array:25 [
  "pii" => "S2013251416000043"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2016.01.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "116"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2015;35:572-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5015
    "formatos" => array:3 [
      "EPUB" => 276
      "HTML" => 4136
      "PDF" => 603
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S021169951500168X"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2015.10.001"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "116"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2015;35:572-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 8459
        "formatos" => array:3 [
          "EPUB" => 320
          "HTML" => 7373
          "PDF" => 766
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>"
        "titulo" => "&#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "572"
            "paginaFinal" => "577"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 4167
                "Ancho" => 1903
                "Tamanyo" => 764251
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A&#41; MAPA normal&#46; &#193;rea de exceso &#40;en c&#237;rculo rojo&#41; menor de 12&#46; B&#41; MAPA patol&#243;gica&#46; &#193;rea de exceso &#40;c&#237;rculo rojo&#41; mayor de 12&#59; la flecha se&#241;ala el &#171;&#225;rea de exceso&#187;&#58; IHB sobre un umbral de presi&#243;n arterial normal para la gestante&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Alfonso Otero Gonz&#225;lez, Silvia Uribe Moya, Ivan Gilberto Arenas Moncaleano, Mar&#237;a Paz Borrajo Prol, Mar&#237;a Jes&#250;s Garc&#237;a Garc&#237;a, Luis L&#243;pez S&#225;nchez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Alfonso"
                "apellidos" => "Otero Gonz&#225;lez"
              ]
              1 => array:2 [
                "nombre" => "Silvia"
                "apellidos" => "Uribe Moya"
              ]
              2 => array:2 [
                "nombre" => "Ivan Gilberto"
                "apellidos" => "Arenas Moncaleano"
              ]
              3 => array:2 [
                "nombre" => "Mar&#237;a Paz"
                "apellidos" => "Borrajo Prol"
              ]
              4 => array:2 [
                "nombre" => "Mar&#237;a Jes&#250;s"
                "apellidos" => "Garc&#237;a Garc&#237;a"
              ]
              5 => array:2 [
                "nombre" => "Luis"
                "apellidos" => "L&#243;pez S&#225;nchez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251416000043"
          "doi" => "10.1016/j.nefroe.2016.01.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000043?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500168X?idApp=UINPBA000064"
      "url" => "/02116995/0000003500000006/v1_201512190045/S021169951500168X/v1_201512190045/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251415000711"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2015.09.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "81"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:578-81"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3528
      "formatos" => array:3 [
        "EPUB" => 276
        "HTML" => 2663
        "PDF" => 589
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Control of proteinuria with increased doses of agalsidase alfa in a patient with Fabry disease with atypical genotype&#8211;phenotype expression"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "578"
          "paginaFinal" => "581"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Control de la proteinuria con aumento de dosis de agalsidasa alfa en un paciente con enfermedad de Fabry y expresi&#243;n de genotipo-fenotipo at&#237;pica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 971
              "Ancho" => 1486
              "Tamanyo" => 138053
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Graphic albuminuria&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Christos Paliouras, Georgios Aperis, Foteini Lamprianou, Giorgos Ntetskas, Konstantinos Roufas, Polichronis Alivanis"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Christos"
              "apellidos" => "Paliouras"
            ]
            1 => array:2 [
              "nombre" => "Georgios"
              "apellidos" => "Aperis"
            ]
            2 => array:2 [
              "nombre" => "Foteini"
              "apellidos" => "Lamprianou"
            ]
            3 => array:2 [
              "nombre" => "Giorgos"
              "apellidos" => "Ntetskas"
            ]
            4 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Roufas"
            ]
            5 => array:2 [
              "nombre" => "Polichronis"
              "apellidos" => "Alivanis"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0211699515001332"
        "doi" => "10.1016/j.nefro.2015.08.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001332?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000711?idApp=UINPBA000064"
    "url" => "/20132514/0000003500000006/v2_201703220324/S2013251415000711/v2_201703220324/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S201325141500067X"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2015.09.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "80"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:567-71"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5146
      "formatos" => array:3 [
        "EPUB" => 304
        "HTML" => 4008
        "PDF" => 834
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Comparative study of impact of hemodialysis and renal transplantation on cognitive functions in ESRD patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "567"
          "paginaFinal" => "571"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estudio comparativo de la influencia de la hemodi&#225;lisis y el trasplante renal en la funci&#243;n cognitiva de los pacientes con enfermedad renal terminal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 737
              "Ancho" => 1638
              "Tamanyo" => 96255
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Comparative presentation of all cognitive function tests in three groups&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Waleed Anwar, Haitham Ezzat, Amr Mohab"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Waleed"
              "apellidos" => "Anwar"
            ]
            1 => array:2 [
              "nombre" => "Haitham"
              "apellidos" => "Ezzat"
            ]
            2 => array:2 [
              "nombre" => "Amr"
              "apellidos" => "Mohab"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0211699515001162"
        "doi" => "10.1016/j.nefro.2015.07.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001162?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141500067X?idApp=UINPBA000064"
    "url" => "/20132514/0000003500000006/v2_201703220324/S201325141500067X/v2_201703220324/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "572"
        "paginaFinal" => "577"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Alfonso Otero Gonz&#225;lez, Silvia Uribe Moya, Ivan Gilberto Arenas Moncaleano, Mar&#237;a Paz Borrajo Prol, Mar&#237;a Jes&#250;s Garc&#237;a Garc&#237;a, Luis L&#243;pez S&#225;nchez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Alfonso Otero"
            "apellidos" => "Gonz&#225;lez"
            "email" => array:1 [
              0 => "alfonso&#46;otero&#46;gonzalez&#64;sergas&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Silvia Uribe"
            "apellidos" => "Moya"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ivan Gilberto"
            "apellidos" => "Arenas Moncaleano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Mar&#237;a Paz"
            "apellidos" => "Borrajo Prol"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a Jes&#250;s"
            "apellidos" => "Garc&#237;a Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Luis"
            "apellidos" => "L&#243;pez S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Centro Hospitalario Universitario de Ourense&#44; Ourense&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Documentaci&#243;n Cl&#237;nica&#44; Centro Hospitalario Universitario de Ourense&#44; Ourense&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 4167
            "Ancho" => 1903
            "Tamanyo" => 757674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Normal ABPM&#46; Excess area &#40;red circle&#41; less than 12&#46; &#40;B&#41; Pathological ABPM&#46; Excess area &#40;red circle&#41; greater than 12&#59; the arrow points to the &#8220;excess area&#8221;&#58; HBI is above a normal blood pressure threshold for pregnant woman&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">High blood pressure &#40;HTN&#41; is the most common clinical complication during pregnancy&#44; and preeclampsia &#40;PE&#41; is a major cause of fetal morbi-mortality &#40;low-birth weight or premature birth&#41;&#44; and maternal complications including acute renal failure&#44; HELLP syndrome&#44; liver failure and even brain edema&#44; seizures and death&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">1</span></a> In the Western world&#44; PE affects a 2&#8211;7&#37; of all pregnancies&#44; and the basic pathogenic phenomenon is endothelial dysfunction caused by an imbalance of angiogenic factors producing placental abnormalities with ischemia&#46; Endothelial dysfunction is not a limited process that is resolved at birth&#44; but may persist and pose a future cardiovascular risk&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Therefore&#44; even though PE should be diagnosed early&#44; angiogenic factors are not sensitive or specific enough to be used in clinical practice<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">3&#44;4</span></a>&#59; neither is hyperuricemia&#44; although it is often correlated with the degree of severity early initiation of PE&#59; according to two recent systematic reviews&#44; evidence supporting a correlation between hyperuricemia and PE is limited&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> In addition&#44; these reviews have shown that uric acid is a poor predictor of maternal-fetal complications&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> In our experience&#44; based on the use of the hyperbaric index &#40;HBI&#41; as the gold standard&#44; risk factors including primiparous pregnancies in advance age&#44; use of oral contraceptive drugs&#44; or a family history of HTN are predictive of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">For instrumental methods&#44; experts do not recommend the use of the uterine artery Doppler<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; the HBI or the area of blood pressure &#40;BP&#41; excess above the upper limit of the tolerance range has a 99&#37; sensitivity and specificity for the early screening of pregnant patients at risk of PE<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a>&#59; only the identification serpina1 by the proteomic profiling of urine<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">10</span></a> or the evidence of podocyturia have a 100&#37; sensitivity