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She had undergone laboratory testing that showed mild kidney failure with a serum Cr of 1&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and proteinuria at 2&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;day&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since she did not have HTN&#44; the presence of pre-eclampsia was ruled out&#44; and she was diagnosed with worsening of renal function in a patient with chronic kidney disease &#40;CKD&#41; in pregnancy&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the severe and persistent proteinuria with the progressive decline in kidney function&#44; it was decided to perform a Caesarean section&#44; which proceeded without complications&#46; After birth&#44; she was started on antiproteinuric treatment with enalapril &#40;10<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#46; Currently &#40;2 years after the birth&#41;&#44; the patient has stage-3 CKD&#44; with plasma creatinine at 1&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; glomerular filtration rate estimated by the MDRD-4 equation at 40<span class="elsevierStyleHsp" style=""></span>ml&#47;min and albuminuria at 74<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">HDR syndrome or Barakat syndrome is a rare autosomal dominant hereditary disease determined by a mutation in the GATA3 gene&#44; a gene located in the short arm of chromosome 10&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> This gene is a transcription factor involved in the embryonic development of the parathyroid glands&#44; kidneys&#44; inner ears&#44; thymus and central nervous system&#46; This syndrome is characterised by the classic triad of familial primary hypoparathyroidism&#44; with the possible occurrence of seizures&#44; as a manifestation of hypocalcaemia&#44; renal dysplasia and various degrees of sensorineural deafness&#46; Most cases are bilateral&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">From a nephrology point of view&#44; it may manifest with hypoplasia&#44; renal dysplasia or agenesis&#44; pyelocalyceal deformity&#44; renal cysts&#44; vesicoureteral reflux&#44; renal tubular acidosis&#44; chronic kidney failure &#40;sometimes requiring renal replacement therapy&#41;&#44; haematuria and various degrees of proteinuria&#46; Nephrotic syndrome&#44; which is typically resistant to steroids&#44; may occur&#46; The most common finding on kidney biopsy is focal segmental glomerulosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment is symptomatic and aimed at managing or treating the clinical abnormalities associated with hypoparathyroidism&#44; deafness and kidney disease&#44; essentially&#44; management of proteinuria&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Barakat syndrome is an uncommon cause of proteinuric nephropathy that should be suspected in cases associated with hypoparathyroidism and hereditary sensorineural deafness&#46; Early diagnosis and treatment with renin&#8211;angiotensin system blockers may help slow the progression of kidney failure and improve prognosis&#44; which essentially depends on the severity of kidney failure&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Letter to the Editor: Brief Case Reports
Barakat syndrome or HDR syndrome: Another association of kidney disease and deafness
Síndrome hipoparathyroidism, deafness and renal displasia o síndrome de Barakat otra asociación de sordera y nefropatía
Patrocinio Rodríguez Beníteza,
Corresponding author
prodriguezb@senefro.org

Corresponding author at: Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain. Tel.: +34 915868319/915868674.
, María Teresa Jaldo Rodríguezb, Andrés Hernández Coronadoa, Esther Torres Aguileraa, Rosa Meleroa, Alberto Tejedora
a Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Nefrología, Complejo Hospitalario de Jaén, Jaén, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">If a patient has kidney disease and deafness&#44; we think on Alport syndrome&#44; a widespread entity&#46; However&#44; this is not always the case&#46; One of the recent issues of the journal Nefrolog&#237;a included an excellent review of kidney disease in the context of mitochondrial diseases and how nephrologists should suspect this diseases in a nephropathy &#40;tubulopathy or glomerular injury&#44; manifested by kidney failure and proteinuria&#41; which is accompanied by hearing loss or sensorineural deafness&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> In this letter&#44; we present a case of Barakat syndrome or hypoparathyroidism&#44; deafness and renal dysplasia &#40;HDR&#41; syndrome&#44; another disease that should be included in the differential diagnosis of kidney disease and hereditary deafness&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 32-year-old patient was admitted to the obstetrics department owing to oedema&#46; She was 36 weeks pregnant and the laboratory tests revealed a plasma creatinine at 1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and 6 grams of proteinuria in a 24-h urine collection&#46; Medical history included familial hypoparathyroidism in chronic treatment with vitamin D and calcium carbonate&#44; bilateral sensorineural deafness and left kidney agenesis&#46; With this history&#44; in 2007&#44; she was diagnosed with HDR syndrome&#46; A