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is the most frequent genetic kidney disorder that affects approximately 1&#58;1000 individuals worldwide&#46; Progressive bilateral kidney cyst enlargement leads to end-stage renal disease in 50&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> Liver cysts&#44; colonic diverticula&#44; or intracranial aneurysms may lead to extrarenal manifestations&#46; Cysts in the pancreas develop in approximately 9&#37; of ADPKD patients&#46; They are usually smaller than 10<span class="elsevierStyleHsp" style=""></span>mm and therefore rarely cause pancreatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this study&#44; we introduce a case of a girl with CP and concomitant polycystic kidney disease&#44; both genetically determined&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case description</span><p id="par0020" class="elsevierStylePara elsevierViewall">The now 12-year-old Caucasian girl was initially diagnosed with the first attack of acute pancreatitis at the age of 8&#46; She was treated with bowel rest&#44; intravenous hydration and antibiotics&#46; As pancreatitis is unusual at this age&#44; a search for predisposing anatomical anomalies was initiated&#46; Magnetic resonance scans raised suspicion of pancreas divisum with no intervention needed&#44; as she was without complaints for the following 2 years&#46; However&#44; at the age of 10&#44; she experienced another attack of pancreatitis&#46; Laboratory tests showed normal findings in hematologic tests&#44; but biochemical parameters supported the diagnosis of pancreatitis&#58; pancreatic amylase 3&#46;84<span class="elsevierStyleHsp" style=""></span>ukat&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; &#8804;0&#46;58<span class="elsevierStyleHsp" style=""></span>ukat&#47;l&#41;&#44; amylase 4&#46;42<span class="elsevierStyleHsp" style=""></span>ukat&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; &#8804;1&#46;70<span class="elsevierStyleHsp" style=""></span>ukat&#47;l&#41;&#44; 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pseudocysts&#44; nor cysts were detected&#46; However&#44; the pancreatic parenchyma displayed a coarse tissue structure&#44; indicating chronic pancreatitis&#46; The previously suspected pancreas divisum was ruled out by magnetic resonance cholangiopancreatography &#40;MRCP&#41;&#46; As a coincidental finding&#44; numerous bilateral cortical kidney cysts up to 11<span class="elsevierStyleHsp" style=""></span>mm large were found&#46; Interestingly&#44; the family history was negative for any gastrointestinal symptoms or pancreatitis&#44; but it was positive for polycystic kidney disease on the maternal side of the pedigree &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The clinical diagnosis ADPKD was stated based on ultrasound diagnostic criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">As pancreatic cysts were excluded&#44; ADPKD was found to be unlikely the cause of CP&#46; By this time&#44; other structural anomalies of the pancreas and biliary tree&#44; infectious&#44; toxic&#44; metabolic&#44; or immunological agents were also ruled out&#46; Hence&#44; mutation screening of 4 genes associated with idiopathic CP was performed&#46; In <span class="elsevierStyleItalic">PRSS1</span>&#44; <span class="elsevierStyleItalic">SPINK1</span>&#44; and <span class="elsevierStyleItalic">CFTR</span>&#44; no mutation was found&#44; but the homozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant in the <span class="elsevierStyleItalic">CTRC</span> gene was identified&#46; Both parents as well as her brother were heterozygous carriers&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The genetic confirmation of clinically diagnosed ADPKD followed by linkage analysis&#44; revealing a link to the <span class="elsevierStyleItalic">PKD1</span> gene&#46; Direct sequencing of its coding sequence identified a novel pathologic nonsense variant c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; in our index patient&#44; her mother&#44; and mother&#39;s relatives with a clinical picture of ADPKD&#46; The nucleotide replacement creates premature termination codon&#44; thus predicts to truncate the protein&#44; leading to ADPKD phenotype&#46; Renal function assessment in our patient confirmed physiologic glomerular filtration rate&#44; adequate concentration capacity&#44; and blood pressure&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A genetic cause of both&#44; CP and polycystic kidney disease could be identified in the same patient&#46; Currently&#44; the girl is doing well&#44; avoiding fatty food and paying attention to sufficient fluid intake&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">We report a rare case of a child with chronic pancreatitis and the incidental finding of numerous renal cysts&#44; confirmed to be due to ADPKD&#46; After excluding pancreatic cysts as a possible cause of CP in ADPKD&#44; we found a homozygous <span class="elsevierStyleItalic">CTRC</span> variant p&#46;G60<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>predisposing to CP&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; only few sporadic cases of concomitant pancreatitis and ADPKD have been described in the literature&#46; It is usually restricted to patients with pancreatic duct compression due to pancreatic cyst development that is causally related to ADPKD&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">A case&#44; presented by Malka et al&#46;&#44; described a 38-year-old female patient with ADPKD&#44; abdominal pain&#44; and biochemical parameters consistent with pancreatitis&#46; A single pancreatic cyst&#44; 15<span class="elsevierStyleHsp" style=""></span>mm large&#44; compressing the main pancreatic duct&#44; was concluded to be the cause of the chronic obstructive pancreatitis &#8211; an extrarenal manifestation of ADPKD&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">9</span></a> An unusual combination of pancreatic cysts and pancreas divisum in a male patient with ADPKD and two consecutive attacks of acute pancreatitis was seen by Basar et al&#46; Surprisingly&#44; both anomalies appeared for the first time when the patient was 63 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a> Multiple pancreatic cysts led to obstructive pancreatitis also in a 47-year-old ADPKD male patient reported by Sastre L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> Most recently&#44; two unrelated cases of recurrent attacks of acute pancreatitis were described in ADPKD individuals with only mild kidney disease&#59; while imaging studies revealed pancreatic cysts in a 38-year-old male described by Yazdanpanah et al&#46;&#44; no pancreatic cysts were detected&#44; in a 70-year-old female patient reported by Thyagarajan et al&#46;&#44; in whom an enlarged cystic liver was recognized to be the underlying condition of pancreatic duct obstruction&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">12&#44;13</span></a> The only pediatric case of pancreatitis due to multiple pancreatic cysts within ADPKD was reported by Kahn and Palmert in 1996&#46; Compression of the main pancreatic duct in its mid-part and mild dilation in the tail area was revealed in a girl as young as 9 years&#46; Pancreatic enzyme release secondary to duct compression was suspected to be the cause of the pancreatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> This was a unique case&#44; as ADPKD-related pancreatic cysts are rare in children&#46; According to autopsy and imaging studies&#44; these are related to ageing with the maximum prevalence after the third