and specificity&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">11</span></a> Once the risk is detected&#44; PE is significantly reduced by the early administration of ASA<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> and vitamin D<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a> at night&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Therefore&#44; the diagnosis is made with an HBI greater than 12&#44; in addition to conventional risk factors&#44; and prevention includes a high-dose of ASA&#44; 100&#8211;300<span class="elsevierStyleHsp" style=""></span>mg at night&#44; resulting in a significantly reduced risk of hypertensive complications resulting from pregnancy before week 17&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The objective of the present work is to assess the use of the HBI for the primary prevention of PE in our health sector&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Materials and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">This was a retrospective study in pregnant women followed in our area between 2007 and 2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;784&#41;&#46; We reviewed the incidence of PE in pregnant women with high risk &#40;HR&#41; consultations and consultations &#8220;without HR&#8221; from three local hospitals &#40;University Hospital Complex of Ourense &#91;<span class="elsevierStyleItalic">Complejo Hospitalario Universitario de Ourense</span>&#44; CHUOU&#93;&#41;&#44; the regional hospital &#40;&#91;<span class="elsevierStyleItalic">Hospital Comarcal</span>&#44; HC&#93; of Ver&#237;n and Valdeorras&#41; and in HR pregnant women referred to Nephrology Consultation &#40;NC&#41; services&#46; In pregnant women referred to NC &#40;before the 17th week of pregnancy&#41;&#44; BP was monitored for 48<span class="elsevierStyleHsp" style=""></span>hs as an outpatients using Spacelab 92007&#46; An HBI of greater than 12 was considered a marker of PE risk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and pregnant women with a pathologic HBI were treated with 100<span class="elsevierStyleHsp" style=""></span>mg of AAS and vitamin D supplements at night provided that they had vitamin D deficiency&#46; These pregnant women were monitored throughout pregnancy in the nephrology outpatient clinics&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">HR pregnant women were defined as women who met any of the following criteria&#58; elderly pregnant woman&#44; morbid obesity&#44; previous history of PE&#44; diabetes mellitus&#44; HTN&#44; systemic disease &#40;DLE&#44; antiphospholipid syndrome&#41;&#44; cardiopathy&#44; family history of cardiovascular disease&#44; smoking&#44; twin pregnancy&#44; or use of oral contraceptives&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The total number of deliveries between 2005 and 2012 was 11&#44;784 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; of which 85&#46;20&#37; took place in the CHUOU&#44; 7&#46;82&#37; in the HC of Valdeorras&#44; and 6&#46;91&#37; in the HC of Ver&#237;n&#44; and the mean age of these pregnant women attended in these different centers ranged from 30 to 31&#46;63 years old &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Referral from Obstetrics to HR clinics in regional centers was exceptional&#58; 0&#46;4&#37; in the HC of Valdeorras and 1&#46;70&#37; in the HC of Ver&#237;n&#44; whereas in the CHUOU&#44; the percent of referrals was of 14&#46;28&#37;&#46; Only 34&#46;93&#37; of these pregnant women were referred to NC&#44; 61&#46;8&#37; of them had a HBI greater than 12&#44; while 32&#46;8&#37; of them showed a normal HBI&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The incidence of PE was 4<span class="elsevierStyleHsp" style=""></span>episodes&#47;year in the HC of Valdeorras and 2&#46;3<span class="elsevierStyleHsp" style=""></span>episodes&#47;year in the HC of Ver&#237;n&#46; In the CHUOU&#44; the incidence of PE among pregnant women who were not referred to NC was 20<span class="elsevierStyleHsp" style=""></span>episodes&#47;year&#44; whereas 0&#46;8<span class="elsevierStyleHsp" style=""></span>episodes&#47;year were reported among patients attending NCs including four pregnant women&#44; two of whom had DLE&#44; the third had intolerance to ASA&#44; and the fourth had HELLP syndrome&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">PE is a syndrome characterized by HTN and proteinuria after the 20th week of pregnancy in women with no previous history of HTN or proteinuria&#46; In the Western world it affects between 2&#37; and 7&#37; of all pregnancies&#44; although it may threefold greater in other geographical regions&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">14</span></a> Mortality is 10&#8211;15&#37;&#44; with nearly 50&#44;000 deaths every year&#46; Therefore&#44; early detection is crucial and may alter its clinical course&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The basic mechanism is a defect in placental implantation&#46; In a normal pregnancy the cytotrophoblast overregulates metalloproteinase expression causing the conversion of epithelium to endothelium&#44; a process mediated by the vascular endothelium growth factor &#40;VEGF&#41;&#44; the placental growth factor &#40;PIGF&#41;&#44; and angiopoietin&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In PE&#44; there is an increase in placental and serum levels of the antiangiogenic circulating factor&#44; sFlt-1&#44; which binds to PIGF and VEGF and inhibits the interaction with its endothelial receptors &#40;FIt1&#41;&#59; as a result&#44; NOSe is also activated&#44; resulting in oxidative stress and placental ischemia&#46; In PE&#44; these factors are elevated levels at weeks 9 and 11&#44; together with a concurrent decrease in PGF before the onset of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In addition to angiopoietin&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a> other factors involved in the development of PE are low oxygen rates&#44; resistance to insulin&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">17</span></a> and vitamin D deficiency&#46; VEGF is regulated by vitamin D&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a> and vitamin D deficiency-insufficiency in PE women leads to endothelial dysfunction and HTN&#46; Finally&#44; among other problems&#44; placental abnormalities in the mother give rise to increased peripheral resistances due to the activity of AT1 agonistic antibodies<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">19</span></a> and increased endoglin levels&#44; a co-receptor of TGF B1 and TGF B3&#44; which acts as a potent anti-angiogenic protein&#44; &#8220;kidnapping&#8221; PGF and VEGF&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Paradoxically&#44; none of these factors have the sensitivity-specificity and availability required for clinical use<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> in the early diagnosis of PE&#44; neither are conventional vascular risk factors<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">5&#44;6</span></a> or instrumental methods&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a> except for BP&#46; In early pregnancy&#44; BP was classically considered to be useful for PE screening&#44; and although accuracy was higher when mean BP was above 90<span class="elsevierStyleHsp" style=""></span>mmHg&#44; its predictive value was low&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> These poor outcomes of the static measurement of BP resulted from the use of the threshold for the definition of essential HTN&#46; The pattern of BP in women with PE or HTN is known to be different and predictable&#59; this way&#44; differences in BP between a normotensive pregnant woman and a pregnant woman with complications &#40;PE or gestational HTN&#41; are detected from the first trimester with significant differences in the circadian MESOR of systolic &#40;12<span class="elsevierStyleHsp" style=""></span>mmHg&#41; and diastolic &#40;7<span class="elsevierStyleHsp" style=""></span>mmHg&#41; BP&#46; As a result&#44; the &#8220;quantification&#8221; of the &#8220;excess&#8221; in the threshold of BP or HBI&#44; with a 99&#37; sensitivity-specificity&#44; allows for the screening of pregnant women at risk of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In our series&#44; HBI was pathological in 61&#46;9&#37; of pregnant women referred from HR visits&#44; but it was normal in 38&#46;2&#37;&#44; thereby showing that HBI allows for a more accurate differentiation than conventional AR criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a> Pregnant women at high risk of PE were identified &#8220;early&#8221;&#44; and treatment decreased its incidence from 26&#46;3 to 0&#46;8<span class="elsevierStyleHsp" style=""></span>episodes&#47;year&#44; mainly in the CHUOU&#44; which accounts for the 34&#37; of HR pregnant women we received&#46; No HR pregnant women came from the 2 HC&#44; and the rate of PE remained similar to that of areas where primary care is not available&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">14</span></a> Protocols are common and this situation may have resulted from &#8220;clinical inertia&#8221;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Activated platelets and coagulation system&#44; leading to an imbalance between the synthesis of prostacyclins and thromboxane A2&#44; result from the ischemic placental damage in PE&#46; Therefore&#44; several studies to assess the use of antiaggregants in the primary prevention of PE were conducted&#44; but the initial results were discouraging&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">21&#8211;23</span></a> although a review report<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> reveals how the risk of PE is reduced by 17&#37; by the use of antiplatelets&#46; All these studies have a methodologic problem&#58; the dose of ASA and the dosing schedule&#46; Several studies have shown that 100&#8211;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dl of ASA is effective compared to lower dosing &#40;50&#8211;80<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">25</span></a> and that it should be administered before week 17 and at night&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> considering that inhibition of the thromboxane A2 synthesis by ASA is dose-dependent and that the dose is administered at night&#46; Consequently&#44; all pregnant women referred to NC &#40;34&#46;92&#37;&#41; and with a HBI greater than 12 &#40;61&#46;8&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; were treated with 100<span class="elsevierStyleHsp" style=""></span>mg of ASA at night during the entire pregnancy&#44; and the incidence of PE episodes was decreased 96&#46;94&#37;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In conclusion&#44; the use of NC for the primary prevention of HTN complications during pregnancy and the use of the HBI as a diagnostic method is highly effective&#44; and this is why routine healthcare exams should be conducted between HR consultations and Nephrology consultations during pregnancy&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres818376"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Material and methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Results"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec815405"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres818377"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:1 [
