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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Hypercalciuria &#40;HC&#41;&#44; whether of resorptive&#44; absorptive or excretory origin&#44; constitutes a risk for nephrolithiasis&#44; nephrocalcinosis and even osteoporosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#8211;5</span></a> In excretory HC&#44; treatment with thiazides decreases urinary calcium elimination by increasing resorption in the proximal tubule&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a> A similar situation of HC occurs frequently in the treatment of hypoparathyroidism&#44; with the exogenous contribution of vitamin D and calcium&#59; calcium is excreted freely by the kidney&#44; since in the absence of parathormone &#40;PTH&#41; there is a reduction in the tubular reabsorption of Ca&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In addition&#44; the excretion of urinary calcium is modulated by multiple nutritional factors such as high intake of animal proteins and salt&#44; calcemia and magnesemia&#44; and acid-base balance&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;7&#8211;12</span></a> Therefore&#44; in addition to thiazide therapy&#44; the treatment of HC should include nutritional modifications&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">11&#44;12</span></a> The restriction of salt in the diet is essential in these processes&#46; We want to quantify the correlation between natriuresis and calciuria&#44; using an artificial diet &#40;Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium&#41; and staggered increases of oral NaCl and the added treatment of thiazides with the maximum dose of ClNa&#46; In addition&#44; we will assess the acute response of plasma renin activity &#40;ARP&#41; and aldosterone levels&#46; Thus&#44; we intend to know the relationship between salt intake with the urinary excretion of Na and Ca and&#44; the modifications that may occur with thiazide treatment&#46; This information will indicate if in the treatment of HC with Thiazides it is essential to reduce salt intake and to what extent&#59; or&#44; whether the limitation of salt intake it is not important if patients are on thiazides&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Objective</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our objective is to assess the normal salt intake in a young&#44; healthy&#44; male population&#44; and study the correlation between urine Na and Ca with on the regular diet and after modification of salt intake while on thiazides&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Material and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#40;A&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Subjects&#58;</span> Nineteen healthy males&#44; 18&#8211;30 years old&#44; height 178&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;75<span class="elsevierStyleHsp" style=""></span>cm&#59; weight 81&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;8<span class="elsevierStyleHsp" style=""></span>kg and body mass index 25&#46;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;0<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Patients signed the informed consent&#46; They did not have high blood pressure&#44; nephrolithiasis&#44; renal failure&#44; dyslipidemia or obesity&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#40;B&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Protocol</span>&#58; The study was conducted for 8 days and&#44; in 12 of them&#44; it was extended up to 10 days&#46; His usual diet was replaced by 2&#189;<span class="elsevierStyleHsp" style=""></span>l of Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium&#44; which provides 2000<span class="elsevierStyleHsp" style=""></span>kcal&#59; Calcium&#58; 1600<span class="elsevierStyleHsp" style=""></span>mg&#44; Sodium&#58; 500<span class="elsevierStyleHsp" style=""></span>mg &#40;equivalent to 1&#46;250<span class="elsevierStyleHsp" style=""></span>g of sodium chloride&#41; and known amounts of macro and micronutrients shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; In addition&#44; a daily intake of 1&#46;5&#8211;2&#46;0<span class="elsevierStyleHsp" style=""></span>L of water was recommended&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></li></ul></p><p id="par0035" class="elsevierStylePara elsevierViewall">During 1st and 2nd days&#44; patients took only Nutrison<span class="elsevierStyleSup">&#174;</span>&#46; During the 3rd and 4th days&#44; 5<span class="elsevierStyleHsp" style=""></span>g of salt per day were added in capsules divided into 3 doses&#44; the dose of salt was increased to 10<span class="elsevierStyleHsp" style=""></span>g during days 5 and 6 and it was further increased to 15<span class="elsevierStyleHsp" style=""></span>g per day during days 7 and 8&#46; In 12 patients the study was continued on days 9 and 10&#44; with 2<span class="elsevierStyleHsp" style=""></span>L of Nutrison<span class="elsevierStyleSup">&#174;</span>&#44; 15<span class="elsevierStyleHsp" style=""></span>g of salt and a thiazide &#40;Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#44; 50<span class="elsevierStyleHsp" style=""></span>mg on day 9 and 100 ng on day 10 &#40;2 pills of 50<span class="elsevierStyleHsp" style=""></span>mg&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Twenty four hours Urine collection was obtained on days &#8211; 1&#44; 2&#44; 4&#44; 6&#44; 8&#44; 9 and 10&#44; for determination of Na&#44; ionic Ca&#44; Cl&#44; K and Mg&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Venous blood was taken on an empty stomach on days 1&#44; 3&#44; 5&#44; 7&#44; 9 and 11&#44; for determination