decade&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a> In summary&#44; the proportion of ADPKD patients who develop pancreatic cysts is small and usually restricted to adult patients&#46; Even among ADPKD patients with pancreatic cysts occurrence of pancreatitis seems to be rare<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a> and the few cases of ADPKD and pancreatitis are clearly defined by the presence of pancreatic cysts with critical pancreatic duct compression&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">9&#8211;12&#44;14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Genetic susceptibility plays an important role in the pathogenesis of CP and genetic alterations in the <span class="elsevierStyleItalic">PRSS1</span>&#44; <span class="elsevierStyleItalic">SPINK1</span>&#44; <span class="elsevierStyleItalic">CFTR</span>&#44; <span class="elsevierStyleItalic">CTRC</span>&#44; <span class="elsevierStyleItalic">CPA1</span>&#44; <span class="elsevierStyleItalic">CEL</span>&#44; <span class="elsevierStyleItalic">CLDN2</span> and <span class="elsevierStyleItalic">CTRB1-CTRB2</span> locus may be associated with chronic pancreatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#8211;4</span></a> The presence of ADPKD and genetically determined CP may be a coincidence&#46; However&#44; CP is a complex genetic disorder that develops through the interaction of environmental and genetic factors&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a> Thus&#44; it cannot be excluded&#44; that changes in CP susceptibility genes together with mutations in ADPKD-causing genes could potentially trigger early-onset pancreatitis&#46; This is supported by our described case with a synonymous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">According to Beer et al&#46; and Paliwal et al&#46; the heterozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; carriers have an increased risk for CP 1&#46;65-fold and 2&#46;5-fold respectively&#44; whereas homozygotes 8&#46;44-fold and tenfold respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">15&#44;16</span></a> It exerts its effect via a loss-of-function mechanism as disease-related <span class="elsevierStyleItalic">CTRC</span> variants are connected to decreased mRNA levels&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The association between the variant and the CP was further supported by the study of LaRusch et al&#46; who observed that the presence of the variant increases the risk of CP specifically in individuals with a known genetic background &#40;disease-causing mutations in the genes <span class="elsevierStyleItalic">SPINK1&#44; CFTR&#44; CTRC</span>&#44; and <span class="elsevierStyleItalic">PRSS1</span>&#41; and alcohol&#47;smoking-related CP etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleItalic">CTRC</span> gene is therefore considered to be a disease modifier gene with pathogenic variants representing one of the most important factors increasing susceptibility to pancreatic damage through the trypsin-dependent pathway&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The increased risk of pediatric CP linked to the c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant in the <span class="elsevierStyleItalic">CTRC</span> gene was confirmed in a large pediatric Polish cohort of 136 children &#40;with either idiopathic CP or CP related to other genetic&#47;non-genetic risk factors&#41;&#46; Heterozygous carriers had 2&#46;8-fold increased risk of CP and homozygotes 23-fold compared to controls&#46; The homozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; genotype was found to be the strongest CP risk factor among all identified variants in the <span class="elsevierStyleItalic">CTRC</span> gene&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">18</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Whether coincidental combination of ADPKD causing <span class="elsevierStyleItalic">PKD1</span>&#44; <span class="elsevierStyleItalic">PKD2</span>&#44; or <span class="elsevierStyleItalic">GANAB</span> mutations<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> and genetic susceptibility to CP has an adverse impact on pancreatic cyst development and&#47;or early pancreatitis manifestation need to be reliably determine by further studies&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">CP might occur also independently from ADPKD&#44; and the case of our patient could be a unique coincidence of both diseases at the same time&#46; Further follow-up of the propositus will be important for better understanding of the behavior and natural course of both diseases appearing together&#46; Also&#44; genetic counseling for the family will inform them about the risk of development of one or both disorders in future generations&#46; From a clinical perspective&#44; we suggest that in children with both ADPKD and CP not related to the presence of pancreatic cysts&#44; genetic causes of CP should be considered&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0085" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this is the first case of a pediatric patient with chronic pancreatitis and coincidental autosomal dominant polycystic kidney disease with molecular evidence of ADPKD causing mutation and genetic propensity to CP&#46; Based on our case&#44; we recommend to include genetic factors contributing to development of pancreatic inflammation in the differential diagnosis of pancreatitis in ADPKD&#46; Further observations and analyses are needed to determine whether mutations causing ADPKD are likely to trigger pancreatitis manifestation in patients with genetic susceptibility to CP&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Compliance with ethical standards</span><p id="par0090" class="elsevierStylePara elsevierViewall">All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards&#46; Informed consent was obtained from all individual participants included in the study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Submission declaration and verification</span><p id="par0095" class="elsevierStylePara elsevierViewall">The work described here has been approved by all authors&#44; it has not been published previously &#40;except for an abstract&#41; and it is not under consideration for publication in other journal&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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            0 => "ADPKD"
            1 => "Chronic pancreatitis"
            2 => "Pancreatic cyst"
            3 => "<span class="elsevierStyleItalic">CTRC</span> gene"
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            0 => "Autosomal dominant polycystic kidney disease"
            1 => "Pancreatitis cr&#243;nica"
