array:25 [
  "pii" => "S2013251415001091"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2015.06.013"
  "estado" => "S300"
  "fechaPublicacion" => "2016-05-01"
  "aid" => "74"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Nefrologia (English Version). 2016;36:327-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4467
    "formatos" => array:3 [
      "EPUB" => 310
      "HTML" => 3422
      "PDF" => 735
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699515001083"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2015.06.023"
      "estado" => "S300"
      "fechaPublicacion" => "2016-05-01"
      "aid" => "74"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "simple-article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "cor"
      "cita" => "Nefrologia. 2016;36:327-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6916
        "formatos" => array:3 [
          "EPUB" => 361
          "HTML" => 5772
          "PDF" => 783
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "327"
            "paginaFinal" => "328"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Role of photopheresis in the treatment of refractory cellular rejection in kidney transplantation"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ernesto Jos&#233; Fern&#225;ndez, Celia L&#243;pez, Ana Ram&#237;rez, Rita Guerra, Luc&#237;a L&#243;pez, Fernando Fern&#225;ndez, Manuel Tapia, C&#233;sar Garc&#237;a-Cant&#243;n"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Ernesto Jos&#233;"
                "apellidos" => "Fern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "Celia"
                "apellidos" => "L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "Ana"
                "apellidos" => "Ram&#237;rez"
              ]
              3 => array:2 [
                "nombre" => "Rita"
                "apellidos" => "Guerra"
              ]
              4 => array:2 [
                "nombre" => "Luc&#237;a"
                "apellidos" => "L&#243;pez"
              ]
              5 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Fern&#225;ndez"
              ]
              6 => array:2 [
                "nombre" => "Manuel"
                "apellidos" => "Tapia"
              ]
              7 => array:2 [
                "nombre" => "C&#233;sar"
                "apellidos" => "Garc&#237;a-Cant&#243;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251415001091"
          "doi" => "10.1016/j.nefroe.2015.06.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415001091?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001083?idApp=UINPBA000064"
      "url" => "/02116995/0000003600000003/v1_201605310108/S0211699515001083/v1_201605310108/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2013251416300268"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.04.012"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "155"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:328-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2817
      "formatos" => array:3 [
        "EPUB" => 305
        "HTML" => 1772
        "PDF" => 740
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Late onset of de novo atypical hemolytic&#8211;uremic syndrome presented on a simultaneous pancreas and kidney transplant recipient successfully treated with eculizumab"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "328"
          "paginaFinal" => "329"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Presentacion tard&#237;a de s&#237;ndrome hemol&#237;tico&#8211;ur&#233;mico at&#237;pico de novo en receptor de trasplante reno-pancre&#225;tico resuelto con eculizumab"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 742
              "Ancho" => 986
              "Tamanyo" => 268695
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acute TMA showing thrombosis at glomerular capillaries and mesangiolysis &#40;Masson&#39;s trichrome stain&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Javier Juega-Mari&#241;o, Neus Sala, Dolores L&#243;pez, Laura Ca&#241;as, Josep Bonet, Ricardo Lauzurica"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Francisco Javier"
              "apellidos" => "Juega-Mari&#241;o"
            ]
            1 => array:2 [
              "nombre" => "Neus"
              "apellidos" => "Sala"
            ]
            2 => array:2 [
              "nombre" => "Dolores"
              "apellidos" => "L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Ca&#241;as"
            ]
            4 => array:2 [
              "nombre" => "Josep"
              "apellidos" => "Bonet"
            ]
            5 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Lauzurica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300268?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000003/v3_201704140402/S2013251416300268/v3_201704140402/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251416300220"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.04.009"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "145"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:325-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4605
