CLINICAL AND HISTOLOGICAL SKIN CHANGES IN CHRONIC RENAL FAILURE: EVIDENCE FOR A DIALYSIS-RESISTANT, TRANSPLANT- RESPONSIVE MICROANGIOPATHY
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Chronic rejection of human face allografts
2019, American Journal of TransplantationSkin Blood Flow and Vascular Endothelium Function in Uremia
2017, Journal of Renal NutritionCitation Excerpt :Their SBF at basal body temperature was not different from that in healthy subjects, but there was a 40% to 50% reduction in heat stimulated flow in diabetic patients compared with the nondiabetic control population.8 Significant microangiopathy was also found in both arterioles and venules in skin biopsy of “normal looking” skin in patients with end-stage kidney disease.9,10 Australian observational study did compare the arterial and venous size of the retinal vasculature in CKD Stages 1 to 2 versus CKD Stages 3 to 5 (n = 126 in each group).
Non-invasive evaluation of skin cytokines secretion: An innovative complementary method for monitoring skin disorders
2013, MethodsCitation Excerpt :CRF is accompanied by a variety of cutaneous manifestations as a consequence of CRF pathogenesis and Hemodyalisis (HD) treatments [36]. Symptoms such as pruritus, xerosis, hyperpigmentations and actinic elastosis have been described and have a considerable toll on quality of life [37–41]. Experimental studies demonstrate that CRF is a prooxidant state, characterized by increased levels of ROS relative to antioxidants.
Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus
2013, Acta HistochemicaCitation Excerpt :Such changes might be partly explained by atrophic changes in the epidermis as a consequence of inadequate skin nourishment. Namely, blood changes have been shown to be a constant and prominent pathological condition associated with skin of dialysis patients (Gilchrest et al., 1980). Our study also revealed extremely deep dermal papillae penetrating the epidermis in some skin samples of long-term dialysis patients, which may be explained by the increased need for epidermal nourishment which is executed through diffusion of nourishing molecules from the blood vessels situated in the papillae into the epidermis.
Noninvasive skin measurements to monitor chronic renal failure pathogenesis
2011, Biomedicine and PharmacotherapyCitation Excerpt :As a consequence of CRF pathogenesis and Hemodialysis (HD) treatments, dermal manifestations have been reported [1]. Symptoms such as pruritus, xerosis, hyperpigmentations and actinic elastosis have been described and have a considerable toll on quality of life [2–6]. Pruritus is the most distressing skin phenomenon affecting HD patients [7–9].