            2 => "Quiste pancre&#225;tico"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In children&#44; chronic pancreatitis &#40;CP&#41; is usually associated with anatomical anomalies of the pancreas and biliary tract or is genetically determined&#46; Autosomal dominant polycystic kidney disease &#40;ADPKD&#41; may present with extrarenal cyst formation&#44; sometimes involving the pancreas&#46; Large enough&#44; these cysts may cause pancreatitis in ADPKD patients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case presentation</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Herein&#44; we present a case of a 12-year-old Caucasian girl with recurrent pancreatitis with no identifiable traumatic&#44; metabolic&#44; infectious&#44; drug&#44; or immunologic causes&#46; Structural anomalies of the pancreas&#44; including cysts&#44; were ruled out by imaging&#46; However&#44; bilateral cystic kidneys were found as an incidental finding&#46; Her family history was negative for pancreatitis&#44; but positive for polycystic kidney disease&#46; Molecular analysis of ADPKD-causing mutations revealed a novel c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; mutation in the <span class="elsevierStyleItalic">PKD1</span> gene confirming the clinical suspicion of ADPKD&#46; Although CP may rarely occur as an extrarenal manifestation of ADPKD with pancreatic cysts&#44; it is unusual in their absence&#46; Thus&#44; molecular analysis of pancreatitis susceptibility genes was performed and a homozygous pathologic c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant of the <span class="elsevierStyleItalic">CTRC</span> gene&#44; known to increase the risk of CP&#44; was confirmed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is the first reported case of a pediatric patient with coincidence of genetically determined CP and ADPKD&#46; Occurrence of pancreatitis in children with ADPKD without pancreatic cysts warrants further investigation of CP causing mutations&#46;</p></span>"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En ni&#241;os&#44; la pancreatitis cr&#243;nica &#40;CP&#44; por sus siglas en ingl&#233;s&#41; generalmente se asocia con anomal&#237;as anat&#243;micas del p&#225;ncreas y el tracto biliar&#44; o est&#225; gen&#233;ticamente determinada&#46; La enfermedad renal poliqu&#237;stica autos&#243;mica dominante &#40;ADPKD&#44; por sus siglas en ingl&#233;s&#41; puede presentarse con la formaci&#243;n de quistes extrarrenales&#44; que a veces afecta al p&#225;ncreas&#46; Suficientemente grandes&#44; estos quistes pueden causar pancreatitis en pacientes con ADPKD&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Presentaci&#243;n del caso</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una ni&#241;a cauc&#225;sica de 12 a&#241;os con pancreatitis recurrente sin causas identificables traum&#225;ticas&#44; metab&#243;licas&#44; infecciosas&#44; farmacol&#243;gicas o inmunol&#243;gicas&#46; Las anomal&#237;as estructurales del p&#225;ncreas&#44; incluidos los quistes&#44; se descartaron mediante im&#225;genes&#46; Sin embargo&#44; los ri&#241;ones qu&#237;sticos bilaterales se encontraron como un hallazgo accidental&#46; Su historia familiar fue negativa para la pancreatitis&#44; pero positiva para la enfermedad renal poliqu&#237;stica&#46; El an&#225;lisis molecular de las mutaciones causantes de ADPKD revel&#243; una nueva mutaci&#243;n c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; en el gen <span class="elsevierStyleItalic">PKD1</span> que confirma la sospecha cl&#237;nica de ADPKD&#46; Aunque la CP rara vez ocurre como una manifestaci&#243;n extrarrenal de ADPKD con quistes pancre&#225;ticos es inusual&#46; Por lo tanto&#44; se realiz&#243; el an&#225;lisis molecular de los genes de susceptibilidad a pancreatitis y se confirm&#243; una variante homocig&#243;tica patol&#243;gica c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; del gen <span class="elsevierStyleItalic">CTRC</span>&#44; que se sabe que aumenta el riesgo de CP&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusi&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Este es el primer caso reportado de un paciente pedi&#225;trico con coincidencia de CP y ADPKD gen&#233;ticamente determinados&#46; La aparici&#243;n de pancreatitis en ni&#241;os con ADPKD sin quistes pancre&#225;ticos justifica una mayor investigaci&#243;n de CP que causan mutaciones&#46;</p></span>"
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                    0 => array:2 [
                      "titulo" => "Pediatric acute recurrent and chronic pancreatitis&#58; lessons from INSPIPRE"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Kumar"
                            1 => "Ch&#46;Y&#46; Ooi"
                            2 => "S&#46; Werlin"
                            3 => "M&#46; Abu-El-Haija"
                            4 => "B&#46; Barth"
                            5 => "M&#46;D&#46; Bellin"
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                      "doi" => "10.1001/jamapediatrics.2015.4955"
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                        "tituloSerie" => "JAMA Pediatr"
                        "fecha" => "2016"
                        "volumen" => "170"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27064572"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genetic risk in chronic pancreatitis&#58; the trypsin-dependent pathway"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Hegyi"
                            1 => "M&#46; Sahin-T&#243;th"
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                    0 => array:2 [
                      "doi" => "10.1007/s10620-017-4601-3"
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                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "2017"
                        "volumen" => "62"
                        "paginaInicial" => "1692"
                        "paginaFinal" => "1701"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28536777"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Rosendahl"
                            1 => "H&#46; Kirsten"
                            2 => "E&#46; Hegyi"
                            3 => "P&#46; Kovacs"
                            4 => "F&#46;U&#46; Weiss"
                            5 => "H&#46; Laumen"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                      "Revista" => array:2 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2017"
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Whitcomb"
                            1 => "J&#46; LaRusch"
                            2 => "A&#46;M&#46; Krasinskas"
                            3 => "L&#46; Klei"
                            4 => "J&#46;P&#46; Smith"
                            5 => "R&#46;E&#46; Brand"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.2466"
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2012"
                        "volumen" => "44"
                        "paginaInicial" => "1349"
                        "paginaFinal" => "1354"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0115"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in GANAB&#44; encoding the glucosidase IIa subunit&#44; cause autosomal-dominant polycystic kidney and liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                        "paginaInicial" => "19"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9021236"
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                    0 => array:2 [
                      "doi" => "10.1016/j.cgh.2016.06.017"
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                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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              "etiqueta" => "8"
              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Autosomal-dominant polycystic kidney disease &#40;ADPKD&#41;&#58; executive summary from a kidney disease&#58; Improving Global Otcomes &#40;KDIGO&#41; Controversies Conference"
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                            1 => "O&#46; Devuyst"
                            2 => "K&#46;U&#46; Eckardt"
                            3 => "R&#46;T&#46; Gansevoort"
                            4 => "T&#46; Harris"
                            5 => "S&#46; Horie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2015.59"
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                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2015"