      "formatos" => array:3 [
        "EPUB" => 437
        "HTML" => 3486
        "PDF" => 682
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Creation of the Working Group on Diagnostic and Interventional Nephrology of the Spanish Society of Nephrology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "325"
          "paginaFinal" => "326"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Creaci&#243;n del Grupo de Trabajo en Nefrolog&#237;a Diagn&#243;stica e Intervencionista de la Sociedad Espa&#241;ola de Nefrolog&#237;a"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maite Rivera Gorr&#237;n, I&#241;aki Cornago Delgado, &#192;ngels Betriu Bars, Manuel Lanuza Luengo, Manuel Ceballos Guerrero, Vicente Para&#237;so Cuevas, Jos&#233; Ibeas L&#243;pez, Ram&#243;n Roca Tey, Pedro Luis Quir&#243;s Ganga"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Rivera Gorr&#237;n"
            ]
            1 => array:2 [
              "nombre" => "I&#241;aki"
              "apellidos" => "Cornago Delgado"
            ]
            2 => array:2 [
              "nombre" => "&#192;ngels"
              "apellidos" => "Betriu Bars"
            ]
            3 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Lanuza Luengo"
            ]
            4 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Ceballos Guerrero"
            ]
            5 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Para&#237;so Cuevas"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Ibeas L&#243;pez"
            ]
            7 => array:2 [
              "nombre" => "Ram&#243;n"
              "apellidos" => "Roca Tey"
            ]
            8 => array:2 [
              "nombre" => "Pedro Luis"
              "apellidos" => "Quir&#243;s Ganga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699515002337"
        "doi" => "10.1016/j.nefro.2015.11.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515002337?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300220?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000003/v3_201704140402/S2013251416300220/v3_201704140402/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Role of photopheresis in the treatment of refractory cellular rejection in kidney transplantation"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "327"
        "paginaFinal" => "328"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ernesto Jos&#233; Fern&#225;ndez, Celia L&#243;pez, Ana Ram&#237;rez, Rita Guerra, Luc&#237;a L&#243;pez, Fernando Fern&#225;ndez, Manuel Tapia, C&#233;sar Garc&#237;a-Cant&#243;n"
        "autores" => array:8 [
          0 => array:3 [
            "nombre" => "Ernesto Jos&#233;"
            "apellidos" => "Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Celia"
            "apellidos" => "L&#243;pez"
            "email" => array:1 [
              0 => "Celia&#46;loap&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ana"
            "apellidos" => "Ram&#237;rez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Rita"
            "apellidos" => "Guerra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Luc&#237;a"
            "apellidos" => "L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Manuel"
            "apellidos" => "Tapia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "C&#233;sar"
            "apellidos" => "Garc&#237;a-Cant&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Trasplante Renal&#44; Servicio de Nefrolog&#237;a&#44; Hospital Universitario Insular de Gran Canaria&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a y Hemoterapia&#44; Hospital Universitario Insular de Gran Canaria&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Extracorporeal photopheresis is an immunomodulatory technique based on the apoptotic effects of 8-methoxypsoralen &#40;8-MOP&#41; and ultraviolet A &#40;UVA&#41; light on leukocytes&#46; It is widely used in T-cell-mediated diseases such as cutaneous T-cell lymphoma&#44; graft vs host disease&#44; rheumatoid arthritis&#44; and systemic lupus erythematosus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Its use as prophylaxis for acute rejection &#40;AR&#41; in lung and heart transplants seems promising&#46; However&#44; there are few published articles on its use in the treatment of acute cellular rejection refractory to conventional treatment in renal transplant patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 56-year-old man&#44; who received a cadaveric donor renal transplant in May 2013&#46; Induction immunosuppression was with basiliximab&#44; tacrolimus&#44; mycophenolate mofetil&#44; and steroids&#46; Renal function was immediate and maintained until 16 days post-transplant&#44; when it deteriorated&#46; Percutaneous renal biopsy was performed&#44; demonstrating Banff type Ib acute cellular rejection&#46; Anti-HLA&#44; anti-MICA&#44; and antiendothelial antibodies were negative&#46; The