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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with particular interest the article published recently by Merino et al&#46;&#44; entitled &#8220;<span class="elsevierStyleItalic">Serratia marcescens</span> bacteraemia outbreak in haemodialysis patients with tunnelled catheters due to colonisation of antiseptic solution&#46; Experience in 4 hospitals&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> to which we would like to contribute our experience&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">As reported in the aforementioned article&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> between December 2014 and January 2015&#44; we recorded several cases of catheter-related bacteraemia &#40;CRB&#41; due to <span class="elsevierStyleItalic">Serratia marcescens</span> &#40;<span class="elsevierStyleItalic">S&#46; marcescens</span>&#41; in our haemodialysis &#40;HD&#41; unit&#46; On 19 December 2014&#44; the Spanish Agency of Medicines and Medical Devices &#40;AEMPS&#41; ordered the withdrawal from the market of BohmClorh<span class="elsevierStyleSup">&#174;</span> chlorhexidine 2&#37; aqueous antiseptic solution for healthy skin as a result of the contamination of several lots with <span class="elsevierStyleItalic">S&#46; marcescens</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Several subsequent warnings were issued extending the restriction of its use to the remaining lots and presentations and&#44; finally&#44; on 9 January 2015&#44; the master formulae developed by the company were withdrawn&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Between 1 December 2014 and 16 January 2015&#44; we recorded 14 cases of blood culture-confirmed CRB due to <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; 26&#46;9&#37; of the patients in our unit&#59; all had been or were catheter users&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Suspicion of an epidemic outbreak arose after the appearance in the same week of 4 cases of bacteraemia caused by a microorganism that was unusual in the HD unit&#44; in patients on different shifts&#44; with differing dialysis stations and healthcare staff&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The Medical Prevention Service was informed and the corresponding protocol was carried out&#44; reviewing the asepsis measures for catheter handling&#44; and investigating the unit consumables and non-consumables and healthcare staff as possible foci and vectors of transmission&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 9 men and 5 women with mean age 64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20 years were affected&#46; Twelve patients &#40;85&#46;7&#37;&#41; were catheter users&#58; 11 had a tunnelled catheter while only one had a temporary catheter&#59; the remaining two recently had temporary catheters&#46; A total of 26 episodes were recorded &#40;mean of 1&#46;85 episodes per patient&#41;&#44; considering these as the onset of general malaise&#44; hypotension and fever during the dialysis session&#44; with blood cultures positive for <span class="elsevierStyleItalic">S&#46; marcescens</span>&#46; Two patients had up to 4 episodes of bacteraemia&#44; one patient had 3 episodes&#44; 4 patients had 2 episodes&#44; and 7 patients had a single episode before the causal agent was identified&#46; The catheter had to be removed in 5 patients&#44; all of who were found to have infection with the same epidemic agent&#46; Half the patients required hospitalisation for sepsis&#44; with an average stay of 3&#46;3 days&#46; There were no deaths&#46; One patient died due to CRB associated with a different microorganism&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In the early cases&#44; patients were empirically administered intravenous vancomycin &#40;1<span class="elsevierStyleHsp" style=""></span>g post-dialysis&#41; and gentamicin &#40;at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;weight post-dialysis&#41; until the blood culture results became available&#46; Ciprofloxacin treatment was then instigated in all patients according to antibiotic susceptibility testing &#40;AST&#41;&#44; and the catheter was locked with the same antibiotic solution&#59; one case required carbapenems due to poor clinical progress&#44; and no antibiotic resistance was noted in the AST&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Pharyngeal and perianal exudates were systematically collected from all patients in the unit&#46; Only one of the patients was a pharyngeal carrier&#46; In two of the controls&#44; the pharyngeal exudate was positive for <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; but for a strain other than the original one in the outbreak&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">There were cases in other hospital units and other Spanish hospitals&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;5</span></a> Once the outbreak had been notified by AEMPS&#44; the antiseptic product was cultured and confirmed as the reservoir of the epidemic&#46; No further cases were recorded after the contaminated lots had been withdrawn&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Most CRB in HD patients is caused by Gram-positive bacteria&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleItalic">S&#46; marcescens</span> is a gram-negative bacillus found predominantly in humid conditions&#59; it is pathogenic for man and causes outbreaks of resistant infections&#44; especially in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The general rule in CRB is to remove the catheter&#44; but conservative treatment is accepted in HD patients despite evidence of serious infection&#44; as a measure to preserve the vascular access&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In our experience&#44; AST-directed treatment and catheter locking provided a good outcome&#44; although the delay in identifying the source and probable formation of <span class="elsevierStyleItalic">biofilms</span> meant that a significant number of catheters had to be removed due to the high percentage of recurrences&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Although the finding of <span class="elsevierStyleItalic">S&#46; marcescens</span> in HD units is rare&#44; and identification of the reservoir in an antiseptic product is paradoxical&#44; outbreaks have previously been described&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> A methodological search for the causal agent and appropriate preventive strategies should therefore be instigated at an early stage when an epidemic outbreak is suspected&#46; An initiative to record the experience in the HD units of all the affected hospitals would be interesting&#46;</p></span>"
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Letter to the Editor
Serratia marcescens bacteraemia outbreak in haemodialysis. Comment on “Serratia marcescens bacteraemia outbreak in haemodialysis patients with tunnelled catheters due to colonisation of antiseptic solution. Experience in 4 hospitals”
Brote de bacteriemia por Serratia marcescens en hemodiálisis. Comentario a «Brote de bacteriemia por Serratia marcescens en pacientes portadores de catéteres tunelizados en hemodiálisis secundario a colonización de la solución antiséptica. Experiencia en 4 centros»
Silvia González Sanchidrián
Corresponding author
silvia_goz@hotmail.com

Corresponding author.
