Corresponding author at: Servicio de Nefrología, Centro Hospitalar e Universitário de Coimbra–Hospital Geral., Rua do Buxo, lote 17, 3040-792 Coimbra, Portugal. Tel.: +351 916699039.
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Tel.: +351 916699039." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eculizumab para el tratamiento de un síndrome urémico hemolítico atípico con mutaciones en los factores I y C3 del sistema del complemento" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3462 "Ancho" => 2390 "Tamanyo" => 405309 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical course: laboratory data and treatment. Corticosteroid therapy was started with intravenous administration of methylprednisolone (1000<span class="elsevierStyleHsp" style=""></span>mg/day for 3 days) followed by oral prednisolone and an initial dosage of 60<span class="elsevierStyleHsp" style=""></span>mg/day. This dosage was maintained until the 53rd day after admission, with posterior tapering. Rituximab (arrows) was administered at a dose of 600<span class="elsevierStyleHsp" style=""></span>mg (375<span class="elsevierStyleHsp" style=""></span>mg/m2) on the 27th, 34th, 41st and 48th days after admission. Cyclophosphamide (arrowhead) was administered in a single dose of 1000<span class="elsevierStyleHsp" style=""></span>mg on the 61st day after admission (2nd day after readmission). Eculizumab was administered at a dose of 900<span class="elsevierStyleHsp" style=""></span>mg for a week for 4 weeks, started on the 158th day after admission, followed by a dosage of 1200<span class="elsevierStyleHsp" style=""></span>mg 1 week later an then a maintenance dose of 1200<span class="elsevierStyleHsp" style=""></span>mg every 2 weeks. This dosage is still being continued. We performed a total of 79 plasma exchange sessions. The last three laboratorial test results were done on the 270th, 340th and 466th days following first admission.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atypical hemolytic-uremic syndrome (aHUS) is a rare, life-threatening complement-mediated thrombotic microangiopathy.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Approximately half of cases have mutations in complement proteins but only 12% have 2 or more mutations.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Eculizumab is nowadays considered first-line therapy for aHUS.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 33-year-old female with unremarkable past medical history presented with a 3-day history of decreased urine output. Physical examination showed hypertension (160/90<span class="elsevierStyleHsp" style=""></span>mmHg) and lower limbs edema. Investigations revealed an acute thrombotic microangiopathy (ATM), hematuria and nephrotic proteinuria (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Daily plasmapheresis (PMP) was started immediately.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Investigations for secondary causes of ATM revealed a low ADAMTS 13 activity, decreased complement C4, C3, C1q and C2 levels and positive serum cryoglobulins (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Considering the hypothesis of an autoimmune disorder, we started 3 daily pulses of 1000<span class="elsevierStyleHsp" style=""></span>mg methylprednisolone followed by oral prednisolone.</p><p id="par0020" class="elsevierStylePara elsevierViewall">PMP was stopped on the eighteenth day of admission (D18) due to normal platelet count during 3 consecutive days (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). On the D19 a renal biopsy was made. It showed a “thrombotic microangiopathy with acute tubular necrosis” and “deposition of IgM, C3 and C1q in the capillary wall”. Due to increased hemolytic activity, PMP was resumed on the D21. On the D27, rituximab was started to enhance immunosuppression. PMP was stopped on the D35 based on the absence of schistocytosis, hemoglobin stability and lactate dehydrogenase (LDH) normalization.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">On the D50, LDH was high but hemoglobin and platelet count were stable. A state of compensated hemolysis was assumed and the patient was discharged home.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ten days later she was readmitted due to increased hemolytic activity (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). PMP was resumed and 1000<span class="elsevierStyleHsp" style=""></span>mg cyclophosphamide was given. At that time ADAMTS13 and complement C4 levels were normal but complement C3 levels remained low.