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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Latin America includes 20 countries&#44; with an estimated population of 625 million according to data from the Economic Commission for Latin America and the Caribbean region &#40;CEPAL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the main stigmas is the prevailing social inequity&#58; Latin America has the world&#39;s second highest level of inequality &#40;Gini coefficient 52&#46;9&#41;&#44; just below that of sub-Saharan Africa &#40;56&#46;5&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The inequalities are mainly based on gender&#44; ethnicity&#44; per capita income&#44; geographic areas &#40;rural vs urban area&#41;&#44; heterogeneity in terms of infrastructure and asymmetry in technological development&#46; These social inequalities determine the evolution of these populations in terms of health&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In a few years&#44; an ageing population will be the predominant in our society&#46; If no changes are made&#44; this ageing population will be exposed to the prevailing inequality phenomenon in the region&#44; with a disproportionate high risk of developing acute and chronic diseases &#40;especially kidney diseases&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">It is estimated that population growth rates for Latin America will reach 680 million by 2025 and 779 million by 2050&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Some organisations warn that a inversion of the ratio between individuals aged over 65 years and children younger than 5 years will be reached by 2047&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In this situation&#44; everything concerning healthcare costs is of particular importance as they will have a huge impact on national budgets&#46; In this regard&#44; the consulting firm Ernst &#38; Young<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> warns about the levels of unsustainability generated by this emerging situation&#44; which must be addressed by the healthcare systems&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">In addition to inequality</span>&#44; an <span class="elsevierStyleItalic">ageing population</span> and <span class="elsevierStyleItalic">unsustainability of healthcare cost&#44; the</span> heterogeneity of the population in the region complicates the situation&#46; Population heterogeneity forces the states to attend a very different healthcare demands&#44; given the geographic dispersion and high vulnerability&#44; with large deficits in logistics and infrastructure in some areas&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In this context&#44; acute kidney injury &#40;AKI&#41; in Latin America is important by itself&#44; given the major impact that it generates in terms of <span class="elsevierStyleItalic">morbidity</span>&#44; <span class="elsevierStyleItalic">mortality</span> and <span class="elsevierStyleItalic">costs&#46;</span><a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> Nowadays&#44; AKI is the most common reason for consultations in nephrology departments<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#58; according to different publications&#44; the incidence varies between 2000<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> and 15&#44;000<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> patients per million inhabitants per year&#46; In addition&#44; the incidence of AKI requiring renal replacement therapy is 533 patients per million inhabitants per year&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> This figure increases significantly if those patients requiring renal support therapy are taken into account &#40;in the context of situations such as refractory septic shock&#44; permissive hypercapnia&#44; parenteral nutrition&#44; volume overload &#62;10&#37; of body weight&#44; etc&#46;&#41;&#46; The purpose of applying these technologies designed to treat kidney failure with support therapies is to regulate volume status&#44; electrolyte balance or acid-base balance&#44; without AKI necessarily being present&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">As stated in previous publications by Lombardi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> currently it is very difficult to establish accurately the incidence of AKI in Latin America&#44; given the lack of data which makes very difficult to approach this condition&#46; The first part of the AKI 0by25<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> initiative demonstrated that the figures on AKI incidence come mostly from epidemiological studies carried out in developed countries with little participation of countries in the region&#46; This means that these data should be interpreted with caution&#44; as the epidemiology of AKI is different in these developed countries&#44; where it is predominantly present in urban environments&#44; with national epidemiological records available and a specific coding system&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">It is t speculated that the incidence of AKI is significantly higher in developing countries&#44; such as Latin America&#46; The epidemiological situation of the countries in the region makes AKI be present in predominantly suburban and rural environments without national epidemiological records&#44; and with a vast majority of published papers concerning single-centre