of Na&#44; Ca<span class="elsevierStyleSup">&#43;&#43;</span>&#44; Cl&#44; P&#44; Mg&#44; K&#44; Cr&#44; PRA and aldosterone&#46;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#40;C&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistics</span>&#58; results are expressed as mean and standard deviation&#46; Wilcoxon test was used to compare different means&#44; and Pearson&#39;s linear correlation was used to study the association between pairs of variables&#46; A 95&#37; was established as statistical significance&#46;</p></li></ul></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#40;a&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Urinary excretion on days &#8211; 1st &#40;&#8220;B&#8221;&#58; free diet&#44; prior to the study&#41;&#59; 2nd &#40;1&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#44; &#8220;0&#8221;&#41;&#44; 4th &#40;6&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#44; &#8220;5&#8221;&#41;&#44; 6th &#40;11&#46;25<span class="elsevierStyleHsp" style=""></span>g NaCl&#44; &#8220;10&#8221;&#41; and 8&#176; &#40;1625<span class="elsevierStyleHsp" style=""></span>g of ClNa&#44; &#8220;15&#8221;&#41;&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Urinary Na &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Relative to the baseline&#44; natriuresis decreases to lowest levels in &#8220;0&#8221; and &#8220;5&#8221;&#46; The increase in salt intake increases natriuresis and the difference is significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#41; between all the values&#44; except between the baseline and &#8220;15&#8221; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Taking into account that Nutrison<span class="elsevierStyleSup">&#174;</span> contains 500<span class="elsevierStyleHsp" style=""></span>ng of Na&#44; equivalent to 1&#46;25<span class="elsevierStyleHsp" style=""></span>ng of NaCl&#44; we assume that the ingestion with Nutrison<span class="elsevierStyleSup">&#174;</span> is 1&#46;25<span class="elsevierStyleHsp" style=""></span>ng of NaCl&#46; Therefore the amount of salt ingested &#40;calculation with respect to sodium ingested&#41; is&#58; unknown &#40;&#8220;B&#8221;&#41;&#59; 1&#46;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#8220;0&#8221;&#41;&#59; 6&#46;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#8220;5&#8221;&#41;&#59; 11&#46;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#8220;10&#8221;&#41;&#59; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#8220;15&#8221;&#41;&#46; The urinary excretion of Na relative to the to the salt intake was&#58; unknown &#40;&#8220;B&#8221;&#41;&#59; 276<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>144&#37; &#40;&#8220;0&#8221;&#41;&#59; 39&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;7&#37; &#40;&#8220;5&#8221;&#41;&#59; 69&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>25&#46;7&#37; &#40;&#8220;10&#8221;&#41;&#59; 79&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#37; &#40;&#8220;15&#8221;&#41;&#46; From these data&#44; it can be concluded that the salt intake with the basal diet is of the order of 15&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;33<span class="elsevierStyleHsp" style=""></span>g&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Urine Ca</span> &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; There is a statistically significant increase in Urine Ca between &#8220;0&#8221; and &#8220;15&#8221;&#44; &#8220;5&#8221; and &#8220;10&#8221;&#44; &#8220;5&#8221; and &#8220;15&#8221;&#44; and &#8220;10&#8221; and &#8220;15&#8221; &#40;all with <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Correlation between Ca and Na in 24<span class="elsevierStyleHsp" style=""></span>h urine&#46; There is no correlation of these 2 parameters with the free diet &#8220;B&#8221; neither in &#8220;0&#8221; nor in &#8220;5&#8221;&#46; However there is a correlation in &#8220;10&#8221; &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;47&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; and in &#8220;15&#8221; &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; An increase in NaCl in the diet of 10<span class="elsevierStyleHsp" style=""></span>g&#44; from 6&#46;25<span class="elsevierStyleHsp" style=""></span>g to 16&#46;25<span class="elsevierStyleHsp" style=""></span>g&#44; produces an increase in natriuresis 182&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>66&#46;4<span class="elsevierStyleHsp" style=""></span>mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h and calciuria 54&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Thus&#44; 1<span class="elsevierStyleHsp" style=""></span>g of ClNa increases calciuria by 5&#46;46<span class="elsevierStyleHsp" style=""></span>mg &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Urine Cl</span> &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; With the increase of salt intake&#44; the excretion of Cl increases&#46; The difference is significant between all the values&#44; except between the basal and 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The modifications in the excretion of ClNa&#44; Mg and K are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#40;b&#41;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Urinary excretion at day 9&#44; with a 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt intake &#40;&#8220;15bis&#8221;&#41; and 50<span class="elsevierStyleHsp" style=""></span>mg&#47;day of Higrotona<span class="elsevierStyleSup">&#174;</span> &#40;&#8220;T1&#8221;&#41; and at day 10 day&#44; with 16&#46;25<span class="elsevierStyleHsp" style=""></span>g de salt and 50<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#47;12<span