</p><p id="par0035" class="elsevierStylePara elsevierViewall">A genetic screening for mutations in complement regulatory proteins was made. Two mutations were found in factor I (C. 452 A>G, pASN 151 Ser) and C3 (C193 A<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>C, pLys 65 Gin) proteins. The process of eculizumab acquisition was lengthy, wherefore this therapy was started only on the 98th day after readmission. At that moment we were performing one PMP session/week, LDH remained high (859<span class="elsevierStyleHsp" style=""></span>U/L) and moderate renal dysfunction (creatinine 2.08<span class="elsevierStyleHsp" style=""></span>mg/dL and urea 60<span class="elsevierStyleHsp" style=""></span>mg/dL) and nephrotic proteinuria persisted (5.2<span class="elsevierStyleHsp" style=""></span>g/24<span class="elsevierStyleHsp" style=""></span>h). Eculizumab was administered at a dose of 900<span class="elsevierStyleHsp" style=""></span>mg per week for 4 weeks followed by subsequent doses of 1200<span class="elsevierStyleHsp" style=""></span>mg every 2 weeks since the 5th week. Complete hematologic remission was attained 2 days after eculizumab initiation. The patient was discharged home on the 105th day after readmission. Four weeks later, proteinuria was only 0.6<span class="elsevierStyleHsp" style=""></span>g/24<span class="elsevierStyleHsp" style=""></span>h.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Currently, 10 months after first infusion, the patient remains under biweekly administration of eculizumab. Hematologic remission persists and there is a significant recover of renal function (urea 43<span class="elsevierStyleHsp" style=""></span>mg/dL, creatinine 1.27<span class="elsevierStyleHsp" style=""></span>mg/dL).</p><p id="par0045" class="elsevierStylePara elsevierViewall">Complement factor I (CFI) and C3 mutations account for 10% and 4% of the overall aHUS-associated mutations, respectively.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> C3 mutations are among the ones with the poorest prognosis: 75% risk of death or end stage renal failure (ESRF) at 3–5 years follow up and 50% risk of recurrence.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> CFI mutations have a 50–60% risk of death and ESRF at 3–5 years follow up and 10–30% risk of recurrence.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Both mutations present in our patient were previously reported.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a> The p.Asn151Ser mutation causes a quantitative deficiency of factor I<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and the p.Lys65Gin mutation weakens the affinity of C3b to complement factor H.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Despite the growing importance of eculizumab,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6,7</span></a> PMP remains the mainstay of treatment while waiting for the immunoglobulin.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Nonetheless, its benefit depends on the underlying genetic defect – only 25% and 57% of those with CFI and C3 mutations, respectively, achieve remission.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In our patient, PMP was critical to prevent further progression of renal failure and the development of other systemic involvement. However, as described by Loirat,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> it was unable to achieve complete and sustained remission.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In our case, the confounding presence of low ADAMTS13, C4, C2 and C1q levels, the presence of cryoglobulins and the existence of immune deposits in the glomerular capillary wall led to the misdiagnosis of a thrombotic thrombocytopenic purpura secondary to an autoimmune disease. It explains the preference for glucocorticoids, rituximab and cyclophosphamide in relation to eculizumab.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Eculizumab is nowadays considered first-line therapy for aHUS.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> It is a humanized monoclonal immunoglobulin IgG that targets C5 and blocks the uncontrolled generation of the cytotoxic membrane attack complex.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> When we started Eculizumab, our patient was still PMP dependent despite the 79 PMP sessions. Contrariwise, complete hematologic remission was attained two days after first infusion and a remarkable recover of renal function and reduction of proteinuria was evident. These findings reinforce the benefits of eculizumab in aHUS, even in cases of severe renal involvement.</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion, our case highlights the diagnostic challenge of aHUS and emphasizes the notion that isolated PMP is no longer the best therapeutic option in aHUS, in which cases a prompt switch to eculizumab is mandatory.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest related to the contents of this article.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ferreira E, Oliveira N, Marques M, Francisco L, Santos A, Carreira A, et al. Eculizumab for the treatment of an atypical hemolytic uremic syndrome with mutations in complement factor I and C3. Nefrologia. 2016;36:72–75.