patient received salvage therapy with methylprednisolone &#40;3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>500<span class="elsevierStyleHsp" style=""></span>mg&#41; and thymoglobulin &#40;1&#46;25<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#59; total cumulative dose&#44; 410<span class="elsevierStyleHsp" style=""></span>mg&#41; without improvement&#46; Seventeen days later a second renal biopsy was performed&#44; reported as Banff type IIa acute cellular rejection&#44; with mild intimal arteritis&#46; Given the clinical course and refractoriness to treatment&#44; with serum creatinine &#40;SCr&#41; of 2&#46;97<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; photopheresis was prescribed &#40;14 sessions&#44; once per week&#44; with Therakos<span class="elsevierStyleSup">&#174;</span> UVAR XTS<span class="elsevierStyleSup">&#174;</span> System&#41; along with nonspecific human gammaglobulin &#40;200<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#59; total dose&#44; 80<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Following this&#44; a progressive improvement was seen in renal function&#44; with SCr of 2&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL on discharge&#46; Renal function remained stable for 9 months&#44; then deteriorated slightly&#44; with a SCr of 2&#46;62<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; so it was decided to start a new course of photopheresis &#40;6 sessions&#44; once weekly&#41;&#46; There was a good response to treatment &#40;7 months later&#44; the current SCr of 1&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and no treatment-related infectious complications were noted&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Prophylactic treatment with photopheresis in renal transplant patients in addition to standard immunosuppression has shown improvement in renal function at 6 months and an increase in regulatory T-cells &#40;Tregs&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Regarding its use in refractory AR&#44; data from the literature are scarce&#44; and&#44; at times&#44; contradictory&#46; Horina et al&#46; describe 3 patients treated with monthly photopheresis&#44; who had no improvement in renal function&#44; re-starting dialysis after a few months&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However&#44; in other publications&#44; more frequent schedules have been associated with improvement of renal function&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Dall&#8217;Amico et al&#46; describe 4 patients with different types of cellular rejection&#44; who had previously received OKT3&#44; with improvement in renal function after the first cycle of photopheresis treatment&#46; Renal function remained stable one year later&#44; allowing a reduction in immunosuppressive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Weekly&#44; fortnightly&#44; and monthly schedules were used&#44; up to a total of 19 sessions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The different mechanisms by which photopheresis exerts its beneficial effects are not completely understood&#46; It seems to be related to triggering an immunomodulatory response of alloreactive T cells exposed to 8-MOP and to UVA light&#46; It is likely that important roles are played by the synthesis of interleukins &#40;especially TNF&#44; IL-10&#44; and IL-6&#41; and the increase in regulatory T-cells &#40;CD4&#43;&#44; CD25&#43; and FoxP3&#43;&#41;&#44; which increase progressively in number after each session&#46; These mechanisms could explain why the benefits in cutaneous T-cell lymphoma are seen from the second or third month&#44; while in AR they can be seen after a few days&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Currently&#44; photopheresis could be useful as salvage therapy in cases of acute cellular rejection refractory to conventional treatment in renal transplants&#46; More extensive investigation is needed to test its efficacy and safety&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Fern&#225;ndez EJ&#44; L&#243;pez C&#44; Ram&#237;rez A&#44; Guerra R&#44; L&#243;pez L&#44; Fern&#225;ndez F&#44; et al&#46; Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal&#46; Nefrologia&#46; 2016&#59;36&#58;327&#8211;328&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracorporeal photopheresis for the treatment of autoinmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Adamski"
                            1 => "T&#46; Kinard"
                            2 => "T&#46; Ipe"
                            3 => "L&#46; Cooling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transci.2015.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transfus Apher Sci"
                        "fecha" => "2015"
                        "volumen" => "52"
                        "paginaInicial" => "171"
