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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Renal biopsy findings in chronic phosphate nephropathy&#46; &#40;a&#41; Case of chronic phosphate nephropathy with abundant intraluminal and intracellular calcifications in distal tubules accompanied by tubular atrophy and fibrosis &#40;hematoxylin and eosin&#41; and &#40;b&#41; a positive histochemical reaction with the von Kossa stain confirms that the tubular concretions are composed of calcium phosphate&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The use of colonoscopy for routine screening for colon and rectal cancer has been one of the most successful public health projects worldwide&#46; Although colonoscopy is the most frequent technique that requires a proper bowel preparation&#44; it could be necessary in others diagnosis tests&#58; CT colonography&#44; barium enema and surgery on the gastrointestinal tract&#46; Effective preparation requires an adequate level of cleansing&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The osmotically balanced&#44; polyethylene glycol-based electrolyte solutions are elected because they are safer and faster than large volume saline-based electrolyte solutions&#46; Many patients have great difficulty to drink the large volume&#44; that can result in unsuccessful preparation and poorly cleansed colon&#44; and therefore&#44; inadequate study assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> The small volume of oral sodium phosphate solution &#40;OSP&#41; was associated with improved patients compliance&#44; less discomfort&#44; and superior colonic cleansing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The OSPS is not exempt from risks&#46; It can cause transient hyperphosphatemia and can induce intravascular volume contraction&#46; There have been reports of serious adverse events&#44; including death&#44; and there have been case reports of nephrocalcinosis with renal failure associated with the use of oral sodium phosphate&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#8211;4</span></a> In fact&#44; in 2008 FDA issued a warning about the use of OSP in patients with chronic kidney disease &#40;CKD&#41; or major cardiovascular comorbidities&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Unfortunately&#44; the results of the available epidemiologic data from large populations are quite confusing some studies reporting a potent association<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#8211;7</span></a> and others reporting non-significant trends toward better kidney outcomes after OSP compared with other purgatives&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#44;8</span></a> A major limitation of most of theses studies is they just consider renal damage when an acute renal failure happens&#46; However the chronic damage has been well documented with the use of this purgative solution&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the large number of patients exposed to OSP annually&#44; clarification of this association is compelling&#46; We present a series of patients with acute and chronic renal damage link to use of OSP&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patient selection and study design</span><p id="par0030" class="elsevierStylePara elsevierViewall">From 2006 to 2009 we identified 12 patients with suspected nephropathy after colonoscopy prepared by phosphosoda&#46; The clinical suspicion of PN &#40;was based on the presence of an acute o chronic renal function deterioration &#40;&#62;50&#37; from basal serum creatinine&#41; chronologically related to colonoscopy&#46; In all the patients&#44; the presence of proteinuria o hematuria was ruled out by repeated urine analysis&#44; also presence of urinary tract obstruction or other urinary tract abnormalities was excluded by appropriate radiological examinations&#46; Patients with clinical or analytical data that suggested systemic diseases were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All included patients had at least one Scr determination in the three months before the colonoscopy and it was considered as baseline Scr&#46; The highest Scr value registered was recorded&#44; as well as the need for acute dialysis&#46; The creatinine concentration at 6 months after the procedure was recorded&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Medical records of the patients were reviewed for this study&#46; We reviewed for age&#44; gender&#44; medical history &#40;high blood pressure&#44; smoker&#44; hypercholesterolemia and diabetes mellitus&#41; and medication &#40;ACE inhibitors&#44; diuretics&#41;&#46; Estimated glomerular filtration rate &#40;eGFR&#41; was calculated according to the MDRD4 formula&#46; All cases happened in a single hospital&#46; The Scr was measured in a single laboratory and by the kinetic Jaff&#233; blank correction method&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Final Scr was defined as the value obtained 6 months after withdrawal of the offending drug&#46; An incomplete recovery of baseline renal function was defined by an Scr value higher than at least 25&#37; of the baseline value&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The recommended regimen of OSP solution &#40;Casen Fleet Laboratories&#41; consisted of two 45<span class="elsevierStyleHsp" style=""></span>ml doses taken 10&#8211;12<span class="elsevierStyleHsp" style=""></span>h apart&#44; the evening before and the morning of colonoscopy&#46; Each 45<span class="elsevierStyleHsp" style=""></span>ml dose contained 21&#46;6<span class="elsevierStyleHsp" style=""></span>g of monobasic sodium phosphate &#40;NaH<span class="elsevierStyleInf">2</span>PO<span class="elsevierStyleInf">4</span>&#41; and 8&#46;1<span class="elsevierStyleHsp" style=""></span>g of dibasic sodium phosphate &#40;Na<span class="elsevierStyleInf">2</span>H-PO<span class="elsevierStyleInf">4</span>&#41;&#44; which is equivalent to 5&#46;8<span class="elsevierStyleHsp" style=""></span>g of elemental phosphorus&#46; The 5&#46;8<span class="elsevierStyleHsp" style=""></span>g of phosphorus was diluted into a single eight ounce glass and administered twice in a 12&#8211;24<span class="elsevierStyleHsp" style=""></span>h period &#40;total dose 11&#46;6<span class="elsevierStyleHsp" style=""></span>g of phosphorus&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">The baseline characteristics are expressed as means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#46; The groups were compared using the 2-sample <span class="elsevierStyleItalic">t</span> test&#44; <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>-test and Fischer exact tests&#44; respectively&#46; The 2-sample <span class="elsevierStyleItalic">t</span> test was used to compare the creatinine level and eGFR between the study and control groups&#46; The <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>-test was used to compare group characteristics of diabetes&#44; hypertension&#44; and use of angiotensin receptor blockers &#40;ARBs&#41;&#44; angiotensin-converting enzyme inhibitors and diuretics&#46; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered significant&#46; Statistics were calculated using SPSS for Windows&#44; version 11 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">Twelve