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3462 "Ancho" => 2390 "Tamanyo" => 405309 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical course: laboratory data and treatment. Corticosteroid therapy was started with intravenous administration of methylprednisolone (1000<span class="elsevierStyleHsp" style=""></span>mg/day for 3 days) followed by oral prednisolone and an initial dosage of 60<span class="elsevierStyleHsp" style=""></span>mg/day. This dosage was maintained until the 53rd day after admission, with posterior tapering. Rituximab (arrows) was administered at a dose of 600<span class="elsevierStyleHsp" style=""></span>mg (375<span class="elsevierStyleHsp" style=""></span>mg/m2) on the 27th, 34th, 41st and 48th days after admission. Cyclophosphamide (arrowhead) was administered in a single dose of 1000<span class="elsevierStyleHsp" style=""></span>mg on the 61st day after admission (2nd day after readmission). Eculizumab was administered at a dose of 900<span class="elsevierStyleHsp" style=""></span>mg for a week for 4 weeks, started on the 158th day after admission, followed by a dosage of 1200<span class="elsevierStyleHsp" style=""></span>mg 1 week later an then a maintenance dose of 1200<span class="elsevierStyleHsp" style=""></span>mg every 2 weeks. This dosage is still being continued. We performed a total of 79 plasma exchange sessions. The last three laboratorial test results were done on the 270th, 340th and 466th days following first admission.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:2 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">On admission</th></tr><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Result \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Normal range \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobin (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12–16 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">White-cell count (×10<span class="elsevierStyleSup">3</span>/mm<span class="elsevierStyleSup">3</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4–10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelet count (×10<span class="elsevierStyleSup">3</span>/mm<span class="elsevierStyleSup">3</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">150–400 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peripheral blood smear<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 schistocytes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><2 schistocytes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Haptoglobin (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.3–2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Direct coombs tests \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urea (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">114 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15–38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.52–1.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sodium (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">135 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">137–145 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Potassium (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.5–5.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lactate dehydrogenase (U/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2827 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">313–618 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">c-Reactive protein (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">URINALYSIS</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protein (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Leukocytes (/HPF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><5/c \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Red blood cells (/HPF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><2/c \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary protein to creatinine ratio (mg/mg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><0.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1381851.png" ] ] 1 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Additional studies</th></tr><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Result \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Normal range \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C3 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.9–1.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C4 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.1–0.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CH50 (U/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">23–46 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C1q (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">118–244 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C1q Inhibitor (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">197 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">180/320 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C2 (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14–25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ADAMTS13 activity (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">40–130 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-ADAMTS13 antibody (U/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum cryoglobulins \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Auto-immune antibodies<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>, Pregnancy test, SPE, Tumoral markers<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>, HIV, HBV, HCV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative/Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Blood, urine and stool cultures \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Upper endoscopy, colonoscopy, cervical, thoracic and abdominopelvic CT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Irrelevant changes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1381850.