studies in critical care areas&#44; and with no uniformity in definitions&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The lack of data on the incidence of AKI in Latin America makes the planning of regional healthcare policies very difficult&#46; Thus&#44; scientific societies face the challenge of providing a response to the pressing demand of the generation of regional coded record of AKI&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this context&#44; and taking into account the latest estimations of the United Nations &#40;UN&#41; on the world&#39;s population &#40;7 billion&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> 9&#37; of which live in Latin America &#40;625 million&#41;&#46; A merely speculative exercise based on these data&#44; would indicate that the projected figures of AKI incidence in Latin America will reach 1&#44;250&#44;000<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> to 9&#44;375&#44;000<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> people per year&#46; Of these people&#44; 333&#44;125 to 2&#44;498&#44;437 patients would require some type of renal replacement therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> This figure would also be much higher if we consider the indications for renal support therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Being aware of this situation&#44; the International Society of Nephrology &#40;ISN&#41; has sponsored global campaigns&#44; such as those mentioned&#44; to address this scourge&#46; Perhaps the most representative is the 0by25 Initiative for AKI&#46; This recognises the medical care of AKI as a human right and sets out the challenge of eliminating all preventable deaths due to AKI by 2025&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">However&#44; in the design of this campaign&#44; different countries were classified according to their level of development&#44; as defined by gross national income &#40;GNI&#41; per capita stipulated by the World Bank in 2014&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> Based on this&#44; the countries were divided up according to their level of development&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">High level of development &#40;HLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> &#62;US&#36; 12&#44;476&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">High&#47;medium level of development &#40;HMLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> is between US&#36; 4035 and 12&#44;476&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall">Medium&#47;low level of development &#40;LMLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> is between US&#36; 1045 and 4035&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall">Low level of development &#40;LLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span></p></li></ul></p><p id="par0095" class="elsevierStylePara elsevierViewall">According to this concept&#44; Latin American countries would be classified as follows&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0100" class="elsevierStylePara elsevierViewall">HLD&#58; Argentina&#44; Chile&#44; Uruguay&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0105" class="elsevierStylePara elsevierViewall">HMLD&#58; Brazil&#44; Colombia&#44; Costa Rica&#44; Ecuador&#44; Mexico&#44; Granada&#44; Jamaica&#44; Panama&#44; Peru&#44; Dominican Rep&#46; Paraguay&#44; Suriname&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall">LMLD&#58; Bolivia&#44; Ecuador&#44; Guatemala&#44; Guyana&#44; Honduras&#44; Nicaragua&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0115" class="elsevierStylePara elsevierViewall">LLD&#58; Haiti&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0120" class="elsevierStylePara elsevierViewall">No data available&#58; Cuba&#44; French Guiana&#44; Puerto Rico&#44; Venezuela&#46;</p></li></ul></p><p id="par0125" class="elsevierStylePara elsevierViewall">The GNI per capita refers to economic growth on its own&#44; based on the value of all goods and services produced by the residents of a country during a specified period of time &#40;generally one year&#41; divided by the number of inhabitants&#46; From this perspective&#44; Latin American countries such as Argentina&#44; Chile and Uruguay would share the same weighting as countries such as Germany&#44; Australia and Sweden&#46; However&#44; if the healthcare costs per capita for 2014&#44; according to the World Bank&#44; are taken into account&#44; the figures are very diverse for these Latin American countries&#58; Argentina US&#36; 605&#44; Chile US&#36; 1137&#44; and Uruguay US&#36; 1442 in contrast with Germany US&#36; 5411&#44; Australia US&#36; 6031 and Sweden US&#36; 6808&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> This generates an unrealistic assessment of this GNI weighting&#46; Furthermore&#44; the GNI does not reveal any information on how this income is invested&#44; or whether it is used to improve health&#44; education or other outcomes in terms of human development&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In order to avoid this bias&#44; it is perhaps more appropriate to use the human development index &#40;HDI&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a> a statistical social indicator based on people and their capabilities which weighs up three parameters &#40;<span class="elsevierStyleItalic">a long and healthy life&#44; being knowledgeable and having a decent standard of