Iglesias" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699519301596" "doi" => "10.1016/j.nefro.2019.07.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301596?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420301188?idApp=UINPBA000064" "url" => "/20132514/0000004000000005/v1_202012090755/S2013251420301188/v1_202012090755/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Author's reply" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "569" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lara Belmar Vega, David San Segundo Arribas, Juan Irure Ventura, Marcos López Hoyos, Gema Fernández Fresnedo, Emilio Rodrigo Calabria, Juan Carlos Ruiz San Millán" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Lara" "apellidos" => "Belmar Vega" "email" => array:1 [ 0 => "belmarvega@outlook.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "David" "apellidos" => "San Segundo Arribas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Juan" "apellidos" => "Irure Ventura" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Marcos" "apellidos" => "López Hoyos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Gema" "apellidos" => "Fernández Fresnedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Emilio" "apellidos" => "Rodrigo Calabria" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Juan Carlos" "apellidos" => "Ruiz San Millán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Réplica a la carta al Editor" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The diagnostic algorithm for drug-allergy combines both <span class="elsevierStyleItalic">in vivo</span> (prick test) and <span class="elsevierStyleItalic">in vitro</span> (specific IgE) tests. The basophil activation test (BAT) is a functional <span class="elsevierStyleItalic">in vitro</span> assay that could help in case of allergen-sensitization suspicion. The indication of BAT could be addressed when specific-IgE test is not commercially available, the allergic patient is at high risk of anaphylactic reaction after new exposition to allergen or due the low sensitivity of specific-IgE test in drug-sensitization cases. In all cases the BAT could support the allergy diagnosis.</p><p id="par0010" class="elsevierStylePara elsevierViewall">An increase of total serum IgE levels could suggest an immediate IgE reaction but also another clinical overlap of food and inhalant allergy or parasite infection should be ruled out. Furthermore, total IgE is not especially increased in cases of drug hypersensitivity. To our knowledge, there is no omeprazole specific-IgE test in the reference system (CAP, Thermo Fisher), so the BAT could be used as <span class="elsevierStyleItalic">in vitro</span> diagnostic tool to confirm sensitization.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The letter to editor comments about several points in order to improve the immunophenotypic assessment of basophils as CD45<span class="elsevierStyleSup">dim</span>CD123<span class="elsevierStyleSup">bright</span>HLA-DR<span class="elsevierStyleSup">neg</span> instead of FSC/SSC dot plot. The authors regret that the format of case report does not allow describe the methods in detail. However, the FSC/SSC dot plot showed in Figure 1 (Belmar et al.)<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> represents the backgating, there is neither gate in the plot nor mention in the figure legend about the gating strategy of basophils based on FSC/SSC, due to space constraints. Moreover, as suggested by the authors, the use of CD203c could help in the identification of basophils. After the performance of the omeprazol-BAT we include the CD203c marker in our routine flow cytometry panel and >97% CD123<span class="elsevierStyleSup">+</span>HLA-DR<span class="elsevierStyleSup">neg</span> were CD203c<span class="elsevierStyleSup">+</span>, confirming the high concordance of basophils identification with both panels.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The authors are aware about the interpretation of the BAT is controversial,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> most of the studies use a single cut-off value, stimulation index (SI) or %CD63. The study with 43 patients with omeprazole-allergy cited by the authors uses a single cut off above 2 SI,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> moreover the same research group in the context of quinolone-allergy used SI >2 or CD63 >5%.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> In the case report both conditions SI and %CD63 were fulfilled.