              "identificador" => "abst0025"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Material y m&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Resultados"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec815406"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-12-23"
    "fechaAceptado" => "2015-04-15"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec815405"
          "palabras" => array:3 [
            0 => "Pregnancy"
            1 => "Hyperbaric index"
            2 => "Hypertension"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec815406"
          "palabras" => array:3 [
            0 => "Embarazo"
            1 => "&#205;ndice hiperb&#225;rico"
            2 => "Hipertensi&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Preeclampsia &#40;PE&#41; is a major cause of fetal morbidity and mortality&#46; In the Western World&#44; PE affects 2&#8211;7&#37; of pregnancies and is responsible for 50&#44;000 deaths annually&#46; Early detection is a priority as it can change the clinical course&#44; but there are no biomarkers or instrumental methods with high sensitivity and specificity&#46; Only the hyperbaric index has a sensitivity and specificity of 99&#37; for early identification of pregnant women at risk of developing PE&#44; but its use is not widespread&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To assess the usefulness of the hyperbaric index in the primary prevention of hypertensive pregnancy complications in a public healthcare area&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is a retrospective study of pregnancies that occurred in our area during the period 2007&#8211;2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;784&#41;&#46; The diagnosis was established by the hyperbaric index and pregnant women at risk were treated with ASA at night&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In pregnant patients referred to the nephrology clinic &#40;38&#46;2&#37;&#41;&#44; diagnosed as high-risk for PE&#44; and treated with 100<span class="elsevierStyleHsp" style=""></span>mg ASA&#47;night &#40;from week 17&#41;&#44; the incidence of PE episodes was reduced by 96&#46;94&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Introducci&#243;n La preeclampsia &#40;PE&#41; es una importante causa de morbimortalidad fetal&#44; que en el mundo occidental afecta al 2&#8211;7&#37; de los embarazos y es responsable de 50&#46;000 muertes anuales&#46; La detecci&#243;n precoz es prioritaria&#44; ya que puede cambiar su curso cl&#237;nico&#44; pero no se dispone de biomarcadores ni m&#233;todos instrumentales de alta sensibilidad y especificidad&#44; solamente el &#237;ndice hiperb&#225;rico tiene una sensibilidad y una especificidad del 99&#37; para la identificaci&#243;n precoz de las gestantes en riesgo de desarrollo de PE&#44; pero est&#225; escasamente difundido&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Valorar la utilidad del &#237;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo en un &#225;rea sanitaria&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo realizado entre los embarazos habidos en nuestra &#225;rea durante el periodo 2007&#8211;2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;784&#41;&#46; El diagn&#243;stico se estableci&#243; mediante el &#237;ndice hiperb&#225;rico y las gestantes en riesgo fueron tratadas con AAS nocturno&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En las gestantes remitidas a consulta de Nefrolog&#237;a &#40;38&#44;2&#37;&#41;&#44; diagnosticadas de alto riesgo de PE y tratadas con AAS 100<span class="elsevierStyleHsp" style=""></span>mg nocturno &#40;desde la semana 17&#41; se redujo la incidencia de episodios de PE un 96&#44;94&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:1 [
            "identificador" => "abst0025"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Material y m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Resultados"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gonz&#225;lez AO&#44; Moya SU&#44; Arenas Moncaleano IG&#44; Borrajo Prol MP&#44; Garc&#237;a Garc&#237;a MJ&#44; L&#243;pez S&#225;nchez L&#46; &#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo&#46; Nefrologia&#46; 2015&#59;35&#58;572&#8211;577&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 4167
            "Ancho" => 1903
            "Tamanyo" => 757674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Normal ABPM&#46; Excess area &#40;red circle&#41; less than 12&#46; &#40;B&#41; Pathological ABPM&#46; Excess area &#40;red circle&#41; greater than 12&#59; the arrow points to the &#8220;excess area&#8221;&#58; HBI is above a normal blood pressure threshold for pregnant woman&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2143
            "Ancho" => 2912
            "Tamanyo" => 257211
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Total number of deliveries between 2005 and 2012&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "NHLBI Working Group on Research on Hypertension During Pregnancy"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;M&#46; Roberts"
                            1 => "G&#46; Pearson"
                            2 => "J&#46; Cutler"
                            3 => "M&#46; Lindheimer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000054981.03589.E9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "437"
                        "paginaFinal" => "445"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12623940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pre-eclampsia and risk of cardiovascular disease and cancer in later life&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Bellamy"
                            1 => "J&#46;P&#46; Casas"
                            2 => "A&#46;D&#46; Hingorani"
                            3 => "D&#46;J&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.39335.385301.BE"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2007"
                        "volumen" => "335"
                        "paginaInicial" => "974"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17975258"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Kuc"
                            1 => "E&#46;J&#46; Wortelboer"
                            2 => "B&#46;B&#46; van Rijn"
                            3 => "A&#46; Franx"
                            4 => "G&#46;H&#46; Visser"
                            5 => "P&#46;C&#46; Schielen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/OGX.0b013e3182227027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obstet Gynecol Surv"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "225"
                        "paginaFinal" => "239"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21756405"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal plasma soluble FMS-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Akolekar"
                            1 => "J&#46; de Cruz"
                            2 => "J&#46;M&#46; Foidart"
                            3 => "C&#46; Munaut"
                            4 => "K&#46;H&#46; Nicolaides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/pd.2433"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prenat Diagn"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "191"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20101671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of serum uric acid determination in predicting pre-eclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Cnossen"
                            1 => "H&#46; de Ruyter-Hanhij&#228;rvi"
                            2 => "J&#46;A&#46; van der Post"
                            3 => "B&#46;W&#46; Mol"
                            4 => "K&#46;S&#46; Khan"
                            5 => "G&#46; ter Riet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Obstet Gynecol Scand"
                        "fecha" => "2006"
                        "volumen" => "85"
                        "paginaInicial" => "519"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16755708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of serum uric acid in predicting complications of pre-eclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Tests in Prediction of Pre-eclampsia Severity review group"
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Thangaratinam"
                            1 => "K&#46;M&#46; Ismail"
                            2 => "S&#46; Sharp"
                            3 => "A&#46; Coomarasamy"
                            4 => "K&#46;S&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1471-0528.2006.00908.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BJOG"
                        "fecha" => "2006"
                        "volumen" => "113"
                        "paginaInicial" => "369"
                        "paginaFinal" => "378"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16553648"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores de riesgo como predictores de preeclampsia&#47;eclampsia en embarazadas con &#237;ndice hiperb&#225;rico patol&#243;gico&#46; XXXVIII Congreso Nacional de la SEN Donostia Octubre 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Borrajo"
                            1 => "J&#46; Santos Nores"
                            2 => "E&#46; Novoa Fernandez"
                            3 => "M&#46; Blanco Garcia"
                            4 => "O&#46; Conde Rivera"
                            5 => "S&#46; Blanco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19018733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of uterine artery Doppler in predicting adverse pregnancy outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;T&#46; Papageorghiou"
                            1 => "C&#46;K&#46; Yu"
                            2 => "K&#46;H&#46; Nicolaides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Best Pract Res Clin Obstet Gynaecol"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "38312"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood pressure excess for the early identification of gestational hypertension and preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "A&#46; Moj&#243;n"
                            3 => "J&#46;R&#46; Fern&#225;ndez"
                            4 => "I&#46; Silva"
                            5 => "R&#46; Ucieda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "83"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9449396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;A&#46; Buhimschi"
                            1 => "G&#46; Zhao"
                            2 => "E&#46;F&#46; Funai"
                            3 => "N&#46; Harris"
                            4 => "I&#46;E&#46; Sasson"
                            5 => "I&#46;M&#46; Bernstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajog.2008.07.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Obstet Gynecol"