living</span>&#41;&#46; This is due to the fact that there is a risk of not fulfilling the premise of the initiative regarding medical care for AKI that is considered a human right&#44; due to the loss of universality of this right&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Irrespective of the data&#44; there are several circumstances that would explain the adverse development of AKI in these countries&#44; which are more closely related to the weighting contained in the HDI&#46; These include&#58; lack of or inadequate training of healthcare personnel&#44; lack of awareness of the consequences&#44; limited access to healthcare services&#44; limited diagnostic tools&#44; lack of clinical practice guidelines and limitations in terms of the treatment offered&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In this regard&#44; the current innovative process is hugely disruptive&#44; focussed mainly on the collection and analysis of data&#44; a phenomenon known as &#8220;big data&#8221;&#44; from which more accurate and effective strategies to tackle AKI can be designed&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In order to take this campaign forward at a regional level&#44; it is essential to make a significant investment in <span class="elsevierStyleItalic">technology</span>&#46; The main obstacle to this objective is <span class="elsevierStyleItalic">funding</span>&#44; which is a serious problem&#44; particularly in Latin America&#44; given the prevailing socio-economic crisis&#46; The criterium of sustainability is therefore key when it comes to evaluating and defining the scenarios&#46; One strategy for dealing with <span class="elsevierStyleItalic">funding</span> commits to innovative ways of purchasing&#44; which include &#8220;shared risk&#8221; schemes between the hospital and the supplying company&#44; with the double objective of providing access to complex technology therapies and reducing the financial risk&#59; the refund of the product is conditioned on the results of planned outcomes and those agreed in the contract &#40;health outcomes&#44; saving&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In this regard&#44; the 15th Acute Dialysis Quality Initiative &#40;ADQI&#41; Conference focussed on the growth of data regarding AKI and the unprecedented opportunity to be able to address certain knowledge gaps and plan public health strategies&#44; developing tangible strategies to reconfigure the infrastructure&#44; in order to improve the quality of scientific studies and characterise the AKI phenotype&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Numerous virtual platforms have now been developed in order to promote and facilitate understanding of innovation in the field of healthcare technology&#46; All agents involved in the innovation and marketing process are brought together in one single forum&#46; An example of this is Medintech &#40;Spain&#41;&#44; or the National Innovation Centre of the NHS&#44; recently transformed into The Knowledge and Information Zone &#40;United Kingdom&#41;&#44; etc&#46; These types of platform appear to be a possible solution given that in a large part of Latin America the scientific and technological capabilities are concentrated in universities and frequently&#44; the university agendas&#44; their prevailing structures and policies and incentive schemes generate dynamics which are barely connected to the daily needs of the people&#46; The connection of investigators and institutions with the community is not usually strong enough to promote the innovative circuits and interactive learning spaces that are required to solve such problems&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conclusion</span><p id="par0160" class="elsevierStylePara elsevierViewall">Technological and scientific advances are taking place at amazing speed&#44; with a deep disruptive significance&#46; It may be possible to exploit these to change the AKI paradigm in one of the world&#39;s most unequal regions&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The capitalisation of this opportunity should aim to integrate the AKI data on a regional basis&#44; creating a coded base&#44; in accordance with the guidelines of the 15th ADQI conference&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a> The objective is to establish strategic plans of action that will benefit the most vulnerable populations&#44; regardless of the place that the country occupies in terms of level of development as estimated by the GNI given that there is a risk of losing the universality of the right to healthcare&#46; Perhaps the measurement of the HDI or the intensity of poverty could be used to focus the care&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Public&#47;private consortiums&#44; regulated by scientific societies and international bodies&#44; could perhaps meet sustainability and funding&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">All efforts should be focussed on achieving the slogan of the 0by25<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> AKI campaign promoted by the ISN&#58; medical care for AKI as a human right and eliminating all preventable deaths from AKI by 2025&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Editorial
Acute kidney injury in Latin America in “big data” era
Lesión renal aguda en Latinoamérica en la era del big data
Fernando Lombia,1,2,
Corresponding author
fernandolombi@gmail.com

Corresponding author.