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar9005">Peripheral blood smear was done to evaluate presence of erythrocyte fragmentation and is reported as schistocytes count in a microscopic field at 100× magnification.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Antinuclear antibodies, extractable nuclear antigens, anti-neutrophil cytoplasmic antibodies, glomerular basement membrane, rheumatoid factor, cyclic citrullinated peptide, anticardiolipin/anti-β2-glycoprotein, Lupus anticoagulant.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Carcinoembryonic antigen, carbohydrate antigen 19-9, α-fetoprotein, cancer antigen 125, neuron-specific enolase, NSE.</p> <p class="elsevierStyleNotepara" id="npar0020"><span class="elsevierStyleItalic">Abbreviations</span>: ADAMTS13; a disintegrin and metalloproteinase with a thrombospondin type 1 motif; member 13. CT; computerized tomography. HBV; hepatitis B virus. HCV; hepatitis C virus. HIV; human immunodeficiency virus. SPE; serum protein electrophoresis.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Laboratorial results on admission and additional studies to establish the cause of the thrombotic microangiopathy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of atypical uraemic syndrome in the era of eculizumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 12 | 18 |
2024 October | 43 | 56 | 99 |
2024 September | 55 | 27 | 82 |
2024 August | 75 | 69 | 144 |
2024 July | 52 | 31 | 83 |
2024 June | 62 | 33 | 95 |
2024 May | 83 | 31 | 114 |
2024 April | 68 | 27 | 95 |
2024 March | 55 | 30 | 85 |
2024 February | 47 | 36 | 83 |
2024 January | 46 | 23 | 69 |
2023 December | 37 | 31 | 68 |
2023 November | 39 | 34 | 73 |
2023 October | 37 | 24 | 61 |
2023 September | 56 | 27 | 83 |
2023 August | 27 | 26 | 53 |
2023 July | 28 | 23 | 51 |
2023 June | 62 | 21 | 83 |
2023 May | 65 | 27 | 92 |
2023 April | 49 | 17 | 66 |
2023 March | 73 | 21 | 94 |
2023 February | 55 | 15 | 70 |
2023 January | 32 | 27 | 59 |
2022 December | 71 | 31 | 102 |
2022 November | 43 | 22 | 65 |
2022 October | 58 | 36 | 94 |
2022 September | 42 | 34 | 76 |
2022 August | 42 | 54 | 96 |
2022 July | 26 | 51 | 77 |
2022 June | 33 | 41 | 74 |
2022 May | 42 | 26 | 68 |
2022 April | 32 | 55 | 87 |
2022 March | 44 | 42 | 86 |
2022 February | 31 | 35 | 66 |
2022 January | 44 | 36 | 80 |
2021 December | 56 | 33 | 89 |
2021 November | 38 | 39 | 77 |
2021 October | 35 | 37 | 72 |
2021 September | 24 | 34 | 58 |
2021 August | 36 | 42 | 78 |
2021 July | 50 | 36 | 86 |
2021 June | 47 | 35 | 82 |
2021 May | 32 | 39 | 71 |
2021 April | 58 | 38 | 96 |
2021 March | 31 | 29 | 60 |
2021 February | 32 | 27 | 59 |
2021 January | 29 | 15 | 44 |
2020 December | 31 | 30 | 61 |
2020 November | 32 | 14 | 46 |
2020 October | 34 | 20 | 54 |
2020 September | 28 | 15 | 43 |
2020 August | 26 | 11 | 37 |
2020 July | 43 | 17 | 60 |
2020 June | 20 | 21 | 41 |
2020 May | 27 | 9 | 36 |
2020 April | 24 | 25 | 49 |
2020 March | 25 | 15 | 40 |
2020 February | 34 | 19 | 53 |
2020 January | 26 | 19 | 45 |
2019 December | 36 | 19 | 55 |
2019 November | 24 | 27 | 51 |
2019 October | 19 | 11 | 30 |
2019 September | 13 | 11 | 24 |
2019 August | 18 | 15 | 33 |
2019 July | 18 | 21 | 39 |
2019 June | 17 | 14 | 31 |
2019 May | 16 | 16 | 32 |
2019 April | 34 | 34 | 68 |
2019 March | 31 | 14 | 45 |
2019 February | 20 | 14 | 34 |
2019 January | 29 | 13 | 42 |
2018 December | 158 | 42 | 200 |
2018 November | 354 | 14 | 368 |
2018 October | 350 | 19 | 369 |
2018 September | 157 | 16 | 173 |
2018 August | 171 | 18 | 189 |
2018 July | 93 | 14 | 107 |
2018 June | 106 | 24 | 130 |
2018 May | 174 | 12 | 186 |
2018 April | 171 | 14 | 185 |
2018 March | 205 | 10 | 215 |
2018 February | 87 | 5 | 92 |
2018 January | 119 | 9 | 128 |
2017 December | 95 | 5 | 100 |
2017 November | 62 | 13 | 75 |
2017 October | 36 | 8 | 44 |
2017 September | 24 | 6 | 30 |
2017 August | 25 | 8 | 33 |
2017 July | 22 | 6 | 28 |
2017 June | 33 | 8 | 41 |
2017 May | 41 | 10 | 51 |
2017 April | 32 | 10 | 42 |
2017 March | 26 | 7 | 33 |
2017 February | 22 | 7 | 29 |
2017 January | 24 | 8 | 32 |
2016 December | 28 | 7 | 35 |
2016 November | 36 | 16 | 52 |
2016 October | 48 | 6 | 54 |
2016 September | 75 | 2 | 77 |
2016 August | 46 | 0 | 46 |
2016 July | 125 | 4 | 129 |
2016 June | 79 | 0 | 79 |
2016 May | 118 | 0 | 118 |
2016 April | 52 | 0 | 52 |