                        "paginaFinal" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25886694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracorporeal photopheresis as an antirejection prophylaxis in kidney transplant recipients&#58; preliminary results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Kusztal"
                            1 => "K&#46; Koscielska-Kasprzak"
                            2 => "W&#46; Gdowska"
                            3 => "M&#46; Zabinska"
                            4 => "M&#46; Myszka"
                            5 => "R&#46; Klak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2011.08.061"
                      "Revista" => array:7 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2011"
                        "volumen" => "43"
                        "paginaInicial" => "2938"
                        "paginaFinal" => "2940"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21996194"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028208014908"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photopheresis for renal allograft rejection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Horina"
                            1 => "R&#46;R&#46; Mullegger"
                            2 => "S&#46; Horn"
                            3 => "H&#46; Holzer"
                            4 => "G&#46; Halwachs"
                            5 => "H&#46; Kerl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1995"
                        "volumen" => "346"
                        "paginaInicial" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7603178"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0210480612003294"
                          "estado" => "S300"
                          "issn" => "02104806"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversal of acute renal allograft rejection by extracorporeal photopheresis&#58; a case presentation and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;T&#46; Wolfe"
                            1 => "J&#46;E&#46; Tomaszewski"
                            2 => "R&#46;A&#46; Grossman"
                            3 => "S&#46;L&#46; Gottlieb"
                            4 => "A&#46; Naji"
                            5 => "K&#46;L&#46; Brayman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1098-1101(1996)11:1<36::AID-JCA8>3.0.CO;2-C"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Apher"
                        "fecha" => "1996"
                        "volumen" => "11"
                        "paginaInicial" => "36"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8722721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Succesful treatment of recurrent rejection in renal transplant patients with photopheresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Dall&#8217;Amico"
                            1 => "L&#46; Murer"
                            2 => "G&#46; Montini"
                            3 => "B&#46; Andreetta"
                            4 => "G&#46; Franco-Zanon"
                            5 => "G&#46; Zacchello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "1998"
                        "volumen" => "9"
                        "paginaInicial" => "121"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9440096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003600000003/v3_201704140402/S2013251415001091/v3_201704140402/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003600000003/v3_201704140402/S2013251415001091/v3_201704140402/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415001091?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Role of photopheresis in the treatment of refractory cellular rejection in kidney transplantation
Papel de la fotoaféresis en el tratamiento del rechazo celular agudo refractario en trasplante renal
Ernesto José Fernándeza, Celia Lópeza,
Corresponding author
Celia.loap@gmail.com

Corresponding author.
, Ana Ramíreza, Rita Guerraa, Lucía Lópeza, Fernando Fernándezb, Manuel Tapiab, César García-Cantóna
a Unidad de Trasplante Renal, Servicio de Nefrología, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, Spain
b Servicio de Hematología y Hemoterapia, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, Spain
Read
9062
Times
was read the article
2614
Total PDF
6448
Total HTML
Share statistics
 array:25 [
  "pii" => "S2013251415001091"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2015.06.013"
  "estado" => "S300"
  "fechaPublicacion" => "2016-05-01"
  "aid" => "74"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:327-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4467
    "formatos" => array:3 [
      "EPUB" => 310
      "HTML" => 3422
      "PDF" => 735
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699515001083"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2015.06.023"
      "estado" => "S300"
      "fechaPublicacion" => "2016-05-01"
      "aid" => "74"
      "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "cor"
      "cita" => "Nefrologia. 2016;36:327-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6916
        "formatos" => array:3 [
          "EPUB" => 361