cases of phosphate nephropathy were diagnosed&#58; four of them were confirmed by renal biopsy&#46; The baseline characteristics of patients in both groups are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">There were a predominance of cases of men&#44; 68&#46;2&#37; with mean age 69&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;2 years&#46; The main co-morbidities in our patients were high blood pressure 91&#46;6&#37; and DM 33&#46;3&#37;&#46; The 73&#46;3&#37; of the patients received treatment with ACE inhibitors or ARBs&#44; and the 66&#46;5&#37; received treatment with diuretics&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients received just one dose of OSP&#46; None of them were subjected to repeated cleanings intestinal in a short period&#46; One patient undergone endoscopy procedures during hospitalization for acute indications &#40;case 1&#41;&#46; The other eleven patients received the OSPS preparation and performed the colonoscopy in outpatient regimen&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Kidney function</span><p id="par0075" class="elsevierStylePara elsevierViewall">Before the procedure&#44; eGFR was &#62;60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> in 7 patients&#46; CKD stage 3a was present in 3 patients and CKD 3b in 2 patients&#46; None has CKD 4 or 5 stage&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Three patients debuted as acute renal failure &#40;two cases confirmed with renal biopsy&#41; and nine patients developed chronic renal damage &#40;two cases confirmed with renal biopsy&#41;&#46; No significant differences were found in the baseline renal function&#44; age&#44; sex&#44; treatment with ACEi or ARBs&#44; diuretics&#44; mellitus diabetes or hypertension&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In the group of patients who debuted as AKI &#40;acute kidney injury&#41;&#44; one of patients begun with nausea and vomiting hours after colonoscopy &#40;case 1&#41;&#46; The others two patients debuted in the week after the OSP administration&#46; In the patients with delayed debut the average time until the diagnosis was 54 days &#40;15&#8211;120 days&#41;&#46; All of them were asymptomatic or pauci symptomatic and the renal damage was an accidental diagnosis&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Patients presented with AKI had a higher initial loss of glomerular filtration rate&#44; but no significantly&#44; than the patients with chronic presentation &#40;52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;9<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> vs 38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;72<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; NS&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Calcium and phosphorus levels were normal in the delayed analysis&#46; None other alterations were finding&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Renal follow up</span><p id="par0100" class="elsevierStylePara elsevierViewall">One patient of the acute course group needed substitutive renal therapy in the moment of diagnosis&#44; without later recovery&#46; Six months later&#44; none of the remainder two patients of this group recovered completely the glomerular filtration rate&#44; although they got it partially&#46; The final average loss was 22&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;7<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In the group with delayed presentation&#44; six months later of colonoscopy just two patients recovered renal function as previous baseline and nine patient did not improved&#46; In the patients who did not recovered baseline renal function&#44; the final average loss of glomerular filtration rate was 26<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Renal biopsy findings</span><p id="par0110" class="elsevierStylePara elsevierViewall">In four patients a biopsy was performed&#46; The renal biopsy findings in PN primary involve the tubules and were dependent on the time interval between the preparation with oral sodium phosphate and renal biopsy&#46; The biopsy from patients with AKI acute degenerative changes predominated a resemble findings seen an acute tubular necrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> The renal biopsies performed in patients with chronic course showed tubular atrophy and interstitial fibrosis&#46; Regardless of the degree of acuity of chronicity&#44; the hallmark of PN was abundant tubular and less prominent interstitial calcium phosphate deposits &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The calcifications do not polarize and have a strong histochemical reaction with the von Kossa stain&#44; indicating that they are composed of calcium phosphate&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Ten years ago some cases of PN began to be published&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">4</span></a> The former cases were presented as an acute illness that manifested as tetany&#44; acute kidney disease or cardiovascular collapse usually within hours of bowel preparation&#46; Patients had marked hyperphosphatemia and hypocalcemia and some patients required even hemodialysis&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">12</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Although case reports and case series provide strong support for an etiological relationship between OSP and the development of PN&#44; epidemiological studies have showed less consistent results&#46; In an retrospective observational study of 9799 patients who filled a prescription for an OSP or PEG &#40;polyethylene glycol&#41;&#44; 114 patients &#40;1&#46;16&#37;&#41; developed AKI&#58; 1&#46;29&#37; of the 6432 patients who received OSPS and 0&#46;92&#37; of the 3367 patients who received PEG&#46; The PEG group included patients who were significantly older and had a higher incidence of diabetes mellitus&#44; hypertension&#44; CHF&#44; CKD&#44; diuretics use and ACEi or ARBs use &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In the multiple logistic regression models adjusted for covariates and suspected risk factors&#44; OSP was found to be the strongest risk factor for the development or AKI after colonoscopy &#40;OR 2&#46;35&#44; CI 95&#37; 1&#46;51&#8211;3&#46;66&#41; when compared with PEG&#46; When a more &#8220;strict&#8221; definition of AKI was considered &#40;doubling of serum creatinine vs &#62;50&#37; serum creatinine increase&#41;&#44; the OSP purgative use remained significantly associated with increased risk for AKI &#40;OR 3&#46;52&#44; CI 95&#37; 1&#46;13&#8211;10&#46;93&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In a recent&#44; large retrospective cohort study using a US-based administrative claims database&#46; The number of the patients included was impressive&#58; 121&#44;226 received OSP pill preparation and 429&#44;430 received PEG&#46; Patients were followed up to 6 months for AKI&#44; renal failure and dialysis&#46; The investigators did not find any increase risk of AKI in OSP pill users compared with PEG &#40;0&#46;2&#37; vs 0&#46;3&#37;&#41;&#46; The investigators acknowledged that the study of administrative claims for AKI outcomes may be an insensitive measure of renal dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Brunelli