class="elsevierStyleHsp" style=""></span>h &#40;&#8220;T2&#8221;&#41;&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Treatment with diuretic produce an increase in the urinary excretion of Na&#44; Cl&#44; ClNa and Mg and no differences were observed with the two doses of diuretics&#46; Calciuria was not different&#44; with 50<span class="elsevierStyleHsp" style=""></span>mg of thiazide &#8220;T1&#8221; and &#8220;15bis&#8221; and with 100<span class="elsevierStyleHsp" style=""></span>mg there is a significant decrease&#44; from both &#8220;15bis&#8221; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; and &#8220;T1&#8221; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41;&#46; The redction of calciuria after 100<span class="elsevierStyleHsp" style=""></span>mg of thiazide is 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows that the restriction of dietary salt decreases natriuresis and calciuria&#44; as observed in the lower and left area of the graph&#46; After the addition of thiazide there is a decrease in calciuria and an increase in urinary sodium&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#40;c&#41;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Modification of plasma electrolytes levels with salt intake and treatment with thiazides are shown in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Plasma sodium is normal in all determinations&#46; The lowest value of ionic calcium is obtained in &#8220;5&#8221;&#44; which statistically significant different as compared with basal &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#41; and &#8220;10&#8221; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41;&#46; No significant differences were observed between the rest of values&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">After the administration of 100<span class="elsevierStyleHsp" style=""></span>mg of Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; there was a decrease in Na &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; Cl &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;00001&#41; and K &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; and an increase in P &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#44; without differences in the levels of ionic Ca and Mg&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#40;d&#41;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Plasma levels of ARP and aldosterone&#46;</p></li></ul></p><p id="par0125" class="elsevierStylePara elsevierViewall">Values of PRA &#40;ng&#47;ml&#47;h&#41;&#46; From &#8220;B&#8221; to &#8220;5&#8221; there is a considerable increase in PRA&#44; which is attenuated with increasing doses of NaCl&#46; The addition of 100<span class="elsevierStyleHsp" style=""></span>mg of Higrotona<span class="elsevierStyleSup">&#174;</span> to 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt produced a marked increase in PRA &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0006&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Values of Aldosterone &#40;pg&#47;ml&#41;&#46; With 10<span class="elsevierStyleHsp" style=""></span>g values are similar to baseline and with15<span class="elsevierStyleHsp" style=""></span>g of salt intake the values were reduced&#46; After thiazide administration there was a remarkable increase in Aldosterone &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0007&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the evolution of natriuresis and serum aldosterone concentration depicting a impeccable mirror image&#59; a reduction of natriuresis due to low intake of Na is accompanied by an increases in aldosterone level and with a high salt intake&#44; natriuresis increases and aldosterone production is blocked&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">Regulation of calciuria is dependent on natriuresis which&#44; in turn&#44; depends closely on the salt intake&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2&#44;5</span></a> Na and Ca are reabsorbed together in the proximal nephron&#44; in the ascending portion of the loop of Henle and in the distal tubule&#59; therefore if natriuresis increases there is also an increase in calciuria&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Some studies have analyzed the correlation between urinary excretion of Na and Ca&#44; in individuals on a regular diet&#44;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">14&#44;15</span></a> or with modification of salt intake&#44;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#44;16</span></a> however these studies have tested very low vs very high salt intake&#46; Our study is the first using a dose of 1&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt intake and evaluating calciuria with gradual increase in salt intake and with the introduction of thiazide&#46; Other studies have evaluated the effect of different Calcium intake&#46; Low calcium intake increases PTH&#44; which can decrease bone mass and maintain or increase calciuria&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> thus in these type of studies may not be appropriate to use a calcium deficient diet&#46; In our opinion&#44; previous studies have some limitations&#59; first&#44; in studies with the usual diet&#44; there is a great heterogeneity in the nutritional habits among the subjects&#46; Even when an elaborated diet has been administered in terms of calories and known amount of macro and micronutrients&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#44;18</span></a> there is important variability of the foods according to their origin&#44; handling&#44; elaboration&#46;&#46;&#46; Our method of supplying a liquid