          "HTML" => 5772
          "PDF" => 783
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "327"
            "paginaFinal" => "328"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Role of photopheresis in the treatment of refractory cellular rejection in kidney transplantation"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ernesto Jos&#233; Fern&#225;ndez, Celia L&#243;pez, Ana Ram&#237;rez, Rita Guerra, Luc&#237;a L&#243;pez, Fernando Fern&#225;ndez, Manuel Tapia, C&#233;sar Garc&#237;a-Cant&#243;n"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Ernesto Jos&#233;"
                "apellidos" => "Fern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "Celia"
                "apellidos" => "L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "Ana"
                "apellidos" => "Ram&#237;rez"
              ]
              3 => array:2 [
                "nombre" => "Rita"
                "apellidos" => "Guerra"
              ]
              4 => array:2 [
                "nombre" => "Luc&#237;a"
                "apellidos" => "L&#243;pez"
              ]
              5 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Fern&#225;ndez"
              ]
              6 => array:2 [
                "nombre" => "Manuel"
                "apellidos" => "Tapia"
              ]
              7 => array:2 [
                "nombre" => "C&#233;sar"
                "apellidos" => "Garc&#237;a-Cant&#243;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251415001091"
          "doi" => "10.1016/j.nefroe.2015.06.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415001091?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001083?idApp=UINPBA000064"
      "url" => "/02116995/0000003600000003/v1_201605310108/S0211699515001083/v1_201605310108/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2013251416300268"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.04.012"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "155"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:328-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2817
      "formatos" => array:3 [
        "EPUB" => 305
        "HTML" => 1772
        "PDF" => 740
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Late onset of de novo atypical hemolytic&#8211;uremic syndrome presented on a simultaneous pancreas and kidney transplant recipient successfully treated with eculizumab"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "328"
          "paginaFinal" => "329"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Presentacion tard&#237;a de s&#237;ndrome hemol&#237;tico&#8211;ur&#233;mico at&#237;pico de novo en receptor de trasplante reno-pancre&#225;tico resuelto con eculizumab"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 742
              "Ancho" => 986
              "Tamanyo" => 268695
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acute TMA showing thrombosis at glomerular capillaries and mesangiolysis &#40;Masson&#39;s trichrome stain&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Javier Juega-Mari&#241;o, Neus Sala, Dolores L&#243;pez, Laura Ca&#241;as, Josep Bonet, Ricardo Lauzurica"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Francisco Javier"
              "apellidos" => "Juega-Mari&#241;o"
            ]
            1 => array:2 [
              "nombre" => "Neus"
              "apellidos" => "Sala"
            ]
            2 => array:2 [
              "nombre" => "Dolores"
              "apellidos" => "L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Ca&#241;as"
            ]
            4 => array:2 [
              "nombre" => "Josep"
              "apellidos" => "Bonet"
            ]
            5 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Lauzurica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300268?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000003/v3_201704140402/S2013251416300268/v3_201704140402/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251416300220"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.04.009"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "145"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:325-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4605
      "formatos" => array:3 [
        "EPUB" => 437
        "HTML" => 3486
        "PDF" => 682
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Creation of the Working Group on Diagnostic and Interventional Nephrology of the Spanish Society of Nephrology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "325"
          "paginaFinal" => "326"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Creaci&#243;n del Grupo de Trabajo en Nefrolog&#237;a Diagn&#243;stica e Intervencionista de la Sociedad Espa&#241;ola de Nefrolog&#237;a"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maite Rivera Gorr&#237;n, I&#241;aki Cornago Delgado, &#192;ngels Betriu Bars, Manuel Lanuza Luengo, Manuel Ceballos Guerrero, Vicente Para&#237;so Cuevas, Jos&#233; Ibeas L&#243;pez, Ram&#243;n Roca Tey, Pedro Luis Quir&#243;s Ganga"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Rivera Gorr&#237;n"
