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we switched to steam-sterilised polysulfone and PVP membranes &#40;Helixona-FX80<span class="elsevierStyleSup">&#174;</span>&#41;&#44; but the patient presented with the same symptoms&#46; We then changed the anticoagulation regimen&#44; suspended iron therapy&#44; and prepared the patient by administering abundant serum&#44; but the episodes continued&#46; No eosinophilia&#44; increased IgE or anti-heparin antibodies were observed&#44; while cultures of the dialysis fluid and endotoxins were negative&#46; The material used was free of ethylene oxide and latex&#46; There were no other cases in the unit&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We finally decided to replace the synthetic membranes with a cellulose triacetate dialyser &#40;Sureflux<span class="elsevierStyleSup">&#174;</span>-21L&#44; Nipro&#41;&#46; Since then the patient has not experienced any similar events&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The case reported falls within the type A anaphylactic hypersensitivity reactions &#40;not measured by IgE&#41;&#44; because of the time of onset&#44; i&#46;e&#46; within the first few minutes of HD after the blood had come into contact with the components of the extracorporeal circuit&#44; and the type of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Other causes of anaphylactic reaction such as endotoxin retro-filtration&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> hypersensitivity to iron&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> anti-heparin antibodies&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> sterilisation methods<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> or use of angiotensin-converting enzyme inhibitors<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> were ruled out&#46; The reaction was attributed to the blood coming into contact with synthetic materials&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Interestingly&#44; although the patient initially presented with a classic triad with severe symptoms&#44; in successive sessions the symptoms were mild and went unnoticed&#46; Although the reaction was subsequently repeated with greater severity and duration in each dialysis&#44; with a potential increase in severity&#44; the symptoms disappeared in all cases after the first 90&#8211;120<span class="elsevierStyleHsp" style=""></span>min of each session&#44; without interrupting the dialysis treatment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As in other published cases&#44; respiratory symptoms were the most common&#44; with all symptoms disappearing after substituting the synthetic dialyser with a cellulose triacetate one&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;10</span></a> This material causes fewer hypersensitivity reactions&#44; probably due to a lower activation of the platelet membrane receptor &#40;GpIIb&#47;IIIa&#41;&#44; with less alteration of the aggregation&#44; although the mechanisms involved are still unclear&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">We report our experience with a case of hypersensitivity to synthetic dialysers with a peculiar clinical course&#44; which included episodes of different severity&#44; which is why it went unnoticed&#46; Because of the potential life-threatening risk involved in this type of reaction&#44; we emphasise the importance of suspecting them when the clinical symptoms or course are unusual&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare no potential conflicts of interest related to the content of this article&#46;</p></span></span>"
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Letter to the Editor: Brief clinical experiences
Reaction to synthetic membranes in hemodialysis
Reacción a membranas sintéticas en hemodiálisis
Silvia González Sanchidrián
Corresponding author
silvia_goz@hotmail.com

Corresponding author.
, Pedro Jesús Labrador Gómez, Jesús Pedro Marín Álvarez, María Carmen Jiménez Herrero, Inés Castellano Cerviño, Sandra Gallego Domínguez, José María Sánchez-Montalbán, Javier Deira Lorenzo, Elena Davin Carrero, Santiago Polanco Candelario, Juan Ramón Gómez-Martino Arroyo
Servicio de Nefrología, Hospital San Pedro de Alcántara, Complejo Hospitalario de Cáceres, Cáceres, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Although the incidence of hypersensitivity reactions in haemodialysis &#40;HD&#41; is low and their severity varies&#44; these reactions are not rare and can be lethal&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Recently several cases associated with the use of synthetic membranes have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> These reactions are either mild to moderate&#44; with minimal clinical repercussions that go unnoticed&#44; or severe with a wide range of symptoms which could prove lethal&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of an 80-year-old man with chronic kidney disease of vascular aetiology&#44; receiving treatment with HD since January 2016&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient is an ex-smoker with a personal history of hypertension&#44; hypercholesterolaemia&#44; hyperuricaemia&#44; anaemia and hyperparathyroidism secondary to kidney disease&#44; intermittent claudication&#44; chronic obstructive pulmonary disease&#44; depressive syndrome and treated lentigo maligna&#46; Although the patient has no allergic history&#44; he does have a dermatological history of sebaceous hyperplasia and lichenoid pityriasis treated with paraben- and cortisone-free moisturising lotions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">On treatment with manidipine&#44; bisoprolol&#44; torasemide&#44; allopurinol&#44; ezetimibe&#47;simvastatin&#44; paricalcitol&#44; calcifediol&#44; sevelamer carbonate&#44; salmeterol&#47;fluticasone&#44; amitriptyline&#44; erythropoietin and intravenous iron sucrose&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient has a poorly developed left humeral-cephalic arteriovenous fistula&#44; and is dialysed through a permanent right jugular catheter&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">He began conventional HD due to uraemic symptoms&#46; Ultrapure water and a gamma-sterilised polyethersulfone dialyser with high permeability &#40;Phylther-LF21SD<span class="elsevierStyleSup">&#174;</span>&#41; were used&#46; In the first HD session&#44; the patient presented with severe bronchospasm with hypotension and desaturation at the beginning of the session&#46; High-flow oxygen therapy&#44; hydrocortisone and bronchodilators were prescribed&#58; the symptoms gradually disappeared within a few minutes of administration&#44; without interrupting the HD session&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">No wheezing was observed in the lung auscultation and no condensation was noticed on the chest X-ray&#46; The electrocardiogram and laboratory tests&#44; which included leukocyte and platelet counts&#44; myocardial damage enzymes and acute-phase reactants&#44; were normal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The bronchospasm symptoms reappeared in successive sessions&#44; although they were milder and gradually disappeared with oxygen therapy&#46; The patient&#39;s symptoms were attributed to an intercurrent episode of upper respiratory tract infection&#46; After the first month&#44; the HD sessions were followed by dyspnoea and bronchospasm after the session&#58; the episodes gradually increased in severity and duration&#46; At the beginning of each dialysis&#44; the patient presented with desaturation&#44; excessive sweating&#44; tachypnoea and blood pressure &#62;200&#47;100<span class="elsevierStyleHsp" style=""></span>mmHg&#59; before the session&#44; blood pressure was 130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg&#46; Premedication was prescribed with hydrocortisone&#44; intravenous methylprednisolone&#44; antihistamines and inhaled bronchodilators&#44; with the patient being asymptomatic and normotensive at the end of the sessions&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">On suspecting an adverse reaction to the dialyser&#44; we switched to steam-sterilised polysulfone and PVP membranes &#40;Helixona-FX80<span class="elsevierStyleSup">&#174;</span>&#41;&#44; but the patient presented with the same symptoms&#46; We then changed the anticoagulation regimen&#44; suspended iron therapy&#44; and prepared the patient by administering abundant serum&#44; but the episodes continued&#46; No eosinophilia&#44; increased IgE or anti-heparin antibodies were observed&#44; while cultures of the dialysis fluid and endotoxins were negative&#46; The material used was free of ethylene oxide and latex&#46; There were no other cases in the unit&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We finally decided to replace the synthetic membranes with a cellulose triacetate dialyser &#40;Sureflux<span class="elsevierStyleSup">&#174;</span>-21L&#44; Nipro&#41;&#46; Since then the patient has not experienced any similar events&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The case reported falls within the type A anaphylactic hypersensitivity reactions &#40;not measured by IgE&#41;&#44; because of the time of onset&#44; i&#46;e&#46; within the first few minutes of HD after the blood had come into contact with the components of the extracorporeal circuit&#44; and the type of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Other causes of anaphylactic reaction such as endotoxin retro-filtration&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> hypersensitivity to iron&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> anti-heparin antibodies&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> sterilisation methods<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> or use of angiotensin-converting enzyme inhibitors<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> were ruled out&#46; The reaction was attributed to the blood coming into contact with synthetic materials&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Interestingly&#44; although the patient initially presented with a classic triad with severe symptoms&#44; in successive sessions the symptoms were mild and went unnoticed&#46; Although the reaction was subsequently repeated with greater severity and duration in each dialysis&#44; with a potential increase in severity&#44; the symptoms disappeared in all cases after the first 90&#8211;120<span class="elsevierStyleHsp" style=""></span>min of each session&#44; without interrupting the dialysis treatment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As in other published cases&#44; respiratory symptoms were the most common&#44; with all symptoms disappearing after substituting the synthetic dialyser with a cellulose triacetate one&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;10</span></a> This material causes fewer hypersensitivity reactions&#44; probably due to a lower activation of the platelet membrane receptor &#40;GpIIb&#47;IIIa&#41;&#44; with less alteration of the aggregation&#44; although the mechanisms involved are still unclear&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">We report our experience with a case of hypersensitivity to synthetic dialysers with a peculiar clinical course&#44; which included episodes of different severity&#44; which is why it went unnoticed&#46; Because of the potential life-threatening risk involved in this type of reaction&#44; we emphasise the importance of suspecting them when the clinical symptoms or course are unusual&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare no potential conflicts of interest related to the content of this article&#46;</p></span></span>"
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Article information
ISSN: 20132514
Original language: English
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