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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Between July 2003 and June 2012&#44; 365 patients received dialysis in our unit&#46; 179 patients had an AV fistula&#46; 186 had a central venous catheter &#40;CVC&#41;&#59; of whom 60 were excluded because they had been treated within the previous month with gentamicin &#40;G&#41; for various reasons&#46; Of the 126 patients studied&#44; 118 had a CVC in the internal jugular vein and 8 had it in the femoral vein&#46; Any procedure involving the CVC employed a strict protocol of complete asepsis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleItalic">Prophylaxis</span>&#58; intraluminal post-HD locking with 5<span class="elsevierStyleHsp" style=""></span>mg Gentamicin &#40;G&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>sodium heparin at 1&#37; or 5&#37; per limb&#46; For 6 months&#44; the trough serum level of G was measured &#40;normal value&#58; 0&#46;2&#8211;2<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; subsequently changing to annual controls&#46; If the level was &#62;0&#46;3&#8211;0&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#44; we reduced the lock to 3<span class="elsevierStyleHsp" style=""></span>mg&#47;limb of G 0&#46;5&#8211;2<span class="elsevierStyleHsp" style=""></span>mg&#47;limb&#46; The diagnosis of CVCB was based on the criteria of Beathard and Urbanes<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> and the NKF guidelines on vascular access published in 2006<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#58; clinical improvement in a patient with fever treated with antibiotics with or without removal of CVC&#44; with positive blood cultures &#40;BC&#43;&#41; normally from blood taken from the HD line and&#47;or infrequently from the CVC limb&#44; having excluded other foci of infection&#46; All patients with CVCB had BC&#43;&#44; except one with BC&#8722;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Treatment of CVCB&#46; Gram positive organisms&#44; vancomycin 1<span class="elsevierStyleHsp" style=""></span>g at the 1st HD and 500<span class="elsevierStyleHsp" style=""></span>mg at subsequent HDs for 3&#8211;4 weeks&#44; or another antibiotics if appropriate&#59; Gram negative&#44; as indicated in the susceptibility testing&#44; for 3&#8211;4 weeks&#46; Key outcomes studied&#58; ototoxicity&#58; clinical hypoacusis and&#47;or vertigo&#46; Bacterial resistance to G&#58; organisms normally sensitive to G&#58; Gram&#43;&#58; coagulase negative <span class="elsevierStyleItalic">Staphylococcus aureus</span> sensitive to methicillin&#46; Gram&#8722;&#58; <span class="elsevierStyleItalic">Escherichia coli</span>&#44; <span class="elsevierStyleItalic">Proteus</span>&#44; <span class="elsevierStyleItalic">Serratia</span>&#44; <span class="elsevierStyleItalic">Klebsiella</span>&#44; <span class="elsevierStyleItalic">Enterobacter</span>&#44; <span class="elsevierStyleItalic">Pseudomona aeruginosa</span>&#44; etc&#46; The minimum inhibitory concentration &#40;MIC&#41; of G for these bacteria is &#8804;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#46; Resistance was detected from the results of BCs and susceptibility testing&#44; which expressed sensitivity &#40;S&#41; or resistance &#40;R&#41; to G and the MIC value for each organism&#46; We present the other variables studied in the results section&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Results&#46; The mean patient age was 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29 years &#40;21&#8211;85 years&#41;&#59; 60 patients &#40;48&#37;&#41; were women&#44; 39 patients &#40;31&#37;&#41; had diabetes&#46; The mean time each patient remained in the study was 24 months&#46; Thirty-eight patients were treated with prophylaxis for &#62;30 months &#40;30&#37; of all study patients&#41;&#44; mean time per patient was 50 months &#40;31&#8211;108&#41;&#46; On susceptibility testing&#44; no resistance was detected in G-sensitive bacteria&#58; the MCI was &#60;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#44; except in two cases of CVCB due to methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; and one case with BC&#40;&#8722;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">No patients had a diagnosis of ototoxicity&#46; The mean trough level of G per patient was 0&#46;17<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#40;0&#46;05&#8211;0&#46;31&#41;&#46; The mean G lock per limb per patient was 3<span class="elsevierStyleHsp" style=""></span>mg &#40;2&#8211;5&#41;&#44; equivalent to 1&#46;1&#8211;1&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#47;limb depending on the volume of the limb according to the type of catheter&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patients diagnosed with CVCB&#58; 11&#40;8&#46;7&#37;&#41;&#46; Patients admitted to hospital for CVCB&#58; 4 &#40;3&#46;2&#37;&#41;&#46; Number of CVCB&#47;CVC&#47;1000 days&#58; 0&#46;17&#46; CVC removed due to CVCB&#58; 3 patients &#40;2&#46;4&#37;&#41;&#46; Mortality due to CVCB&#58; 1 &#40;0&#46;8&#37;&#41;&#46; Number of CVCB&#58; 15&#44; <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#58; 8&#59; <span class="elsevierStyleItalic">Staphylococcus epidermidis</span>&#58; 4&#59; <span class="elsevierStyleItalic">Escherichia coli</span>&#58; 1&#59; <span class="elsevierStyleItalic">Streptococcus bovis</span>&#58; 1&#44; and BC&#40;&#8722;&#41;&#58; 1&#46; CVC was removed due to recurrent CVCB in one patient&#44; for failure to improve clinically of in one patient&#44; and due to BC&#40;&#8722;&#41; in one patient with clinical remission&#46; There were no other CVCB complications &#40;endocarditis&#44; spondylodiscitis&#41;&#44; except in one patient who died due to sepsis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Discussion&#46; The scientific literature demonstrates that in HD patients&#44; prophylaxis with post-HD antibiotic locking of CVC limbs&#44; including G&#44; reduces morbidity and mortality from bacterial infection associated with CVCB &#40;number of CVCB&#47;CVC&#47;1000 days&#44; mortality and hospital admission due to CVCB&#41; compared with patients with heparin lock alone&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Bacterial resistance to G has been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> However&#44; our experience since July 2003 in patients with CVC attending to the unit and treated with G locking in doses lower than those given in other units &#40;a detail we consider fundamental due to iatrogenic effects&#41;&#44; no bacterial resistance or ototoxicity was demonstrated after 9 years of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Having seen our results&#44; we must refer to the publication by Beathar and Urbanes<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> in which they rate the quality of care of a HD unit according to the number of CVCB&#47;CVC&#47;1000 days it obtains when complete asepsis is employed&#44; an excellent result being a value &#8804;1&#46; In our case&#44; the practice of complete asepsis<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>prophylaxis meant that the number of CVCB&#47;CVC&#47;1000 days was 0&#46;17&#46; Although we are unable to compare another study&#44; in 9 years&#44; to obtain a mortality&#44; removal of CVC&#44; and hospital admission due to CVCB of 0&#46;8&#37;&#44; 2&#46;4&#37;&#44; and 3&#46;2&#37;&#44; respectively&#44; is an appreciable standard&#44; obtained thanks to G prophylaxis<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>universal asepsis&#46; This is further underlined by the absence of endocarditis or spondylodiscitis&#44; except for one patient who died due to sepsis&#46; Strict complete asepsis<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> for all handling procedures of CVC is integral to prophylaxis in reducing morbidity and mortality from bacterial infection associated with CVCB&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Conclusions&#46; This prospective observational study of 9 years&#8217; duration in 126 HD patients with a CVC showed&#58; &#40;1&#41; Prophylaxis with intraluminal G locking in CVC limbs does not cause antibiotic resistance in microorganisms sensitive to the antibiotic&#46; &#40;2&#41; There were no diagnoses of clinical ototoxicity&#44; and &#40;3&#41; Prophylaxis with administration of low-dose G &#40;compared with higher doses in other studies&#41;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> can result in the absence of resistance and ototoxicity&#46;</p></span>"
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Letter to the Editor – Brief papers about basic research or clinical experiences
Gentamicin-based prophylaxis in tunnelled indwelling central venous catheter limbs for haemodialysis do not result in bacterial resistances after a 9 year follow up period
La profilaxis con gentamicina de las ramas del catéter venoso central permanente tunelizado en hemodiálisis no causa resistencia bacteriana durante 9 años de evolución
Juan Fernandez-Gallego
Corresponding author