                        "volumen" => "88"
                        "paginaInicial" => "17"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25786098"
                            "web" => "Medline"
                          ]
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                ]
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pancreatitis due to a pancreatic cyst in a patient with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "P&#46; Hammel"
                            2 => "V&#46; Vilgrain"
                            3 => "J&#46;F&#46; Fl&#233;jou"
                            4 => "J&#46; Belghiti"
                            5 => "P&#46; Bernades"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gut"
                        "fecha" => "1998"
                        "volumen" => "48"
                        "paginaInicial" => "131"
                        "paginaFinal" => "134"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
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                ]
              ]
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              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent pancreatitis in a patient with autosomal-dominant polycystic kidney disease"
                      "autores" => array:1 [
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                          "autores" => array:6 [
                            0 => "&#214;&#46; Basar"
                            1 => "M&#46; Ibis"
                            2 => "E&#46; Ucar"
                            3 => "I&#46; Ertgrul"
                            4 => "&#214;&#46;F&#46; Yolcu"
                            5 => "S&#46; K&#246;kl&#252;"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000090258"
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                        "tituloSerie" => "Pancreatology"
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                        "volumen" => "6"
                        "paginaInicial" => "160"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16354965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute pancreatitis and polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Sastre Lopez"
                            1 => "M&#46; Bernabeu Lafuente"
                            2 => "M&#46;V&#46; Inigo Vanrell"
                            3 => "J&#46;M&#46; Gasco Company"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
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                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18590508"
                            "web" => "Medline"
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                ]
              ]
            ]
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              "identificador" => "bib0150"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent acute pancreatitis and cholangoitis in a patient with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Yazdanpanah"
                            1 => "N&#46; Manouchehri"
                            2 => "E&#46; Hosseinzadeh"
                            3 => "M&#46;H&#46; Emami"
                            4 => "M&#46; Karami"
                            5 => "A&#46;H&#46; Sarrami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Prev Med"
                        "fecha" => "2013"
                        "volumen" => "4"
                        "paginaInicial" => "233"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23543834"
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              "etiqueta" => "13"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple fluid-filled liver cysts presenting as acute pancreatitis in a patient with known autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Thyagarajan"
                            1 => "P&#46; Ghatage"
                            2 => "S&#46;S&#46; Alagusundaramoorthy"
                            3 => "S&#46; Patel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bcr-2016-216051"
                      "Revista" => array:2 [
                        "tituloSerie" => "BMJ Case Rep"
                        "fecha" => "2016"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "14"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A 9-year-old girl with vomiting&#44; abdominal pain and pancreatic and renal cysts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Kahn"
                            1 => "M&#46;R&#46; Palmert"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Pediatrics"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "152"
                        "paginaFinal" => "156"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
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              ]
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              "etiqueta" => "15"
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                0 => array:1 [
                  "referenciaCompleta" => "Beer S&#44; Ludwig M&#44; N&#233;meth BC&#44; Witt H&#44; Sahin-T&#243;th M&#44; Rosendahl J&#46; Synonymous CTRC variant c&#46;180C&#62;T contributes significantly to chronic pancreatitis risk&#46; Pancreatology&#46; 2013&#59;14&#58;S15&#46; <a target="_blank" href="doi:10.1016/j.pan.2014.05.427">doi&#58;10&#46;1016&#47;j&#46;pan&#46;2014&#46;05&#46;427</a>&#46;"
                ]
              ]
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              "identificador" => "bib0170"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comprehensive screening of chymotrypsin C &#40;CTRC&#41; gene in tropical calcific pancreatitis identifies novel variants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46; Bhaskar"
                            2 => "K&#46;R&#46; Mani"
                            3 => "D&#46;N&#46; Reddy"
                            4 => "G&#46;V&#46; Rao"
                            5 => "S&#46;P&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/gutjnl-2012-302448"
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                        "tituloSerie" => "Gut"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "1602"
                        "paginaFinal" => "1606"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22580415"
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                    0 => array:2 [
                      "titulo" => "The common chymotrypsinogen C &#40;CTRC&#41; variant G60G &#40;C&#46;180T&#41; increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population"
                      "autores" => array:1 [
                        0 => array:2 [
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                            4 => "K&#46; Muddana"
                            5 => "M&#46; O&#8217;Connel"
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                        "fecha" => "2015"
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              ]
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              "etiqueta" => "18"
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                      "titulo" => "Chymotrypsinogen C genetic variants&#44; including c&#46;180TT&#44; are strongly associated with chronic pancreatitis in pediatric patients"
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                            5 => "E&#46; Kolodziejczyk"
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Case report
Chronic pancreatitis with polycystic kidney disease: A rare coincidence?
Pancreatitis crónica con enfermedad renal poliquística: ¿una rara coincidencia?
Gabriela Hrčkováa,
Corresponding author
hrckova.g@gmail.com

Corresponding author.