et al&#46; undertook a systematic review and metaanalysis that concluded that it is not possible to discern if an association between OSP exposure and AKI exits&#46; The use of different AKI definitions and significant heterogeneity among the studies referred to choice of bowel preparation&#44; patients populations&#44; baseline renal function&#44; limited the result of the study&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">13</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The chronic form of kidney damage due to OSP agents may present weeks after the initial exposure and may be identified as the result of an investigation of mild or non-specific symptoms such as fatigue&#46; Sometimes&#44; it is just discovered by a casual analysis and the anamnesis is the clue&#46; This was the most frequent pattern in our study&#46; The 65&#37; of the patients were referred for study by nephrologist for increasing in serum creatinine in casual analysis&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">This form of presentation requires the inclusion of this entity in the differential diagnosis of CKD&#46; The nephrologist or physician who treats these patients should consider the possibility of PN in patients with renal damage without proteinuria or hematuria when the patient has undergone a digestive test prepared OSD&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Whereas until now to estimate the incidence of kidney disease for OSP we consider just the case presented as AKI&#44; ignoring cases of delaying presentation&#46; It may mean that this problem is more prevalent than is currently recognized&#46; In fact&#44; in the studies that analyze the safe of bowel preparation for colonoscopy the follow up was too short to identify it&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">But&#44; the true issue of this complication is not to know the AKI incidence if the secondary chronic loss of renal function over time&#46; The outcomes of these patients are very inconstant&#58; in most of cases of our study represent a substantial and irreversible loss of glomerular filtration&#46; In Hurst et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> just the 16&#37; of patients returned to baseline renal function&#46; They could not know if any of these patients requires renal replacement&#46; In cases reported at least four patients developed ESRD&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> In most of studies this information is not available&#46; In our study one patient &#40;case 3&#41; required renal replacement at diagnosis time and she did not recover renal function&#46; The other patients had an average chronic loss glomerular filtration<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;72<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Different options to get an adequate level of cleansing&#44; such as PEG&#44; can also cause renal damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#44;15</span></a> The AKI incidence reported for PEG vary between 0&#46;92&#37; and 6&#37;&#46; If we consider that the damage is mainly due to renal hypoperfusion by dehydration&#44; we could think that this injury would less severe and more reversible&#44; although to our knowledge&#44; none study has analyzed the long lasting effect of this injury&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The presence of CKD before the colonoscopy has been considered as the most weighty risk factor to develop kidney damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;14&#44;16</span></a> However in our study the 63&#37; of the patients had an eGFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In fact&#44; a lot of cases with normal o nearly normal baseline renal function with kidney injury induced OSP have been published&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">17</span></a> Some studies have suggested that females&#44; above all elderly females&#44; are at greater risk than males for developing PN&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> They might have reduced renal capacity of handle a phosphate load and their smaller body mass makes then more sensitive to fluid loss&#46; This loss of volumen in conjunction with limited oral intake dictated by precolonoscopy protocols&#44; may exacerbate some of the electrolyte abnormalities and the risk of renal failure among patients receiving these agents&#46; Drugs that impact intravascular volumen and renal perfusion may increase the risk of kidney injury after OSP use&#44; including diuretics&#44; ACE inhibitors&#44; angiotensin receptor blockers and non-steroidal anti-inflammatory agents&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The standard dose of OSP contains 11&#46;6<span class="elsevierStyleHsp" style=""></span>g of phosphorus&#46; About 57&#37; of the dose is excreted in feces&#44; 15&#37; in urine and 28&#37; is retained in the body for 24<span class="elsevierStyleHsp" style=""></span>h&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">18</span></a> The total amount of phosphate increases after the first and second doses to fourfold and eightfold of the baseline level respectably and remains elevates at 24<span class="elsevierStyleHsp" style=""></span>h&#46; These results suggest that the second dose of OSP is particularly dangerous because renal reabsorption of phosphate is fully inhibited at the time of dosing and thus the urinary concentrations of phosphate remains elevated for prolonged period&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">In summary&#44; the administration of oral sodium phosphate can cause an intense renal injury&#44; sometimes depend of dialysis and often irreversible&#46; This side effect does not always occur in high-risk patients and the most common pattern of presentation was renal chronic disease&#46; The series that study this adverse effect should consider both the acute and chronic pattern damage&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Authors contribution</span><p id="par0175" class="elsevierStylePara elsevierViewall">G&#46; Fernandez-Ju&#225;rez and L&#46; Parejo designed the study&#46; They have drafted and made the critical revision of the manuscript&#46; A&#46; Tato&#44; J&#46; Villacorta&#44; J&#46; Oca&#241;a&#44; R&#46; Cazar&#44; I&#46; Martinez&#44; A&#46; Mendez&#44; J&#46; Oca&#241;a&#44; K&#46; Lopez&#44; E&#46; Gruss&#44; E&#46; Gallego have collected the data and made the critical reviewed of the manuscript&#46; C&#46; Guerrero performed the renal biopsies studies and reviewed the manuscript&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Support</span><p id="par0180" class="elsevierStylePara elsevierViewall">The study has not received any support&#44; grants&#46; None of the authors have received any consulting fees or honoraria related to the study&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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            0 => "Chronic renal failure"
            1 => "Renal failure"
            2 => "Nephropathy"
          ]
        ]
        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec824434"
          "palabras" => array:12 [
            0 => "OSP"
            1 => "PEG"
            2 => "AKI"
            3 => "CKD"
            4 => "PN"
            5 => "ACE inhibitor"