, Luis Cermeño, Edison Rudas
Servicio de Nefrología, Hospital Regional Universitario Carlos Haya, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Between July 2003 and June 2012&#44; 365 patients received dialysis in our unit&#46; 179 patients had an AV fistula&#46; 186 had a central venous catheter &#40;CVC&#41;&#59; of whom 60 were excluded because they had been treated within the previous month with gentamicin &#40;G&#41; for various reasons&#46; Of the 126 patients studied&#44; 118 had a CVC in the internal jugular vein and 8 had it in the femoral vein&#46; Any procedure involving the CVC employed a strict protocol of complete asepsis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleItalic">Prophylaxis</span>&#58; intraluminal post-HD locking with 5<span class="elsevierStyleHsp" style=""></span>mg Gentamicin &#40;G&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>sodium heparin at 1&#37; or 5&#37; per limb&#46; For 6 months&#44; the trough serum level of G was measured &#40;normal value&#58; 0&#46;2&#8211;2<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; subsequently changing to annual controls&#46; If the level was &#62;0&#46;3&#8211;0&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#44; we reduced the lock to 3<span class="elsevierStyleHsp" style=""></span>mg&#47;limb of G 0&#46;5&#8211;2<span class="elsevierStyleHsp" style=""></span>mg&#47;limb&#46; The diagnosis of CVCB was based on the criteria of Beathard and Urbanes<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> and the NKF guidelines on vascular access published in 2006<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#58; clinical improvement in a patient with fever treated with antibiotics with or without removal of CVC&#44; with positive blood cultures &#40;BC&#43;&#41; normally from blood taken from the HD line and&#47;or infrequently from the CVC limb&#44; having excluded other foci of infection&#46; All patients with CVCB had BC&#43;&#44; except one with BC&#8722;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Treatment of CVCB&#46; Gram positive organisms&#44; vancomycin 1<span class="elsevierStyleHsp" style=""></span>g at the 1st HD and 500<span class="elsevierStyleHsp" style=""></span>mg at subsequent HDs for 3&#8211;4 weeks&#44; or another antibiotics if appropriate&#59; Gram negative&#44; as indicated in the susceptibility testing&#44; for 3&#8211;4 weeks&#46; Key outcomes studied&#58; ototoxicity&#58; clinical hypoacusis and&#47;or vertigo&#46; Bacterial resistance to G&#58; organisms normally sensitive to G&#58; Gram&#43;&#58; coagulase negative <span class="elsevierStyleItalic">Staphylococcus aureus</span> sensitive to methicillin&#46; Gram&#8722;&#58; <span class="elsevierStyleItalic">Escherichia coli</span>&#44; <span class="elsevierStyleItalic">Proteus</span>&#44; <span class="elsevierStyleItalic">Serratia</span>&#44; <span class="elsevierStyleItalic">Klebsiella</span>&#44; <span class="elsevierStyleItalic">Enterobacter</span>&#44; <span class="elsevierStyleItalic">Pseudomona aeruginosa</span>&#44; etc&#46; The minimum inhibitory concentration &#40;MIC&#41; of G for these bacteria is &#8804;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#46; Resistance was detected from the results of BCs and susceptibility testing&#44; which expressed sensitivity &#40;S&#41; or resistance &#40;R&#41; to G and the MIC value for each organism&#46; We present the other variables studied in the results section&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Results&#46; The mean patient age was 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29 years &#40;21&#8211;85 years&#41;&#59; 60 patients &#40;48&#37;&#41; were women&#44; 39 patients &#40;31&#37;&#41; had diabetes&#46; The mean time each patient remained in the study was 24 months&#46; Thirty-eight patients were treated with prophylaxis for &#62;30 months &#40;30&#37; of all study patients&#41;&#44; mean time per patient was 50 months &#40;31&#8211;108&#41;&#46; On susceptibility testing&#44; no resistance was detected in G-sensitive bacteria&#58; the MCI was &#60;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#44; except in two cases of CVCB due to methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; and one case with BC&#40;&#8722;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">No patients had a diagnosis of ototoxicity&#46; The mean trough level of G per patient was 0&#46;17<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#40;0&#46;05&#8211;0&#46;31&#41;&#46; The mean G lock per limb per patient