, Eszter Hegyia,b, Katarína Skalickáa, Iveta Čiernaa, Tomáš Dallosa, Denisa Ilenčíkováa,c
a Department of Pediatrics of the Faculty of Medicine, Comenius University and the National Institute of Children's Diseases, Bratislava, Slovakia
b Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary
c Department of Medical Genetics, Kepler University Hospital, Linz, Austria
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">While alcohol abuse and gallstones are the most common triggers of chronic pancreatitis &#40;CP&#41; in adults&#44; structural anomalies of the pancreas and biliary tract&#44; as well as genetic factors&#44; have to be considered in CP in children&#46; The estimated incidence of CP in young adults is 0&#46;5&#58;100&#44;000 per year and the rare&#44; genetically determined CP represents only a part of it&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> A growing number of genes has been associated with increased risk of CP development&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Autosomal dominant polycystic kidney disease &#40;ADPKD&#41; is the most frequent genetic kidney disorder that affects approximately 1&#58;1000 individuals worldwide&#46; Progressive bilateral kidney cyst enlargement leads to end-stage renal disease in 50&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> Liver cysts&#44; colonic diverticula&#44; or intracranial aneurysms may lead to extrarenal manifestations&#46; Cysts in the pancreas develop in approximately 9&#37; of ADPKD patients&#46; They are usually smaller than 10<span class="elsevierStyleHsp" style=""></span>mm and therefore rarely cause pancreatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this study&#44; we introduce a case of a girl with CP and concomitant polycystic kidney disease&#44; both genetically determined&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case description</span><p id="par0020" class="elsevierStylePara elsevierViewall">The now 12-year-old Caucasian girl was initially diagnosed with the first attack of acute pancreatitis at the age of 8&#46; She was treated with bowel rest&#44; intravenous hydration and antibiotics&#46; As pancreatitis is unusual at this age&#44; a search for predisposing anatomical anomalies was initiated&#46; Magnetic resonance scans raised suspicion of pancreas divisum with no intervention needed&#44; as she was without complaints for the following 2 years&#46; However&#44; at the age of 10&#44; she experienced another attack of pancreatitis&#46; Laboratory tests showed normal findings in hematologic tests&#44; but biochemical parameters supported the diagnosis of pancreatitis&#58; pancreatic amylase 3&#46;84<span class="elsevierStyleHsp" style=""></span>ukat&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; &#8804;0&#46;58<span class="elsevierStyleHsp" style=""></span>ukat&#47;l&#41;&#44; amylase 4&#46;42<span class="elsevierStyleHsp" style=""></span>ukat&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; &#8804;1&#46;70<span class="elsevierStyleHsp" style=""></span>ukat&#47;l&#41;&#44; lipase 108&#46;62<span class="elsevierStyleHsp" style=""></span>ukat&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; 0&#46;67&#8211;2&#46;34<span class="elsevierStyleHsp" style=""></span>ukat&#47;l&#41;&#44; calcium 2&#46;23<span class="elsevierStyleHsp" style=""></span>mmol&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; 2&#46;25&#8211;2&#46;85<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#41;&#44; C-reactive protein 24<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;<span class="elsevierStyleItalic">N</span>&#58; 0&#8211;10<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#41;&#44; amylase and pancreatic amylase in urine were elevated more than 10 times above the upper normal values&#46; On ultrasonography&#44; the pancreas increased in echogenicity and size &#40;from 120<span class="elsevierStyleHsp" style=""></span>mm at admission to 150<span class="elsevierStyleHsp" style=""></span>mm on day 3&#41;&#46; Neither necrosis&#44; abscesses&#44; pseudocysts&#44; nor cysts were detected&#46; However&#44; the pancreatic parenchyma displayed a coarse tissue structure&#44; indicating chronic pancreatitis&#46; The previously suspected pancreas divisum was ruled out by magnetic resonance cholangiopancreatography &#40;MRCP&#41;&#46; As a coincidental finding&#44; numerous bilateral cortical kidney cysts up to 11<span class="elsevierStyleHsp" style=""></span>mm large were found&#46; Interestingly&#44; the family history was negative for any gastrointestinal symptoms or pancreatitis&#44; but it was positive for polycystic kidney disease on the maternal side of the pedigree &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The clinical diagnosis ADPKD was stated based on ultrasound diagnostic criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">As pancreatic cysts were excluded&#44; ADPKD was found to be unlikely the cause of CP&#46; By this time&#44; other structural anomalies of the pancreas and biliary tree&#44; infectious&#44; toxic&#44; metabolic&#44; or immunological agents were also ruled out&#46; Hence&#44; mutation screening of 4 genes associated with idiopathic CP was performed&#46; In <span class="elsevierStyleItalic">PRSS1</span>&#44; <span class="elsevierStyleItalic">SPINK1</span>&#44; and <span class="elsevierStyleItalic">CFTR</span>&#44; no mutation was found&#44; but the homozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant in the <span class="elsevierStyleItalic">CTRC</span> gene was identified&#46; Both parents as well as her brother were heterozygous carriers&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The genetic confirmation of clinically diagnosed ADPKD followed by linkage analysis&#44; revealing a link to the <span class="elsevierStyleItalic">PKD1</span> gene&#46; Direct sequencing of its coding sequence identified a novel pathologic nonsense variant c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; in our index patient&#44; her mother&#44; and mother&#39;s relatives with a clinical picture of ADPKD&#46; The nucleotide replacement creates premature termination codon&#44; thus predicts to truncate the protein&#44; leading to ADPKD phenotype&#46; Renal function assessment in our patient confirmed physiologic glomerular filtration rate&#44; adequate concentration capacity&#44; and blood pressure&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A genetic cause of both&#44; CP and polycystic kidney disease could be identified in the same patient&#46; Currently&#44; the girl is doing well&#44; avoiding fatty food and paying attention to sufficient fluid intake&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">We report a rare case of a child with chronic pancreatitis and the incidental finding of numerous renal cysts&#44; confirmed to be due to ADPKD&#46; After excluding pancreatic cysts as a possible cause of CP in ADPKD&#44; we found a homozygous <span class="elsevierStyleItalic">CTRC</span> variant p&#46;G60<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>predisposing to CP&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; only few sporadic cases of concomitant pancreatitis and ADPKD have been described in the literature&#46; It is usually restricted to patients with pancreatic duct compression due to pancreatic cyst development that is causally related to ADPKD&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">A case&#44; presented by Malka et al&#46;&#44; described a 38-year-old female patient with ADPKD&#44; abdominal pain&#44; and biochemical parameters consistent with pancreatitis&#46; A single pancreatic cyst&#44; 15<span class="elsevierStyleHsp" style=""></span>mm large&#44; compressing the main pancreatic duct&#44; was concluded to be the cause of the chronic obstructive pancreatitis &#8211; an extrarenal manifestation of ADPKD&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">9</span></a> An