                        "fecha" => "2008"
                        "volumen" => "199"
                        "paginaInicial" => "551&#46;e1"
                        "paginaFinal" => "551&#46;e16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18984079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Podocyturia predates proteinuria and clinical features of preeclampsia&#58; longitudinal prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Craici"
                            1 => "S&#46;J&#46; Wagner"
                            2 => "K&#46;R&#46; Bailey"
                            3 => "P&#46;D&#46; Fitz-Gibbon"
                            4 => "C&#46;M&#46; Wood-Wentz"
                            5 => "S&#46;T&#46; Turner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2013"
                        "volumen" => "61"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "M&#46; Iglesias"
                            3 => "A&#46; Moj&#243;n"
                            4 => "I&#46; Silva"
                            5 => "R&#46; Ucieda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "589"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9322987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal vitamin D deficiency increases the risk of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;M&#46; Bodnar"
                            1 => "J&#46;M&#46; Catov"
                            2 => "H&#46;N&#46; Simhan"
                            3 => "M&#46;F&#46; Holick"
                            4 => "R&#46;W&#46; Powers"
                            5 => "J&#46;M&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2007-0718"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2007"
                        "volumen" => "92"
                        "paginaInicial" => "3517"
                        "paginaFinal" => "3522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17535985"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eclampsia and pre-eclampsia a health problem for 2000 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Villar"
                            1 => "L&#46; Say"
                            2 => "A&#46;M&#46; Gulmezoglu"
                            3 => "M&#46; Meraldi"
                            4 => "M&#46;D&#46; Lindheimer"
                            5 => "A&#46;P&#46; Betran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Pre-eclampsia"
                        "paginaInicial" => "189"
                        "paginaFinal" => "207"
                        "serieFecha" => "2003"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating angiogenic factors and the risk of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Levine"
                            1 => "S&#46;E&#46; Maynard"
                            2 => "C&#46; Qian"
                            3 => "K&#46;H&#46; Lim"
                            4 => "L&#46;J&#46; England"
                            5 => "K&#46;F&#46; Yu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa031884"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "672"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14764923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of vascular growth and function in the human placenta"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;J&#46; Burton"
                            1 => "D&#46;S&#46; Charnock-Jones"
                            2 => "E&#46; Jauniaux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/REP-09-0092"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reproduction"
                        "fecha" => "2009"
                        "volumen" => "138"
                        "paginaInicial" => "895"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19470597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The renin&#8211;aldosterone system during normal and hypertensive pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Elsheikh"
                            1 => "G&#46; Creatsas"
                            2 => "G&#46; Mastorakos"
                            3 => "S&#46; Milingos"
                            4 => "D&#46; Loutradis"
                            5 => "S&#46; Michalas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Gynecol Obstet"
                        "fecha" => "2001"
                        "volumen" => "264"
                        "paginaInicial" => "182"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11205704"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 25-hydroxyvitamin D3 and 1&#44;25-dihydroxyvitamin D3 on cytokine production by human decidual cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;N&#46; Evans"
                            1 => "L&#46; Nguyen"
                            2 => "J&#46; Chan"
                            3 => "B&#46;A&#46; Innes"
                            4 => "J&#46;N&#46; Bulmer"
                            5 => "M&#46;D&#46; Kilby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1095/biolreprod.106.054056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biol Reprod"
                        "fecha" => "2006"
                        "volumen" => "75"
                        "paginaInicial" => "816"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiotensin receptors&#44; autoimmunity&#44; and preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46; Xia"
                            1 => "C&#46;C&#46; Zhou"
                            2 => "S&#46;M&#46; Ramin"
                            3 => "R&#46;E&#46; Kellens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2007"
                        "volumen" => "179"
                        "paginaInicial" => "3391"
                        "paginaFinal" => "3395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17785770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of mean arterial pressure in the middle trimester upon the outcome of pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;W&#46; Page"
                            1 => "R&#46; Christianson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Obstet Gynecol"
                        "fecha" => "1976"
                        "volumen" => "125"
                        "paginaInicial" => "740"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/937399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CLASP&#58; a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Collaborative Low-dose Aspirin Study in Pregnancy Collaborative Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1994"
                        "volumen" => "343"
                        "paginaInicial" => "619"
                        "paginaFinal" => "629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7906809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-dose aspirin to prevent preeclampsia in women at high risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Caritis"
                            1 => "B&#46;M&#46; Sibai"
                            2 => "J&#46; Hauth"
                            3 => "M&#46;D&#46; Lindheimer"
                            4 => "M&#46; Klebanoff"
                            5 => "E&#46; Thom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803123381101"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "701"
                        "paginaFinal" => "705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9494145"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiplatelets agents for prevention of pre-eclampsia&#58; a meta-analysis of individual patient data"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "on behalf of the PARIS Collaborative Group"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;M&#46; Askie"
                            1 => "L&#46; Duley"
                            2 => "D&#46;J&#46; Henderson-Smart"
                            3 => "L&#46;A&#46; Stewart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)60712-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "369"
                        "paginaInicial" => "1791"
                        "paginaFinal" => "1798"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17512048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiplatelet agents for preventing and treating pre-eclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Knight"
                            1 => "L&#46; Duley"
                            2 => "D&#46;J&#46; Henderson-Smart"
                            3 => "J&#46;F&#46; King"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2007"
                        "volumen" => "18"
                        "paginaInicial" => "CD000492"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Leitich"
                            1 => "C&#46; Egarter"
                            2 => "P&#46; Husslein"
                            3 => "A&#46; Kaider"
                            4 => "M&#46; Schemper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Obstet Gynaecol"
                        "fecha" => "1997"
                        "volumen" => "104"
                        "paginaInicial" => "450"
                        "paginaFinal" => "459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9141582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003500000006/v2_201703220324/S2013251416000043/v2_201703220324/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42660"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003500000006/v2_201703220324/S2013251416000043/v2_201703220324/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000043?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original article
Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy
Índice hiperbárico en la prevención primaria de las complicaciones hipertensivas del embarazo de alto riesgo
Alfonso Otero Gonzáleza,
Corresponding author
, Silvia Uribe Moyaa, Ivan Gilberto Arenas Moncaleanoa, María Paz Borrajo Prola, María Jesús García Garcíaa, Luis López Sánchezb
a Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, Spain
b Documentación Clínica, Centro Hospitalario Universitario de Ourense, Ourense, Spain
Read
9149
Times
was read the article
2362
Total PDF
6787
Total HTML
Share statistics
 array:25 [
  "pii" => "S2013251416000043"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2016.01.003"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "116"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:572-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5015
    "formatos" => array:3 [
      "EPUB" => 276
      "HTML" => 4136
      "PDF" => 603
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S021169951500168X"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2015.10.001"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "116"
      "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2015;35:572-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 8459
        "formatos" => array:3 [
          "EPUB" => 320
          "HTML" => 7373
          "PDF" => 766
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>"
        "titulo" => "&#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "572"
            "paginaFinal" => "577"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 4167
