13th Congress of the Asian Society of Transplantation: Advances in Kidney TransplantationKidney TransplantationOutcome of Lupus Nephritis After Entering Into End-Stage Renal Disease and Comparison Between Different Treatment Modalities: A Nationwide Population-Based Cohort Study in Taiwan
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Materials and Methods
This study obtained data from the catastrophic illness registration of the Taiwan National Health Insurance Research Database (NHIRD). The nationwide cohort includes data from all SLE patients in Taiwan's NHIRD. The NHIRD has been described in many studies [3]. This social health insurance system started in 1995 and covered more than 23 million residents by 2010. Representing approximately 99% of Taiwan's population, this study includes all patients with SLE from 1998 to 2009. The diagnosis in
Results
In total, 1998 SLE patients with ESRD were identified (Table 1). The mean age was 38.3 ± 16.0 years; 84.3% was female. The incidences of hypertension, diabetes mellitus, hyperlipidemia, cardiovascular disease, chronic liver disease, and cancer were 63.1%, 10.1%, 20.7%, 13%, 12.4%, and 2.5%, respectively. They received hemodialysis, peritoneal dialysis, or KT with the proportion of 82.1%, 9.8%, and 8.1%, respectively. In the KT group, the pretransplantation duration was 4.4 ± 3.1 years. The mean
Discussion
Costenbader et al reported that more lupus patients received hemodialysis and fewer received peritoneal dialysis [4]. The frequency of pre-emptive KT at ESRD onset increased slightly. Overall mortality rates did not change during the 12 years in the United States. A poor prognosis of ESRD in SLE patients had been reported from the southern part of Taiwan about 10 years ago [2]. Patients have been considered to receive peritoneal dialysis or kidney donation only when they were clinically stable
References (7)
End-stage renal disease in lupus: disease activity, dialysis, and the outcome of transplantation
Lupus
(1998)- et al.
Poor prognosis of end-stage renal disease in systemic lupus erythematosus: a cohort of Chinese patients
Lupus
(2003) - et al.
Predicting mortality of incident dialysis patients in Taiwan - a longitudinal population-based study
PLoS One
(2013)
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