Graft loss and death: changing causes after kidney transplantation
Section snippets
Patients and methods
We analyzed the causes of graft loss and patient death among kidney transplant recipients. Patients were divided into cohorts who had transplants (for graft loss) or died within 10 years of transplantation (for cause of death analysis) during three periods: 1970 to 1979, 1980 to 1989, and 1990 to 1999. All patients are included. The data were analyzed using the chi-square test with Yates’ correction. A P-value of .05 was considered to be significant.
Results
Relatively more recipients of kidneys from cadaveric donors lost their grafts in the 1980 to 1989 and 1990 to 1999 decades than in the 1970 to 1979 period, but this difference reflects the relative number of cadaveric transplants performed in those periods. The number of patients with renal failure due to diabetes mellitus and patient age increased during the study. Patient age increased from 30.3 ± 14.4 years for 1970 to 1979, to 42.3 ± 17.2 for 1990 to 1999 (P < .05).
An increasing percentage
Discussion
There are many reasons for the improvement in the results of kidney transplantation. The better results have occurred despite transplanting higher risk patients. Because fewer grafts are being lost to rejection and other causes, it is not surprising that patients are living longer and die from cancer, stroke, and heart disease with grafts still functioning. Decreasing patient death after transplantation is becoming a more important method of increasing graft survival; a patient who dies with a
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Revisional bariatric surgery in a transplant patient
2017, International Journal of Surgery Case ReportsCitation Excerpt :These include wound healing complications, longer hospital stays, new onset diabetes, delayed graft function, acute organ rejection and reduced graft survival [5–8]. Medical weight loss regimens prior to kidney transplants have proven to have high failure rates, with patients spending years on the donor waitlist without achieving the target BMI, with 5% of potential candidates attaining a BMI of <30 when attempting conservative weight loss measures [9]. However, bariatric surgeries have now provided a new option for these patients.
Increase in Malignancies as Cause of Death in Renal Transplant Patients
2009, Transplantation ProceedingsCitation Excerpt :Thus it is important to know the causes of death and the changes in these causes that have taken place over time. As observed in many other global studies, the main cause of death among our transplant patients was cardiovascular disease.1–4 However, when the causes of death were compared for different posttransplantation times and according to the era of transplantation, interesting changes were observed in the incidence of these causes.
Risk factors for graft loss in pediatric renal transplant recipients after transfer of care
2016, Progress in Transplantation