                "Ancho" => 1903
                "Tamanyo" => 764251
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A&#41; MAPA normal&#46; &#193;rea de exceso &#40;en c&#237;rculo rojo&#41; menor de 12&#46; B&#41; MAPA patol&#243;gica&#46; &#193;rea de exceso &#40;c&#237;rculo rojo&#41; mayor de 12&#59; la flecha se&#241;ala el &#171;&#225;rea de exceso&#187;&#58; IHB sobre un umbral de presi&#243;n arterial normal para la gestante&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Alfonso Otero Gonz&#225;lez, Silvia Uribe Moya, Ivan Gilberto Arenas Moncaleano, Mar&#237;a Paz Borrajo Prol, Mar&#237;a Jes&#250;s Garc&#237;a Garc&#237;a, Luis L&#243;pez S&#225;nchez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Alfonso"
                "apellidos" => "Otero Gonz&#225;lez"
              ]
              1 => array:2 [
                "nombre" => "Silvia"
                "apellidos" => "Uribe Moya"
              ]
              2 => array:2 [
                "nombre" => "Ivan Gilberto"
                "apellidos" => "Arenas Moncaleano"
              ]
              3 => array:2 [
                "nombre" => "Mar&#237;a Paz"
                "apellidos" => "Borrajo Prol"
              ]
              4 => array:2 [
                "nombre" => "Mar&#237;a Jes&#250;s"
                "apellidos" => "Garc&#237;a Garc&#237;a"
              ]
              5 => array:2 [
                "nombre" => "Luis"
                "apellidos" => "L&#243;pez S&#225;nchez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251416000043"
          "doi" => "10.1016/j.nefroe.2016.01.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000043?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951500168X?idApp=UINPBA000064"
      "url" => "/02116995/0000003500000006/v1_201512190045/S021169951500168X/v1_201512190045/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251415000711"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2015.09.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "81"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:578-81"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3528
      "formatos" => array:3 [
        "EPUB" => 276
        "HTML" => 2663
        "PDF" => 589
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Control of proteinuria with increased doses of agalsidase alfa in a patient with Fabry disease with atypical genotype&#8211;phenotype expression"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "578"
          "paginaFinal" => "581"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Control de la proteinuria con aumento de dosis de agalsidasa alfa en un paciente con enfermedad de Fabry y expresi&#243;n de genotipo-fenotipo at&#237;pica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 971
              "Ancho" => 1486
              "Tamanyo" => 138053
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Graphic albuminuria&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Christos Paliouras, Georgios Aperis, Foteini Lamprianou, Giorgos Ntetskas, Konstantinos Roufas, Polichronis Alivanis"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Christos"
              "apellidos" => "Paliouras"
            ]
            1 => array:2 [
              "nombre" => "Georgios"
              "apellidos" => "Aperis"
            ]
            2 => array:2 [
              "nombre" => "Foteini"
              "apellidos" => "Lamprianou"
            ]
            3 => array:2 [
              "nombre" => "Giorgos"
              "apellidos" => "Ntetskas"
            ]
            4 => array:2 [
              "nombre" => "Konstantinos"
              "apellidos" => "Roufas"
            ]
            5 => array:2 [
              "nombre" => "Polichronis"
              "apellidos" => "Alivanis"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0211699515001332"
        "doi" => "10.1016/j.nefro.2015.08.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001332?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000711?idApp=UINPBA000064"
    "url" => "/20132514/0000003500000006/v2_201703220324/S2013251415000711/v2_201703220324/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S201325141500067X"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2015.09.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "80"
    "copyright" => "The Authors"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2015;35:567-71"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5146
      "formatos" => array:3 [
        "EPUB" => 304
        "HTML" => 4008
        "PDF" => 834
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Comparative study of impact of hemodialysis and renal transplantation on cognitive functions in ESRD patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "567"
          "paginaFinal" => "571"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estudio comparativo de la influencia de la hemodi&#225;lisis y el trasplante renal en la funci&#243;n cognitiva de los pacientes con enfermedad renal terminal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 737
              "Ancho" => 1638
              "Tamanyo" => 96255
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Comparative presentation of all cognitive function tests in three groups&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Waleed Anwar, Haitham Ezzat, Amr Mohab"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Waleed"
              "apellidos" => "Anwar"
            ]
            1 => array:2 [
              "nombre" => "Haitham"
              "apellidos" => "Ezzat"
            ]
            2 => array:2 [
              "nombre" => "Amr"
              "apellidos" => "Mohab"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0211699515001162"
        "doi" => "10.1016/j.nefro.2015.07.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001162?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141500067X?idApp=UINPBA000064"
    "url" => "/20132514/0000003500000006/v2_201703220324/S201325141500067X/v2_201703220324/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "572"
        "paginaFinal" => "577"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Alfonso Otero Gonz&#225;lez, Silvia Uribe Moya, Ivan Gilberto Arenas Moncaleano, Mar&#237;a Paz Borrajo Prol, Mar&#237;a Jes&#250;s Garc&#237;a Garc&#237;a, Luis L&#243;pez S&#225;nchez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Alfonso Otero"
            "apellidos" => "Gonz&#225;lez"
            "email" => array:1 [
              0 => "alfonso&#46;otero&#46;gonzalez&#64;sergas&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Silvia Uribe"
            "apellidos" => "Moya"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ivan Gilberto"
            "apellidos" => "Arenas Moncaleano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Mar&#237;a Paz"
            "apellidos" => "Borrajo Prol"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a Jes&#250;s"
            "apellidos" => "Garc&#237;a Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Luis"
            "apellidos" => "L&#243;pez S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Centro Hospitalario Universitario de Ourense&#44; Ourense&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Documentaci&#243;n Cl&#237;nica&#44; Centro Hospitalario Universitario de Ourense&#44; Ourense&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 4167
            "Ancho" => 1903
            "Tamanyo" => 757674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Normal ABPM&#46; Excess area &#40;red circle&#41; less than 12&#46; &#40;B&#41; Pathological ABPM&#46; Excess area &#40;red circle&#41; greater than 12&#59; the arrow points to the &#8220;excess area&#8221;&#58; HBI is above a normal blood pressure threshold for pregnant woman&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">High blood pressure &#40;HTN&#41; is the most common clinical complication during pregnancy&#44; and preeclampsia &#40;PE&#41; is a major cause of fetal morbi-mortality &#40;low-birth weight or premature birth&#41;&#44; and maternal complications including acute renal failure&#44; HELLP syndrome&#44; liver failure and even brain edema&#44; seizures and death&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">1</span></a> In the Western world&#44; PE affects a 2&#8211;7&#37; of all pregnancies&#44; and the basic pathogenic phenomenon is endothelial dysfunction caused by an imbalance of angiogenic factors producing placental abnormalities with ischemia&#46; Endothelial dysfunction is not a limited process that is resolved at birth&#44; but may persist and pose a future cardiovascular risk&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Therefore&#44; even though PE should be diagnosed early&#44; angiogenic factors are not sensitive or specific enough to be used in clinical practice<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">3&#44;4</span></a>&#59; neither is hyperuricemia&#44; although it is often correlated with the degree of severity early initiation of PE&#59; according to two recent systematic reviews&#44; evidence supporting a correlation between hyperuricemia and PE is limited&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> In addition&#44; these reviews have shown that uric acid is a poor predictor of maternal-fetal complications&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> In our experience&#44; based on the use of the hyperbaric index &#40;HBI&#41; as the gold standard&#44; risk factors including primiparous pregnancies in advance age&#44; use of oral contraceptive drugs&#44; or a family history of HTN are predictive of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">For instrumental methods&#44; experts do not recommend the use of the uterine artery Doppler<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; the HBI or the area of blood pressure &#40;BP&#41; excess above the upper limit of the tolerance range has a 99&#37; sensitivity and specificity for the early screening of pregnant patients at risk of PE<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a>&#59; only the identification serpina1 by the proteomic profiling of urine<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">10</span></a> or the evidence of podocyturia have a 100&#37; sensitivity and specificity&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">11</span></a> Once the risk is detected&#44; PE is significantly reduced by the early administration of ASA<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> and vitamin D<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a> at night&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Therefore&#44; the diagnosis is made with an HBI greater than 12&#44; in addition to conventional risk factors&#44; and prevention includes a high-dose of ASA&#44; 100&#8211;300<span class="elsevierStyleHsp" style=""></span>mg at night&#44; resulting in a significantly reduced risk of hypertensive complications resulting from pregnancy before week 17&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The objective of the present work is to assess the use of the HBI for the primary prevention of PE in our health sector&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Materials