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The patient was seen in nephrology consultation for a rise in serum creatinine level from 1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl upon admission to 5&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;estimated glomerular filtration rate of 9<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; and purpuric lesions on the bilateral lower extremities&#46; At the general medicine service&#44; oral glucocorticoid was initiated for a presumed diagnosis of IgA vasculitis &#40;Henoch-Sch&#246;nlein purpura&#41;&#46; However&#44; the kidney function continued to worsen&#44; and oliguria ensued despite infusion of lactated ringer&#39;s solution&#46; Upon physical examination&#44; he was not in distress&#46; The blood pressure was 110&#47;78<span class="elsevierStyleHsp" style=""></span>mmHg&#46; There were trace pretibial oedema and purpuric lesions on the bilateral legs&#46; Urinalysis showed &#62;100 red blood cells per high-power field &#40;70&#37; dysmorphic&#41; and 5&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h of proteinuria&#46; Immunological analysis showed that increased immunoglobulins &#40;IgG 1427<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; IgA 1373<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; IgM 48<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and decreased complement levels &#40;C3 77<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; C4 30<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; CH50 44<span class="elsevierStyleHsp" style=""></span>IU&#47;ml&#41;&#46; Antinuclear antibodies&#44; antimyeloperoxidase antibodies&#44; antiproteinase 3 antibodies&#44; and a glomerular basement membrane antibody were negative&#46; Renal biopsy showed 10 glomeruli&#44; 4 of them sclerosed and 2 with endocapillary proliferation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There was a mild interstitial infiltrate of polymorphonuclear cells&#44; and the arteries had no significant lesions&#46; Immunofluorescence microscopy showed diffuse depositions of IgA &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and C3&#46; Electron microscopy could not be performed because of insufficient specimens&#46; Based on clinical features and pathologic findings&#44; IgA-IRGN was diagnosed&#46; Intravenous cefazolin was administered for another four weeks&#44; and oral glucocorticoid was tapered and stopped gradually without relapse of infection&#46; However&#44; the patient progressed to end-stage kidney disease even after 20<span class="elsevierStyleHsp" style=""></span>mg of olmesartan was initiated&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">IgA-IRGN is a morphologic variant of acute postinfectious glomerulonephritis mainly associated with staphylococcal infection&#44; low serum complement&#44; and underlying diabetic nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> At least three of the following criteria are required for diagnosis&#58; clinical or laboratory evidence of infection preceding or at the onset of glomerulonephritis&#59; depressed serum complement&#59; endocapillary proliferative and exudative glomerulonephritis&#59; C3-dominant or co-dominant glomerular immunofluorescence staining&#59; and hump-shaped subepithelial deposits on electron microscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> The patient fulfilled four of the criteria&#46; The mainstays of treatment are eradication of infection and management of nephritis&#44; but the role of steroids is controversial&#46; The prognosis is unfavourable&#44; and 23&#37; of patients progressed to dialysis-dependent end-stage kidney disease&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">IgA vasculitis should be differentiated from IgA-IRGN&#44; but it may be difficult on morphologic grounds because endocapillary hypercellularity is common in IgA vasculitis&#46; Clinical features that favour IgA vasculitis over IgA-IRGN include purpura&#44; arthritis&#44; abdominal pain and gastrointestinal bleeding&#44; and the presence of normal serum complement levels&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> However&#44; vasculitic skin rash can be observed in patients with IgA-IRGN&#46; One research reported that 18&#37; of patients with IgA-IRGN had purpura&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> and another reported that IgA-IRGN may have IgA vasculitis-like lower extremity purpuric lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Our patient was diagnosed with IgA-IRGN because of the absence of arthritis&#44; abdominal pain&#44; gastrointestinal bleeding&#44; and decreased complement levels&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical approval</span><p id="par0025" class="elsevierStylePara elsevierViewall">All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and&#47;or national research committee at which the studies were conducted &#40;IRB approval number&#58; 2017-107&#41; and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Informed consent</span><p id="par0030" class="elsevierStylePara elsevierViewall">Informed consent was obtained from all individual participants included in the study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding</span><p id="par0035" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span></span>"
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Letter to the Editor
IgA-dominant infection-related glomerulonephritis
Glomerulonefritis relacionada con la infección por IgA-Dominante
Yoshinosuke Shimamuraa,
Corresponding author
yshimamura.tkh@gmail.com

Corresponding author.