unusual combination of pancreatic cysts and pancreas divisum in a male patient with ADPKD and two consecutive attacks of acute pancreatitis was seen by Basar et al&#46; Surprisingly&#44; both anomalies appeared for the first time when the patient was 63 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">10</span></a> Multiple pancreatic cysts led to obstructive pancreatitis also in a 47-year-old ADPKD male patient reported by Sastre L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> Most recently&#44; two unrelated cases of recurrent attacks of acute pancreatitis were described in ADPKD individuals with only mild kidney disease&#59; while imaging studies revealed pancreatic cysts in a 38-year-old male described by Yazdanpanah et al&#46;&#44; no pancreatic cysts were detected&#44; in a 70-year-old female patient reported by Thyagarajan et al&#46;&#44; in whom an enlarged cystic liver was recognized to be the underlying condition of pancreatic duct obstruction&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">12&#44;13</span></a> The only pediatric case of pancreatitis due to multiple pancreatic cysts within ADPKD was reported by Kahn and Palmert in 1996&#46; Compression of the main pancreatic duct in its mid-part and mild dilation in the tail area was revealed in a girl as young as 9 years&#46; Pancreatic enzyme release secondary to duct compression was suspected to be the cause of the pancreatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> This was a unique case&#44; as ADPKD-related pancreatic cysts are rare in children&#46; According to autopsy and imaging studies&#44; these are related to ageing with the maximum prevalence after the third decade&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a> In summary&#44; the proportion of ADPKD patients who develop pancreatic cysts is small and usually restricted to adult patients&#46; Even among ADPKD patients with pancreatic cysts occurrence of pancreatitis seems to be rare<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;7</span></a> and the few cases of ADPKD and pancreatitis are clearly defined by the presence of pancreatic cysts with critical pancreatic duct compression&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">9&#8211;12&#44;14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Genetic susceptibility plays an important role in the pathogenesis of CP and genetic alterations in the <span class="elsevierStyleItalic">PRSS1</span>&#44; <span class="elsevierStyleItalic">SPINK1</span>&#44; <span class="elsevierStyleItalic">CFTR</span>&#44; <span class="elsevierStyleItalic">CTRC</span>&#44; <span class="elsevierStyleItalic">CPA1</span>&#44; <span class="elsevierStyleItalic">CEL</span>&#44; <span class="elsevierStyleItalic">CLDN2</span> and <span class="elsevierStyleItalic">CTRB1-CTRB2</span> locus may be associated with chronic pancreatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#8211;4</span></a> The presence of ADPKD and genetically determined CP may be a coincidence&#46; However&#44; CP is a complex genetic disorder that develops through the interaction of environmental and genetic factors&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a> Thus&#44; it cannot be excluded&#44; that changes in CP susceptibility genes together with mutations in ADPKD-causing genes could potentially trigger early-onset pancreatitis&#46; This is supported by our described case with a synonymous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">According to Beer et al&#46; and Paliwal et al&#46; the heterozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; carriers have an increased risk for CP 1&#46;65-fold and 2&#46;5-fold respectively&#44; whereas homozygotes 8&#46;44-fold and tenfold respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">15&#44;16</span></a> It exerts its effect via a loss-of-function mechanism as disease-related <span class="elsevierStyleItalic">CTRC</span> variants are connected to decreased mRNA levels&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The association between the variant and the CP was further supported by the study of LaRusch et al&#46; who observed that the presence of the variant increases the risk of CP specifically in individuals with a known genetic background &#40;disease-causing mutations in the genes <span class="elsevierStyleItalic">SPINK1&#44; CFTR&#44; CTRC</span>&#44; and <span class="elsevierStyleItalic">PRSS1</span>&#41; and alcohol&#47;smoking-related CP etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleItalic">CTRC</span> gene is therefore considered to be a disease modifier gene with pathogenic variants representing one of the most important factors increasing susceptibility to pancreatic damage through the trypsin-dependent pathway&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The increased risk of pediatric CP linked to the c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant in the <span class="elsevierStyleItalic">CTRC</span> gene was confirmed in a large pediatric Polish cohort of 136 children &#40;with either idiopathic CP or CP related to other genetic&#47;non-genetic risk factors&#41;&#46; Heterozygous carriers had 2&#46;8-fold increased risk of CP and homozygotes 23-fold compared to controls&#46; The homozygous c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; genotype was found to be the strongest CP risk factor among all identified variants in the <span class="elsevierStyleItalic">CTRC</span> gene&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">18</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Whether coincidental combination of ADPKD causing <span class="elsevierStyleItalic">PKD1</span>&#44; <span class="elsevierStyleItalic">PKD2</span>&#44; or <span class="elsevierStyleItalic">GANAB</span> mutations<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> and genetic susceptibility to CP has an adverse impact on pancreatic cyst development and&#47;or early pancreatitis manifestation need to be reliably determine by further studies&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">CP might occur also independently from ADPKD&#44; and the case of our patient could be a unique coincidence of both diseases at the same time&#46; Further follow-up of the propositus will be important for better understanding of the behavior and natural course of both diseases appearing together&#46; Also&#44; genetic counseling for the family will inform them about the risk of development of one or both disorders in future generations&#46; From a clinical perspective&#44; we suggest that in children with both ADPKD and CP not related to the presence of pancreatic cysts&#44; genetic causes of CP should be considered&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0085" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this is the first case of a pediatric patient with chronic pancreatitis and coincidental autosomal dominant polycystic kidney disease with molecular evidence of ADPKD causing mutation and genetic propensity to CP&#46; Based on our case&#44; we recommend to include genetic factors contributing to development of pancreatic inflammation in the differential diagnosis of pancreatitis in ADPKD&#46; Further observations and analyses are needed to determine whether mutations causing ADPKD are likely to trigger pancreatitis manifestation in patients with genetic susceptibility to CP&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Compliance with ethical standards</span><p id="par0090" class="elsevierStylePara elsevierViewall">All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards&#46; Informed consent was obtained from all individual participants included in the study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Submission declaration and verification</span><p id="par0095" class="elsevierStylePara elsevierViewall">The work described here has been approved by all authors&#44; it has not been