and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">This was a retrospective study in pregnant women followed in our area between 2007 and 2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;784&#41;&#46; We reviewed the incidence of PE in pregnant women with high risk &#40;HR&#41; consultations and consultations &#8220;without HR&#8221; from three local hospitals &#40;University Hospital Complex of Ourense &#91;<span class="elsevierStyleItalic">Complejo Hospitalario Universitario de Ourense</span>&#44; CHUOU&#93;&#41;&#44; the regional hospital &#40;&#91;<span class="elsevierStyleItalic">Hospital Comarcal</span>&#44; HC&#93; of Ver&#237;n and Valdeorras&#41; and in HR pregnant women referred to Nephrology Consultation &#40;NC&#41; services&#46; In pregnant women referred to NC &#40;before the 17th week of pregnancy&#41;&#44; BP was monitored for 48<span class="elsevierStyleHsp" style=""></span>hs as an outpatients using Spacelab 92007&#46; An HBI of greater than 12 was considered a marker of PE risk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and pregnant women with a pathologic HBI were treated with 100<span class="elsevierStyleHsp" style=""></span>mg of AAS and vitamin D supplements at night provided that they had vitamin D deficiency&#46; These pregnant women were monitored throughout pregnancy in the nephrology outpatient clinics&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">HR pregnant women were defined as women who met any of the following criteria&#58; elderly pregnant woman&#44; morbid obesity&#44; previous history of PE&#44; diabetes mellitus&#44; HTN&#44; systemic disease &#40;DLE&#44; antiphospholipid syndrome&#41;&#44; cardiopathy&#44; family history of cardiovascular disease&#44; smoking&#44; twin pregnancy&#44; or use of oral contraceptives&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The total number of deliveries between 2005 and 2012 was 11&#44;784 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; of which 85&#46;20&#37; took place in the CHUOU&#44; 7&#46;82&#37; in the HC of Valdeorras&#44; and 6&#46;91&#37; in the HC of Ver&#237;n&#44; and the mean age of these pregnant women attended in these different centers ranged from 30 to 31&#46;63 years old &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Referral from Obstetrics to HR clinics in regional centers was exceptional&#58; 0&#46;4&#37; in the HC of Valdeorras and 1&#46;70&#37; in the HC of Ver&#237;n&#44; whereas in the CHUOU&#44; the percent of referrals was of 14&#46;28&#37;&#46; Only 34&#46;93&#37; of these pregnant women were referred to NC&#44; 61&#46;8&#37; of them had a HBI greater than 12&#44; while 32&#46;8&#37; of them showed a normal HBI&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The incidence of PE was 4<span class="elsevierStyleHsp" style=""></span>episodes&#47;year in the HC of Valdeorras and 2&#46;3<span class="elsevierStyleHsp" style=""></span>episodes&#47;year in the HC of Ver&#237;n&#46; In the CHUOU&#44; the incidence of PE among pregnant women who were not referred to NC was 20<span class="elsevierStyleHsp" style=""></span>episodes&#47;year&#44; whereas 0&#46;8<span class="elsevierStyleHsp" style=""></span>episodes&#47;year were reported among patients attending NCs including four pregnant women&#44; two of whom had DLE&#44; the third had intolerance to ASA&#44; and the fourth had HELLP syndrome&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">PE is a syndrome characterized by HTN and proteinuria after the 20th week of pregnancy in women with no previous history of HTN or proteinuria&#46; In the Western world it affects between 2&#37; and 7&#37; of all pregnancies&#44; although it may threefold greater in other geographical regions&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">14</span></a> Mortality is 10&#8211;15&#37;&#44; with nearly 50&#44;000 deaths every year&#46; Therefore&#44; early detection is crucial and may alter its clinical course&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The basic mechanism is a defect in placental implantation&#46; In a normal pregnancy the cytotrophoblast overregulates metalloproteinase expression causing the conversion of epithelium to endothelium&#44; a process mediated by the vascular endothelium growth factor &#40;VEGF&#41;&#44; the placental growth factor &#40;PIGF&#41;&#44; and angiopoietin&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In PE&#44; there is an increase in placental and serum levels of the antiangiogenic circulating factor&#44; sFlt-1&#44; which binds to PIGF and VEGF and inhibits the interaction with its endothelial receptors &#40;FIt1&#41;&#59; as a result&#44; NOSe is also activated&#44; resulting in oxidative stress and placental ischemia&#46; In PE&#44; these factors are elevated levels at weeks 9 and 11&#44; together with a concurrent decrease in PGF before the onset of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In addition to angiopoietin&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a> other factors involved in the development of PE are low oxygen rates&#44; resistance to insulin&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">17</span></a> and vitamin D deficiency&#46; VEGF is regulated by vitamin D&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a> and vitamin D deficiency-insufficiency in PE women leads to endothelial dysfunction and HTN&#46; Finally&#44; among other problems&#44; placental abnormalities in the mother give rise to increased peripheral resistances due to the activity of AT1 agonistic antibodies<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">19</span></a> and increased endoglin levels&#44; a co-receptor of TGF B1 and TGF B3&#44; which acts as a potent anti-angiogenic protein&#44; &#8220;kidnapping&#8221; PGF and VEGF&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Paradoxically&#44; none of these factors have the sensitivity-specificity and availability required for clinical use<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> in the early diagnosis of PE&#44; neither are conventional vascular risk factors<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">5&#44;6</span></a> or instrumental methods&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a> except for BP&#46; In early pregnancy&#44; BP was classically considered to be useful for PE screening&#44; and although accuracy was higher when mean BP was above 90<span class="elsevierStyleHsp" style=""></span>mmHg&#44; its predictive value was low&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> These poor outcomes of the static measurement of BP resulted from the use of the threshold for the definition of essential HTN&#46; The pattern of BP in women with PE or HTN is known to be different and predictable&#59; this way&#44; differences in BP between a normotensive pregnant woman and a pregnant woman with complications &#40;PE or gestational HTN&#41; are detected from the first trimester with significant differences in the circadian MESOR of systolic &#40;12<span class="elsevierStyleHsp" style=""></span>mmHg&#41; and diastolic &#40;7<span class="elsevierStyleHsp" style=""></span>mmHg&#41; BP&#46; As a result&#44; the &#8220;quantification&#8221; of the &#8220;excess&#8221; in the threshold of BP or HBI&#44; with a 99&#37; sensitivity-specificity&#44; allows for the screening of pregnant women at risk of PE&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In our series&#44; HBI was pathological in 61&#46;9&#37; of pregnant women referred from HR visits&#44; but it was normal in 38&#46;2&#37;&#44; thereby showing that HBI allows for a more accurate differentiation than conventional AR criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a> Pregnant women at high risk of PE were identified &#8220;early&#8221;&#44; and treatment decreased its incidence from 26&#46;3 to 0&#46;8<span class="elsevierStyleHsp" style=""></span>episodes&#47;year&#44; mainly in the CHUOU&#44; which accounts for the 34&#37; of HR pregnant women we received&#46; No HR pregnant women came from the 2 HC&#44; and the rate of PE remained similar to that of areas where primary care is not available&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">14</span></a> Protocols are common and this situation may have resulted from &#8220;clinical inertia&#8221;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Activated platelets and coagulation system&#44; leading to an imbalance between the synthesis of prostacyclins and thromboxane A2&#44; result from the ischemic placental damage in PE&#46; Therefore&#44; several studies to assess the use of antiaggregants in the primary prevention of PE were conducted&#44; but the initial results were discouraging&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">21&#8211;23</span></a> although a review report<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> reveals how the risk of PE is reduced by 17&#37; by the use of antiplatelets&#46; All these studies have a methodologic problem&#58; the dose of ASA and the dosing schedule&#46; Several studies have shown that 100&#8211;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dl of ASA is effective compared to lower dosing &#40;50&#8211;80<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">25</span></a> and that it should be administered before week 17 and at night&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> considering that inhibition of the thromboxane A2 synthesis by ASA is dose-dependent and that the dose is administered at night&#46; Consequently&#44; all pregnant women referred to NC &#40;34&#46;92&#37;&#41; and with a HBI greater than 12 &#40;61&#46;8&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; were treated with 100<span class="elsevierStyleHsp" style=""></span>mg of ASA at night during the entire pregnancy&#44; and the incidence of PE episodes was decreased 96&#46;94&#37;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In conclusion&#44; the use of NC for the primary prevention of HTN complications during pregnancy and the use of the HBI as a diagnostic method is highly effective&#44; and this is why routine healthcare exams should be conducted between HR consultations and Nephrology consultations during pregnancy&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres818376"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Material and methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Results"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec815405"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres818377"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:1 [
              "identificador" => "abst0025"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Material y m&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Resultados"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec815406"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-12-23"
    "fechaAceptado" => "2015-04-15"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec815405"
          "palabras" => array:3 [
            0 => "Pregnancy"
            1 => "Hyperbaric index"
            2 => "Hypertension"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec815406"