            ]
            1 => array:2 [
              "nombre" => "I&#241;aki"
              "apellidos" => "Cornago Delgado"
            ]
            2 => array:2 [
              "nombre" => "&#192;ngels"
              "apellidos" => "Betriu Bars"
            ]
            3 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Lanuza Luengo"
            ]
            4 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Ceballos Guerrero"
            ]
            5 => array:2 [
              "nombre" => "Vicente"
              "apellidos" => "Para&#237;so Cuevas"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Ibeas L&#243;pez"
            ]
            7 => array:2 [
              "nombre" => "Ram&#243;n"
              "apellidos" => "Roca Tey"
            ]
            8 => array:2 [
              "nombre" => "Pedro Luis"
              "apellidos" => "Quir&#243;s Ganga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699515002337"
        "doi" => "10.1016/j.nefro.2015.11.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515002337?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300220?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000003/v3_201704140402/S2013251416300220/v3_201704140402/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Role of photopheresis in the treatment of refractory cellular rejection in kidney transplantation"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "327"
        "paginaFinal" => "328"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ernesto Jos&#233; Fern&#225;ndez, Celia L&#243;pez, Ana Ram&#237;rez, Rita Guerra, Luc&#237;a L&#243;pez, Fernando Fern&#225;ndez, Manuel Tapia, C&#233;sar Garc&#237;a-Cant&#243;n"
        "autores" => array:8 [
          0 => array:3 [
            "nombre" => "Ernesto Jos&#233;"
            "apellidos" => "Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Celia"
            "apellidos" => "L&#243;pez"
            "email" => array:1 [
              0 => "Celia&#46;loap&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ana"
            "apellidos" => "Ram&#237;rez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Rita"
            "apellidos" => "Guerra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Luc&#237;a"
            "apellidos" => "L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Manuel"
            "apellidos" => "Tapia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "C&#233;sar"
            "apellidos" => "Garc&#237;a-Cant&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Trasplante Renal&#44; Servicio de Nefrolog&#237;a&#44; Hospital Universitario Insular de Gran Canaria&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a y Hemoterapia&#44; Hospital Universitario Insular de Gran Canaria&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Extracorporeal photopheresis is an immunomodulatory technique based on the apoptotic effects of 8-methoxypsoralen &#40;8-MOP&#41; and ultraviolet A &#40;UVA&#41; light on leukocytes&#46; It is widely used in T-cell-mediated diseases such as cutaneous T-cell lymphoma&#44; graft vs host disease&#44; rheumatoid arthritis&#44; and systemic lupus erythematosus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Its use as prophylaxis for acute rejection &#40;AR&#41; in lung and heart transplants seems promising&#46; However&#44; there are few published articles on its use in the treatment of acute cellular rejection refractory to conventional treatment in renal transplant patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 56-year-old man&#44; who received a cadaveric donor renal transplant in May 2013&#46; Induction immunosuppression was with basiliximab&#44; tacrolimus&#44; mycophenolate mofetil&#44; and steroids&#46; Renal function was immediate and maintained until 16 days post-transplant&#44; when it deteriorated&#46; Percutaneous renal biopsy was performed&#44; demonstrating Banff type Ib acute cellular rejection&#46; Anti-HLA&#44; anti-MICA&#44; and antiendothelial antibodies were negative&#46; The patient received salvage therapy with methylprednisolone &#40;3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>500<span class="elsevierStyleHsp" style=""></span>mg&#41; and thymoglobulin &#40;1&#46;25<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#59; total cumulative dose&#44; 410<span class="elsevierStyleHsp" style=""></span>mg&#41; without improvement&#46; Seventeen days later a second renal biopsy was performed&#44; reported as Banff type IIa acute cellular rejection&#44; with mild intimal arteritis&#46; Given the clinical course and refractoriness to treatment&#44; with serum creatinine &#40;SCr&#41; of 2&#46;97<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; photopheresis was prescribed &#40;14 sessions&#44; once per week&#44; with Therakos<span class="elsevierStyleSup">&#174;</span> UVAR XTS<span class="elsevierStyleSup">&#174;</span> System&#41; along with nonspecific