published previously &#40;except for an abstract&#41; and it is not under consideration for publication in other journal&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In children&#44; chronic pancreatitis &#40;CP&#41; is usually associated with anatomical anomalies of the pancreas and biliary tract or is genetically determined&#46; Autosomal dominant polycystic kidney disease &#40;ADPKD&#41; may present with extrarenal cyst formation&#44; sometimes involving the pancreas&#46; Large enough&#44; these cysts may cause pancreatitis in ADPKD patients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case presentation</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Herein&#44; we present a case of a 12-year-old Caucasian girl with recurrent pancreatitis with no identifiable traumatic&#44; metabolic&#44; infectious&#44; drug&#44; or immunologic causes&#46; Structural anomalies of the pancreas&#44; including cysts&#44; were ruled out by imaging&#46; However&#44; bilateral cystic kidneys were found as an incidental finding&#46; Her family history was negative for pancreatitis&#44; but positive for polycystic kidney disease&#46; Molecular analysis of ADPKD-causing mutations revealed a novel c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; mutation in the <span class="elsevierStyleItalic">PKD1</span> gene confirming the clinical suspicion of ADPKD&#46; Although CP may rarely occur as an extrarenal manifestation of ADPKD with pancreatic cysts&#44; it is unusual in their absence&#46; Thus&#44; molecular analysis of pancreatitis susceptibility genes was performed and a homozygous pathologic c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; variant of the <span class="elsevierStyleItalic">CTRC</span> gene&#44; known to increase the risk of CP&#44; was confirmed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is the first reported case of a pediatric patient with coincidence of genetically determined CP and ADPKD&#46; Occurrence of pancreatitis in children with ADPKD without pancreatic cysts warrants further investigation of CP causing mutations&#46;</p></span>"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En ni&#241;os&#44; la pancreatitis cr&#243;nica &#40;CP&#44; por sus siglas en ingl&#233;s&#41; generalmente se asocia con anomal&#237;as anat&#243;micas del p&#225;ncreas y el tracto biliar&#44; o est&#225; gen&#233;ticamente determinada&#46; La enfermedad renal poliqu&#237;stica autos&#243;mica dominante &#40;ADPKD&#44; por sus siglas en ingl&#233;s&#41; puede presentarse con la formaci&#243;n de quistes extrarrenales&#44; que a veces afecta al p&#225;ncreas&#46; Suficientemente grandes&#44; estos quistes pueden causar pancreatitis en pacientes con ADPKD&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Presentaci&#243;n del caso</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una ni&#241;a cauc&#225;sica de 12 a&#241;os con pancreatitis recurrente sin causas identificables traum&#225;ticas&#44; metab&#243;licas&#44; infecciosas&#44; farmacol&#243;gicas o inmunol&#243;gicas&#46; Las anomal&#237;as estructurales del p&#225;ncreas&#44; incluidos los quistes&#44; se descartaron mediante im&#225;genes&#46; Sin embargo&#44; los ri&#241;ones qu&#237;sticos bilaterales se encontraron como un hallazgo accidental&#46; Su historia familiar fue negativa para la pancreatitis&#44; pero positiva para la enfermedad renal poliqu&#237;stica&#46; El an&#225;lisis molecular de las mutaciones causantes de ADPKD revel&#243; una nueva mutaci&#243;n c&#46;9659C&#62;A &#40;p&#46;Ser3220&#42;&#41; en el gen <span class="elsevierStyleItalic">PKD1</span> que confirma la sospecha cl&#237;nica de ADPKD&#46; Aunque la CP rara vez ocurre como una manifestaci&#243;n extrarrenal de ADPKD con quistes pancre&#225;ticos es inusual&#46; Por lo tanto&#44; se realiz&#243; el an&#225;lisis molecular de los genes de susceptibilidad a pancreatitis y se confirm&#243; una variante homocig&#243;tica patol&#243;gica c&#46;180C&#62;T &#40;p&#46;G60&#61;&#41; del gen <span class="elsevierStyleItalic">CTRC</span>&#44; que se sabe que aumenta el riesgo de CP&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusi&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Este es el primer caso reportado de un paciente pedi&#225;trico con coincidencia de CP y ADPKD gen&#233;ticamente determinados&#46; La aparici&#243;n de pancreatitis en ni&#241;os con ADPKD sin quistes pancre&#225;ticos justifica una mayor investigaci&#243;n de CP que causan mutaciones&#46;</p></span>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pediatric acute recurrent and chronic pancreatitis&#58; lessons from INSPIPRE"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Kumar"
                            1 => "Ch&#46;Y&#46; Ooi"
                            2 => "S&#46; Werlin"
                            3 => "M&#46; Abu-El-Haija"
                            4 => "B&#46; Barth"
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                    0 => array:2 [
                      "doi" => "10.1001/jamapediatrics.2015.4955"
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                        "tituloSerie" => "JAMA Pediatr"
                        "fecha" => "2016"
                        "volumen" => "170"
                        "paginaInicial" => "562"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27064572"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic risk in chronic pancreatitis&#58; the trypsin-dependent pathway"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Hegyi"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1007/s10620-017-4601-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "2017"
                        "volumen" => "62"
                        "paginaInicial" => "1692"
                        "paginaFinal" => "1701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28536777"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0105"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "H&#46; Kirsten"
                            2 => "E&#46; Hegyi"
                            3 => "P&#46; Kovacs"
                            4 => "F&#46;U&#46; Weiss"
                            5 => "H&#46; Laumen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/gutjnl-2017-314454"
                      "Revista" => array:2 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2017"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Whitcomb"
                            1 => "J&#46; LaRusch"
                            2 => "A&#46;M&#46; Krasinskas"
                            3 => "L&#46; Klei"
                            4 => "J&#46;P&#46; Smith"
                            5 => "R&#46;E&#46; Brand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.2466"
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2012"
                        "volumen" => "44"
                        "paginaInicial" => "1349"
                        "paginaFinal" => "1354"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in GANAB&#44; encoding the glucosidase IIa subunit&#44; cause autosomal-dominant polycystic kidney and liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "V&#46;G&#46; Gainullin"
                            2 => "E&#46; Cornec-Le Gall"
                            3 => "E&#46;K&#46; Dillinger"
                            4 => "C&#46;M&#46; Heyer"
                            5 => "K&#46; Hopp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2016.05.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2016"
                        "volumen" => "98"
                        "paginaInicial" => "1193"
                        "paginaFinal" => "1207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27259053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasonographic study of pancreatic cysts in autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Torra"
                            1 => "C&#46; Nicolau"