          "palabras" => array:3 [
            0 => "Embarazo"
            1 => "&#205;ndice hiperb&#225;rico"
            2 => "Hipertensi&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Preeclampsia &#40;PE&#41; is a major cause of fetal morbidity and mortality&#46; In the Western World&#44; PE affects 2&#8211;7&#37; of pregnancies and is responsible for 50&#44;000 deaths annually&#46; Early detection is a priority as it can change the clinical course&#44; but there are no biomarkers or instrumental methods with high sensitivity and specificity&#46; Only the hyperbaric index has a sensitivity and specificity of 99&#37; for early identification of pregnant women at risk of developing PE&#44; but its use is not widespread&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To assess the usefulness of the hyperbaric index in the primary prevention of hypertensive pregnancy complications in a public healthcare area&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is a retrospective study of pregnancies that occurred in our area during the period 2007&#8211;2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;784&#41;&#46; The diagnosis was established by the hyperbaric index and pregnant women at risk were treated with ASA at night&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In pregnant patients referred to the nephrology clinic &#40;38&#46;2&#37;&#41;&#44; diagnosed as high-risk for PE&#44; and treated with 100<span class="elsevierStyleHsp" style=""></span>mg ASA&#47;night &#40;from week 17&#41;&#44; the incidence of PE episodes was reduced by 96&#46;94&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Introducci&#243;n La preeclampsia &#40;PE&#41; es una importante causa de morbimortalidad fetal&#44; que en el mundo occidental afecta al 2&#8211;7&#37; de los embarazos y es responsable de 50&#46;000 muertes anuales&#46; La detecci&#243;n precoz es prioritaria&#44; ya que puede cambiar su curso cl&#237;nico&#44; pero no se dispone de biomarcadores ni m&#233;todos instrumentales de alta sensibilidad y especificidad&#44; solamente el &#237;ndice hiperb&#225;rico tiene una sensibilidad y una especificidad del 99&#37; para la identificaci&#243;n precoz de las gestantes en riesgo de desarrollo de PE&#44; pero est&#225; escasamente difundido&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Valorar la utilidad del &#237;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo en un &#225;rea sanitaria&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo realizado entre los embarazos habidos en nuestra &#225;rea durante el periodo 2007&#8211;2012 &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;784&#41;&#46; El diagn&#243;stico se estableci&#243; mediante el &#237;ndice hiperb&#225;rico y las gestantes en riesgo fueron tratadas con AAS nocturno&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En las gestantes remitidas a consulta de Nefrolog&#237;a &#40;38&#44;2&#37;&#41;&#44; diagnosticadas de alto riesgo de PE y tratadas con AAS 100<span class="elsevierStyleHsp" style=""></span>mg nocturno &#40;desde la semana 17&#41; se redujo la incidencia de episodios de PE un 96&#44;94&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:1 [
            "identificador" => "abst0025"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Material y m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Resultados"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gonz&#225;lez AO&#44; Moya SU&#44; Arenas Moncaleano IG&#44; Borrajo Prol MP&#44; Garc&#237;a Garc&#237;a MJ&#44; L&#243;pez S&#225;nchez L&#46; &#205;ndice hiperb&#225;rico en la prevenci&#243;n primaria de las complicaciones hipertensivas del embarazo de alto riesgo&#46; Nefrologia&#46; 2015&#59;35&#58;572&#8211;577&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 4167
            "Ancho" => 1903
            "Tamanyo" => 757674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Normal ABPM&#46; Excess area &#40;red circle&#41; less than 12&#46; &#40;B&#41; Pathological ABPM&#46; Excess area &#40;red circle&#41; greater than 12&#59; the arrow points to the &#8220;excess area&#8221;&#58; HBI is above a normal blood pressure threshold for pregnant woman&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2143
            "Ancho" => 2912
            "Tamanyo" => 257211
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Total number of deliveries between 2005 and 2012&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "NHLBI Working Group on Research on Hypertension During Pregnancy"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;M&#46; Roberts"
                            1 => "G&#46; Pearson"
                            2 => "J&#46; Cutler"
                            3 => "M&#46; Lindheimer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000054981.03589.E9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "437"
                        "paginaFinal" => "445"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12623940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pre-eclampsia and risk of cardiovascular disease and cancer in later life&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Bellamy"
                            1 => "J&#46;P&#46; Casas"
                            2 => "A&#46;D&#46; Hingorani"
                            3 => "D&#46;J&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.39335.385301.BE"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2007"
                        "volumen" => "335"
                        "paginaInicial" => "974"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17975258"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Kuc"
                            1 => "E&#46;J&#46; Wortelboer"
                            2 => "B&#46;B&#46; van Rijn"
                            3 => "A&#46; Franx"
                            4 => "G&#46;H&#46; Visser"
                            5 => "P&#46;C&#46; Schielen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/OGX.0b013e3182227027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obstet Gynecol Surv"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "225"
                        "paginaFinal" => "239"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21756405"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal plasma soluble FMS-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Akolekar"
                            1 => "J&#46; de Cruz"
                            2 => "J&#46;M&#46; Foidart"
                            3 => "C&#46; Munaut"
                            4 => "K&#46;H&#46; Nicolaides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/pd.2433"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prenat Diagn"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "191"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20101671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of serum uric acid determination in predicting pre-eclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Cnossen"
                            1 => "H&#46; de Ruyter-Hanhij&#228;rvi"
                            2 => "J&#46;A&#46; van der Post"
                            3 => "B&#46;W&#46; Mol"
                            4 => "K&#46;S&#46; Khan"
                            5 => "G&#46; ter Riet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Obstet Gynecol Scand"
                        "fecha" => "2006"
                        "volumen" => "85"
                        "paginaInicial" => "519"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16755708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of serum uric acid in predicting complications of pre-eclampsia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Tests in Prediction of Pre-eclampsia Severity review group"
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Thangaratinam"
                            1 => "K&#46;M&#46; Ismail"
                            2 => "S&#46; Sharp"
                            3 => "A&#46; Coomarasamy"
                            4 => "K&#46;S&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1471-0528.2006.00908.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BJOG"
                        "fecha" => "2006"
                        "volumen" => "113"
                        "paginaInicial" => "369"
                        "paginaFinal" => "378"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16553648"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores de riesgo como predictores de preeclampsia&#47;eclampsia en embarazadas con &#237;ndice hiperb&#225;rico patol&#243;gico&#46; XXXVIII Congreso Nacional de la SEN Donostia Octubre 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Borrajo"
                            1 => "J&#46; Santos Nores"
                            2 => "E&#46; Novoa Fernandez"
                            3 => "M&#46; Blanco Garcia"
                            4 => "O&#46; Conde Rivera"
                            5 => "S&#46; Blanco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19018733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of uterine artery Doppler in predicting adverse pregnancy outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;T&#46; Papageorghiou"
                            1 => "C&#46;K&#46; Yu"
                            2 => "K&#46;H&#46; Nicolaides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Best Pract Res Clin Obstet Gynaecol"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "38312"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood pressure excess for the early identification of gestational hypertension and preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "A&#46; Moj&#243;n"
                            3 => "J&#46;R&#46; Fern&#225;ndez"
                            4 => "I&#46; Silva"
                            5 => "R&#46; Ucieda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "83"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9449396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;A&#46; Buhimschi"
                            1 => "G&#46; Zhao"
                            2 => "E&#46;F&#46; Funai"
                            3 => "N&#46; Harris"
                            4 => "I&#46;E&#46; Sasson"
                            5 => "I&#46;M&#46; Bernstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajog.2008.07.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Obstet Gynecol"
                        "fecha" => "2008"
                        "volumen" => "199"
                        "paginaInicial" => "551&#46;e1"
                        "paginaFinal" => "551&#46;e16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18984079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Podocyturia predates proteinuria and clinical features of preeclampsia&#58; longitudinal prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Craici"
                            1 => "S&#46;J&#46; Wagner"
                            2 => "K&#46;R&#46; Bailey"
                            3 => "P&#46;D&#46; Fitz-Gibbon"
                            4 => "C&#46;M&#46; Wood-Wentz"
                            5 => "S&#46;T&#46; Turner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2013"