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The formil-Metionin Leucin Prolin (fMLP) activate basophils in a IgE-independent way, the authors assume that it is not the best positive control for basophil IgE-dependent degranulation and anti-IgE should be used instead. Nonetheless, the fMLP allows validate the BAT, confirming the ability of basophils to degranulate.</p><p id="par0030" class="elsevierStylePara elsevierViewall">We could not exclude a possible immune-mediated reaction through the binding of the drug to H2 and H4 in basophils, as indicated by the authors in their reply. It could modulate the Th2 immune response by producing IgG that would induce the nephritis. Despite the suggested inhibition by omeprazol on basophils that we could not discard, we demonstrated an <span class="elsevierStyleItalic">in vitro</span> basophils degranulation after exposure to the drug.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0025" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basophil activation test. Tool for the diagnosis of interstitial nephritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Belmar Vega" 1 => "M. López Hoyos" 2 => "D. San Segundo Arribas" 3 => "J. Irure Ventura" 4 => "G. Fernández Fresnedo" 5 => "J.C. Ruiz San Millán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Nefrologia" "fecha" => "2019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11217655" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0030" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Major pitfalls in BAT performance may be caused by gating protocols and CD63% cut off evaluation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Chirumbolo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cyto.a.22466" "Revista" => array:6 [ "tituloSerie" => "Cytometry A" "fecha" => "2014" "volumen" => "85" "paginaInicial" => "382" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24753185" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0035" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The basophil activation test can be of value for diagnosing immediate allergic reactions to omeprazole" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.J. Laguna" 1 => "G. Bogas" 2 => "M. Salas" 3 => "C. Mayorga" 4 => "J. Dionicio" 5 => "R. Gonzalez-Mendiola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "J Allergy Clin Immunol Pract" "fecha" => "2018" "volumen" => "6" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0040" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Aranda" 1 => "C. Mayorga" 2 => "A. Ariza" 3 => "I. Doña" 4 => "A. Rosado" 5 => "N. Blanca-Lopez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2010.02460.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "247" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20722637" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000004000000005/v1_202012090755/S2013251420301255/v1_202012090755/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000004000000005/v1_202012090755/S2013251420301255/v1_202012090755/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420301255?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 8 | 16 |
| 2024 October | 76 | 31 | 107 |
| 2024 September | 63 | 29 | 92 |
| 2024 August | 91 | 78 | 169 |
| 2024 July | 56 | 26 | 82 |
| 2024 June | 70 | 35 | 105 |
| 2024 May | 136 | 30 | 166 |
| 2024 April | 149 | 26 | 175 |
| 2024 March | 202 | 26 | 228 |
| 2024 February | 197 | 35 | 232 |
| 2024 January | 80 | 33 | 113 |
| 2023 December | 32 | 23 | 55 |
| 2023 November | 64 | 39 | 103 |
| 2023 October | 112 | 30 | 142 |
| 2023 September | 69 | 23 | 92 |
| 2023 August | 43 | 29 | 72 |
| 2023 July | 50 | 25 | 75 |
| 2023 June | 108 | 17 | 125 |
| 2023 May | 120 | 32 | 152 |
| 2023 April | 61 | 14 | 75 |
| 2023 March | 108 | 17 | 125 |
| 2023 February | 87 | 18 | 105 |
| 2023 January | 105 | 28 | 133 |
| 2022 December | 67 | 26 | 93 |
| 2022 November | 56 | 31 | 87 |
| 2022 October | 118 | 42 | 160 |
| 2022 September | 91 | 30 | 121 |
| 2022 August | 82 | 45 | 127 |
| 2022 July | 93 | 41 | 134 |
| 2022 June | 79 | 36 | 115 |
| 2022 May | 86 | 23 | 109 |
| 2022 April | 85 | 35 | 120 |
| 2022 March | 97 | 45 | 142 |
| 2022 February | 77 | 42 | 119 |
| 2022 January | 60 | 45 | 105 |
| 2021 December | 61 | 32 | 93 |
| 2021 November | 75 | 34 | 109 |
| 2021 October | 82 | 49 | 131 |
| 2021 September | 51 | 28 | 79 |
| 2021 August | 54 | 40 | 94 |
| 2021 July | 44 | 28 | 72 |
| 2021 June | 65 | 17 | 82 |
| 2021 May | 53 | 58 | 111 |
| 2021 April | 90 | 80 | 170 |
| 2021 March | 75 | 36 | 111 |
| 2021 February | 34 | 23 | 57 |
| 2021 January | 37 | 18 | 55 |
| 2020 December | 30 | 25 | 55 |
Show all