                            2 => "C&#46; Badenas"
                            3 => "S&#46; Navarro"
                            4 => "L&#46; P&#233;rez"
                            5 => "X&#46; Estivill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "1997"
                        "volumen" => "47"
                        "paginaInicial" => "19"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9021236"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gastrointestinal manifestations of autosomal-dominant polycystic kidney disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;E&#46; Mikolajczyk"
                            1 => "H&#46;S&#46; Te"
                            2 => "A&#46;B&#46; Chapman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cgh.2016.06.017"
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                        "tituloSerie" => "Clin Gastroenterol Hepatol"
                        "fecha" => "2017"
                        "volumen" => "15"
                        "paginaInicial" => "17"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27374006"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0130"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal-dominant polycystic kidney disease &#40;ADPKD&#41;&#58; executive summary from a kidney disease&#58; Improving Global Otcomes &#40;KDIGO&#41; Controversies Conference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            2 => "K&#46;U&#46; Eckardt"
                            3 => "R&#46;T&#46; Gansevoort"
                            4 => "T&#46; Harris"
                            5 => "S&#46; Horie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2015.59"
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                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2015"
                        "volumen" => "88"
                        "paginaInicial" => "17"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25786098"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0135"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pancreatitis due to a pancreatic cyst in a patient with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Malka"
                            1 => "P&#46; Hammel"
                            2 => "V&#46; Vilgrain"
                            3 => "J&#46;F&#46; Fl&#233;jou"
                            4 => "J&#46; Belghiti"
                            5 => "P&#46; Bernades"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gut"
                        "fecha" => "1998"
                        "volumen" => "48"
                        "paginaInicial" => "131"
                        "paginaFinal" => "134"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;pubmed&#47;9505899"
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                  ]
                ]
              ]
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              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent pancreatitis in a patient with autosomal-dominant polycystic kidney disease"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "&#214;&#46; Basar"
                            1 => "M&#46; Ibis"
                            2 => "E&#46; Ucar"
                            3 => "I&#46; Ertgrul"
                            4 => "&#214;&#46;F&#46; Yolcu"
                            5 => "S&#46; K&#246;kl&#252;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000090258"
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                        "tituloSerie" => "Pancreatology"
                        "fecha" => "2006"
                        "volumen" => "6"
                        "paginaInicial" => "160"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16354965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute pancreatitis and polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Sastre Lopez"
                            1 => "M&#46; Bernabeu Lafuente"
                            2 => "M&#46;V&#46; Inigo Vanrell"
                            3 => "J&#46;M&#46; Gasco Company"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "352"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18590508"
                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent acute pancreatitis and cholangoitis in a patient with autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Yazdanpanah"
                            1 => "N&#46; Manouchehri"
                            2 => "E&#46; Hosseinzadeh"
                            3 => "M&#46;H&#46; Emami"
                            4 => "M&#46; Karami"
                            5 => "A&#46;H&#46; Sarrami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Prev Med"
                        "fecha" => "2013"
                        "volumen" => "4"
                        "paginaInicial" => "233"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23543834"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple fluid-filled liver cysts presenting as acute pancreatitis in a patient with known autosomal dominant polycystic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "P&#46; Ghatage"
                            2 => "S&#46;S&#46; Alagusundaramoorthy"
                            3 => "S&#46; Patel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bcr-2016-216051"
                      "Revista" => array:2 [
                        "tituloSerie" => "BMJ Case Rep"
                        "fecha" => "2016"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "14"
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                    0 => array:2 [
                      "titulo" => "A 9-year-old girl with vomiting&#44; abdominal pain and pancreatic and renal cysts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Kahn"
                            1 => "M&#46;R&#46; Palmert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Pediatrics"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "152"
                        "paginaFinal" => "156"
                      ]
                    ]
                    1 => array:1 [
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              ]
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                  "referenciaCompleta" => "Beer S&#44; Ludwig M&#44; N&#233;meth BC&#44; Witt H&#44; Sahin-T&#243;th M&#44; Rosendahl J&#46; Synonymous CTRC variant c&#46;180C&#62;T contributes significantly to chronic pancreatitis risk&#46; Pancreatology&#46; 2013&#59;14&#58;S15&#46; <a target="_blank" href="doi:10.1016/j.pan.2014.05.427">doi&#58;10&#46;1016&#47;j&#46;pan&#46;2014&#46;05&#46;427</a>&#46;"
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              "etiqueta" => "16"
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                0 => array:2 [
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                      "titulo" => "Comprehensive screening of chymotrypsin C &#40;CTRC&#41; gene in tropical calcific pancreatitis identifies novel variants"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
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                            4 => "G&#46;V&#46; Rao"
                            5 => "S&#46;P&#46; Singh"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The common chymotrypsinogen C &#40;CTRC&#41; variant G60G &#40;C&#46;180T&#41; increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "K&#46; Stello"
                            3 => "A&#46; Moore"
                            4 => "K&#46; Muddana"
                            5 => "M&#46; O&#8217;Connel"
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                        "volumen" => "8"
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                          "etal" => true
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                            5 => "E&#46; Kolodziejczyk"
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