                        "volumen" => "61"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Hermida"
                            1 => "D&#46;E&#46; Ayala"
                            2 => "M&#46; Iglesias"
                            3 => "A&#46; Moj&#243;n"
                            4 => "I&#46; Silva"
                            5 => "R&#46; Ucieda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "589"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9322987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal vitamin D deficiency increases the risk of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;M&#46; Bodnar"
                            1 => "J&#46;M&#46; Catov"
                            2 => "H&#46;N&#46; Simhan"
                            3 => "M&#46;F&#46; Holick"
                            4 => "R&#46;W&#46; Powers"
                            5 => "J&#46;M&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2007-0718"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2007"
                        "volumen" => "92"
                        "paginaInicial" => "3517"
                        "paginaFinal" => "3522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17535985"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eclampsia and pre-eclampsia a health problem for 2000 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Villar"
                            1 => "L&#46; Say"
                            2 => "A&#46;M&#46; Gulmezoglu"
                            3 => "M&#46; Meraldi"
                            4 => "M&#46;D&#46; Lindheimer"
                            5 => "A&#46;P&#46; Betran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Pre-eclampsia"
                        "paginaInicial" => "189"
                        "paginaFinal" => "207"
                        "serieFecha" => "2003"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating angiogenic factors and the risk of preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Levine"
                            1 => "S&#46;E&#46; Maynard"
                            2 => "C&#46; Qian"
                            3 => "K&#46;H&#46; Lim"
                            4 => "L&#46;J&#46; England"
                            5 => "K&#46;F&#46; Yu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa031884"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "672"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14764923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of vascular growth and function in the human placenta"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;J&#46; Burton"
                            1 => "D&#46;S&#46; Charnock-Jones"
                            2 => "E&#46; Jauniaux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/REP-09-0092"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reproduction"
                        "fecha" => "2009"
                        "volumen" => "138"
                        "paginaInicial" => "895"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19470597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The renin&#8211;aldosterone system during normal and hypertensive pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Elsheikh"
                            1 => "G&#46; Creatsas"
                            2 => "G&#46; Mastorakos"
                            3 => "S&#46; Milingos"
                            4 => "D&#46; Loutradis"
                            5 => "S&#46; Michalas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Gynecol Obstet"
                        "fecha" => "2001"
                        "volumen" => "264"
                        "paginaInicial" => "182"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11205704"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 25-hydroxyvitamin D3 and 1&#44;25-dihydroxyvitamin D3 on cytokine production by human decidual cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;N&#46; Evans"
                            1 => "L&#46; Nguyen"
                            2 => "J&#46; Chan"
                            3 => "B&#46;A&#46; Innes"
                            4 => "J&#46;N&#46; Bulmer"
                            5 => "M&#46;D&#46; Kilby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1095/biolreprod.106.054056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biol Reprod"
                        "fecha" => "2006"
                        "volumen" => "75"
                        "paginaInicial" => "816"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiotensin receptors&#44; autoimmunity&#44; and preeclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46; Xia"
                            1 => "C&#46;C&#46; Zhou"
                            2 => "S&#46;M&#46; Ramin"
                            3 => "R&#46;E&#46; Kellens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2007"
                        "volumen" => "179"
                        "paginaInicial" => "3391"
                        "paginaFinal" => "3395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17785770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of mean arterial pressure in the middle trimester upon the outcome of pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;W&#46; Page"
                            1 => "R&#46; Christianson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Obstet Gynecol"
                        "fecha" => "1976"
                        "volumen" => "125"
                        "paginaInicial" => "740"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/937399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CLASP&#58; a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Collaborative Low-dose Aspirin Study in Pregnancy Collaborative Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1994"
                        "volumen" => "343"
                        "paginaInicial" => "619"
                        "paginaFinal" => "629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7906809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-dose aspirin to prevent preeclampsia in women at high risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Caritis"
                            1 => "B&#46;M&#46; Sibai"
                            2 => "J&#46; Hauth"
                            3 => "M&#46;D&#46; Lindheimer"
                            4 => "M&#46; Klebanoff"
                            5 => "E&#46; Thom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803123381101"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "701"
                        "paginaFinal" => "705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9494145"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiplatelets agents for prevention of pre-eclampsia&#58; a meta-analysis of individual patient data"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "on behalf of the PARIS Collaborative Group"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;M&#46; Askie"
                            1 => "L&#46; Duley"
                            2 => "D&#46;J&#46; Henderson-Smart"
                            3 => "L&#46;A&#46; Stewart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)60712-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "369"
                        "paginaInicial" => "1791"
                        "paginaFinal" => "1798"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17512048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiplatelet agents for preventing and treating pre-eclampsia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Knight"
                            1 => "L&#46; Duley"
                            2 => "D&#46;J&#46; Henderson-Smart"
                            3 => "J&#46;F&#46; King"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2007"
                        "volumen" => "18"
                        "paginaInicial" => "CD000492"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Leitich"
                            1 => "C&#46; Egarter"
                            2 => "P&#46; Husslein"
                            3 => "A&#46; Kaider"
                            4 => "M&#46; Schemper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Obstet Gynaecol"
                        "fecha" => "1997"
                        "volumen" => "104"
                        "paginaInicial" => "450"
                        "paginaFinal" => "459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9141582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003500000006/v2_201703220324/S2013251416000043/v2_201703220324/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42660"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003500000006/v2_201703220324/S2013251416000043/v2_201703220324/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000043?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 11 13 24
2024 October 70 61 131
2024 September 46 39 85
2024 August 67 66 133
2024 July 40 27 67
2024 June 44 40 84
2024 May 54 34 88
2024 April 49 34 83
2024 March 56 30 86
2024 February 46 36 82
2024 January 40 28 68
2023 December 24 20 44
2023 November 49 28 77
2023 October 44 20 64
2023 September 31 24 55
2023 August 40 31 71
2023 July 29 31 60
2023 June 65 18 83
2023 May 88 27 115
2023 April 74 19 93
2023 March 108 17 125
2023 February 77 20 97
2023 January 56 22 78
2022 December 71 30 101
2022 November 68 18 86
2022 October 46 39 85
2022 September 33 31 64
2022 August 42 43 85
2022 July 37 52 89
2022 June 41 33 74
2022 May 41 36 77
2022 April 34 42 76
2022 March 38 47 85
2022 February 42 38 80
2022 January 40 26 66
2021 December 45 43 88
2021 November 35 46 81
2021 October 27 49 76
2021 September 37 34 71
2021 August 26 37 63
2021 July 37 40 77
2021 June 19 31 50
2021 May 40 43 83
2021 April 96 40 136
2021 March 52 47 99
2021 February 40 23 63
2021 January 41 21 62
2020 December 34 26 60
2020 November 32 17 49
2020 October 40 23 63
2020 September 37 28 65
2020 August 41 11 52
2020 July 32 13 45
2020 June 33 13 46
2020 May 62 14 76
2020 April 32 23 55
2020 March 48 8 56
2020 February 41 23 64
2020 January 47 12 59
2019 December 60 20 80
2019 November 70 26 96
2019 October 34 15 49
2019 September 37 12 49
2019 August 38 21 59
2019 July 43 27 70
2019 June 34 22 56
2019 May 32 18 50
2019 April 79 26 105
2019 March 50 25 75
2019 February 26 19 45
2019 January 32 18 50
2018 December 207 47 254
2018 November 429 14 443
2018 October 419 20 439
2018 September 134 12 146
2018 August 54 15 69
2018 July 68 11 79
2018 June 48 15 63
2018 May 52 14 66
2018 April 65 7 72
2018 March 85 14 99
2018 February 40 9 49
2018 January 29 7 36
2017 December 47 9 56
2017 November 36 6 42
2017 October 34 7 41
2017 September 45 13 58
2017 August 52 5 57
2017 July 51 11 62
2017 June 56 6 62
2017 May 51 11 62
2017 April 55 10 65
2017 March 43 6 49
2017 February 102 11 113
2017 January 34 6 40
2016 December 32 1 33
2016 November 71 19 90
2016 October 118 6 124
2016 September 156 7 163
2016 August 151 3 154
2016 July 146 6 152
2016 June 119 0 119
2016 May 129 0 129
2016 April 128 0 128
2016 March 105 0 105
2016 February 117 0 117
2016 January 29 0 29
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?