artificial is the method to assure that Ingested quantities are known and always the same&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the majority of cross-sectional studies there is a correlation between natriuresis and calciuria&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2&#44;10&#44;19</span></a> however others do not find this correlation in hyper- or normocalciuric patients<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> or if calcium intake is high&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> Probably the lack of correlation is not only due to differences in salt intake&#44; but to the complexity of inter-relationships with dietary calcium and with the intake of proteins of animal origin&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">In our study&#44; natriuresis decreased from the free diet to the first phase with Nutrison<span class="elsevierStyleSup">&#174;</span>&#44; without addition of NaCl&#46; In a study in Spain&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a> with a diet of less than 2&#46;5<span class="elsevierStyleHsp" style=""></span>g of salt the natriuresis was 25&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;04<span class="elsevierStyleHsp" style=""></span>mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h and with a 17&#46;5<span class="elsevierStyleHsp" style=""></span>g of salt intake the natriuresis rises to 340&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>156mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; In our subjects taking 6&#46;25<span class="elsevierStyleHsp" style=""></span>g&#44; the natriuresis continues to decrease as compared with &#8220;0&#8221; with a 1&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt intake because there is a marked increase in PRA and aldosterone due to the low salt intake&#46; In &#8220;5&#8221; the levels of these hormones remain high&#44; so the excretion of Na is reduced &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; These data provides information on normal salt intake that is much higher than 6&#46;25<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46; With 11&#46;25 and 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt Natriuresis increases&#46; As compared with the free diet&#44; the natriuresis is lower in &#8220;10&#8221; and similar in &#8220;15&#8221;&#46; Our results regarding the amount of Na excreted in grams have allowed us to calculate in what amount of NaCl these values are contained&#46; We have been able to verify that the urinary excretion of Na is reduced with low or normal salt intakes and increases with the amount of salt ingested&#46; Thus&#44; with a total intake of 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#44; 79&#46;4&#37; is excreted&#44; and with 6&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl intake the excretion is 39&#46;2&#37;&#46; So&#44; since the results of natriuresis with the basal diet are similar to &#8220;15&#8221;&#44; assuming that in &#8220;B&#8221; 79&#46;4&#37; have been excreted&#44; the salt intake with the free diet should be 15&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;33<span class="elsevierStyleHsp" style=""></span>g of ClNa&#47;day&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The calciuria reproduces the dynamics of natriuresis&#59; decreasing the excretion of Na between &#8220;0&#8221; and &#8220;5&#8221;&#44; calciuria does not increase&#44; despite the higher intake of NaCl&#46; Between &#8220;5&#8221; and &#8220;15&#8221;&#44; that is&#44; a net increase of 10<span class="elsevierStyleHsp" style=""></span>g of NaCl intake &#40;from 6&#46;25 to 16&#46;25<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; calciuria increases to 54&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; so that 1<span class="elsevierStyleHsp" style=""></span>g of salt in the diet increases calciuria by 5&#46;46<span class="elsevierStyleHsp" style=""></span>mg &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The increased natriuresis inhibits the calcium reabsorption in the proximal tubule&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> Another possible mechanism to explain the increase in calciuria could be the increase in extracellular volume due to the increase in salt intake&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> Our results are similar to those published in most of the dynamic studies with modification of the salt intake &#40;1<span class="elsevierStyleHsp" style=""></span>g of ClNa added to the diet increases the calciuria 4&#46;19<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Thiazides produce a decrease in calciuria by acting in the distal tubule independent of natriuresis&#46; Twelve of the subjects continued the study adding 50<span class="elsevierStyleHsp" style=""></span>mg of Higrotona<span class="elsevierStyleSup">&#174;</span> on the 9th day and 100<span class="elsevierStyleHsp" style=""></span>mg on the 10th day&#46; We have not seen this protocol done in any previous study&#46; After Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; natriuria increases&#44; with no differences between the 2 doses and there is a decrease in calciuria of 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h with 100<span class="elsevierStyleHsp" style=""></span>mg&#44; and not observed with the dose of 50<span class="elsevierStyleHsp" style=""></span>mg &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; With a salt intake between 11&#46;25 and 16&#46;25<span class="elsevierStyleHsp" style=""></span>g&#47;day &#40;assuming that this is the usual amount of NaCl in the free diet&#41; it can be quantified the decrease in calciuria obtained by adding