            6 => "ARB"
            7 => "MDRD4"
            8 => "eGFR"
            9 => "Scr"
            10 => "CHF"
            11 => "ESRD"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec824436"
          "palabras" => array:3 [
            0 => "Insuficiencia renal cr&#243;nica"
            1 => "Insuficiencia renal"
            2 => "Nefropat&#237;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Screening colonoscopy with polipectomy reduces colonorectal cancer incidence and mortality&#46; An adequate bowel cleansing is one of the keys to achieving best results with this technique&#46; Oral sodium phosphate solution &#40;OSP&#41; had a widespread use in the 90s decade&#46; Its efficacy was similar to polyethylene glycol &#40;PEG&#41; solution&#44; but with less cost and convenient administration&#46; Series of patients with acute renal failure due to OSP use have been reported&#46; However&#44; large cohorts of patients found no difference in the incidence of renal damage between these two solutions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">From 2006 to 2009 we identified twelve cases of phosphate nephropathy after colonoscopy prepared with OSP&#46; All patients were followed up to six months&#46; All patients had received just a single dose&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We analyzed 12 cases with phosphate nephropathy&#59; three patients debuted with AKI and nine patients had chronic renal injury&#46; Four cases were confirmed with renal biopsy&#46; One patient with AKI needed hemodialysis at diagnosis without subsequent recovery&#46; Two patients &#40;both with chronic damage&#41; fully recovered their previous renal function&#46; The remaining patients &#40;nine&#41; had an average loss of estimated glomerular filtration rate of 24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of OSP can lead to both acute and chronic renal damage&#46; However&#44; chronic injury was the most common pattern&#46; Both forms of presentation imply a significant and irreversible loss of renal function&#46; Further studies analyzing renal damage secondary to bowel cleaning should consider these two different patterns of injury&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La colonoscopia con polipectom&#237;a con fines de cribado reduce la incidencia del c&#225;ncer colorrectal y la mortalidad por esta enfermedad&#46; Una preparaci&#243;n col&#243;nica aceptable es una de las claves para conseguir mejores resultados con esta t&#233;cnica&#46; Las soluciones de fosfato de sodio oral &#40;OSP&#41; fueron muy utilizadas en la d&#233;cada de los noventa del siglo pasado&#46; Su eficacia era similar a la de las soluciones de polietilenglicol &#40;PEG&#41;&#44; pero m&#225;s baratas y con una administraci&#243;n sencilla&#46; Se han descrito series de casos de pacientes con insuficiencia renal aguda provocada por OSP&#46; Sin embargo&#44; en cohortes amplias de pacientes no se observ&#243; ninguna diferencia en la incidencia de da&#241;o renal entre estas dos soluciones&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Entre 2006 y 2009 identificamos 12&#160;casos de nefropat&#237;a por fosfato tras preparaci&#243;n con OSP para colonoscopia&#46; Se realiz&#243; el seguimiento de todos los pacientes durante 6&#160;meses&#46; Todos los pacientes hab&#237;an recibido una &#250;nica dosis&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizamos 12&#160;casos de nefropat&#237;a por fosfato&#59; 3 se manifestaron con IRA y 9 presentaron da&#241;o renal cr&#243;nico&#46; Cuatro de los casos se confirmaron mediante biopsia renal&#46; Un paciente con IRA precis&#243; hemodi&#225;lisis en el momento del diagn&#243;stico&#44; sin que experimentara recuperaci&#243;n posterior&#46; Dos pacientes &#40;ambos con da&#241;o cr&#243;nico&#41; recuperaron totalmente su funci&#243;n renal anterior&#46; Los dem&#225;s pacientes &#40;9&#41; presentaron una p&#233;rdida media en la filtraci&#243;n glomerular estimada de 24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El uso de OSP puede ocasionar da&#241;o renal tanto agudo como cr&#243;nico&#46; Sin embargo&#44; el da&#241;o cr&#243;nico fue el m&#225;s frecuente&#46; Ambas formas de presentaci&#243;n suponen una p&#233;rdida considerable e irreversible de funci&#243;n renal&#46; Nuevos estudios que analicen el da&#241;o renal secundario a preparaci&#243;n col&#243;nica deben considerar estos dos patrones distintos de da&#241;o&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1502
            "Ancho" => 978
            "Tamanyo" => 415104
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Renal biopsy findings in chronic phosphate nephropathy&#46; &#40;a&#41; Case of chronic phosphate nephropathy with abundant intraluminal and intracellular calcifications in distal tubules accompanied by tubular atrophy and fibrosis &#40;hematoxylin and eosin&#41; and &#40;b&#41; a positive histochemical reaction with the von Kossa stain confirms that the tubular concretions are composed of calcium phosphate&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#169; Modification of the diet in renal disease &#40;MDRD&#41;-4 equation was used to estimate glomerular filtration rate &#40;eGFR&#41;&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">ACEi&#44; angiotensin-converting enzyme inhibitors&#59; ARB&#44; angiotensin II receptor blockers&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&#169;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ACEi-ARB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Renal biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1393515.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Baseline clinical characteristics of 12 patients with phosphate nephropathy&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">HD&#58; hemodialysis&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Peak eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR 6 month after &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#916;eGFR 6<span class="elsevierStyleHsp" style=""></span>m after &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1393516.png"
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Renal outcome in 12 patients with phosphate nephropathy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution &#40;Golytely&#41; in the preparation of patients for colonoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;J&#46; Vanner"
                            1 => "P&#46;H&#46; MacDonald"
                            2 => "W&#46;G&#46; Paterson"
                            3 => "R&#46;S&#46; Prentice"
                            4 => "L&#46;R&#46; Da Costa"
                            5 => "I&#46;T&#46; Beck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1990"
                        "volumen" => "85"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "2"
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Original article
Kidney injury after sodium phosphate solution beyond the acute renal failure
Daño renal después de preparación colónica con soluciones de fosfato. Más allá del fracaso renal agudo
Gema Fernández-Juáreza,
Corresponding author
gmfernandez@fhalcorcon.es

Corresponding author at: Department of Nephrology, Hospital Fundación Alcorcón, Alcorcón, Madrid, Spain. Tel.: +34 607288402.
