Elsevier

Transplantation Proceedings

Volume 33, Issues 7–8, November–December 2001, Page 3416
Transplantation Proceedings

Graft loss and death: changing causes after kidney transplantation

https://doi.org/10.1016/S0041-1345(01)02472-1Get rights and content

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Patients and methods

We analyzed the causes of graft loss and patient death among kidney transplant recipients. Patients were divided into cohorts who had transplants (for graft loss) or died within 10 years of transplantation (for cause of death analysis) during three periods: 1970 to 1979, 1980 to 1989, and 1990 to 1999. All patients are included. The data were analyzed using the chi-square test with Yates’ correction. A P-value of .05 was considered to be significant.

Results

Relatively more recipients of kidneys from cadaveric donors lost their grafts in the 1980 to 1989 and 1990 to 1999 decades than in the 1970 to 1979 period, but this difference reflects the relative number of cadaveric transplants performed in those periods. The number of patients with renal failure due to diabetes mellitus and patient age increased during the study. Patient age increased from 30.3 ± 14.4 years for 1970 to 1979, to 42.3 ± 17.2 for 1990 to 1999 (P < .05).

An increasing percentage

Discussion

There are many reasons for the improvement in the results of kidney transplantation. The better results have occurred despite transplanting higher risk patients. Because fewer grafts are being lost to rejection and other causes, it is not surprising that patients are living longer and die from cancer, stroke, and heart disease with grafts still functioning. Decreasing patient death after transplantation is becoming a more important method of increasing graft survival; a patient who dies with a

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