human gammaglobulin &#40;200<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#59; total dose&#44; 80<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Following this&#44; a progressive improvement was seen in renal function&#44; with SCr of 2&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL on discharge&#46; Renal function remained stable for 9 months&#44; then deteriorated slightly&#44; with a SCr of 2&#46;62<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; so it was decided to start a new course of photopheresis &#40;6 sessions&#44; once weekly&#41;&#46; There was a good response to treatment &#40;7 months later&#44; the current SCr of 1&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and no treatment-related infectious complications were noted&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Prophylactic treatment with photopheresis in renal transplant patients in addition to standard immunosuppression has shown improvement in renal function at 6 months and an increase in regulatory T-cells &#40;Tregs&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Regarding its use in refractory AR&#44; data from the literature are scarce&#44; and&#44; at times&#44; contradictory&#46; Horina et al&#46; describe 3 patients treated with monthly photopheresis&#44; who had no improvement in renal function&#44; re-starting dialysis after a few months&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However&#44; in other publications&#44; more frequent schedules have been associated with improvement of renal function&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Dall&#8217;Amico et al&#46; describe 4 patients with different types of cellular rejection&#44; who had previously received OKT3&#44; with improvement in renal function after the first cycle of photopheresis treatment&#46; Renal function remained stable one year later&#44; allowing a reduction in immunosuppressive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Weekly&#44; fortnightly&#44; and monthly schedules were used&#44; up to a total of 19 sessions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The different mechanisms by which photopheresis exerts its beneficial effects are not completely understood&#46; It seems to be related to triggering an immunomodulatory response of alloreactive T cells exposed to 8-MOP and to UVA light&#46; It is likely that important roles are played by the synthesis of interleukins &#40;especially TNF&#44; IL-10&#44; and IL-6&#41; and the increase in regulatory T-cells &#40;CD4&#43;&#44; CD25&#43; and FoxP3&#43;&#41;&#44; which increase progressively in number after each session&#46; These mechanisms could explain why the benefits in cutaneous T-cell lymphoma are seen from the second or third month&#44; while in AR they can be seen after a few days&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Currently&#44; photopheresis could be useful as salvage therapy in cases of acute cellular rejection refractory to conventional treatment in renal transplants&#46; More extensive investigation is needed to test its efficacy and safety&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Fern&#225;ndez EJ&#44; L&#243;pez C&#44; Ram&#237;rez A&#44; Guerra R&#44; L&#243;pez L&#44; Fern&#225;ndez F&#44; et al&#46; Papel de la fotoaf&#233;resis en el tratamiento del rechazo celular agudo refractario en trasplante renal&#46; Nefrologia&#46; 2016&#59;36&#58;327&#8211;328&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracorporeal photopheresis for the treatment of autoinmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Adamski"
                            1 => "T&#46; Kinard"
                            2 => "T&#46; Ipe"
                            3 => "L&#46; Cooling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transci.2015.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transfus Apher Sci"
                        "fecha" => "2015"
                        "volumen" => "52"
                        "paginaInicial" => "171"
                        "paginaFinal" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25886694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracorporeal photopheresis as an antirejection prophylaxis in kidney transplant recipients&#58; preliminary results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Kusztal"
                            1 => "K&#46; Koscielska-Kasprzak"
                            2 => "W&#46; Gdowska"
                            3 => "M&#46; Zabinska"
                            4 => "M&#46; Myszka"
                            5 => "R&#46; Klak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2011.08.061"
                      "Revista" => array:7 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2011"
                        "volumen" => "43"
                        "paginaInicial" => "2938"