, Leticia Parejoa, Javier Villacortaa, Ana Tatoa, Ramiro Cazara, Carmen Guerrerob, Isabel Martinez Marina, Javier Ocañaa, Angel Mendez-Abreua, Katia Lópeza, Enrique Grussa, Eduardo Gallegoa
a Department of Nephrology, Hospital Universitario Fundación de Alcorcón, Alcorcón, Spain
b Department of Pathology, Hospital Universitario Fundación de Alcorcón, Alcorcón, Spain
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Renal biopsy findings in chronic phosphate nephropathy&#46; &#40;a&#41; Case of chronic phosphate nephropathy with abundant intraluminal and intracellular calcifications in distal tubules accompanied by tubular atrophy and fibrosis &#40;hematoxylin and eosin&#41; and &#40;b&#41; a positive histochemical reaction with the von Kossa stain confirms that the tubular concretions are composed of calcium phosphate&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The use of colonoscopy for routine screening for colon and rectal cancer has been one of the most successful public health projects worldwide&#46; Although colonoscopy is the most frequent technique that requires a proper bowel preparation&#44; it could be necessary in others diagnosis tests&#58; CT colonography&#44; barium enema and surgery on the gastrointestinal tract&#46; Effective preparation requires an adequate level of cleansing&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The osmotically balanced&#44; polyethylene glycol-based electrolyte solutions are elected because they are safer and faster than large volume saline-based electrolyte solutions&#46; Many patients have great difficulty to drink the large volume&#44; that can result in unsuccessful preparation and poorly cleansed colon&#44; and therefore&#44; inadequate study assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> The small volume of oral sodium phosphate solution &#40;OSP&#41; was associated with improved patients compliance&#44; less discomfort&#44; and superior colonic cleansing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The OSPS is not exempt from risks&#46; It can cause transient hyperphosphatemia and can induce intravascular volume contraction&#46; There have been reports of serious adverse events&#44; including death&#44; and there have been case reports of nephrocalcinosis with renal failure associated with the use of oral sodium phosphate&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#8211;4</span></a> In fact&#44; in 2008 FDA issued a warning about the use of OSP in patients with chronic kidney disease &#40;CKD&#41; or major cardiovascular comorbidities&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Unfortunately&#44; the results of the available epidemiologic data from large populations are quite confusing some studies reporting a potent association<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#8211;7</span></a> and others reporting non-significant trends toward better kidney outcomes after OSP compared with other purgatives&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#44;8</span></a> A major limitation of most of theses studies is they just consider renal damage when an acute renal failure happens&#46; However the chronic damage has been well documented with the use of this purgative solution&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the large number of patients exposed to OSP annually&#44; clarification of this association is compelling&#46; We present a series of patients with acute and chronic renal damage link to use of OSP&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patient selection and study design</span><p id="par0030" class="elsevierStylePara elsevierViewall">From 2006 to 2009 we identified 12 patients with suspected nephropathy after colonoscopy prepared by phosphosoda&#46; The clinical suspicion of PN &#40;was based on the presence of an acute o chronic renal function deterioration &#40;&#62;50&#37; from basal serum creatinine&#41; chronologically related to colonoscopy&#46; In all the patients&#44; the presence of proteinuria o hematuria was ruled out by repeated urine analysis&#44; also presence of urinary tract obstruction or other urinary tract abnormalities was excluded by appropriate radiological examinations&#46; Patients with clinical or analytical data that suggested systemic diseases were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All included patients had at least one Scr determination in the three months before the colonoscopy and it was considered as baseline Scr&#46; The highest Scr value registered was recorded&#44; as well as the need for acute dialysis&#46; The creatinine concentration at 6 months after the procedure was recorded&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Medical records of the patients were reviewed for this study&#46; We reviewed for age&#44; gender&#44; medical history &#40;high blood pressure&#44; smoker&#44; hypercholesterolemia and diabetes mellitus&#41; and medication &#40;ACE inhibitors&#44; diuretics&#41;&#46; Estimated glomerular filtration rate &#40;eGFR&#41; was calculated according to the MDRD4 formula&#46; All cases happened in a single hospital&#46; The Scr was measured in a single laboratory and by the kinetic Jaff&#233; blank correction method&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Final Scr was defined as the value obtained 6 months after withdrawal of the offending drug&#46; An incomplete recovery of baseline renal function was defined by an Scr value higher than at least 25&#37; of the baseline value&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The recommended regimen of OSP solution &#40;Casen Fleet Laboratories&#41; consisted of two 45<span class="elsevierStyleHsp" style=""></span>ml doses taken 10&#8211;12<span class="elsevierStyleHsp" style=""></span>h apart&#44; the evening before and the morning of colonoscopy&#46; Each 45<span class="elsevierStyleHsp" style=""></span>ml dose contained 21&#46;6<span class="elsevierStyleHsp" style=""></span>g of monobasic sodium phosphate &#40;NaH<span class="elsevierStyleInf">2</span>PO<span class="elsevierStyleInf">4</span>&#41; and 8&#46;1<span class="elsevierStyleHsp" style=""></span>g of dibasic sodium phosphate &#40;Na<span class="elsevierStyleInf">2</span>H-PO<span class="elsevierStyleInf">4</span>&#41;&#44; which is equivalent to 5&#46;8<span class="elsevierStyleHsp" style=""></span>g of elemental phosphorus&#46; The 5&#46;8<span class="elsevierStyleHsp" style=""></span>g of phosphorus was diluted into a single eight ounce glass and administered twice in a 12&#8211;24<span class="elsevierStyleHsp" style=""></span>h period &#40;total dose 11&#46;6<span class="elsevierStyleHsp" style=""></span>g of phosphorus&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">The baseline characteristics are expressed as means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#46; The groups were compared using the 2-sample <span class="elsevierStyleItalic">t</span> test&#44; <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>-test and Fischer exact tests&#44; respectively&#46; The 2-sample <span class="elsevierStyleItalic">t</span> test was used to compare the creatinine level and eGFR between the study and control groups&#46; The <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>-test was used to compare group characteristics of diabetes&#44; hypertension&#44; and use of angiotensin receptor blockers &#40;ARBs&#41;&#44; angiotensin-converting enzyme inhibitors and diuretics&#46; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered significant&#46; Statistics were calculated using SPSS for Windows&#44; version 11 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">Twelve cases of phosphate nephropathy were