the effect of Higrotona<span class="elsevierStyleSup">&#174;</span> to the of the salt restriction &#40;difference between &#8220;15&#8221; and &#8220;5&#8221;&#41;&#46; With a salt intake of 6&#46;25<span class="elsevierStyleHsp" style=""></span>g &#40;compared to 16&#46;25<span class="elsevierStyleHsp" style=""></span>g&#41; and Higrotona<span class="elsevierStyleSup">&#174;</span> 100<span class="elsevierStyleHsp" style=""></span>mg&#44; the decrease in calciuria is 105&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;54&#46;6<span class="elsevierStyleHsp" style=""></span>mg due to the decrease in NaCl and 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg due to Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#46; This is an important reduction of calciuria with expected clinical impact on the risk of nephrolithiasis or nephrocalcinosis&#46; Although we have used thiazide with a dose of 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#44; we believe that its effect is maintained&#44; with lower salt intake&#44; as the mechanism of action is independent of natriuresis&#46; The increase in natriuresis due to thiazides is accompanied by a decrease in serum Na concentration&#44; with no change in calcemia&#46; Also serum potassium decreases due to the loss of potassium in the urine&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The renin-angiotensin-aldosterone system is stimulated in a situation of low salt intake and it is inhibited by high salt diet&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">20&#8211;23</span></a> Salt restriction produces an increase in PRA and serum aldosterone concentration&#59; the highest levels are observed in &#8220;0&#8221; and &#8220;5&#8221;&#44; with a subsequent progressive decrease with the increase in salt intake&#46; In &#8220;5&#8221;&#44; despite ingesting 6&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#44; the levels of PRA and aldosterone are higher than basal&#44; which explains why natriuresis was not increased yet&#46; The level of aldosterone in &#8220;15&#8221; is lower than &#8220;B&#8221;&#44; which confirms that the basal intake of salt is less than 16&#46;25<span class="elsevierStyleHsp" style=""></span>&#956;g NaCl&#46; After treatment with Higrotona<span class="elsevierStyleSup">&#174;</span> there is a significant increase in PRA and aldosterone&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">According to our study&#44; the salt intake in the studied population is higher than that recommended by the WHO and it can be estimated at 14&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;day&#46; With an increase in intake of 6&#46;25 to 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#44; calciuria increases by 54&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h and after thiazide there is a decrease of 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The data obtained could be useful for dietary and therapeutic management of patients with excretory hypercalciuria or hypoparathyroidism&#46; The choice of salt restriction in the diet or use of thiazides will be conditioned by factors such as the severity of hypercalciuria&#44; the degree of adherence to dietary and pharmacological treatment&#44; economic availability&#44; the presence of side effects such as hypotension or hypokalemia and the choice of the patient&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">It would probably be recommendable to start with reduction of salt intake in all hypercalciuric patients and&#44; given its different mechanism of action&#44; in case of not achieving therapeutic objectives&#44; will be recommended to associate an effective dose of thiazide&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Both dietary restriction of sodium chloride &#40;NaCl&#41; and treatment with thiazides have been used in hypercalciuric patients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To calculate regular salt intake and investigate the correlation between natriuresis and urinary calcium with usual diet &#40;B&#41; and after changing the amount of NaCl intake and administration of thiazides&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nineteen healthy young individuals had their diet replaced by 2<span class="elsevierStyleHsp" style=""></span>l of Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium &#40;500<span class="elsevierStyleHsp" style=""></span>mg sodium&#47;day&#41; daily for two days&#46; Then&#44; 5<span class="elsevierStyleHsp" style=""></span>g of NaCl were added every two days &#40;&#8220;5&#8221;&#44; &#8220;10&#8221; and &#8220;15&#8221;&#41;&#44; administering 50<span class="elsevierStyleHsp" style=""></span>mg &#40;H50&#41; and 100<span class="elsevierStyleHsp" style=""></span>mg &#40;H100&#41; of Higroton<span class="elsevierStyleSup">&#174;</span> on the last two days&#46; Blood sodium&#44; plasma renin activity &#40;PRA&#41; and aldosterone were determined in venous blood samples&#44; as were urinary sodium and calcium&#46; <span class="elsevierStyleItalic">Statistical analysis</span>&#58; Wilcoxon <span class="elsevierStyleItalic">t</span>-test and the Pearson linear correlation were calculated&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Urinary Na &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 210&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;6 &#40;&#8220;B&#8221;&#41;&#59; 42&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;4 &#40;&#8220;5&#8221;&#41;&#59; 135&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;6 &#40;&#8220;10&#8221;&#41;&#59; 225&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#46;7 &#40;&#8220;15&#8221;&#41;&#46; Urinary calcium &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 207&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>93&#46;6 &#40;&#8220;B&#8221;&#41;&#59; 172&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#46;1 &#40;&#8220;5&#8221;&#41;&#59; 206&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;7 &#40;&#8220;10&#8221;&#41;&#59; 227&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#46;1 &#40;&#8220;15&#8221;&#41;&#46; A positive correlation was observed between natriuresis and urinary calcium in &#8220;10&#8221; &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;47&#41; and &#8220;15&#8221; &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#41;&#46; After Higroton<span class="elsevierStyleSup">&#174;</span>&#44; natriuresis&#58; 232&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;7&#59; 377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 &#40;H50&#41;&#59; 341&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#46;4 &#40;H100&#41;&#59; Ca in urine&#58; 209&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>57&#46;4&#59; 213&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#46;6 &#40;H50&#41;&#59; 159&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#46;2 &#40;H100&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Salt intake in the population studied was estimated to be 14&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;day with a positive correlation found between sodium and calcium urine output with daily intakes of 11&#46;25 and 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#46; With the usual intake&#44; for each gram of salt&#44; urinary calcium increased by 5&#46;46<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h and with 100<span class="elsevierStyleHsp" style=""></span>mg of Higroton<span class="elsevierStyleSup">&#174;</span> it decreased by 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; These data could be useful for the management of patients with excretory hypercalciuria or hypoparathyroidism&#46;</p></span>"
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        "resumen" => "<span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introducci&#243;n</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La restricci&#243;n de ClNa en la dieta y el tratamiento con tiazidas han sido utilizados en pacientes hipercalci&#250;ricos&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Conocer la ingesta habitual de sal y la correlaci&#243;n entre natriuria y calciuria con la dieta habitual &#40;B&#41; y tras la modificaci&#243;n de la cantidad de ClNa y la administraci&#243;n de tiazidas&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Material y m&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Diecinueve j&#243;venes sanos&#44; a los que se les sustituy&#243; su dieta por 2<span class="elsevierStyleHsp" style=""></span>l diarios de Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium &#40;500<span class="elsevierStyleHsp" style=""></span>mg de Na&#41; durante 2 d&#237;as&#46; Posteriormente se a&#241;adieron cada 2 d&#237;as 5<span class="elsevierStyleHsp" style=""></span>g de ClNa &#40;&#171;5&#187;&#44; &#171;10&#187; y &#171;15&#187;&#41; y durante los 2 &#250;ltimos d&#237;as 50 y 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span> &#40;H50&#41; y &#40;H100&#41;&#46; Se determinaron iones&#44; ARP y aldosterona en sangre venosa&#44; as&#237; como la natriuria y calciuria&#46; <span class="elsevierStyleItalic">Valoraci&#243;n estad&#237;stica&#58;</span> se calcula la t de Wilcoxon y la correlaci&#243;n lineal de Pearson&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Natriuria &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 210&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#44;6 &#40;&#171;B&#187;&#41;&#59; 42&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;4 &#40;&#171;5&#187;&#41;&#59; 135&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#44;6 &#40;&#171;10&#187;&#41;&#59; 225&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#44;7 &#40;&#171;15&#187;&#41;&#46; Calciuria &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 207&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>93&#44;6 &#40;&#171;B&#187;&#41;&#59; 172&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#44;1 &#40;&#171;5&#187;&#41;&#59; 206&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#44;7 &#40;&#171;10&#187;&#41;&#59; 227&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#44;1 &#40;&#171;15&#187;&#41;&#46; Correlaci&#243;n positiva entre natriuria y calciuria en &#171;10&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;47&#41; y en &#171;15&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;67&#41;&#46; Tras Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; natriuria&#58; 232&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#44;7&#59; 377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 &#40;H50&#41;&#59; 341&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#44;4 &#40;H100&#41;&#59; Ca en orina&#58; 209&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>57&#44;4&#59; 213&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#44;6 &#40;H50&#41;&#59; 159&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#44;2 &#40;H100&#41;&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La ingesta de sal en la poblaci&#243;n estudiada es de 14&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;9<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#46; Encontramos correlaci&#243;n entre natriuria y calciuria con ingestas de 11&#44;25 y 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal&#46; Con la ingesta habitual&#44; por cada gramo de sal aumenta la calciuria 5&#44;46<span