Preliminary CommunicationNATURE OF CONCENTRATING DEFECT IN SICKLE-CELL NEPHROPATHY: Microradioangiographic Studies
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2021, NefrologiaCitation Excerpt :Individuals with sickle cell trait carry a single allele affected by the hemoglobinopathy S mutation, while the other allele is normal. As observed by renal microangiography, they present distortion and destruction of the vasa rectus, although considerably less than patients with SCD.46 However, according to a meta-analysis published in 2018, hematuria is 2 times more frequent than in SCD.17
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2019, Blood ReviewsCitation Excerpt :Vaso-occlusion causes ischaemia in the renal medulla. Contributing factors include volume depletion due to hyposthenuria, frequent and chronic use of non-steroidal anti-inflammatory drugs (NSAIDS), infections, massive haemolysis and rhabdomyolysis [150–152]. Recent studies have established an association between episodes of acute kidney injury and progression to chronic kidney disease [153–157].
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