, Takuto Maedaa, Yufu Gochoa, Yayoi Ogawab, Hideki Takizawaa
a Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Hokkaido, Japan
b Hokkaido Renal Pathology Center, Sapporo, Hokkaido, Japan
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acute post-infectious glomerulonephritis is an immune complex-mediated glomerulonephritis that classically occurs in children following streptococcal upper respiratory or skin infections&#46; However&#44; cases of IgA-dominant infection-related glomerulonephritis &#40;IgA-IRGN&#41;&#44; a diffuse endocapillary proliferative glomerulonephritis associated with intense IgA deposits following staphylococcus infection&#44; have been increasingly reported in recent literature&#46; In contrast to typical acute post-infectious glomerulonephritis&#44; the causative infection is ongoing at the time of diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> It often occurs in diabetic elderly patients and presents with acute kidney injury and heavy proteinuria&#46; The prognosis is unfavourable&#46; Here&#44; we report an elderly-male patient with IgA-IGRN who demonstrated vasculitic skin rash&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">An 80-year-old Japanese man with stage G3a chronic kidney disease due to diabetes mellitus was admitted to the general medicine service for management of right haemopneumothorax after a motor vehicle accident and subsequent empyema caused by methicillin-sensitive <span class="elsevierStyleItalic">Staphylococcus aureus</span> treated with four weeks of intravenous cefazolin and drainage&#46; The patient was seen in nephrology consultation for a rise in serum creatinine level from 1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl upon admission to 5&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;estimated glomerular filtration rate of 9<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; and purpuric lesions on the bilateral lower extremities&#46; At the general medicine service&#44; oral glucocorticoid was initiated for a presumed diagnosis of IgA vasculitis &#40;Henoch-Sch&#246;nlein purpura&#41;&#46; However&#44; the kidney function continued to worsen&#44; and oliguria ensued despite infusion of lactated ringer&#39;s solution&#46; Upon physical examination&#44; he was not in distress&#46; The blood pressure was 110&#47;78<span class="elsevierStyleHsp" style=""></span>mmHg&#46; There were trace pretibial oedema and purpuric lesions on the bilateral legs&#46; Urinalysis showed &#62;100 red blood cells per high-power field &#40;70&#37; dysmorphic&#41; and 5&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h of proteinuria&#46; Immunological analysis showed that increased immunoglobulins &#40;IgG 1427<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; IgA 1373<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; IgM 48<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and decreased complement levels &#40;C3 77<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; C4 30<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; CH50 44<span class="elsevierStyleHsp" style=""></span>IU&#47;ml&#41;&#46; Antinuclear antibodies&#44; antimyeloperoxidase antibodies&#44; antiproteinase 3 antibodies&#44; and a glomerular basement membrane antibody were negative&#46; Renal biopsy showed 10 glomeruli&#44; 4 of them sclerosed and 2 with endocapillary proliferation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There was a mild interstitial infiltrate of polymorphonuclear cells&#44; and the arteries had no significant lesions&#46; Immunofluorescence microscopy showed diffuse depositions of IgA &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and C3&#46; Electron microscopy could not be performed because of insufficient specimens&#46; Based on clinical features and pathologic findings&#44; IgA-IRGN was diagnosed&#46; Intravenous cefazolin was administered for another four weeks&#44; and oral glucocorticoid was tapered and stopped gradually without relapse of infection&#46; However&#44; the patient progressed to end-stage kidney disease even after 20<span class="elsevierStyleHsp" style=""></span>mg of olmesartan was initiated&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">IgA-IRGN is a morphologic variant of acute postinfectious glomerulonephritis mainly associated with staphylococcal infection&#44; low serum complement&#44; and underlying diabetic nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> At least three of the following criteria are required for diagnosis&#58; clinical or laboratory evidence of infection preceding or at the onset of glomerulonephritis&#59; depressed serum complement&#59; endocapillary proliferative and exudative glomerulonephritis&#59; C3-dominant or co-dominant glomerular immunofluorescence staining&#59; and hump-shaped subepithelial deposits on electron microscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> The patient fulfilled four of the criteria&#46; The mainstays of treatment are eradication of infection and management of nephritis&#44; but the role of steroids is controversial&#46; The prognosis is unfavourable&#44; and 23&#37; of patients progressed to dialysis-dependent end-stage kidney disease&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">IgA vasculitis should be differentiated from IgA-IRGN&#44; but it may be difficult on morphologic grounds because endocapillary hypercellularity is common in IgA vasculitis&#46; Clinical features that favour IgA vasculitis over IgA-IRGN include purpura&#44; arthritis&#44; abdominal pain and gastrointestinal bleeding&#44; and the presence of normal serum complement levels&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> However&#44; vasculitic skin rash can be observed in patients with IgA-IRGN&#46; One research reported that 18&#37; of patients with IgA-IRGN had purpura&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> and another reported that IgA-IRGN may have IgA vasculitis-like lower extremity purpuric lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Our patient was diagnosed with IgA-IRGN because of the absence of arthritis&#44; abdominal pain&#44; gastrointestinal bleeding&#44; and decreased complement levels&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical approval</span><p id="par0025" class="elsevierStylePara elsevierViewall">All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and&#47;or national research committee at which the studies were conducted &#40;IRB approval number&#58; 2017-107&#41; and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Informed consent</span><p id="par0030" class="elsevierStylePara elsevierViewall">Informed consent was obtained from all individual participants included in the study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding</span><p id="par0035" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span></span>"
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