, Carlos Federico Varelab,1,2, Ricardo Martinezc,1,2, Gustavo Grelonib,1,2, Vicente Campolo Girardd,1, Guillermo Rosa-Diezb,1,2
a Servicio de Nefrología, Hospital Británico de Buenos Aires, Buenos Aires, Argentina
b Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
c Servicio de Nefrología, Hospital Churruca Visca Buenos Aires, Buenos Aires, Argentina
d Servicio de Terapia Intensiva, Clínica Pasteur, Neuquén, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Latin America includes 20 countries&#44; with an estimated population of 625 million according to data from the Economic Commission for Latin America and the Caribbean region &#40;CEPAL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the main stigmas is the prevailing social inequity&#58; Latin America has the world&#39;s second highest level of inequality &#40;Gini coefficient 52&#46;9&#41;&#44; just below that of sub-Saharan Africa &#40;56&#46;5&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The inequalities are mainly based on gender&#44; ethnicity&#44; per capita income&#44; geographic areas &#40;rural vs urban area&#41;&#44; heterogeneity in terms of infrastructure and asymmetry in technological development&#46; These social inequalities determine the evolution of these populations in terms of health&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In a few years&#44; an ageing population will be the predominant in our society&#46; If no changes are made&#44; this ageing population will be exposed to the prevailing inequality phenomenon in the region&#44; with a disproportionate high risk of developing acute and chronic diseases &#40;especially kidney diseases&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">It is estimated that population growth rates for Latin America will reach 680 million by 2025 and 779 million by 2050&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Some organisations warn that a inversion of the ratio between individuals aged over 65 years and children younger than 5 years will be reached by 2047&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In this situation&#44; everything concerning healthcare costs is of particular importance as they will have a huge impact on national budgets&#46; In this regard&#44; the consulting firm Ernst &#38; Young<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> warns about the levels of unsustainability generated by this emerging situation&#44; which must be addressed by the healthcare systems&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">In addition to inequality</span>&#44; an <span class="elsevierStyleItalic">ageing population</span> and <span class="elsevierStyleItalic">unsustainability of healthcare cost&#44; the</span> heterogeneity of the population in the region complicates the situation&#46; Population heterogeneity forces the states to attend a very different healthcare demands&#44; given the geographic dispersion and high vulnerability&#44; with large deficits in logistics and infrastructure in some areas&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In this context&#44; acute kidney injury &#40;AKI&#41; in Latin America is important by itself&#44; given the major impact that it generates in terms of <span class="elsevierStyleItalic">morbidity</span>&#44; <span class="elsevierStyleItalic">mortality</span> and <span class="elsevierStyleItalic">costs&#46;</span><a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> Nowadays&#44; AKI is the most common reason for consultations in nephrology departments<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#58; according to different publications&#44; the incidence varies between 2000<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> and 15&#44;000<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> patients per million inhabitants per year&#46; In addition&#44; the incidence of AKI requiring renal replacement therapy is 533 patients per million inhabitants per year&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> This figure increases significantly if those patients requiring renal support therapy are taken into account &#40;in the context of situations such as refractory septic shock&#44; permissive hypercapnia&#44; parenteral nutrition&#44; volume overload &#62;10&#37; of body weight&#44; etc&#46;&#41;&#46; The purpose of applying these technologies designed to treat kidney failure with support therapies is to regulate volume status&#44; electrolyte balance or acid-base balance&#44; without AKI necessarily being present&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">As stated in previous publications by Lombardi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> currently it is very difficult to establish accurately the incidence of AKI in Latin America&#44; given the lack of data which makes very difficult to approach this condition&#46; The first part of the AKI 0by25<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> initiative demonstrated that the figures on AKI incidence come mostly from epidemiological studies carried out in developed countries with little participation of countries in the region&#46; This means that these data should be interpreted with caution&#44; as the epidemiology of AKI is different in these developed countries&#44; where it is predominantly present in urban environments&#44; with national epidemiological records available and a specific coding system&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">It is t speculated that the incidence of AKI is significantly higher in developing countries&#44; such