diagnosed&#58; four of them were confirmed by renal biopsy&#46; The baseline characteristics of patients in both groups are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">There were a predominance of cases of men&#44; 68&#46;2&#37; with mean age 69&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;2 years&#46; The main co-morbidities in our patients were high blood pressure 91&#46;6&#37; and DM 33&#46;3&#37;&#46; The 73&#46;3&#37; of the patients received treatment with ACE inhibitors or ARBs&#44; and the 66&#46;5&#37; received treatment with diuretics&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients received just one dose of OSP&#46; None of them were subjected to repeated cleanings intestinal in a short period&#46; One patient undergone endoscopy procedures during hospitalization for acute indications &#40;case 1&#41;&#46; The other eleven patients received the OSPS preparation and performed the colonoscopy in outpatient regimen&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Kidney function</span><p id="par0075" class="elsevierStylePara elsevierViewall">Before the procedure&#44; eGFR was &#62;60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> in 7 patients&#46; CKD stage 3a was present in 3 patients and CKD 3b in 2 patients&#46; None has CKD 4 or 5 stage&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Three patients debuted as acute renal failure &#40;two cases confirmed with renal biopsy&#41; and nine patients developed chronic renal damage &#40;two cases confirmed with renal biopsy&#41;&#46; No significant differences were found in the baseline renal function&#44; age&#44; sex&#44; treatment with ACEi or ARBs&#44; diuretics&#44; mellitus diabetes or hypertension&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In the group of patients who debuted as AKI &#40;acute kidney injury&#41;&#44; one of patients begun with nausea and vomiting hours after colonoscopy &#40;case 1&#41;&#46; The others two patients debuted in the week after the OSP administration&#46; In the patients with delayed debut the average time until the diagnosis was 54 days &#40;15&#8211;120 days&#41;&#46; All of them were asymptomatic or pauci symptomatic and the renal damage was an accidental diagnosis&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Patients presented with AKI had a higher initial loss of glomerular filtration rate&#44; but no significantly&#44; than the patients with chronic presentation &#40;52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;9<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> vs 38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;72<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; NS&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Calcium and phosphorus levels were normal in the delayed analysis&#46; None other alterations were finding&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Renal follow up</span><p id="par0100" class="elsevierStylePara elsevierViewall">One patient of the acute course group needed substitutive renal therapy in the moment of diagnosis&#44; without later recovery&#46; Six months later&#44; none of the remainder two patients of this group recovered completely the glomerular filtration rate&#44; although they got it partially&#46; The final average loss was 22&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;7<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In the group with delayed presentation&#44; six months later of colonoscopy just two patients recovered renal function as previous baseline and nine patient did not improved&#46; In the patients who did not recovered baseline renal function&#44; the final average loss of glomerular filtration rate was 26<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Renal biopsy findings</span><p id="par0110" class="elsevierStylePara elsevierViewall">In four patients a biopsy was performed&#46; The renal biopsy findings in PN primary involve the tubules and were dependent on the time interval between the preparation with oral sodium phosphate and renal biopsy&#46; The biopsy from patients with AKI acute degenerative changes predominated a resemble findings seen an acute tubular necrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">11</span></a> The renal biopsies performed in patients with chronic course showed tubular atrophy and interstitial fibrosis&#46; Regardless of the degree of acuity of chronicity&#44; the hallmark of PN was abundant tubular and less prominent interstitial calcium phosphate deposits &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The calcifications do not polarize and have a strong histochemical reaction with the von Kossa stain&#44; indicating that they are composed of calcium phosphate&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Ten years ago some cases of PN began to be published&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">4</span></a> The former cases were presented as an acute illness that manifested as tetany&#44; acute kidney disease or cardiovascular collapse usually within hours of bowel preparation&#46; Patients had marked hyperphosphatemia and hypocalcemia and some patients required even hemodialysis&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">12</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Although case reports and case series provide strong support for an etiological relationship between OSP and the development of PN&#44; epidemiological studies have showed less consistent results&#46; In an retrospective observational study of 9799 patients who filled a prescription for an OSP or PEG &#40;polyethylene glycol&#41;&#44; 114 patients &#40;1&#46;16&#37;&#41; developed AKI&#58; 1&#46;29&#37; of the 6432 patients who received OSPS and 0&#46;92&#37; of the 3367 patients who received PEG&#46; The PEG group included patients who were significantly older and had a higher incidence of diabetes mellitus&#44; hypertension&#44; CHF&#44; CKD&#44; diuretics use and ACEi or ARBs use &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In the multiple logistic regression models adjusted for covariates and suspected risk factors&#44; OSP was found to be the strongest risk factor for the development or AKI after colonoscopy &#40;OR 2&#46;35&#44; CI 95&#37; 1&#46;51&#8211;3&#46;66&#41; when compared with PEG&#46; When a more &#8220;strict&#8221; definition of AKI was considered &#40;doubling of serum creatinine vs &#62;50&#37; serum creatinine increase&#41;&#44; the OSP purgative use remained significantly associated with increased risk for AKI &#40;OR 3&#46;52&#44; CI 95&#37; 1&#46;13&#8211;10&#46;93&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In a recent&#44; large retrospective cohort study using a US-based administrative claims database&#46; The number of the patients included was impressive&#58; 121&#44;226 received OSP pill preparation and 429&#44;430 received PEG&#46; Patients were followed up to 6 months for AKI&#44; renal failure and dialysis&#46; The investigators did not find any increase risk of AKI in OSP pill users compared with PEG &#40;0&#46;2&#37; vs 0&#46;3&#37;&#41;&#46; The investigators acknowledged that the study of administrative claims for AKI outcomes may be an insensitive measure of renal dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">8</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Brunelli et al&#46; undertook a systematic review and metaanalysis that concluded that it is not possible to discern if an association between OSP exposure and AKI exits&#46; The use of different AKI definitions and significant heterogeneity among the studies referred to choice of bowel preparation&#44; patients populations&#44; baseline