Letter to the Editor
Reply to the comment “Infection with hepatitis C virus, interferon α and lupus: An odd association”
Respuesta al comentario de «Infección por virus de la hepatitis C, interferón α y lupus, una curiosa asociación»
Pilar Auñón
, Enrique Morales
Corresponding author
Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, Spain
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"idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor – Comments on published articles</span>" "titulo" => "ANA, lupus and hepatitis C. 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This rules out associated diseases, such as autoimmune hepatitis or drug-induced lupus.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Following treatment, our patient had fever, asthenia, and arthralgia, as well as positive anti-histone antibodies. The temporal relationship between concomitant interferon treatment and negative HCV tests resulted in the diagnosis and subsequent therapy of the patient.</p><p id="par0025" class="elsevierStylePara elsevierViewall">By contrast, the advent of new drugs for the treatment of HCV, such as the nucleotide NS5B polymerase inhibitor, sofosbuvir, and the NS5A inhibitor, daclatasvir, paves the way for interferon-free treatments. These new drugs will avoid the interferon-associated adverse effects, while achieving highly sustained virologic response rates. However, further studies should be conducted in special populations,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> including patients with end-stage renal disease undergoing haemodialysis.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Auñón P, Morales E. Respuesta al comentario de «Infección por virus de la hepatitis C, interferón α y lupus, una curiosa asociación». Nefrologia. 2015;35:507–508.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infección por virus de la hepatitis C, interferón alfa y lupus, una curiosa asociación" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Auñón-Rubio" 1 => "E. Hernández-Martínez" 2 => "A. Sevillano-Prieto" 3 => "E. Morales-Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3265/Nefrologia.pre2014.Apr.12349" "Revista" => array:6 [ "tituloSerie" => "Nefrologia" "fecha" => "2014" "volumen" => "34" "paginaInicial" => "534" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25036072" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Palazzi" 1 => "D. Buskila" 2 => "S. D’Angelo" 3 => "E. D’Amico" 4 => "I. Olivieri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2011.11.011" "Revista" => array:6 [ "tituloSerie" => "Autoimmun Rev" "fecha" => "2012" "volumen" => "11" "paginaInicial" => "659" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22155016" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.S. Sulkowski" 1 => "D.F. Gardiner" 2 => "M. Rodríguez-Torres" 3 => "K.R. Reddy" 4 => "T. Hassanein" 5 => "I. Jacobson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1306218" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2014" "volumen" => "370" "paginaInicial" => "211" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24428467" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003500000005/v2_201602120114/S2013251415000826/v2_201602120114/en/main.assets" "Apartado" => array:4 [ "identificador" => "35439" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Comments on published articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003500000005/v2_201602120114/S2013251415000826/v2_201602120114/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251415000826?idApp=UINPBA000064" ]
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