as Latin America&#46; The epidemiological situation of the countries in the region makes AKI be present in predominantly suburban and rural environments without national epidemiological records&#44; and with a vast majority of published papers concerning single-centre studies in critical care areas&#44; and with no uniformity in definitions&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The lack of data on the incidence of AKI in Latin America makes the planning of regional healthcare policies very difficult&#46; Thus&#44; scientific societies face the challenge of providing a response to the pressing demand of the generation of regional coded record of AKI&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this context&#44; and taking into account the latest estimations of the United Nations &#40;UN&#41; on the world&#39;s population &#40;7 billion&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> 9&#37; of which live in Latin America &#40;625 million&#41;&#46; A merely speculative exercise based on these data&#44; would indicate that the projected figures of AKI incidence in Latin America will reach 1&#44;250&#44;000<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> to 9&#44;375&#44;000<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> people per year&#46; Of these people&#44; 333&#44;125 to 2&#44;498&#44;437 patients would require some type of renal replacement therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> This figure would also be much higher if we consider the indications for renal support therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Being aware of this situation&#44; the International Society of Nephrology &#40;ISN&#41; has sponsored global campaigns&#44; such as those mentioned&#44; to address this scourge&#46; Perhaps the most representative is the 0by25 Initiative for AKI&#46; This recognises the medical care of AKI as a human right and sets out the challenge of eliminating all preventable deaths due to AKI by 2025&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">However&#44; in the design of this campaign&#44; different countries were classified according to their level of development&#44; as defined by gross national income &#40;GNI&#41; per capita stipulated by the World Bank in 2014&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> Based on this&#44; the countries were divided up according to their level of development&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">High level of development &#40;HLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> &#62;US&#36; 12&#44;476&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">High&#47;medium level of development &#40;HMLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> is between US&#36; 4035 and 12&#44;476&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall">Medium&#47;low level of development &#40;LMLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span> is between US&#36; 1045 and 4035&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall">Low level of development &#40;LLD&#41; if GNI <span class="elsevierStyleItalic">per capita</span></p></li></ul></p><p id="par0095" class="elsevierStylePara elsevierViewall">According to this concept&#44; Latin American countries would be classified as follows&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0100" class="elsevierStylePara elsevierViewall">HLD&#58; Argentina&#44; Chile&#44; Uruguay&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0105" class="elsevierStylePara elsevierViewall">HMLD&#58; Brazil&#44; Colombia&#44; Costa Rica&#44; Ecuador&#44; Mexico&#44; Granada&#44; Jamaica&#44; Panama&#44; Peru&#44; Dominican Rep&#46; Paraguay&#44; Suriname&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall">LMLD&#58; Bolivia&#44; Ecuador&#44; Guatemala&#44; Guyana&#44; Honduras&#44; Nicaragua&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0115" class="elsevierStylePara elsevierViewall">LLD&#58; Haiti&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0120" class="elsevierStylePara elsevierViewall">No data available&#58; Cuba&#44; French Guiana&#44; Puerto Rico&#44; Venezuela&#46;</p></li></ul></p><p id="par0125" class="elsevierStylePara elsevierViewall">The GNI per capita refers to economic growth on its own&#44; based on the value of all goods and services produced by the residents of a country during a specified period of time &#40;generally one year&#41; divided by the number of inhabitants&#46; From this perspective&#44; Latin American countries such as Argentina&#44; Chile and Uruguay would share the same weighting as countries such as Germany&#44; Australia and Sweden&#46; However&#44; if the healthcare costs per capita for 2014&#44; according to the World Bank&#44; are taken into account&#44; the figures are very diverse for these Latin American countries&#58; Argentina US&#36; 605&#44; Chile US&#36; 1137&#44; and Uruguay US&#36; 1442 in contrast with Germany US&#36; 5411&#44; Australia US&#36; 6031 and Sweden US&#36; 6808&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> This generates an unrealistic assessment of this GNI weighting&#46; Furthermore&#44; the GNI does not reveal any information on how this income is invested&#44; or whether it is used to improve health&#44; education or other outcomes in terms of human development&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In order to avoid this bias&#44; it is perhaps more appropriate to use the human development index &#40;HDI&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a> a statistical social