was 3<span class="elsevierStyleHsp" style=""></span>mg &#40;2&#8211;5&#41;&#44; equivalent to 1&#46;1&#8211;1&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#47;limb depending on the volume of the limb according to the type of catheter&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patients diagnosed with CVCB&#58; 11&#40;8&#46;7&#37;&#41;&#46; Patients admitted to hospital for CVCB&#58; 4 &#40;3&#46;2&#37;&#41;&#46; Number of CVCB&#47;CVC&#47;1000 days&#58; 0&#46;17&#46; CVC removed due to CVCB&#58; 3 patients &#40;2&#46;4&#37;&#41;&#46; Mortality due to CVCB&#58; 1 &#40;0&#46;8&#37;&#41;&#46; Number of CVCB&#58; 15&#44; <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#58; 8&#59; <span class="elsevierStyleItalic">Staphylococcus epidermidis</span>&#58; 4&#59; <span class="elsevierStyleItalic">Escherichia coli</span>&#58; 1&#59; <span class="elsevierStyleItalic">Streptococcus bovis</span>&#58; 1&#44; and BC&#40;&#8722;&#41;&#58; 1&#46; CVC was removed due to recurrent CVCB in one patient&#44; for failure to improve clinically of in one patient&#44; and due to BC&#40;&#8722;&#41; in one patient with clinical remission&#46; There were no other CVCB complications &#40;endocarditis&#44; spondylodiscitis&#41;&#44; except in one patient who died due to sepsis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Discussion&#46; The scientific literature demonstrates that in HD patients&#44; prophylaxis with post-HD antibiotic locking of CVC limbs&#44; including G&#44; reduces morbidity and mortality from bacterial infection associated with CVCB &#40;number of CVCB&#47;CVC&#47;1000 days&#44; mortality and hospital admission due to CVCB&#41; compared with patients with heparin lock alone&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Bacterial resistance to G has been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> However&#44; our experience since July 2003 in patients with CVC attending to the unit and treated with G locking in doses lower than those given in other units &#40;a detail we consider fundamental due to iatrogenic effects&#41;&#44; no bacterial resistance or ototoxicity was demonstrated after 9 years of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Having seen our results&#44; we must refer to the publication by Beathar and Urbanes<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> in which they rate the quality of care of a HD unit according to the number of CVCB&#47;CVC&#47;1000 days it obtains when complete asepsis is employed&#44; an excellent result being a value &#8804;1&#46; In our case&#44; the practice of complete asepsis<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>prophylaxis meant that the number of CVCB&#47;CVC&#47;1000 days was 0&#46;17&#46; Although we are unable to compare another study&#44; in 9 years&#44; to obtain a mortality&#44; removal of CVC&#44; and hospital admission due to CVCB of 0&#46;8&#37;&#44; 2&#46;4&#37;&#44; and 3&#46;2&#37;&#44; respectively&#44; is an appreciable standard&#44; obtained thanks to G prophylaxis<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>universal asepsis&#46; This is further underlined by the absence of endocarditis or spondylodiscitis&#44; except for one patient who died due to sepsis&#46; Strict complete asepsis<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> for all handling procedures of CVC is integral to prophylaxis in reducing morbidity and mortality from bacterial infection associated with CVCB&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Conclusions&#46; This prospective observational study of 9 years&#8217; duration in 126 HD patients with a CVC showed&#58; &#40;1&#41; Prophylaxis with intraluminal G locking in CVC limbs does not cause antibiotic resistance in microorganisms sensitive to the antibiotic&#46; &#40;2&#41; There were no diagnoses of clinical ototoxicity&#44; and &#40;3&#41; Prophylaxis with administration of low-dose G &#40;compared with higher doses in other studies&#41;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> can result in the absence of resistance and ototoxicity&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Fernandez-Gallego J&#44; Cerme&#241;o L&#44; Rudas E&#46; La profilaxis con gentamicina de las ramas del cat&#233;ter venoso central permanente tunelizado en hemodi&#225;lisis no causa resistencia bacteriana durante 9 a&#241;os de evoluci&#243;n&#46; Nefrologia&#46; 2015&#59;35&#58;418&#8211;419&#46;</p>"
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ISSN: 20132514
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