, Jesús Pedro Marín Álvarez, Javier Deira Lorenzo, Pedro Jesús Labrador Gómez, Juan Ramón Gómez-Martino Arroyo
Servicio de Nefrología, Complejo Hospitalario Universitario de Cáceres, Hospital San Pedro de Alcántara, Cáceres, Spain
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            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Histological characteristics of the lymphoid infiltrates that affected both the renal parenchyma &#40;A&#58; H&#38;E&#44; &#215;10&#41; and the perirenal tissue &#40;B&#58; H&#38;E&#44; &#215;10&#41;&#46; The lymphoid infiltrate had destroyed the parenchyma&#44; leaving isolated residual tubules with images that may suggest lymphoepithelial lesion &#40;C&#58; H&#38;E&#44; &#215;20&#41;&#46; Cells were monomorphic&#44; small in size&#44; with an irregular nuclear outline&#44; barely visible nucleolus and no significant mitotic activity &#40;D&#58; H&#38;E&#44; &#215;40&#41;&#46;</p>"
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    "titulo" => "Serratia marcescens bacteraemia outbreak in haemodialysis&#46; Comment on &#8220;Serratia marcescens bacteraemia outbreak in haemodialysis patients with tunnelled catheters due to colonisation of antiseptic solution&#46; Experience in 4 hospitals&#8221;"
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        "autoresLista" => "Silvia Gonz&#225;lez Sanchidri&#225;n, Jes&#250;s Pedro Mar&#237;n &#193;lvarez, Javier Deira Lorenzo, Pedro Jes&#250;s Labrador G&#243;mez, Juan Ram&#243;n G&#243;mez-Martino Arroyo"
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        "titulo" => "Brote de bacteriemia por Serratia marcescens en hemodi&#225;lisis&#46; Comentario a &#171;Brote de bacteriemia por Serratia marcescens en pacientes portadores de cat&#233;teres tunelizados en hemodi&#225;lisis secundario a colonizaci&#243;n de la soluci&#243;n antis&#233;ptica&#46; Experiencia en 4 centros&#187;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with particular interest the article published recently by Merino et al&#46;&#44; entitled &#8220;<span class="elsevierStyleItalic">Serratia marcescens</span> bacteraemia outbreak in haemodialysis patients with tunnelled catheters due to colonisation of antiseptic solution&#46; Experience in 4 hospitals&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> to which we would like to contribute our experience&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">As reported in the aforementioned article&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> between December 2014 and January 2015&#44; we recorded several cases of catheter-related bacteraemia &#40;CRB&#41; due to <span class="elsevierStyleItalic">Serratia marcescens</span> &#40;<span class="elsevierStyleItalic">S&#46; marcescens</span>&#41; in our haemodialysis &#40;HD&#41; unit&#46; On 19 December 2014&#44; the Spanish Agency of Medicines and Medical Devices &#40;AEMPS&#41; ordered the withdrawal from the market of BohmClorh<span class="elsevierStyleSup">&#174;</span> chlorhexidine 2&#37; aqueous antiseptic solution for healthy skin as a result of the contamination of several lots with <span class="elsevierStyleItalic">S&#46; marcescens</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Several subsequent warnings were issued extending the restriction of its use to the remaining lots and presentations and&#44; finally&#44; on 9 January 2015&#44; the master formulae developed by the company were withdrawn&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Between 1 December 2014 and 16 January 2015&#44; we recorded 14 cases of blood culture-confirmed CRB due to <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; 26&#46;9&#37; of the patients in our unit&#59; all had been or were catheter users&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Suspicion of an epidemic outbreak arose after the appearance in the same week of 4 cases of bacteraemia caused by a microorganism that was unusual in the HD unit&#44; in patients on different shifts&#44; with differing dialysis stations and healthcare staff&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The Medical Prevention Service was informed and the corresponding protocol was carried out&#44; reviewing the asepsis measures for catheter handling&#44; and investigating the unit consumables and non-consumables and healthcare staff as possible foci and vectors of transmission&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 9 men and 5 women with mean age 64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20 years were affected&#46; Twelve patients &#40;85&#46;7&#37;&#41; were catheter users&#58; 11 had a tunnelled catheter while only one had a temporary