renal function&#44; limited the result of the study&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">13</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The chronic form of kidney damage due to OSP agents may present weeks after the initial exposure and may be identified as the result of an investigation of mild or non-specific symptoms such as fatigue&#46; Sometimes&#44; it is just discovered by a casual analysis and the anamnesis is the clue&#46; This was the most frequent pattern in our study&#46; The 65&#37; of the patients were referred for study by nephrologist for increasing in serum creatinine in casual analysis&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">This form of presentation requires the inclusion of this entity in the differential diagnosis of CKD&#46; The nephrologist or physician who treats these patients should consider the possibility of PN in patients with renal damage without proteinuria or hematuria when the patient has undergone a digestive test prepared OSD&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Whereas until now to estimate the incidence of kidney disease for OSP we consider just the case presented as AKI&#44; ignoring cases of delaying presentation&#46; It may mean that this problem is more prevalent than is currently recognized&#46; In fact&#44; in the studies that analyze the safe of bowel preparation for colonoscopy the follow up was too short to identify it&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">But&#44; the true issue of this complication is not to know the AKI incidence if the secondary chronic loss of renal function over time&#46; The outcomes of these patients are very inconstant&#58; in most of cases of our study represent a substantial and irreversible loss of glomerular filtration&#46; In Hurst et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">5</span></a> just the 16&#37; of patients returned to baseline renal function&#46; They could not know if any of these patients requires renal replacement&#46; In cases reported at least four patients developed ESRD&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> In most of studies this information is not available&#46; In our study one patient &#40;case 3&#41; required renal replacement at diagnosis time and she did not recover renal function&#46; The other patients had an average chronic loss glomerular filtration<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;72<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Different options to get an adequate level of cleansing&#44; such as PEG&#44; can also cause renal damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#44;15</span></a> The AKI incidence reported for PEG vary between 0&#46;92&#37; and 6&#37;&#46; If we consider that the damage is mainly due to renal hypoperfusion by dehydration&#44; we could think that this injury would less severe and more reversible&#44; although to our knowledge&#44; none study has analyzed the long lasting effect of this injury&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The presence of CKD before the colonoscopy has been considered as the most weighty risk factor to develop kidney damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">6&#44;14&#44;16</span></a> However in our study the 63&#37; of the patients had an eGFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In fact&#44; a lot of cases with normal o nearly normal baseline renal function with kidney injury induced OSP have been published&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">17</span></a> Some studies have suggested that females&#44; above all elderly females&#44; are at greater risk than males for developing PN&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> They might have reduced renal capacity of handle a phosphate load and their smaller body mass makes then more sensitive to fluid loss&#46; This loss of volumen in conjunction with limited oral intake dictated by precolonoscopy protocols&#44; may exacerbate some of the electrolyte abnormalities and the risk of renal failure among patients receiving these agents&#46; Drugs that impact intravascular volumen and renal perfusion may increase the risk of kidney injury after OSP use&#44; including diuretics&#44; ACE inhibitors&#44; angiotensin receptor blockers and non-steroidal anti-inflammatory agents&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The standard dose of OSP contains 11&#46;6<span class="elsevierStyleHsp" style=""></span>g of phosphorus&#46; About 57&#37; of the dose is excreted in feces&#44; 15&#37; in urine and 28&#37; is retained in the body for 24<span class="elsevierStyleHsp" style=""></span>h&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">18</span></a> The total amount of phosphate increases after the first and second doses to fourfold and eightfold of the baseline level respectably and remains elevates at 24<span class="elsevierStyleHsp" style=""></span>h&#46; These results suggest that the second dose of OSP is particularly dangerous because renal reabsorption of phosphate is fully inhibited at the time of dosing and thus the urinary concentrations of phosphate remains elevated for prolonged period&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">In summary&#44; the administration of oral sodium phosphate can cause an intense renal injury&#44; sometimes depend of dialysis and often irreversible&#46; This side effect does not always occur in high-risk patients and the most common pattern of presentation was renal chronic disease&#46; The series that study this adverse effect should consider both the acute and chronic pattern damage&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Authors contribution</span><p id="par0175" class="elsevierStylePara elsevierViewall">G&#46; Fernandez-Ju&#225;rez and L&#46; Parejo designed the study&#46; They have drafted and made the critical revision of the manuscript&#46; A&#46; Tato&#44; J&#46; Villacorta&#44; J&#46; Oca&#241;a&#44; R&#46; Cazar&#44; I&#46; Martinez&#44; A&#46; Mendez&#44; J&#46; Oca&#241;a&#44; K&#46; Lopez&#44; E&#46; Gruss&#44; E&#46; Gallego have collected the data and made the critical reviewed of the manuscript&#46; C&#46; Guerrero performed the renal biopsies studies and reviewed the manuscript&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Support</span><p id="par0180" class="elsevierStylePara elsevierViewall">The study has not received any support&#44; grants&#46; None of the authors have received any consulting fees or honoraria related to the study&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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            0 => "Chronic renal failure"
            1 => "Renal failure"
            2 => "Nephropathy"
          ]
        ]
        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec824434"
          "palabras" => array:12 [
            0 => "OSP"
            1 => "PEG"
            2 => "AKI"
            3 => "CKD"
            4 => "PN"
            5 => "ACE inhibitor"
            6 => "ARB"
            7 => "MDRD4"
            8 => "eGFR"
            9 => "Scr"
            10 => "CHF"
            11 => "ESRD"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec824436"
          "palabras" => array:3 [
            0 => "Insuficiencia renal cr&#243;nica"
            1 => "Insuficiencia renal"