indicator based on people and their capabilities which weighs up three parameters &#40;<span class="elsevierStyleItalic">a long and healthy life&#44; being knowledgeable and having a decent standard of living</span>&#41;&#46; This is due to the fact that there is a risk of not fulfilling the premise of the initiative regarding medical care for AKI that is considered a human right&#44; due to the loss of universality of this right&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Irrespective of the data&#44; there are several circumstances that would explain the adverse development of AKI in these countries&#44; which are more closely related to the weighting contained in the HDI&#46; These include&#58; lack of or inadequate training of healthcare personnel&#44; lack of awareness of the consequences&#44; limited access to healthcare services&#44; limited diagnostic tools&#44; lack of clinical practice guidelines and limitations in terms of the treatment offered&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In this regard&#44; the current innovative process is hugely disruptive&#44; focussed mainly on the collection and analysis of data&#44; a phenomenon known as &#8220;big data&#8221;&#44; from which more accurate and effective strategies to tackle AKI can be designed&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In order to take this campaign forward at a regional level&#44; it is essential to make a significant investment in <span class="elsevierStyleItalic">technology</span>&#46; The main obstacle to this objective is <span class="elsevierStyleItalic">funding</span>&#44; which is a serious problem&#44; particularly in Latin America&#44; given the prevailing socio-economic crisis&#46; The criterium of sustainability is therefore key when it comes to evaluating and defining the scenarios&#46; One strategy for dealing with <span class="elsevierStyleItalic">funding</span> commits to innovative ways of purchasing&#44; which include &#8220;shared risk&#8221; schemes between the hospital and the supplying company&#44; with the double objective of providing access to complex technology therapies and reducing the financial risk&#59; the refund of the product is conditioned on the results of planned outcomes and those agreed in the contract &#40;health outcomes&#44; saving&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In this regard&#44; the 15th Acute Dialysis Quality Initiative &#40;ADQI&#41; Conference focussed on the growth of data regarding AKI and the unprecedented opportunity to be able to address certain knowledge gaps and plan public health strategies&#44; developing tangible strategies to reconfigure the infrastructure&#44; in order to improve the quality of scientific studies and characterise the AKI phenotype&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Numerous virtual platforms have now been developed in order to promote and facilitate understanding of innovation in the field of healthcare technology&#46; All agents involved in the innovation and marketing process are brought together in one single forum&#46; An example of this is Medintech &#40;Spain&#41;&#44; or the National Innovation Centre of the NHS&#44; recently transformed into The Knowledge and Information Zone &#40;United Kingdom&#41;&#44; etc&#46; These types of platform appear to be a possible solution given that in a large part of Latin America the scientific and technological capabilities are concentrated in universities and frequently&#44; the university agendas&#44; their prevailing structures and policies and incentive schemes generate dynamics which are barely connected to the daily needs of the people&#46; The connection of investigators and institutions with the community is not usually strong enough to promote the innovative circuits and interactive learning spaces that are required to solve such problems&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conclusion</span><p id="par0160" class="elsevierStylePara elsevierViewall">Technological and scientific advances are taking place at amazing speed&#44; with a deep disruptive significance&#46; It may be possible to exploit these to change the AKI paradigm in one of the world&#39;s most unequal regions&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The capitalisation of this opportunity should aim to integrate the AKI data on a regional basis&#44; creating a coded base&#44; in accordance with the guidelines of the 15th ADQI conference&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a> The objective is to establish strategic plans of action that will benefit the most vulnerable populations&#44; regardless of the place that the country occupies in terms of level of development as estimated by the GNI given that there is a risk of losing the universality of the right to healthcare&#46; Perhaps the measurement of the HDI or the intensity of poverty could be used to focus the care&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Public&#47;private consortiums&#44; regulated by scientific societies and international bodies&#44; could perhaps meet sustainability and funding&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">All efforts should be focussed on achieving the slogan of the 0by25<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> AKI campaign promoted by the ISN&#58; medical care for AKI as a human right and eliminating all preventable deaths from AKI by 2025&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 20132514
Original language: English
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