genetic study demonstrated the presence of the c&#46;431 mutation in the GATA3 gene &#40;gene for the transcription factor GATA3&#44; located in the short arm of chromosome 10&#41;&#46; Both the patient and her mother were heterozygous for this mutation&#46; The rest of the family &#40;father&#44; sister and maternal aunt&#41; did not have any clinical manifestations of the syndrome&#59; nevertheless&#44; a molecular genetic study ruled out the presence of this mutation&#46; Prior to pregnancy&#44; the patient had been examined in the urology department as she was a single-kidney patient&#46; She had undergone laboratory testing that showed mild kidney failure with a serum Cr of 1&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and proteinuria at 2&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;day&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since she did not have HTN&#44; the presence of pre-eclampsia was ruled out&#44; and she was diagnosed with worsening of renal function in a patient with chronic kidney disease &#40;CKD&#41; in pregnancy&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the severe and persistent proteinuria with the progressive decline in kidney function&#44; it was decided to perform a Caesarean section&#44; which proceeded without complications&#46; After birth&#44; she was started on antiproteinuric treatment with enalapril &#40;10<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#46; Currently &#40;2 years after the birth&#41;&#44; the patient has stage-3 CKD&#44; with plasma creatinine at 1&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; glomerular filtration rate estimated by the MDRD-4 equation at 40<span class="elsevierStyleHsp" style=""></span>ml&#47;min and albuminuria at 74<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">HDR syndrome or Barakat syndrome is a rare autosomal dominant hereditary disease determined by a mutation in the GATA3 gene&#44; a gene located in the short arm of chromosome 10&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> This gene is a transcription factor involved in the embryonic development of the parathyroid glands&#44; kidneys&#44; inner ears&#44; thymus and central nervous system&#46; This syndrome is characterised by the classic triad of familial primary hypoparathyroidism&#44; with the possible occurrence of seizures&#44; as a manifestation of hypocalcaemia&#44; renal dysplasia and various degrees of sensorineural deafness&#46; Most cases are bilateral&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">From a nephrology point of view&#44; it may manifest with hypoplasia&#44; renal dysplasia or agenesis&#44; pyelocalyceal deformity&#44; renal cysts&#44; vesicoureteral reflux&#44; renal tubular acidosis&#44; chronic kidney failure &#40;sometimes requiring renal replacement therapy&#41;&#44; haematuria and various degrees of proteinuria&#46; Nephrotic syndrome&#44; which is typically resistant to steroids&#44; may occur&#46; The most common finding on kidney biopsy is focal segmental glomerulosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment is symptomatic and aimed at managing or treating the clinical abnormalities associated with hypoparathyroidism&#44; deafness and kidney disease&#44; essentially&#44; management of proteinuria&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Barakat syndrome is an uncommon cause of proteinuric nephropathy that should be suspected in cases associated with hypoparathyroidism and hereditary sensorineural deafness&#46; Early diagnosis and treatment with renin&#8211;angiotensin system blockers may help slow the progression of kidney failure and improve prognosis&#44; which essentially depends on the severity of kidney failure&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rodr&#237;guez Ben&#237;tez P&#44; Jaldo Rodr&#237;guez MT&#44; Hern&#225;ndez Coronado A&#44; Torres Aguilera E&#44; Melero R&#44; Tejedor A&#46; S&#237;ndrome hipoparathyroidism&#44; deafness and renal displasia o s&#237;ndrome de Barakat otra asociaci&#243;n de sordera y nefropat&#237;a&#46; Nefrologia&#46; 2016&#59;36&#58;188&#8211;189&#46;</p>"
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                            0 => "A&#46; Taslipinar"
                            1 => "L&#46; Kebapcilar"
                            2 => "M&#46; Kutlu"
                            3 => "M&#46; Sahin"
                            4 => "A&#46; Aydogdu"
                            5 => "G&#46; Uckaya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2008"
                        "volumen" => "47"
                        "paginaInicial" => "1003"
                        "paginaFinal" => "1007"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18520110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003600000002/v4_201703310238/S2013251416000353/v4_201703310238/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "51800"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief comments on case report"
      "idiomaDefecto" => true
    ]
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  ]
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Article information
ISSN: 20132514
Original language: English
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Idiomas
Nefrología (English Edition)
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