            2 => "Nefropat&#237;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Screening colonoscopy with polipectomy reduces colonorectal cancer incidence and mortality&#46; An adequate bowel cleansing is one of the keys to achieving best results with this technique&#46; Oral sodium phosphate solution &#40;OSP&#41; had a widespread use in the 90s decade&#46; Its efficacy was similar to polyethylene glycol &#40;PEG&#41; solution&#44; but with less cost and convenient administration&#46; Series of patients with acute renal failure due to OSP use have been reported&#46; However&#44; large cohorts of patients found no difference in the incidence of renal damage between these two solutions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">From 2006 to 2009 we identified twelve cases of phosphate nephropathy after colonoscopy prepared with OSP&#46; All patients were followed up to six months&#46; All patients had received just a single dose&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We analyzed 12 cases with phosphate nephropathy&#59; three patients debuted with AKI and nine patients had chronic renal injury&#46; Four cases were confirmed with renal biopsy&#46; One patient with AKI needed hemodialysis at diagnosis without subsequent recovery&#46; Two patients &#40;both with chronic damage&#41; fully recovered their previous renal function&#46; The remaining patients &#40;nine&#41; had an average loss of estimated glomerular filtration rate of 24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of OSP can lead to both acute and chronic renal damage&#46; However&#44; chronic injury was the most common pattern&#46; Both forms of presentation imply a significant and irreversible loss of renal function&#46; Further studies analyzing renal damage secondary to bowel cleaning should consider these two different patterns of injury&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La colonoscopia con polipectom&#237;a con fines de cribado reduce la incidencia del c&#225;ncer colorrectal y la mortalidad por esta enfermedad&#46; Una preparaci&#243;n col&#243;nica aceptable es una de las claves para conseguir mejores resultados con esta t&#233;cnica&#46; Las soluciones de fosfato de sodio oral &#40;OSP&#41; fueron muy utilizadas en la d&#233;cada de los noventa del siglo pasado&#46; Su eficacia era similar a la de las soluciones de polietilenglicol &#40;PEG&#41;&#44; pero m&#225;s baratas y con una administraci&#243;n sencilla&#46; Se han descrito series de casos de pacientes con insuficiencia renal aguda provocada por OSP&#46; Sin embargo&#44; en cohortes amplias de pacientes no se observ&#243; ninguna diferencia en la incidencia de da&#241;o renal entre estas dos soluciones&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Entre 2006 y 2009 identificamos 12&#160;casos de nefropat&#237;a por fosfato tras preparaci&#243;n con OSP para colonoscopia&#46; Se realiz&#243; el seguimiento de todos los pacientes durante 6&#160;meses&#46; Todos los pacientes hab&#237;an recibido una &#250;nica dosis&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizamos 12&#160;casos de nefropat&#237;a por fosfato&#59; 3 se manifestaron con IRA y 9 presentaron da&#241;o renal cr&#243;nico&#46; Cuatro de los casos se confirmaron mediante biopsia renal&#46; Un paciente con IRA precis&#243; hemodi&#225;lisis en el momento del diagn&#243;stico&#44; sin que experimentara recuperaci&#243;n posterior&#46; Dos pacientes &#40;ambos con da&#241;o cr&#243;nico&#41; recuperaron totalmente su funci&#243;n renal anterior&#46; Los dem&#225;s pacientes &#40;9&#41; presentaron una p&#233;rdida media en la filtraci&#243;n glomerular estimada de 24<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El uso de OSP puede ocasionar da&#241;o renal tanto agudo como cr&#243;nico&#46; Sin embargo&#44; el da&#241;o cr&#243;nico fue el m&#225;s frecuente&#46; Ambas formas de presentaci&#243;n suponen una p&#233;rdida considerable e irreversible de funci&#243;n renal&#46; Nuevos estudios que analicen el da&#241;o renal secundario a preparaci&#243;n col&#243;nica deben considerar estos dos patrones distintos de da&#241;o&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1502
            "Ancho" => 978
            "Tamanyo" => 415104
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Renal biopsy findings in chronic phosphate nephropathy&#46; &#40;a&#41; Case of chronic phosphate nephropathy with abundant intraluminal and intracellular calcifications in distal tubules accompanied by tubular atrophy and fibrosis &#40;hematoxylin and eosin&#41; and &#40;b&#41; a positive histochemical reaction with the von Kossa stain confirms that the tubular concretions are composed of calcium phosphate&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#169; Modification of the diet in renal disease &#40;MDRD&#41;-4 equation was used to estimate glomerular filtration rate &#40;eGFR&#41;&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">ACEi&#44; angiotensin-converting enzyme inhibitors&#59; ARB&#44; angiotensin II receptor blockers&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&#169;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ACEi-ARB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Renal biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1393515.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Baseline clinical characteristics of 12 patients with phosphate nephropathy&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">HD&#58; hemodialysis&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Peak eGFR &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR 6 month after &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#916;eGFR 6<span class="elsevierStyleHsp" style=""></span>m after &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">HD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Case 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1393516.png"
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Renal outcome in 12 patients with phosphate nephropathy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution &#40;Golytely&#41; in the preparation of patients for colonoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;J&#46; Vanner"
                            1 => "P&#46;H&#46; MacDonald"
                            2 => "W&#46;G&#46; Paterson"
                            3 => "R&#46;S&#46; Prentice"
                            4 => "L&#46;R&#46; Da Costa"
                            5 => "I&#46;T&#46; Beck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1990"
                        "volumen" => "85"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "2"
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Article information
ISSN: 20132514
Original language: English
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2021 February 60 41 101
2021 January 58 31 89
2020 December 56 25 81
2020 November 62 19 81
2020 October 42 29 71
2020 September 50 31 81
2020 August 57 26 83
2020 July 48 15 63
2020 June 55 21 76
2020 May 75 22 97
2020 April 42 21 63
2020 March 59 18 77
2020 February 53 30 83
2020 January 71 27 98
2019 December 79 30 109
2019 November 88 20 108
2019 October 53 17 70
2019 September 57 20 77
2019 August 54 11 65
2019 July 62 24 86
2019 June 64 21 85
2019 May 62 14 76
2019 April 113 31 144
2019 March 71 25 96
2019 February 36 13 49
2019 January 39 14 53
2018 December 154 43 197
2018 November 239 21 260
2018 October 91 32 123
2018 September 53 20 73
2018 August 43 16 59
2018 July 36 14 50
2018 June 38 15 53
2018 May 48 12 60
2018 April 60 14 74
2018 March 40 10 50
2018 February 42 6 48
2018 January 43 9 52
2017 December 47 7 54
2017 November 64 15 79
2017 October 37 11 48
2017 September 50 6 56
2017 August 59 13 72
2017 July 56 18 74
2017 June 50 9 59
2017 May 52 13 65
2017 April 41 14 55
2017 March 39 5 44
2017 February 29 10 39
2017 January 21 10 31
2016 December 39 12 51
2016 November 87 16 103
2016 October 96 11 107
2016 September 104 4 108
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?