                        "paginaFinal" => "2940"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21996194"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028208014908"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photopheresis for renal allograft rejection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Horina"
                            1 => "R&#46;R&#46; Mullegger"
                            2 => "S&#46; Horn"
                            3 => "H&#46; Holzer"
                            4 => "G&#46; Halwachs"
                            5 => "H&#46; Kerl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1995"
                        "volumen" => "346"
                        "paginaInicial" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7603178"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0210480612003294"
                          "estado" => "S300"
                          "issn" => "02104806"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversal of acute renal allograft rejection by extracorporeal photopheresis&#58; a case presentation and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;T&#46; Wolfe"
                            1 => "J&#46;E&#46; Tomaszewski"
                            2 => "R&#46;A&#46; Grossman"
                            3 => "S&#46;L&#46; Gottlieb"
                            4 => "A&#46; Naji"
                            5 => "K&#46;L&#46; Brayman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1098-1101(1996)11:1<36::AID-JCA8>3.0.CO;2-C"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Apher"
                        "fecha" => "1996"
                        "volumen" => "11"
                        "paginaInicial" => "36"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8722721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Succesful treatment of recurrent rejection in renal transplant patients with photopheresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Dall&#8217;Amico"
                            1 => "L&#46; Murer"
                            2 => "G&#46; Montini"
                            3 => "B&#46; Andreetta"
                            4 => "G&#46; Franco-Zanon"
                            5 => "G&#46; Zacchello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "1998"
                        "volumen" => "9"
                        "paginaInicial" => "121"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9440096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003600000003/v3_201704140402/S2013251415001091/v3_201704140402/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35436"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003600000003/v3_201704140402/S2013251415001091/v3_201704140402/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415001091?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 October 47 43 90
2024 September 48 36 84
2024 August 56 59 115
2024 July 47 37 84
2024 June 57 38 95
2024 May 76 29 105
2024 April 46 28 74
2024 March 46 26 72
2024 February 58 36 94
2024 January 50 23 73
2023 December 40 31 71
2023 November 50 36 86
2023 October 111 31 142
2023 September 42 26 68
2023 August 45 28 73
2023 July 43 31 74
2023 June 80 19 99
2023 May 99 34 133
2023 April 38 14 52
2023 March 51 21 72
2023 February 31 23 54
2023 January 37 22 59
2022 December 45 31 76
2022 November 48 29 77
2022 October 40 41 81
2022 September 55 39 94
2022 August 52 49 101
2022 July 34 50 84
2022 June 30 37 67
2022 May 33 38 71
2022 April 42 42 84
2022 March 61 65 126
2022 February 65 50 115
2022 January 59 30 89
2021 December 51 31 82
2021 November 37 44 81
2021 October 48 28 76
2021 September 49 35 84
2021 August 40 43 83
2021 July 89 32 121
2021 June 53 29 82
2021 May 69 51 120
2021 April 128 85 213
2021 March 87 42 129
2021 February 51 40 91
2021 January 78 23 101
2020 December 51 16 67
2020 November 48 27 75
2020 October 39 24 63
2020 September 42 26 68
2020 August 48 21 69
2020 July 44 21 65
2020 June 41 28 69
2020 May 62 11 73
2020 April 33 16 49
2020 March 55 25 80
2020 February 40 21 61
2020 January 54 36 90
2019 December 51 30 81
2019 November 47 25 72
2019 October 32 18 50
2019 September 36 17 53
2019 August 28 24 52
2019 July 24 23 47
2019 June 40 26 66
2019 May 28 26 54
2019 April 56 44 100
2019 March 51 23 74
2019 February 35 21 56
2019 January 31 22 53
2018 December 120 40 160
2018 November 228 27 255
2018 October 212 24 236
2018 September 130 14 144
2018 August 63 17 80
2018 July 62 12 74
2018 June 79 18 97
2018 May 78 14 92
2018 April 115 10 125
2018 March 96 10 106
2018 February 88 7 95
2018 January 92 8 100
2017 December 82 8 90
2017 November 67 11 78
2017 October 50 6 56
2017 September 38 10 48
2017 August 36 7 43
2017 July 31 11 42
2017 June 55 10 65
2017 May 52 15 67
2017 April 35 12 47
2017 March 28 6 34
2017 February 34 11 45
2017 January 24 19 43
2016 December 39 9 48
2016 November 47 20 67
2016 October 61 13 74
2016 September 111 12 123
2016 August 94 3 97
2016 July 109 4 113
2016 June 94 0 94
2016 May 125 0 125
2016 April 102 0 102
2016 March 66 0 66
2016 February 69 0 69
2016 January 57 0 57
2015 December 21 0 21
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)