class="elsevierStyleHsp" style=""></span>mg y con 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; la calciuria disminuye 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Los datos podr&#237;an ser de utilidad para el manejo de pacientes con hipercalciuria excretora o hipoparatiroidismo&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;nez Garc&#237;a M&#44; Trincado Aznar P&#44; P&#233;rez Fern&#225;ndez L&#44; Azcona Monreal I&#44; L&#243;pez Alaminos ME&#44; Acha P&#233;rez J&#44; et al&#46; Comparaci&#243;n de los efectos inducidos sobre la calciuria por tiazidas y diferentes dosis de sal en la dieta&#58; implicaciones en la pr&#225;ctica cl&#237;nica&#46; Nefrologia&#46; 2019&#59;39&#58;73&#8211;79&#46;</p>"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Correlation between natriuresis and calciuria in &#8220;0&#8221;&#58; 1&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa&#59; &#8220;5&#8221;&#58; 6&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa&#59; &#8220;10&#8221;&#58; 11&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa&#59; &#8220;15&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa&#59; &#8220;T1&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa and 50<span class="elsevierStyleHsp" style=""></span>mg of Higrotona<span class="elsevierStyleSup">&#174;</span> and &#8220;T2&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa and 100<span class="elsevierStyleHsp" style=""></span>mg of Higrotona<span class="elsevierStyleSup">&#174;</span><span class="elsevierStyleItalic">p</span>&#58; level of significance&#59; <span class="elsevierStyleItalic">r</span>&#58; correlation coefficient&#46;</p>"
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Upper curve&#58; plasma aldosterone &#40;pg&#47;ml&#41;&#46; Lower curve&#58; Na in urine&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">100<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">2000<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">100<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">2000<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calories&#44; kcal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Na &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteins&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">K &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Carbohydrates&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cl &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sugars&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ca &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lactose&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;025&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">P &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1440&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fat&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mg &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46; 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">460&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Saturated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fe &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monounsaturated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zn &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Polyunsaturated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cu &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; A&#44; &#956;g-RE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mn &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; D3&#44; &#956;g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Se &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; E&#44; mg-o-TE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cr &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; K&#44; &#956;g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">I &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; B1&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Carotenoids &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; B2&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hill &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">740&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Niacin&#44; mg NG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">mOsm&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A&#46; pantot&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">H2O &#40;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1700&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; B6&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A&#46; folic&#44; &#956;g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">540&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; B12&#44; &#956;g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Biotin&#44; &#956;g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vit&#46; C&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Composition of Nutrison<span class="elsevierStyleSup">&#174;</span> low in sodium&#46;</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Basal&#58; free diet&#44; prior to the study&#59; &#8220;0&#8221;&#58; 1&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;5&#8221;&#58; 6&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;10&#8221;&#58; 