catheter&#59; the remaining two recently had temporary catheters&#46; A total of 26 episodes were recorded &#40;mean of 1&#46;85 episodes per patient&#41;&#44; considering these as the onset of general malaise&#44; hypotension and fever during the dialysis session&#44; with blood cultures positive for <span class="elsevierStyleItalic">S&#46; marcescens</span>&#46; Two patients had up to 4 episodes of bacteraemia&#44; one patient had 3 episodes&#44; 4 patients had 2 episodes&#44; and 7 patients had a single episode before the causal agent was identified&#46; The catheter had to be removed in 5 patients&#44; all of who were found to have infection with the same epidemic agent&#46; Half the patients required hospitalisation for sepsis&#44; with an average stay of 3&#46;3 days&#46; There were no deaths&#46; One patient died due to CRB associated with a different microorganism&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In the early cases&#44; patients were empirically administered intravenous vancomycin &#40;1<span class="elsevierStyleHsp" style=""></span>g post-dialysis&#41; and gentamicin &#40;at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;weight post-dialysis&#41; until the blood culture results became available&#46; Ciprofloxacin treatment was then instigated in all patients according to antibiotic susceptibility testing &#40;AST&#41;&#44; and the catheter was locked with the same antibiotic solution&#59; one case required carbapenems due to poor clinical progress&#44; and no antibiotic resistance was noted in the AST&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Pharyngeal and perianal exudates were systematically collected from all patients in the unit&#46; Only one of the patients was a pharyngeal carrier&#46; In two of the controls&#44; the pharyngeal exudate was positive for <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; but for a strain other than the original one in the outbreak&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">There were cases in other hospital units and other Spanish hospitals&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;5</span></a> Once the outbreak had been notified by AEMPS&#44; the antiseptic product was cultured and confirmed as the reservoir of the epidemic&#46; No further cases were recorded after the contaminated lots had been withdrawn&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Most CRB in HD patients is caused by Gram-positive bacteria&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleItalic">S&#46; marcescens</span> is a gram-negative bacillus found predominantly in humid conditions&#59; it is pathogenic for man and causes outbreaks of resistant infections&#44; especially in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The general rule in CRB is to remove the catheter&#44; but conservative treatment is accepted in HD patients despite evidence of serious infection&#44; as a measure to preserve the vascular access&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In our experience&#44; AST-directed treatment and catheter locking provided a good outcome&#44; although the delay in identifying the source and probable formation of <span class="elsevierStyleItalic">biofilms</span> meant that a significant number of catheters had to be removed due to the high percentage of recurrences&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Although the finding of <span class="elsevierStyleItalic">S&#46; marcescens</span> in HD units is rare&#44; and identification of the reservoir in an antiseptic product is paradoxical&#44; outbreaks have previously been described&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> A methodological search for the causal agent and appropriate preventive strategies should therefore be instigated at an early stage when an epidemic outbreak is suspected&#46; An initiative to record the experience in the HD units of all the affected hospitals would be interesting&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sanchidri&#225;n SG&#44; &#193;lvarez JP&#44; Lorenzo JD&#44; G&#243;mez PJ&#44; Arroyo JR&#46; Brote de bacteriemia por Serratia marcescens en hemodi&#225;lisis&#46; Comentario a &#171;Brote de bacteriemia por Serratia marcescens en pacientes portadores de cat&#233;teres tunelizados en hemodi&#225;lisis secundario a colonizaci&#243;n de la soluci&#243;n antis&#233;ptica&#46; Experiencia en 4 centros&#187;&#46; Nefrologia&#46; 2018&#59;38&#58;94&#8211;96&#46;</p>"
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Article information
ISSN: 20132514
Original language: English
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Idiomas
Nefrología (English Edition)