11&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;15&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Basal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;0&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;5&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;10&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;15&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Na&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">210&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>31&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">135&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">225&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ca&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">207&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>93&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">191&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">172&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">206&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">227&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">209&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>81&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">126&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">225&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>53&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NaCL&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">389<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>143&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">115&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">263&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>92&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">453&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mg&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">102&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">135&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">149&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">K&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Urinary excretion of electrolytes with different salt intake&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;15bis&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;T1&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;T2&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Na&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">232&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">341&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ca&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">209&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>57&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">213&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">233&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">397&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">351&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>65&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NaCl&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">466<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">775&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">659&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mg&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">136&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">182&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>59&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">166&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">K&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Urinary excretion of electrolytes with 16&#46;25 salt intake &#40;&#8220;15 bis&#8221;&#41; and after adding 50 &#40;&#8220;T1&#8221;&#41; and 100<span class="elsevierStyleHsp" style=""></span>mg &#40;&#8220;T2&#8221;&#41; of Higrotona<span class="elsevierStyleSup">&#174;</span>&#46;</p>"
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          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Basal&#58; free diet&#44; prior to the study&#59; &#8220;0&#8221;&#58; 1&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;5&#8221;&#58; 6&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;10&#8221;&#58; 11&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;15&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;15bis&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of NaCl&#59; &#8220;T2&#8221;&#58; 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of ClNa and 100<span class="elsevierStyleHsp" style=""></span>mg of thiazide &#40;Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#46; PRA&#58; plasma renin activity</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Basal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;0&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;5&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;10&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;15&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;15bis&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#8220;T2&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Na&#44; mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">141&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">140&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">142&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">141&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">141&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ca&#43;&#43;&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;8 &#177; 0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">105&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">102&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">105&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">103&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mg&#44; mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;02 <span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;91<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">K&#44; mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PRA&#44; ng&#47;ml&#47;h&nbsp;\t\t\t\t\t\t\n
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